FR3118874A1 - COSMETIC METAL SEQUESTRATION COMPOSITION - Google Patents

Abstract

COSMETIC COMPOSITION FOR METAL SEQUESTRATION A cosmetic composition including a metal chelation system includes a combination of ascorbic acid, ferulic acid, and phytic acid in a carrier system that includes water, and further includes one or more other ingredients to provide one of a variety of forms of cosmetic products. The cosmetic composition demonstrates removal of free metal ions in the material in contact with the cosmetic composition, the removal of free metal ions being in a range of at least about 40% and up to about 99%. Figure for abstract: NIL

Description

COSMETIC METAL SEQUESTRATION COMPOSITION

DOMAIN

The present invention relates to a cosmetic composition for keratinous tissue, in particular the skin, which includes a metal chelation system in a water-based carrier, which demonstrates a very effective chelation/sequestration of metals to minimize the formation of radicals free.

CONTEXT

UV exposure and environmental pollution can accelerate skin aging by producing free radicals in the skin. Antioxidants, including vitamin C, and other active ingredients protect cells from damage caused by oxidative stress by scavenging free radicals and inhibiting oxidation reactions. Topical application of antioxidants and other skin actives is widely used in skincare products to prevent skin aging. Antioxidants are known for their chemical properties which are associated with reduced tissue damage. Antioxidants are known to participate in the sequestration of chemically active species in order to prevent the formation of free radicals which can contribute to oxidative stress leading to skin aging. There remains a need for enhanced compositions which demonstrate greater efficacy in sequestering chemically reactive species, for example metal species which negatively impact biological pathways through the formation of free radicals.

SUMMARY

The disclosure relates to an antioxidant system and a cosmetic composition comprising the antioxidant system that demonstrates high efficacy in sequestering metal ions. The antioxidant system includes a combination of vitamin C, ferulic acid and phytic acid in a water-based system.

In certain embodiments, the disclosure provides a cosmetic composition comprising:

(a) a metal chelation system comprising:

i. ferulic acid; And

ii. phytic acid;

(b) ascorbic acid; And

(c) a carrier system comprising an aqueous phase.

In various embodiments, the cosmetic composition exhibits metal chelation and/or metal oxidation of at least one metal ion species. In certain specific examples, the metal ions which are chelated or oxidized are selected from the group consisting of iron and copper. In some embodiments, the cosmetic composition exhibits metal chelation or metal oxidation of one or more metal ions, or both. In certain particular embodiments, the cosmetic composition exhibits metal chelation or metal oxidation of iron and copper, each being characterized by an elimination of free metal ions in the material in contact with the cosmetic composition, the elimination of free metal ions being in a range of at least about 40% up to about 99% metal ion removal.

In various embodiments, the cosmetic composition is formed by providing the carrier system having an aqueous phase that includes water. In various embodiments, the carrier system may further comprise one or more additional ingredients, each of which is present in the aqueous phase or in another phase, such as an oil phase. In various embodiments, the one or more additional ingredients include one or more of the following: a glycol, a humectant, a preservative, a surfactant, a thickener, an active compound, or a combination thereof. In certain embodiments, the cosmetic composition may include one or more of these additional ingredients. In certain embodiments, the cosmetic composition may also include emulsifiers, emollients, perfumes, pH correctors, other cosmetically acceptable additives, or a combination thereof.

The cosmetic composition may be any suitable form, such as, without limitation, a single-phase solution comprising the aqueous phase, a multi-phase solution comprising at least one aqueous phase, an emulsion comprising an aqueous phase, such that, without limit, a water-in-oil emulsion, an oil-in-water emulsion, or a silicone-in-water emulsion. The cosmetic composition can be provided in a product form intended to be applied to keratinous tissue, such as, but not limited to, a skin care product or a hair care product, and can be a product such as, without limitation, hydroglycolic solution, micellar water, cream or lotion, toner, cleanser or make-up remover. The cosmetic composition of any of the product forms can be either a leave-on formulation or a rinse-off formulation.

In various embodiments, ascorbic acid is present in the cosmetic composition in a range of from about 5% to about 30% by weight, based on the weight of the composition, the ascorbic acid being present in a water/acid ratio ascorbic acid of between about 3:1 and about 10:1, based on the weight of the cosmetic composition.

In various embodiments, ferulic acid is present in the cosmetic composition in a range of about 0.2% to about 5% by weight, based on the weight of the composition.

In some embodiments, the cosmetic composition includes phytic acid present in the cosmetic composition in a range from about 0.25% to about 10% by weight, based on the weight of the composition.

In certain embodiments, the disclosure provides a cosmetic composition comprising:

(a) a metal chelation system comprising:

i. ferulic acid; And

ii. phytic acid, chlorogenic acid or a combination thereof;

(b) ascorbic acid; And

(c) a carrier system comprising an aqueous phase.

In certain embodiments, the disclosure provides a cosmetic composition comprising:

(a) a metal chelation system comprising:

i. ferulic acid; And

ii. phytic acid;

(b) ascorbic acid; And

(c) a carrier system comprising: an aqueous phase, and one or more additional components comprising a glycol, humectant, preservative, surfactant, thickener, active compound, emulsifier, emollient, or a combination thereof -this.

In certain embodiments, the disclosure provides a cosmetic composition comprising:

(a) a metal chelation system comprising:

i. ferulic acid present in a range from about 0.2% to about 5%;

ii. phytic acid present in a range from about 0.25% to about 10%;

(b) ascorbic acid present in a range from about 5% to about 30%; And

(c) a carrier system comprising an aqueous phase;

all amounts by weight, based on the weight of the composition.

In certain embodiments, the cosmetic composition comprises one or a combination of active compounds selected from the group consisting of vitamin E, carnosine, hyaluronic acid, panthenol, at least one sunscreen, at least one hydroxy acid, and combinations of these. In some embodiments, an active compound is selected from the group consisting of alpha, beta, or polyhydroxy acids selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, tartaric acid, citric acid, mandelic acid, lactobionic acid, gluconolactone, galactose and combinations thereof.

In some embodiments, the cosmetic composition is formed by providing the carrier system having an aqueous phase that comprises water and a glycol or a combination of glycols selected from the group consisting of: dipropylene glycol, pentylene glycol, hexylene glycol , ethoxydiglycol, a combination of dipropylene glycol and pentylene glycol, and a combination of dipropylene glycol and hexylene glycol. In these embodiments, the cosmetic composition includes water in a range from about 40% to about 75%, based on the weight of the cosmetic composition.

In various embodiments, the cosmetic composition further includes one or more additives selected from emulsifiers, emollients, fragrances, pH correctors and other cosmetically acceptable additives, or a combination thereof, and is free or essentially free of powders and solid particles, including but not limited to titanium dioxide, zinc oxide, tin oxide, iron oxides, mica, silica, ferric ferrocyanide , alumina, silicates, synthetic fluorphlogopite, polyethylene, polypropylene, polymethyl methacrylate, talc, pearlites, hectorites, bentonite, kaolin, pumice stone, boron nitride and combinations thereof. In certain particular embodiments, the cosmetic composition excludes propylene glycol or butylene glycol.

These and other aspects of the invention are set forth in the appended claims and further described in the Detailed Description of the Invention.

This disclosure describes exemplary embodiments in accordance with general inventive concepts and is not intended to limit the scope of the invention in any way. Indeed, the invention as described in the specification is broader than and not limited to the exemplary embodiments set forth herein, and the terms used herein have their full ordinary meaning.

