KR20230114314A - Metal Containment Cosmetic Composition - Google Patents

Abstract

A cosmetic composition comprising a metal chelating system comprises a combination of ascorbic acid, ferulic acid and phytic acid in a carrier system comprising water, and further comprises one or more other ingredients to provide one of a variety of cosmetic products. do. The cosmetic composition exhibits removal of free metal ions from materials in contact with the cosmetic composition, and the removal of free metal ions ranges from at least about 40% to at most about 99%.

Description

Metal Containment Cosmetic Composition

Priority and Related Applications

This application is filed on December 17, 2020, US Patent Application Serial No. 17/125,945, and on January 21, 2021, French Application No. 2100579, both of which are entitled METAL SEQUESTERING COSMETIC COMPOSITION Containing cosmetic composition)), the entirety of which is incorporated herein by reference.

technology field

The present invention relates to a cosmetic composition for keratinous tissue, in particular the skin, comprising a metal chelation system in an aqueous carrier, exhibiting highly efficient metal chelation/blockade effective in minimizing free radical formation.

UV exposure and environmental pollution can accelerate skin aging by generating free radicals in the skin. Antioxidants, including vitamin C, and other active agents protect cells from the damage of oxidative stress by scavenging free radicals and inhibiting oxidative reactions. Topical application of antioxidants and other skin actives is widely used in skin care products to prevent skin aging. Antioxidants are known to exhibit chemical properties associated with reduced tissue damage. Antioxidants are known to participate in sequestering chemically active species to prevent the formation of free radicals that can contribute to oxidative stress leading to skin aging. There remains a need for improved compositions that exhibit greater efficiency in sequestering chemically reactive species, such as metal species that adversely affect biological pathways through free radical formation.

The present disclosure relates to an antioxidant system exhibiting high efficiency in blocking metal ions and a cosmetic composition comprising the antioxidant system. The antioxidant system includes a combination of vitamin C, ferulic acid and phytic acid combined in an aqueous system.

In some embodiments, this disclosure

(a) i. ferulic acid; and

ii. phytic acid

A metal chelation system comprising a;

(b) ascorbic acid; and

(c) Carrier system comprising an aqueous phase

It provides a cosmetic composition comprising a.

In various embodiments, the cosmetic composition exhibits one or both of metal chelation and metal oxidation of at least one species of metal ion. In some specific examples, the metal ion to be chelated or oxidized is selected from the group consisting of iron and copper. In some embodiments, the cosmetic composition exhibits one or both of metal chelation and metal oxidation of one or a combination of metal ions. In some specific embodiments, the cosmetic composition exhibits metal chelation or metal oxidation of iron and copper, each of which is characterized by the removal of free metal ions from materials in contact with the cosmetic composition, wherein the removal of free metal ions is at least about It removes metal ions ranging from 40% up to about 99%.

In various embodiments, the cosmetic composition is formed by providing a carrier system having an aqueous phase comprising water. In various embodiments, the carrier system may further include more than one additional component, each present in an aqueous phase or another phase, such as an oil phase. In various embodiments, the one or more additional ingredients include one or more of glycols, humectants, preservatives, surfactants, thickeners, active compounds, or combinations thereof. In some embodiments, the cosmetic composition may include one or more of any one of the additional ingredients. In some embodiments, the cosmetic composition may also include emulsifiers, emollients, fragrances, pH adjusting agents, other cosmetically acceptable additives, or combinations thereof.

The cosmetic composition includes, for example, a single-phase solution containing an aqueous phase, a multi-phase solution containing at least one aqueous phase, a water-in-oil emulsion, an oil-in-water emulsion, or an aqueous phase such as (but not limited to) a water-in-water silicone emulsion. It may be in any suitable form, such as but not limited to emulsion. The cosmetic composition may be provided in the form of a product for application to keratin tissue, such as skin care products or hair care products (but not limited thereto), and may include hydroglycol solutions, micellar water, creams or lotions. , toners, cleansers, or makeup removers, such as but not limited to. The cosmetic composition in any product form may be a leave-on or rinse-off formulation.

In various embodiments, ascorbic acid is present in the cosmetic composition in a range of about 5% to about 30% by weight of the composition, and ascorbic acid is present in an amount of about 3:1 to about 10:1 by weight of the cosmetic composition. range of water to ascorbic acid ratios.