It should be understood that the foregoing general description and the following detailed description are both exemplary and explanatory only and do not limit the disclosure.

DETAILED DESCRIPTION

“Cosmetically acceptable” means a vector which is compatible with any keratinous substrate.

"Keratinous substrate" and "keratinous tissue" each include, but are not limited to, skin, hair, and nails.

In various embodiments, the cosmetic composition includes a metal chelating system comprising the combination of ascorbic acid, ferulic acid, and phytic acid in a carrier system that includes water, and further includes a or more other ingredients to provide one of a variety of cosmetic product forms, the ingredients including, but not limited to, a glycol, humectant, preservative, surfactant, thickener, active compound, or combination of these. The cosmetic composition may also include emulsifiers, emollients, perfumes, pH correctors, other cosmetically acceptable additives or a combination thereof. For the avoidance of doubt, the cosmetic composition may include one or more of the additional ingredients. For example, the cosmetic composition can include one or more glycol(s), or one or more humectant(s), and the like. It will be understood that the additional ingredients, when present, are present in the carrier system in either an aqueous phase or an oil phase.

The cosmetic composition may be any suitable cosmetic composition, such as, without limitation, a single-phase solution comprising the aqueous phase, a multi-phase solution comprising at least one aqueous phase, an emulsion comprising an aqueous phase, such that, without limited thereto, a water-in-oil emulsion, an oil-in-water emulsion or a silicone-in-water emulsion. The cosmetic composition may be provided in a product form intended to be applied to keratinous tissue, such as, but not limited to, a skin care product or a hair care product, and may be a product form such as, but not limited to, hydroglycolic solution, micellar water, cream or lotion, toner, cleanser or makeup remover. The cosmetic composition of any of the product forms can be either a leave-on formulation or a rinse-off formulation.

In certain embodiments, the cosmetic composition according to the disclosure is a monophasic solution which comprises one or more solutes dissolved in one or more solvents to form a substantially homogeneous liquid which appears substantially clear to the naked eye. In such an embodiment, the cosmetic composition is a monophasic aqueous solution. In certain particular embodiments, the cosmetic composition is a hydroglycolic solution which comprises one or more glycols

The inventors have shown the astonishing and unexpected effect of the combination of ascorbic acid, ferulic acid and phytic acid as a powerful chelating/sequestering agent for metals. Thanks to this combination, the ability to chelate different metal ions such as iron and copper was increased in a representative cosmetic composition comprising a hydroglycolic solution. The combination of ascorbic acid, ferulic acid and phytic acid was found to be the most chelating compared to any other combination. Through a combination of oxidation and coordination, the level of copper and iron (II) has been kept to a minimum in the cosmetic composition in order to decrease or eliminate oxidative reaction catalysis by metal ions and to minimize thus oxidative stress in the treated keratinous tissues.

In various embodiments, the cosmetic composition exhibits metal chelation and/or metal oxidation of at least one metal ion species. In some embodiments, the cosmetic composition exhibits metal chelation and/or metal oxidation, or both, of one or more metal ions. In certain particular embodiments, the cosmetic composition exhibits metal chelation or metal oxidation of iron and copper, each characterized by the elimination of free metal ions in a material, for example a fluid or a keratinous substrate, contacted with the cosmetic composition, removal of free metal ions in a range from at least about 40% to about 99% removal of metal ions.

System of metal chelation and ascorbic acid optional

In accordance with the disclosure, embodiments of the cosmetic composition include a metal chelating system comprising a combination of ferulic acid and phytic acid. In some embodiments, the chelating system includes ferulic acid and phytic acid or chlorogenic acid, or both. In some embodiments, the cosmetic composition includes in the chelation system ferulic acid and phytic acid. In yet other embodiments, the cosmetic composition includes ascorbic acid, ferulic acid, and phytic acid. In addition to the metal chelating system, the cosmetic composition may, in certain embodiments, include ascorbic acid (vitamin C).

In certain embodiments, the pH of the cosmetic composition in the range of about 3.0 to about 4.0, and more particularly about 3.5, ensures that greater than 82% of the ascorbic acid remains under a protonated, uncharged form, as disclosed in U.S. Patent No. 5,140,043, August 18, 1992, the full disclosure of which is incorporated by reference herein. Ascorbic acid can be provided by the addition of any reducing analog of ascorbic acid, such as D-isoascorbic acid, or by the addition of other small reducing compounds such as, but not limited to, glutathione, L-cysteamine, and others. These forms would be expected to provide a composition equivalent to that claimed and fall within the scope of the invention.

In the various embodiments, the cosmetic composition includes ferulic acid, which is a derivative of cinnamic acid. Cinnamic acid or a derivative thereof includes ferulic acid, p-coumaric acid, caffeic acid, sinapinic acid, chlorogenic acids, caftaric acid, chicoric acid, coutaric acid, rosmarinic acid, their derivatives and their combinations. Their equivalents include cinnamic acid derivatives having substitutions on the hydroxyl groups of the aromatic ring, such as short-chain aliphatic groups (one to six carbon atoms) or long-chain aliphatic groups (seven to twenty-four carbon atoms). carbon) to form an ether, or such alkyl, alkoxy, hydroxyl, amino or amido substituted aliphatic groups, for example, to form a substituted ether. Their equivalent derivatives also include cinnamic acid derivatives whose methoxy group(s) of the aromatic ring has (have) been modified into short-chain aliphatic groups (2 to 6 carbon atoms) or aliphatic groups long chain (7 to 24 carbon atoms) to form a longer chain ether, or such aliphatic groups substituted by alkyl, alkoxy, hydroxyl, amino or amido, for example, to form a substituted long chain ether. The 3-carboxy group of a cinnamic acid derivative can also be converted to esters or amides having aliphatic groups of up to 24 carbon atoms or an aromatic group, for example. Both cis and trans isomers of cinnamic acid derivatives are included here because the cis isomer is readily converted to the trans isomer. Salts of cinnamic acid derivatives are included here. In one embodiment, the cinnamic acid derivative is a triethanolamine salt. Caffeic acid, also known as 3-(3,4-dihydroxyphenyl)-2-propenoic acid, is found in many fruits, vegetables, seasonings, and beverages consumed by humans. Caffeic acid is present in these products in conjugated forms such as chlorogenic acid. Para-coumaric acid, also known as 3-(4-hydroxyphenyl)-2-propenoic acid or p-hydroxycinnamic acid, is found in various plants, including lignin-forming plants. Trans-ferulic acid, also known as 3-(4-hydroxy-3-methoxyp-henyl)-2-propenoic acid or 4-hydroxy-3-methoxycinnamic acid, is also widely distributed in small amounts in plants. Sinapinic acid, also known as 3,5-dimethoxy4-hydroxycinnamic acid, comes from black mustard seeds. Caffeic acid, para-coumaric acid, trans-ferulic acid and sinapinic acid are commercially available from Sigma-Aldrich.

In various embodiments, the cosmetic composition comprises at least one phytic acid and one chlorogenic acid or a combination of these two acids. In certain particular embodiments, the cosmetic composition comprises phytic acid. Phytic acid is also known as phytate and is a sixfold dihydrogen phosphate ester of inositol (specifically, the myo isomer), also known as inositol hexakisphosphate (IP6) or inositol polyphosphate. At physiological pH, phosphates are partially ionized, yielding the phytate anion. Phytic acid is found naturally in the seeds of plants and is a storage form of phosphorus. In certain other embodiments, the cosmetic composition includes chlorogenic acid. Chlorogenic acid is also known as chlorogenate or 3-caffeoylquinate and belongs to the class of organic compounds known as quinic acids and derivatives. Chlorogenic acid is the ester of caffeic acid (a hydroxycinnamic acid related to ferulic acid, as described above) and (-)-quinic acid.

In some embodiments, the composition further includes ascorbic acid.

In various embodiments, each skin active in at least one skin active or combination of skin actives comprises at least one of ascorbic acid, cinnamic acid derivative and vitamin E or a combination thereof. ci, wherein the combination is present in the cosmetic composition at a concentration of, from about 15% to about 30%, and in some embodiments, from about 16% to about 30%, and in some embodiments, of about 16% to about 25%, and in some embodiments, about 16.5% to about 24%, or any suitable intermediate combination, sub-combination, range or sub-range by weight, based on the weight of the cosmetic composition.

Cinnamic acid derivatives, including but not limited to ferulic acid, and triethanolamine salts may be present in cosmetic compositions in an amount from about 0.1% to about 5%, and in some embodiments, from about 0.1% to about 3%, and in some embodiments, from about 0.5% to about 1.0%, or any combination, sub-combination, range or sub-range suitable intermediate by weight, based on the weight of the cosmetic composition.

Phytic acid may be present in the cosmetic compositions in an amount from about 0.5% to about 5%, and in some embodiments from about 1% to about 4%, and in some embodiments, from about 1% to about 2%, or any suitable intermediate combination, sub-combination, range or sub-range by weight, based on the weight of the cosmetic composition. As exemplified in this disclosure, the phytic acid raw material is provided at a 50% dilution, so the exemplified weight percentages in the cosmetic compositions are multiplied by 0.5 to obtain the final weight percentage of phytic acid. .

The chlorogenic acid may be present in the cosmetic compositions in an amount from about 0.5% to about 1.5%, and in some embodiments, from about 1% to about 1.5%, and in some embodiments, from about 1.1% to about 1.2%, or any suitable intermediate combination, sub-combination, range or sub-range by weight, based on the weight of the cosmetic composition.

Ascorbic acid and its derivatives may be present in the cosmetic composition in an amount of from about 1% to about 30%, and in some embodiments, from about 5% to about 25%, and in some embodiments , from about 10% to about 20%, and in some embodiments, from about 10% to about 15%, or any suitable intermediate combination, sub-combination, range or sub-range by weight, based on the weight of the cosmetic composition.

Phytic acid, carnosine, chlorogenic acid, hyaluronic acid, panthenol may be present in the cosmetic composition in an amount from about 0.1% to about 5%, and in certain embodiments, d about 0.1% to about 3%, and in some embodiments, about 0.5% to about 1.0%, or any suitable combination, sub-combination, range or sub-range in between by weight, based on the weight of the cosmetic composition.

Thus, in various embodiments, each of the components of the metal chelation system and optionally ascorbic acid is present in a composition according to the disclosure, and each of the individual components within the ranges as described above, from about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0 .40, 0.50, 0.60, 0.70, 0.80, 0.90, 1, 0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 , 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28 to about 30 percent by weight, including increments and ranges in between.

In various embodiments, the cosmetic composition exhibits metal chelation and/or metal oxidation of at least one metal ion species. In certain specific examples, the metal ions which are chelated or oxidized are selected from the group consisting of iron and copper. In some embodiments, the cosmetic composition exhibits metal chelation or metal oxidation of one or more metal ions, or both.

In certain particular embodiments, the cosmetic composition exhibits metal chelation or metal oxidation of iron and copper, each characterized by elimination of free metal ions in the material in contact with the cosmetic composition, elimination of free metal ions being in a range of at least about 40% and up to about 99% metal ion removal.

In certain particular embodiments, it is observed that an antioxidant solution of ferulic acid or phytic acid, to which metal is added in a ratio of 1:1 and 1:10, metal to antioxidant, allows an elimination metal ions characterized by the aggregation/elimination of free metal ions. In some examples, as shown here, phytic acid helps to decrease free radicals in a fluid or on a keratinous substrate by chelating metal, particularly iron ions, and ferulic acid helps to decrease free radicals in a fluid or on a keratinous substrate by chelating the metal, in particular the copper ions. In certain particular embodiments, as exemplified herein, phytic acid chelates/removes metal, particularly iron, to thereby decrease the amount of iron ions by about 60%, and about 80%, thereby leaving an iron residue of about 20% and about 40% in respective examples. And according to such exemplified embodiments, ferulic acid chelates/removes metal, particularly copper, to decrease the amount of copper ions by about 60% and about 90%, thereby leaving an amount of copper residual of about 10% and about 40% in respective examples.

Thus, in various embodiments, the cosmetic composition comprising a metal chelating system exhibits chelation or elimination of one or a combination of metal ions in a fluid or on a keratinous substrate in a range of approximately 40% to about 99%, or about 40% to about 90%, or about 40% to about 80%, or about 80% to about 90%, or about 40, 41, 42, 43 , 44, 45, 46, 47, 48, 49, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 to approximately 99%, including increments and ranges in between.

System of vector

In various embodiments, the cosmetic composition is formed by providing a carrier system having an aqueous phase that includes water.

E At

According to the various embodiments, water is present in the cosmetic compositions in a range from about 10% to about 95%, and in some embodiments, from about 25% to about 80%, and in some embodiments, about 40% to about 65%, and in some embodiments, about 55% to about 60%, or any suitable intermediate combination, sub-combination, range or sub-range by weight, based on the weight of the cosmetic composition. In accordance with the particular embodiments in which the cosmetic composition is a hydroglycolic solution, water is present in the cosmetic compositions in a range from about 40% to about 75%, and in certain embodiments, from about 45% to about 70%, and in some embodiments from about 50% to about 65%, and in some embodiments from about 55% to about 60%, and in some embodiments, from about 68% or any suitable intermediate combination, sub-combination, range or sub-range by weight, based on the weight of the cosmetic composition. However, those skilled in the art will appreciate that other ranges fall within the scope of the invention. Thus, the water is present, by weight, relative to the total weight of the cosmetic composition, at a rate of approximately 40, 41, 42, 43, 44.45, 46, 47, 48, 49, 50, 51, 52 , 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, at about 75 percent, in weight, including intermediate increments and ranges. Those skilled in the art will however appreciate that other ranges fall within the scope of the invention.

The water used can be chosen from, for example, sterile demineralised water and/or floral water such as rose water, cornflower water, chamomile water or lime water, and/or a natural thermal or mineral water such as, for example: water from Vittel, water from the Vichy basin, water from Uriage, water from Roche Posay, water from La Bourboule, water from Enghien-les-Bains, water from Saint Gervais-les-Bains, water from Néris-les-Bains, water from Allevar-les-Bains, water from Digne, water from Maizières, water from Neyrac-les-Bains, water from Lons-le-Saunier, water from Eaux Bonnes, water from Rochefort, water from Saint Christau, water from Fumades, water from Tercis-les-Bains or water from Avène. The aqueous phase may also include reconstituted thermal water, i.e. water comprising trace elements such as zinc, copper, magnesium, etc. restoring the characteristics of thermal water.