In various embodiments, ferulic acid is present in the cosmetic composition in the range of about 0.2% to about 5% by weight of the composition.

In some embodiments, the cosmetic composition comprises phytic acid present in the cosmetic composition in a range of about 0.25% to about 10% by weight, based on the weight of the composition.

In some embodiments, this disclosure

(a) i. ferulic acid; and

ii. Phytic acid, chlorogenic acid or a combination thereof

A metal chelation system comprising a;

(b) ascorbic acid; and

(c) Carrier system comprising an aqueous phase

It provides a cosmetic composition comprising a.

In some embodiments, this disclosure

(a) i. ferulic acid; and

ii. phytic acid

A metal chelation system comprising a;

(b) ascorbic acid; and

(c) A carrier system comprising an aqueous phase and one or more additional ingredients comprising glycols, humectants, preservatives, surfactants, thickeners, active compounds, emulsifiers, emollients, or combinations thereof

It provides a cosmetic composition comprising a.

In some embodiments, this disclosure

(a) i. ferulic acid present in the range of about 0.2% to about 5%;

ii. Phytic acid present in the range of about 0.25% to about 10%

A metal chelation system comprising a;

(b) ascorbic acid present in the range of about 5% to about 30%; and

(c) Carrier system comprising an aqueous phase

To provide a cosmetic composition comprising a;

All amounts are by weight based on the weight of the composition.

In some embodiments, the cosmetic composition comprises one of the active compounds selected from the group consisting of vitamin E, carnosine, hyaluronic acid, panthenol, at least one sun filter, at least one hydroxy acid, and combinations thereof. or combinations thereof. In some embodiments, the active compound is alpha, beta selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, tartaric acid, citric acid, mandelic acid, lactobionic acid, gluconolactone, galactose, and combinations thereof. or polyhydroxy acids.

In some embodiments, the cosmetic composition is water and dipropylene glycol, pentylene glycol, hexylene glycol, ethoxydiglycol, a combination of dipropylene glycol and pentylene glycol , and a glycol selected from the group consisting of a combination of dipropylene glycol and hexylene glycol, or a combination thereof. In this embodiment, the cosmetic composition comprises water in the range of about 40% up to about 75% by weight of the cosmetic composition.

In various embodiments, the cosmetic composition further comprises one or more additives selected from emulsifiers, emollients, fragrances, pH adjusting agents, and other cosmetically acceptable additives, or combinations thereof, wherein the cosmetic composition includes titanium dioxide, zinc oxide , tin oxide, iron oxide, mica, silica, iron ferrocyanide, alumina, silicate, synthetic fluorophlogopite, polyethylene, polypropylene, poly methyl methacrylate, talc, perlite, hectorite, bentonite, kaolin clay, pumice stone, nitride It is free or essentially free of powder and solid particles, including but not limited to boron, and combinations thereof. In some specific embodiments, the cosmetic composition excludes propylene glycol or butylene glycol.

These and other aspects of the invention are set forth in the appended claims and described in more detail in the Detailed Description of the Invention.

This disclosure describes exemplary embodiments according to general inventive concepts and is not intended to limit the scope of the invention in any way. Indeed, the invention as described herein is broader than and not limited by the exemplary embodiments presented herein, and the terms used herein have their full and general meaning.

It should be understood that both the foregoing general description and the following detailed description are illustrative and explanatory only and do not limit the present disclosure.

"Cosmetic acceptable" means a carrier that is compatible with any keratin substrate.

“Keratinous matrix” and “keratinous tissue” include, but are not limited to, skin, hair, and nails, respectively.

In various embodiments, the cosmetic composition comprises a metal chelating system comprising a combination of ascorbic acid, ferulic acid and phytic acid in a carrier system comprising water, wherein the cosmetic composition comprises one or more of the various types of cosmetic products to provide one of them. It may further include other ingredients, including but not limited to glycols, humectants, preservatives, surfactants, thickeners, active compounds, or combinations thereof. The cosmetic composition may also include emulsifiers, emollients, fragrances, pH adjusting agents, other cosmetically acceptable additives, or combinations thereof. For the avoidance of doubt, the cosmetic composition may comprise one or more of any one of the additional ingredients. For example, the cosmetic composition may include one or more than one glycol, or one or more than one humectant, and the like. It will be appreciated that additional components, if present, are present in the carrier system in either an aqueous or oily phase.