The pH of the cosmetic composition is not limited but is generally between 3.0 and 4.0, and in some embodiments between 3 and 3.5. The pH can be adjusted to the desired value by adding a base (organic or inorganic) to the cosmetic composition, for example ammonia or a primary, secondary or tertiary (poly)amine, such as monoethanolamine, diethanolamine , triethanolamine, isopropanolamine or 1,3-propanediamine, or by adding an inorganic or organic acid, advantageously a carboxylic acid, such as citric acid. A skilled person will understand that pH is a measure of the concentration of hydrogen ions in water which is determined by measuring the electrode potential using electrodes attached to a pH meter. It will also be understood that due to the inherent variability in pH measurements, a skilled person would anticipate at least 10% variability in pH measurements of compositions such as those described herein when measured in a typical laboratory by a typical skilled person using a typical pH meter.

Other ingredients

In various embodiments, the cosmetic composition also includes an additional ingredient, such as, but not limited to, a glycol, humectant, preservative, surfactant, thickener, active compound, or a combination thereof. To avoid any ambiguity, the cosmetic composition can include one or more of these additional ingredients. For example, the cosmetic composition can include one or more glycol(s), or one or more humectant(s), and the like. It will be understood that the additional ingredients, when present, are present in the carrier system in either an aqueous phase or an oil phase.

The cosmetic composition may be any suitable cosmetic composition, such as, without limitation, a single-phase solution comprising the aqueous phase, a multi-phase solution comprising at least one aqueous phase, an emulsion comprising an aqueous phase, such that, without limited thereto, a water-in-oil emulsion, an oil-in-water emulsion, or a silicone-in-water emulsion. The cosmetic composition can be provided in a product form intended to be applied to keratinous tissue, such as, but not limited to, a skin care product or a hair care product, and can be a product such as, but not limited to, hydroglycolic solution, micellar water, leave-in cream or lotion, toner, cleanser or makeup remover.

In certain embodiments, the cosmetic composition comprises one or a combination of active compounds selected from the group consisting of vitamin E, carnosine, hyaluronic acid, panthenol, at least one sunscreen, at least one hydroxy acid, and combinations of these. In some embodiments, an active compound is selected from the group consisting of alpha, beta, or polyhydroxy acids selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, tartaric acid, citric acid, mandelic acid, lactobionic acid, gluconolactone, galactose and combinations thereof.

In various embodiments, the cosmetic composition further includes one or more additives selected from emulsifiers, emollients, perfumes, pH correctors, other cosmetically acceptable additives, or a combination thereof, and is free or essentially free of powders and solid particles, including but not limited to titanium dioxide, zinc oxide, tin oxide, iron oxides, mica, silica, ferric ferrocyanide , alumina, silicates, synthetic fluorphlogopite, polyethylene, polypropylene, polymethyl methacrylate, talc, pearlites, hectorites, bentonite, kaolin, pumice stone, boron nitride and combinations thereof. In certain particular embodiments, the cosmetic composition excludes propylene glycol or butylene glycol.

Humectants/Glycols

In accordance with the disclosure, one or more humectants may be present in the cosmetic composition.

In certain embodiments, the humectant can comprise one or more of the polyols, including, for example, hexylene glycol, dipropylene glycol, glycerin, glycerol, glycols such as caprylyl glycol, butylene glycol, propylene glycol, isoprene glycol, polyethylene glycol, monoethylene glycol, diethylene glycol, triethylene glycol, diethylene glycol, hexylene glycol, glycol ethers, such as monopropylene alkyl(C1-C4)ethers , dipropylene and tripropylene glycol, squalane, triacetin, sugars, such as glucose, xylitol, maltitol, sorbitol, sucrose, pentaerythritol, inositol, pyrrolidone carboxylic acid, lactic acid, lithium chloride, acetamide MEA, sodium lactate, urea, dicyanamide, hyaluronic acid, aloe vera, honey and seaweed extract.

In accordance with certain embodiments, the glycols, when present, may be present in the cosmetic composition alone or with at least one other glycol, each glycol being present in an amount that is within a range of about 0 1% to about 30%, or from about 5% to about 25%, or from about 10% to about 15%, or any suitable intermediate combination, sub-combination, range or sub-range by weight, based on weight of the composition, by weight, relative to the weight of the cosmetic composition. In some embodiments, the total amount of glycol is less than about 30%, for example, the total is about 29.5%, or about 29%. As indicated herein, certain glycols, when present alone in the cosmetic composition, are present in an amount which is at least about 8%, or at least about 8.5%, or at least about 9%, or at least about 9.5%, or at least about 10%, or at least about 10.5%.

Thus, in various embodiments, each of the glycols is present in a cosmetic composition according to the disclosure, each alone and/or in combination as described in the paragraphs presented above from approximately 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.5, 2, 3, 4, 5, 6, 7, 8, 9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29 less than about 30% by weight , including intermediate increments and ranges.

In some embodiments, the composition includes a glycolic humectant selected from the group consisting of hexylene glycol, dipropylene glycol, pentylene glycol, propylene glycol, ethoxydiglycol, and combinations thereof. In some embodiments, the composition includes ethoxydiglycol, propylene glycol and pentylene glycol, or hexylene glycol, pentylene glycol and dipropylene glycol, or dipropylene glycol, or hexylene glycol and dipropylene glycol. In some embodiments, the composition includes glycerin.

According to the various embodiments, the amount of humectant present in the cosmetic composition can vary from about 1% to about 10%, or from about 1% to about 8%, or from about 1% to about 5%, or from about 2% to about 3%, or any suitable intermediate combination, sub-combination, range or sub-range by weight, based on the weight of the composition. Those skilled in the art will however appreciate that other ranges fall within the scope of the invention.

Thus, any humectant or combination of humectants, when present, may be present, by weight, based on the total weight of the composition, between about 1, 2, 3, 4, 5, 6, 7, 8 , 9, and about 10 percent, by weight, based on the weight of the cosmetic composition, including increments and ranges in between.

Conservatives

In accordance with the disclosure, one or more preservatives and/or antimicrobials may be present in the composition. Any preservative commonly used in cosmetic formulations is an acceptable preservative for the cosmetic compositions mentioned herein, such as phenoxyethanol, members of the paraben family such as methyl, ethyl, propyl, butyl or isobutyl parabens, 4-hydroxybenzoic acid , benzoic acid, sorbic acid, dehydroacetic acid, triclosan, benzyl alcohol, chlorophenesin or salicylic acid, for example. For more concentrated amounts of solvents suitable for optional additives, especially solvents suitable for antimicrobials and preservatives, members of the paraben family can be used as a preservative.

In some embodiments, the preservative may include one or more preservatives selected from the group consisting of organic acids, parabens, formaldehyde donors, phenol derivatives, quaternary ammoniums, alcohols, isothiazolinones and combinations thereof. Preservatives having antibacterial activity are optionally present in the cosmetic compositions of the present invention. Examples of organic acid preservatives include, but are not limited to, sodium benzoate, potassium sorbate, benzoic acid and dehydroacetic acid, sorbic acid, and combinations thereof. A preferred organic acid preservative system includes a mixture of sodium benzoate and potassium sorbate. Examples of paraben preservatives include, but are not limited to, alkyl para-hydroxybenzoates, in which the alkyl radical has 1, 2, 3, 4, 5 or 6 carbon atoms and for example 1 to 4 eg, methyl para-hydroxybenzoate (methylparaben), ethyl para-hydroxybenzoate (ethylparaben), propyl para-hydroxybenzoate (propylparaben), butyl para-hydroxybenzoate (butylparaben) and para-hydroxybenzoate isobutyl (isobutylparaben). Examples of formaldehyde-donating preservatives include, but are not limited to, 1,3-dimethylol-5,5-dimethylhydantoin (DMDM hydantoin), imidazolidinyl urea, gluteraldehyde, and combinations thereof. Examples of quaternary ammonium preservatives include, but are not limited to, benzalkonium chloride, methene ammonium chloride, benzethonium chloride, and combinations thereof. Examples of alcohol preservatives include, but are not limited to, ethanol, benzyl alcohol, dichlorobenzyl alcohol, phenoxyethanol, and combinations thereof. Examples of isothiazolone preservatives include, but are not limited to, methylchloroisothiazolinone, methylisothiazolinone, and combinations thereof.

Other suitable preservatives include, but are not limited to, chloracetamide, triclosan and iodopropynyl butylcarbamate, pyridine derivatives (e.g., pyrithione and zinc pyrithione), chlorphenesin, phenylmercuric salts, phenoxyethanol and other known preservative systems.

In some embodiments, the preservative includes one or more preservatives, present at a concentration, by weight, of from about 0.001% to about 5%, or from about 0.05% to about 2.5% or from about 0.1% to about 2.0%, based on the weight of the composition.

Thus, any one of the preservatives or a combination thereof, when present, may be present, by weight, based on the total weight of the composition, at a concentration of about 0.001, 0.002, 0.003, 0.004 , 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03 ,0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 1.0 , 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4, at about 5% by weight, including intermediate increments and ranges.

surfactant

In accordance with the disclosure, the various non-limiting embodiments of the cosmetic composition may optionally include at least one surfactant. And In accordance with the disclosure, the various non-limiting embodiments of the cosmetic composition that include an oil, for example, but not limited to, a vitamin E component, such as tocopherol, may optionally include at least one surfactant . In some embodiments, the cosmetic composition does not contain oil. In some embodiments, the cosmetic composition does not include a surfactant. In certain embodiments, the cosmetic composition comprises at least one oil, for example, tocopherol, with at least one surfactant. In some embodiments, the cosmetic composition includes at least one oil with more than one surfactant. In certain embodiments, the cosmetic composition comprises at least one oil without any surfactant, the total quantity of oil present not inhibiting the formation of the cosmetic composition in the form of a clear monophasic solution.

The at least one surfactant can be a nonionic, cationic, anionic or zwitterionic surfactant. The at least one surfactant may be chosen from the group consisting of polyoxyethylenated sorbitan monolaurate, laureth-23, polyoxyethylated octylphenol, 3-((3-cholamidopropyl) dimethylammonio)-1 propane sulfonate, dilauramidoglutamide lysine sodium, cholate, deoxycholate, sodium dodecyl sulfate, TWEEN-80, and combinations thereof. At least one surfactant can exclude esters. The at least one surfactant may be present in the cosmetic composition in a range ranging from about 1% to about 5%, based on the weight of the cosmetic composition.

In certain particular embodiments, the at least one surfactant, when present, comprises polyoxyethylene sorbitan monolaurate and laureth-23, or a combination thereof.

In various embodiments, the at least one surfactant present, when present, may be present at from about 1% to about 5% by weight of the cosmetic composition, and in some embodiments, at from about 1% to about 2%, and in some embodiments, from about 3% to about 6%, and in some embodiments, from about 3% to about 4.5%, or any suitable intermediate combination, sub-combination, range or sub-range by weight, based on the weight of the cosmetic composition. In some embodiments, laureth-23 may be present at about 1% to about 5% by weight of the cosmetic composition, and in some embodiments, at about 3% to about 4.5 %, or any suitable intermediate combination, sub-combination, range or sub-range by weight, based on the weight of the cosmetic composition. In some embodiments, the polyoxyethylene sorbitan monolaurate may be present at about 1% to about 5% by weight of the cosmetic composition, and in some embodiments, at about 1% to about 2% , or any suitable intermediate combination, sub-combination, range or sub-range by weight, based on the weight of the cosmetic composition. In some embodiments, the cosmetic composition includes more than one surfactant. Those skilled in the art will however appreciate that other ranges fall within the scope of the invention.

Thus, in various embodiments, when present, each of the at least one surfactant may be present in a composition according to the disclosure from about 1, 2, 3, 4, to about 5 percent, by weight , including intermediate increments and ranges.

Thickened polymeric ss

According to the various embodiments, the composition can include one or more polymeric thickeners. In some embodiments, the thickener(s) may be selected from one or more natural gums and synthetic polymers, for example, the thickener may be selected from the group consisting of starches (corn, rice, tapioca, potato), gums (carrageenan, xanthan, gellan, sclerotia, tarabiotech fermentation). In certain particular embodiments, the thickener can be chosen from acrylates/C10-30 alkyl acrylates, carbomer, xanthan gum, cross-linked polymer of hydroxypropyl guar, ceratonia siliqua (locust bean) gum, polyacryloyldimethyl taurate of ammonium, cross-linked polymer of ammonium acryloyldimethyltaurate/steareth-25 methacrylate and cross-linked polymer-6 of polyacrylate.

In certain embodiments, the polymeric thickener may be one of a carbomer, cross-linked polymer of acrylates/C10-30 alkyl acrylates, cross-linked polymer-6 of polyacrylate, microcrystalline cellulose (and) cellulose gum, xanthan gum, sodium carboxymethyl starch, sclerotium gum (and) xanthan gum, xanthan gum (and) ceratonia siliqua (locust bean) gum (50/50), dehydroxanthan gum, hydroxypropyl starch phosphate, sclerotium (and) xanthan gum (75/25), sclerotium gum, xanthan gum (and) sclerotium gum (and) lecithin (and) pullulan, or combinations thereof.

In some embodiments, the composition may include two or more polymeric thickeners. The amount of the at least one polymeric thickener, when present, may be present in the composition in a range of from about 0.01% to about 2%, or from about 0.01% to about 1, 5%, or from about 0.3% to about 1.2%, or any suitable intermediate combination, sub-combination, range or sub-range by weight, based on the weight of the composition. Those skilled in the art will however appreciate that other ranges fall within the scope of the invention.

In some embodiments, the total amount of polymeric thickener in the composition, when present, is between about 0.01% and about 5%, or between about 0.02% and about 2%, or between about 0.03% and about 1.5%, or between about 0.1% and about 0.2%, or any suitable intermediate combination, sub-combination, range or sub-range by weight, based on the weight of the composition . Those skilled in the art will however appreciate that other ranges fall within the scope of the invention.

Thus, one or more polymeric thickeners, when present, are present by weight, based on the total weight of the composition, from about 0.01, 0.02, 0.03, 0.04, 0, 05, 0.06, 0.07, 0.08, 0.09, 1, 0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3, 0, 3.5, 4.0, 4.5 to approximately 5.0 percent, including increments and ranges in between.

Active compounds optional

In accordance with the disclosure, embodiments of the cosmetic composition may include one or more additional compounds selected from active compounds, in particular actives for keratinous tissues, such as, without limitation, actives for the skin. In some embodiments, the optional active compounds may be selected from the group consisting of: vitamins, eg, vitamin E, carnosine, hyaluronic acid, panthenol, at least one sunscreen, at least one hydroxy acid, and combinations thereof. In some embodiments, an active compound is selected from the group consisting of alpha, beta, or polyhydroxy acids selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, tartaric acid, citric acid, mandelic acid, lactobionic acid, gluconolactone, galactose and combinations thereof. To avoid any ambiguity, the cosmetic composition can include one or more of the optional active compounds. For example, the cosmetic composition can include one or more hydroxy acids, one or more vitamins, and the like.