The cosmetic composition includes, for example, a single-phase solution containing an aqueous phase, a multi-phase solution containing at least one aqueous phase, a water-in-oil emulsion, an oil-in-water emulsion, or an aqueous phase such as (but not limited to) a water-in-water silicone emulsion. It may be any suitable cosmetic composition such as, but not limited to, an emulsion. The cosmetic composition may be provided in the form of a product for application to keratin tissue, such as skin care products or hair care products (but not limited thereto), and may include hydroglycol solutions, micellar water, creams or lotions. , toners, cleansers, or makeup removers, such as but not limited to. The cosmetic composition in any product form may be a leave-on or rinse-off formulation.

In some embodiments, a cosmetic composition according to the present disclosure is a single phase solution comprising one or more solutes dissolved in one or more solvents to form a substantially homogeneous liquid that appears substantially transparent to the naked eye. In one such embodiment, the cosmetic composition is a single phase aqueous solution. In some specific embodiments, the cosmetic composition is a hydroglycol solution comprising one or a combination of glycols.

The inventors have shown a surprising and unexpected effect of a combination of ascorbic acid, ferulic acid and phytic acid as powerful metal chelating/sequestering agents. Using this combination, the ability to chelate different metal ions such as iron and copper is increased in a representative cosmetic composition comprising a hydroglycol solution. The combination of ascorbic acid, ferulic acid and phytic acid showed the most chelation compared to any other combination. Through a combination of oxidation and coordination, the levels of copper and iron (II) in the cosmetic composition are kept to a minimum to reduce or eliminate oxidation reaction catalysis by metal ions to minimize oxidative stress in the treated keratin tissue.

In various embodiments, the cosmetic composition exhibits one or both of metal chelation and metal oxidation of at least one species of metal ion. In some embodiments, the cosmetic composition exhibits one or both of metal chelation and metal oxidation of one or a combination of metal ions. In some specific embodiments, the cosmetic composition exhibits metal chelation or metal oxidation of iron and copper, each of which is characterized by the removal of free metal ions from a material in contact with the cosmetic composition, such as a fluid or keratin matrix, The removal of free metal ions removes metal ions in the range of at least about 40% and up to about 99%.

Metal chelation system and optional ascorbic acid

According to the present disclosure, embodiments of the cosmetic composition include a metal chelating system comprising a combination of ferulic acid and phytic acid. In some embodiments, the chelating system includes ferulic acid and one or both of phytic acid and chlorogenic acid. In some specific embodiments, the cosmetic composition includes each of ferulic acid and phytic acid in a chelating system. In another embodiment, the cosmetic composition includes each of ascorbic acid, ferulic acid and phytic acid. In addition to the metal chelating system, in some embodiments the cosmetic composition may include ascorbic acid (vitamin C).

In some embodiments, the cosmetic composition has a pH in the range of about 3.0 to about 4.0, more particularly about 3.5, wherein greater than about 82% of the ascorbic acid is protonated, as disclosed in U.S. Patent No. 5,140,043 (Aug. 18, 1992) Ensured that it remains in uncharged form, the entire disclosure of this patent is hereby incorporated by reference. Ascorbic acid can be provided by addition of any reducing analog of ascorbic acid, such as D-isoascorbic acid, or by addition of other small reducing compounds such as, but not limited to, glutathione, L-cysteamine, and the like. there is. This form is expected to provide compositions equivalent to those claimed and is within the scope of this invention.