Vitamin E can be selected from the group consisting of alpha-tocopherol, beta-tocopherol, delta-tocopherol, gamma-tocopherol, and alpha-tocotrienol, beta-tocotrienol, delta-tocotrienol, gamma-tocotrienol and their derivatives. The salts or derivatives of tocopherols include pharmaceutically acceptable compounds such as acetate, sulphate, succinate, nicotinate, palmitate, allophanate, phosphate, quinone, or halogenated derivatives, esters or stereoisomers, For example. The invention includes the use of vitamin E derivatives in which substitutions, additions and other modifications have been made in the ring and/or side chain of the 6-chromanol, provided that the derivatives retain the antioxidant activity of vitamin E. Additional tocopherols can be constructed by conjugation to the ring structure or side chain of various other moieties, such as those containing oxygen, nitrogen, sulfur and/or sulfur. phosphorus. Tocopherol derivatives can also be prepared by altering the length of the side chain from that not found in tocopherols such as alpha-, beta-, delta-, and gamma-tocopherol. Tocopherols can also vary in stereochemistry and bond saturation in ring structure and side chain. Other tocopherol derivatives, including prodrugs, can be prepared by conjugation of sugars or other moieties to the side chain or ring structure. Tocopherols include without limitation stereoisomers (e.g., the + and - stereoisomers of alpha-tocopherol; (+/-) indicates a racemic mixture) or mixtures of structurally distinct tocopherols (e.g., alpha-plus gamma-tocopherol ). Tocopherols can be obtained from Roche, Nutley, N.J., for example.

In some embodiments, additional actives may also include at least one hydroxy acid selected from alpha, beta, or polyhydroxy acids. Thus, in various embodiments, a hydroxy acid may be selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, tartaric acid, citric acid, mandelic acid, lactobionic acid, gluconolactone, galactose and combinations thereof.

In certain embodiments, additional actives may also include one or more of the antioxidants selected from the group consisting of mangiferin, baicalin, resveratrol, tannic acid, polyphenols, amino acids and their derivatives, imidazoles, carnosine derivatives, carotenoids, carotenes ( such as α-carotene, β-carotene and lycopene), vitamin A, co-enzyme Q10, bioflavonoids, glutathione, plant extracts (such as rosemary extract, olive leaf extracts), green tea extracts and combinations thereof.

In certain particular embodiments, the cosmetic composition includes a combination of active compounds present in the cosmetic composition including tocopherol, panthenol, hyaluronic acid, a hydroxy acid, carnosine, or a combination thereof.

Generally, each of the optional active compounds is present in the cosmetic composition in an amount from about 0.1% to about 30%, and in some embodiments, from about 0.5% to about 30%, and in some embodiments from about 0.5% to about 15%, and in some embodiments from about 0.1% to about 1%, and in some embodiments from about 1% to about 2%, or any suitable intermediate combination, sub-combination, range or sub-range by weight, based on the weight of the cosmetic composition.

Vitamin E and its derivatives, including but not limited to tocopherol, may be present in the cosmetic compositions in an amount of from about 0.5% to about 2%, and in some embodiments, from about 0.5% to about 1%, and in some embodiments, from about 1% to about 2.0%, or any suitable intermediate combination, sub-combination, range or sub-range by weight, based on the weight of the cosmetic composition.

Carnosine, hyaluronic acid, panthenol, may be present in the cosmetic compositions in an amount of about 0.1% to about 5%, and in some embodiments, about 0.1% to about 3 %, and in some embodiments, from about 0.5% to about 1.0%, or any suitable intermediate combination, sub-combination, range or sub-range by weight, based on the weight of the cosmetic composition.

Carnosine may be present in the cosmetic compositions in an amount from about 0.10% to about 1%, and in some embodiments, from about 0.20% to about 0.5%, and in some embodiment, from about 0.20% to about 0.25%, or any suitable intermediate combination, sub-combination, range or sub-range by weight, based on the weight of the cosmetic composition.

Hyaluronic acid may be present in cosmetic compositions in an amount from about 0.01% to about 1%, and in some embodiments from about 0.01% to about 0.1%, and in some embodiments, from about 0.05% to about 0.07%, or any suitable intermediate combination, sub-combination, range or sub-range by weight, based on the weight of the cosmetic composition.

Panthenol may be present in the cosmetic compositions in an amount from about 0.1% to about 1%, and in some embodiments from about 0.1% to about 0.5%, and in some embodiment, from about 0.2% to about 0.4%, and in some embodiments, from about 0.2% to about 0.25%, or any combination, sub-combination, range or sub-range suitable intermediate by weight, based on the weight of the cosmetic composition.

A hydroxy acid may be present in the cosmetic compositions in an amount from about 0.25% to about 10%, and in some embodiments, from about 0.5% to about 8%, and in some embodiments, from about 1% to about 5%, and in some embodiments, from about 0.25% to about 0.5%, or any suitable intermediate combination, sub-combination, range or sub-range by weight, reported to the weight of the cosmetic composition.

Thus, in various embodiments, the optional active compounds, if present, are present in a composition according to the disclosure, and each of the individual components within the ranges described above, of about 0.01, 0, 02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28 to about 30 percent by weight, including increments and ranges in between.

Optional Additives

The compositions may also comprise at least one additive used in the cosmetics field which does not affect the properties of the compositions according to the invention, such as emulsifiers, emollients, perfumes, pH-correcting agents (citric acid, sodium chloride; neutralizing or pH-correcting agents (eg, triethanolamine (TEA) and sodium hydroxide), and combinations thereof), other cosmetically acceptable additives, such as, but not limited to, beading agents, silica and dyestuffs; essential oils; fruit extracts, for example, Pyrus Malus (apple) fruit extract, and Aloe Barbadensis leaf juice powder. Although the optional additives are given by way of example, it will be appreciated that other optional components compatible with cosmetic applications known in the profession can be used.

In accordance with the various embodiments, the amount of one or more additives, alone or in combination, present in the composition may be present in the composition according to the disclosure in a range from about 0.001% to about 20%, by weight, or from about 0.005% to about 0.01%, or from about 0.01% to about 0.1%, or from about 0.15% to about 5%, or from about 0, 40% to about 4%, or from about 0.5% to about 2.5% by weight, or from about 1% to about 2%, or any suitable combination, subcombination, range or subrange therebetween by weight, based on the total weight of the composition.

Thus, one or more additives may be present, by weight, relative to the total weight of the composition, each or the combination present at a rate of approximately 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0 .01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40 , 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 , 15, 16, 17, 18, 19 to about 20% by weight, including intermediate ranges and subranges.

Although the optional additives are given by way of example, it will be appreciated that other optional components compatible with cosmetic applications known in the art can be used, if suitable. A qualified person will appreciate that optional additives are present only to the extent and in amounts that do not significantly affect the basic and novel feature(s) of the claimed disclosure. Thus, in some embodiments that include optional additives, these optional additives will not have a significant negative effect on the solubility of the skin actives of the cosmetic composition. And in some embodiments that include optional additives, these optional additives will not materially affect the single phase solution forming cosmetic composition.

In certain particular embodiments, the cosmetic composition may include optional additives, for example one or more of the following: phenoxyethanol, terephthalylidene dicamphorsulfonic acid, trisodium ethylenediamine disuccinate, sodium citrate, sodium chloride, hydroxyacetophenone, sodium benzoate, sorbate potassium, citric acid, caprylyl glycol, trisodium ethylenediamine disuccinate, or combinations thereof. In some embodiments, phenoxyethanol is present as a preservative in the cosmetic composition in a range of about 0.5% to about 2%, and in some embodiments in a range of about 1% to about 2%.

In accordance with the various embodiments, the amount of one or more actives and additives, alone or in combination, when they are present in the cosmetic composition according to the disclosure, can be comprised, in a range of approximately 0.001% to about 20%, and in some embodiments from about 0.05% to about 0.01%, and in some embodiments from about 0.01% to about 0.1%, and in some embodiments, from about 0.15% to about 5%, and in some embodiments, from about 0.40% to about 4%, and in some embodiments, from about 0.5% to about 2.5%, and in some embodiments about 0.1% to about 0.5%, and in some embodiments about 1% to about 2%, or any combination, sub- intermediate suitable combination, range or sub-range by weight, based on the total weight of the cosmetic composition. However, those skilled in the art will appreciate that other ranges fall within the scope of the invention.

Thus, any one or a combination of active ingredients and additives may be present, each or the combination being present from about 0.001, 0.005, 0.01, 0.02, 0.03, 0.04 , 0.05, 0.06, 0.07, 0.08, 0.09, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0 .08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2, 3 , 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 to approximately 20 percent, by weight, including increments and ranges in between.

Wordings

The cosmetic composition of the present invention can be used for the production of cosmetic preparations, or dermatological preparations, more particularly topical treatment preparations, which can be formulated as monophasic solution compositions, cosmetic serums or aerosols, For example. Topical application to a surface can be a surface such as mucous membrane or skin, for example.

The examples below according to the invention are given by way of illustration and without limitation in nature. The names are the chemical name or the INCI name. The amounts of active principles are indicated therein in % by weight on the basis of compositions of raw materials comprising 100% of the listed ingredients, unless otherwise stated.

Examples

EXAMPLE 1 : Inventive Compositions :

Various representative embodiments of the inventive compositions and articles are exemplified herein.

REV 1 REV 2 REV 3 REV 4 EU INCI FERULIC + (1% MA PHYTIC ACID) FERULIC + (2% MA PHYTIC ACID) FERULIC + (3% MA PHYTIC ACID) FERULIC + (2% MA PHYTIC ACID, 189N Glycol Blend) GLYCERIN 5 5 5 WATER qs qs qs qs PHENOXYETHANOL 1 1 1 1 ACTIVE (PANTHENOL, TOCOPHEROL, SODIUM HYALURONATE) ~1.3 ~1.3 ~1.3 ~1.3 FERULIC ACID 0.5 0.5 0.5 0.5 TRIETHANOLAMINE 0.5 0.5 0.5 0.5 LAURETH-23 3 3 3 3 PHYTIC ACID 2 4 6 4 ASCORBIC ACID 15 15 15 15 DIPROPYLENE GLYCOL 20 20 20 15.71 HEXYLENE GLYCOL 9.29

*Phytic acid raw material = 50% phytic acid in carrier

REV 5 REV 6 REV 7 REV 8 EU INCI FERULIC + (2% MA PHYTIC ACID, 190N Glycol Blend) FERULIC + (0.5% MA PHYTIC ACID) FERULIC + (4% MA PHYTIC ACID) BASE GLYCERIN 5 5 5 WATER QS qs qs qs PHENOXYETHANOL 1 1 1 1 FERULIC ACID 0.5 0.5 0.5 0.5 TRIETHANOLAMINE 0.5 0.5 0.5 0.5 LAURETH-23 3 3 3 3 PHYTIC ACID 4 1 8 2 ASCORBIC ACID 15 15 15 15 DIPROPYLENE GLYCOL 9.28 20 20 HEXYLENE GLYCOL & PENTYLENE GLYCOL ~15 PROPYLENE GLYCOL & ETHOXYDIGLYCOL ~25

*Phytic acid raw material = 50% phytic acid in carrier

COMP FERULIC ACID PHYTIC ACID ASCORBIC ACID GLYCOLS REV 1 0.5% 2% 15% 20% DIPROPYLENE GLYCOL REV 2 0.5% 4% 15% 20% DIPROPYLENE GLYCOL REV 3 0.5% 6% 15% 20% DIPROPYLENE GLYCOL REV 4 0.5% 4% 15% 16% DIPROPYLENE GLYCOL
9% HEXYLENE GLYCOL REV 5 0.5% 1% 15% 9% DIPROPYLENE GLYCOL
5% PENTYLENE GLYCOL
11% HEXYLENE GLYCOL REV 6 0.5% 8% 15% 20% DIPROPYLENE GLYCOL REV 7 0.5% 2% 15% 20% DIPROPYLENE GLYCOL REV 8 0.5% 2% 15% 5% PROPYLENE GLYCOL
20% ETHOXYDIGLYCOL

**all compositions include other active ingredients including HA, VIT E + SURFACTANT, PANTHENOL, PRESERVATIVE, and other ingredients including GLYCERIN

EXAMPLE 2 : Demonstration of the chelation /metal sequestration

Electron paramagnetic resonance (EPR) tests were performed, in which a solution of Fe(II) or Cu(II) was added to solutions of ferulic acid and phytic acid, both alone, in combination (ferulic+phytic), and with ascorbic acid (ferulic+phytic+ascorbic). Metal chelation/coordination was observed over time.

In the tests, a volume of 10 microliters of stock solutions (5000 or 500 ppm) of Fe(II) or Cu(II) was combined with 90 microliters of phytic acid solution. The EPR was measured as a function of time and a colorimetric measurement was carried out to measure residual free metals.

EPR tests have shown that ferulic acid chelates Cu(II) very well. When testing phytic acid by EPR, it was determined that Fe(II) was strongly chelated. In addition, phytic acid oxidized Fe(II) to Fe(III). In the presence of ascorbic acid and phytic acid, 90% of Fe(II) is oxidized to Fe(III) by ascorbic acid. The remaining Fe(II) is chelated and oxidized to Fe(III) by phytic acid. That is to say that the association of ascorbic acid, ferulic acid and phytic acid takes care of the chelation of Fe and Cu to inhibit any catalysis of oxidative reaction by these transition metals . This chelation/oxidation is essential because Fe(III) generates fewer free radicals than Fe(II), relative to biological pathways and oxidative stress.

In certain particular embodiments, it is observed that an antioxidant solution of ferulic acid or phytic acid, to which metal is added in a ratio of 1:1 and 1:10, metal to antioxidant, allows an elimination of metal ions characterized by the aggregation/elimination of free metal ions. Referring now to Table 4, the results show reduction of metal ions by ferulic and phytic acids.

Ferulic acid Iron Acid
phytic Copper % coordinated or reduced metal % uncoordinated or unreduced metal 1 1 0 ~100 10 1 0 ~100 1 1 60 40 10 1 ~60 ~40 1 1 90 10 1 10 ~65 ~35 1 1 80 (reduced) 20 10 1 >90 (reduced) <10

As shown in Table 4, ferulic acid chelates copper thereby decreasing the amount of copper ions by about 60% in a 1:1 ratio with the metal, and about the same (60%) in a 10:1 ratio (ferulic acid to metal). Phytic acid will chelate to form aggregates with iron, which will decrease the amount of iron ions by about 90% at a 1:1 ratio with the metal, and about 65% at a 10 ratio. :1 (phytic acid on metal). The data further show that ferulic acid has no discernible effect on iron ions and that phytic acid effectively reduced copper(II), but did not chelate it.