In various embodiments, the cosmetic composition includes ferulic acid, a cinnamic acid derivative. Cinnamic acid or derivatives thereof include ferulic acid, p-coumaric acid, caffeic acid, cinapic acid, chlorogenic acid, captharic acid, chichoric acid, cutariic acid, rosmarinic acid, derivatives thereof, and combinations thereof. Equivalent derivatives thereof include cinnamic acid derivatives having substitutions on the hydroxyl groups of aromatic rings, such as short-chain aliphatic groups (1 to 6 carbon atoms) or long-chain aliphatic groups (7 to 24 carbon atoms), ether, or alkyl , such aliphatic groups substituted with alkoxy, hydroxyl, amino, or amido, for example to form substituted ethers. Equivalent derivatives thereof further include cinnamic acid derivatives having modification of the methoxy group(s) of the aromatic ring to a short chain aliphatic group (2 to 6 carbon atoms) or a long chain aliphatic group (7 to 24 carbon atoms), , or such aliphatic groups substituted with alkyl, alkoxy, hydroxyl, amino, or amido, for example forming substituted long-chain ethers. The 3-carboxy group of the cinnamic acid derivative can also be converted into esters or amides with, for example, aliphatic or aromatic groups of up to 24 carbons. Cis and trans isomers of cinnamic acid derivatives are included herein as the cis isomer readily converts to the trans isomer. Salts of cinnamic acid derivatives are included herein. In one embodiment, the cinnamic acid derivative is a triethanolamine salt. Caffeic acid, also known as 3-(3,4-dihydroxyphenyl)-2-propenoic acid, is found in many fruits, vegetables, condiments, and beverages consumed by humans. Caffeic acid is present in these products in the same conjugated form as chlorogenic acid. Para-coumaric acid, also known as 3-(4-hydroxyphenyl)-2-propenoic acid or p-hydroxycinnamic acid, is found in a variety of plants, including lignin-forming plants. Trans-ferulic acid, also known as 3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid or 4-hydroxy-3-methoxycinnamic acid, is also widely distributed in plants in small amounts. Sinapinic acid, also known as 3,5-dimethoxy4-hydroxycinnamic acid, is derived from black mustard seeds. Caffeic acid, para-coumaric acid, trans-ferulic acid and sinapinic acid are commercially available from Sigma-Aldrich.

In various embodiments, the cosmetic composition includes at least one or a combination of phytic acid and chlorogenic acid. In some specific embodiments, the cosmetic composition includes phytic acid. Phytic acid, also known as phytate, is a 6-fold dihydrogenphosphate ester of inositol (specifically, the myo isomer), also called inositol hexakisphosphate (IP6) or inositol polyphosphate. At physiological pH, phosphate is partially ionized, resulting in phytate anions. Phytic acid is found naturally in plant seeds and is a storage form of phosphorus. In some other embodiments, the cosmetic composition includes chlorogenic acid. Chlorogenic acid, also known as chlorogenate or 3-caffeoylquinate, belongs to the class of organic compounds known as quinic acid and derivatives. Chlorogenic acid is an ester of caffeic acid (hydroxycinnamic acid, related to ferulic acid as described herein above) and (-)-quinic acid.

In some embodiments, the composition further comprises ascorbic acid.

In various embodiments, each skin active is at least one or a combination of skin actives comprising at least one of ascorbic acid, a cinnamic acid derivative, and vitamin E, or a combination thereof, wherein the combination is a cosmetic composition in a cosmetic composition. from about 15% to about 30%, in some embodiments from about 16% to about 30%, in some embodiments from about 16% to about 25%, in some embodiments from about 16.5% by weight, based on the weight of % to about 24% by weight, or any suitable combination, subcombination, range, or subrange thereof.

Ferulic acid and cinnamic acid derivatives, including but not limited to triethanolamine salts, are present in the cosmetic composition in an amount of about 0.1% to about 5%, in some embodiments, about 0.1% to about 3% by weight of the cosmetic composition. weight percent, in some embodiments from about 0.5 weight percent to about 1.0 weight percent, or any suitable combination, subcombination, range, or subrange thereof.

The phytic acid is present in the cosmetic composition in an amount of about 0.5% to about 5%, in some embodiments, about 1% to about 4%, in some embodiments, about 1% to about 2% by weight, based on the weight of the cosmetic composition, or in any suitable combination, subcombination, range, or subrange thereof. As exemplified in this disclosure, the phytic acid source is provided at a dilution of 50%, so the exemplified weight percentage of the cosmetic composition is multiplied by 0.5 to obtain the final weight percentage of phytic acid.

The chlorogenic acid is present in the cosmetic composition in an amount of about 0.5% to about 1.5%, in some embodiments, about 1% to about 1.5%, in some embodiments, about 1.1% to about 1.2% by weight, based on the weight of the cosmetic composition, or in any suitable combination, subcombination, range, or subrange thereof.