Example 3 : Elimination of metals by the cosmetic composition

In certain particular embodiments, it is observed that a cosmetic composition according to the disclosure and comprising both ferulic acid and phytic acid, makes it possible to eliminate the metal ions added to the composition. Referring now to Table 5, the results show a reduction of metal ions by ferulic and phytic acids, as evidenced by the residual metal ions measured.

Composition : Fe Residual Residual Cu Negative control (no ferulic or phytic acid) 500ppm 500ppm Inventive 2 (includes both ferulic and phytic acids) 100 ppm (reduced by 80%) 200 ppm (reduced by 60%)

As shown in Table 5, a composition according to the disclosure demonstrates a removal of free metal ions of about 60% for copper and about 80% for iron.

Together, Tables 4 and 5 show that phytic acid clearly and unexpectedly chelates iron, but not copper, and ferulic acid clearly and unexpectedly chelates copper, but not iron. These two acids together, in combination with vitamin C, give the best overall result, as shown in Table 5.

Although the disclosure has been described with reference to the described embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of disclosure. In addition, many modifications may be made to adapt a particular situation or matter to the teachings of the disclosure without departing from the essential scope thereof. Accordingly, the disclosure is not intended to be limited to the particular embodiment disclosed as being the best mode contemplated for carrying out that disclosure, but the disclosure is intended to include all embodiments falling within the scope of the appended claims.

The articles "a" and "an", as used herein, mean one or more when applied to any particular feature of the embodiments of this disclosure described in the specification and claims. The use of "a" and "an" does not limit the meaning to any one particular feature, unless such limit is specifically stated. The article "the", "the" or "the" preceding nouns or nouns in the singular or plural denotes a specified feature or specified features and may have a singular or plural connotation depending on the context in which it is used. . The adjective "all" means one, several or all without distinction of quantity.

"At least one", as used herein, means one or more and therefore includes individual components as well as mixtures/combinations.

The transitional terms "comprising", "consisting essentially of" and "consisting of", when used in the appended claims, in their original and amended form, define the scope of the claim with respect to the additional elements or steps not cited, if any, which are excluded from the scope of the claim(s). The term "comprising" is intended to be inclusive or open ended and does not exclude any additional elements, processes, steps or materials not listed. The term "consisting of" excludes any element, step or material other than those specified in the claim and, in the latter case, the impurities usually associated with the specified material(s). The term "consisting essentially of" limits the scope of a claim to the specified elements, steps or matters and to those which do not materially affect the fundamental and novel feature(s) of the claimed disclosure. All of the materials and processes described in this disclosure may, in other forms, be defined more specifically by one of the transitional terms "comprising", "consisting essentially of", and "consisting of".

The terms "free" and "free" indicate that no reliably measurable excluded material is present in the cosmetic composition, typically 0% by weight, based on the total weight of the cosmetic composition. The term "substantially free" means that, although it is preferred that no excluded material be present in the cosmetic composition, it is possible to have very small amounts of the excluded material in the cosmetic composition of the invention. , provided that these amounts do not materially affect the beneficial properties of the cosmetic composition. In particular, "essentially free" means that the excluded material may be present in the cosmetic composition in an amount less than about 0.1% by weight, based on the total weight of the cosmetic composition.

Outside of the working examples, or unless otherwise indicated, all numbers expressing quantities of ingredients and/or reaction conditions are to be understood as being modified in all cases by the term "about", i.e. say to the nearest 10% the number indicated (for example, “about 10%” means 9% - 11% and “about 2%” means 1.8% - 2.2%).

All percentages and ratios are calculated by weight unless otherwise stated. All percentages are calculated on the basis of the total composition, unless otherwise indicated. As a general rule, unless expressly stated otherwise, the "weight" or "amount" used herein in relation to the percentage amount of an ingredient refers to the amount of raw material comprising the ingredient, which raw material may be described as having a lower ingredient activity of up to 100%. Therefore, the weight percentage of an active in a composition is represented by the amount of raw material containing the active that is used, and may or may not reflect the final percentage of active, the final percentage of active depending on the percentage by weight of the active ingredient in the raw material.

The terms "percent by weight" and "% by weight" may be used interchangeably and mean percent by weight, based on the total weight of a composition, article or material, except where this may be specified with respect to, for example, a phase or system which is a component of a composition, article or material. All ranges and quantities given herein are intended to include subranges and quantities using any point disclosed as an end point. Thus, a range of "1% to 10%, e.g. 2% to 8%, e.g. 3% to 5%" is intended to encompass ranges of "1% to 8%", "1% to 5%", “2% to 10%”, etc. All figures, quantities, ranges, etc. are intended to be modified by the term "about", whether or not expressly indicated. Similarly, a given range of "about 1% to 10%" is understood so that the term "about" changes both thresholds by 1% and 10%. Further, it is understood that where an amount of a component is given, it is intended to mean the amount of active ingredient, unless expressly stated otherwise.

Although the numerical ranges and parameters specifying the general scope of the disclosure are approximations, unless otherwise indicated, the numerical values specified in the specific examples are reported as accurately as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective test measurements. The following example serves to illustrate embodiments of this disclosure without being limiting in nature.

All publications and patent applications cited in this specification are hereby incorporated by reference, and for all intents and purposes, as if each individual publication or patent application were specifically and individually indicated as being incorporated by reference. In the event of any inconsistency between this disclosure and any publication or patent application incorporated herein by reference, this disclosure prevails.

Claims (9)

Cosmetic composition comprising:
(a) a metal chelation system comprising:
i. ferulic acid; And
ii. phytic acid;
(b) ascorbic acid; And
(c) a carrier system comprising an aqueous phase. A cosmetic composition according to claim 1, wherein the carrier system further comprises one or more additional ingredients, each being present in the aqueous phase or in a second phase. Cosmetic composition according to Claim 2, in which the second phase is an oily phase. A cosmetic composition according to claim 4, wherein the one or more additional ingredients include one or more of a glycol, humectant, preservative, surfactant, thickener, active compound, or a combination thereof. Cosmetic composition according to Claim 1, in which the cosmetic composition is one of a single-phase solution comprising the aqueous phase, of a multi-phase solution comprising at least one additional phase, or of an emulsion comprising an oily phase. A cosmetic composition according to claim 1, wherein ascorbic acid is present in the cosmetic composition in a range from about 5% to about 30%, by weight, based on the weight of the composition. A cosmetic composition according to claim 1, wherein ferulic acid is present in the cosmetic composition in a range from about 0.2% to about 5%, by weight, based on the weight of the composition. A cosmetic composition according to claim 1, wherein phytic acid is present in the cosmetic composition in a range from about 0.25% to about 10%, by weight, based on the weight of the composition. A method for providing a cosmetic composition, the method comprising:
(a) providing a metal chelation system comprising:
i. ferulic acid; And
ii. phytic acid;
(b) providing ascorbic acid;
(c) providing a vector system comprising:
(i) an aqueous phase; And
ii) one or more additional ingredients including one or more of a glycol, humectant, preservative, surfactant, thickener, active compound or combination thereof; And
iii) optionally one or more additives, emulsifiers, emollients, fragrances, pH correctors, other cosmetically acceptable additives, or a combination thereof; And
(d) combining the metal chelating system and ascorbic acid in the aqueous phase of the carrier system with the one or more additional ingredients and one or more optional additives to provide a cosmetic composition in which each of the acids of the system of metal chelation is dissolved in the cosmetic composition.