Ascorbic acid and its derivatives are present in the cosmetic composition in an amount of about 1% to about 30%, in some embodiments, about 5% to about 25%, and in some embodiments, about 10% to about 10% by weight, based on the weight of the cosmetic composition. 20 wt%, and in some embodiments from about 10 wt% to about 15 wt%, or any suitable combination, subcombination, range, or subrange thereof.

Phytic acid, carnosine, chlorogenic acid, hyaluronic acid, panthenol is present in the cosmetic composition in an amount of from about 0.1% to about 5%, in some embodiments, from about 0.1% to about 3%, in some embodiments, by weight of the cosmetic composition may be present from about 0.5% to about 1.0% by weight, or any suitable combination, subcombination, range, or subrange thereof.

Thus, in various embodiments, each of the components of the metal chelating system and optionally ascorbic acid are present in a composition according to the present disclosure, and each of the individual components includes increments and ranges therebetween, as described hereinabove. About 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2, 3, 4 , 5, 6, 7 , 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28 to about 30% by weight there is.

In various embodiments, the cosmetic composition exhibits one or both of metal chelation and metal oxidation of at least one species of metal ion. In some specific examples, the metal ion to be chelated or oxidized is selected from the group consisting of iron and copper. In some embodiments, the cosmetic composition exhibits one or both of metal chelation and metal oxidation of one or a combination of metal ions.

In some specific embodiments, the cosmetic composition exhibits metal chelation or metal oxidation of iron and copper, each of which is characterized by the removal of free metal ions from materials in contact with the cosmetic composition, wherein the removal of free metal ions is at least about It removes metal ions ranging from 40% up to about 99%.

In some specific embodiments, an antioxidant solution of ferulic acid or phytic acid with added metal in metal to antioxidant ratios of 1:1 and 1:10 removes metal ions, characterized by clustering/removal of free metal ions. It is observed to provide In some instances, as shown herein, phytic acid helps reduce free radicals in fluids or keratinous matrix by chelating metals, particularly iron ions, and ferulic acid helps reduce free radicals in fluids or keratinous matrixes by chelating metals, particularly copper ions. helps reduce free radicals. In some specific embodiments, as exemplified herein, phytic acid chelates/removes metals, particularly iron, reducing the amount of iron ions by about 60%, about 80%, in each instance about 20% and about 40% residual iron. And according to this illustrated embodiment, ferulic acid chelates/removes metals, particularly copper, reducing the amount of copper ions by about 60% and about 90%, in each instance about 10% and about 40% leaves residual copper in quantity.

Thus, in various embodiments, a cosmetic composition comprising a metal chelating system may contain from about 40% to about 99%, or from about 40% to about 90% or from about 40% to about 80%, including increments and ranges therebetween, or about 80% to about 90%, or about 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 to about 99% of one or a combination of metal ions in the fluid or keratin matrix.

carrier system

In various embodiments, the cosmetic composition is formed by providing a carrier system having an aqueous phase comprising water.

water

According to various embodiments, water is present in the cosmetic composition from about 10% to about 95%, in some embodiments from about 25% to about 80%, and in some embodiments from about 40% by weight, based on the weight of the cosmetic composition. to about 65% by weight, in some embodiments from about 55% to about 60% by weight, or any suitable combination, subcombination, range, or subrange thereof. According to some specific embodiments in which the cosmetic composition is a hydroglycol solution, water is present in the cosmetic composition in an amount of from about 40% to about 75% by weight, in some embodiments from about 45% to about 70% by weight of the cosmetic composition. %, in some embodiments in the range of about 50% to about 65% by weight, in some embodiments in the range of about 55% to about 60% by weight, in some embodiments about 68% by weight or any suitable combination, subcombination thereof, It exists as a range, or subrange. However, one skilled in the art will understand that other scopes are within the scope of this invention. Therefore, water is about 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58 based on the total weight of the cosmetic composition. , 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, to about 75 weight percent, including increments and ranges within and between exist. However, one skilled in the art will understand that other scopes are within the scope of this invention.

The water is, for example, sterile demineralized water and/or floral water, such as rose water, cornflower water, chamomile water or lime water, and/or natural thermal or mineral water, such as water from Vittel, water from the Vichy basin, Water of Uriage, water of La Roche Posay, water of La Bourboule, water of Enghien-les-Bains, water of Saint Gervais-les-Bains, water of Nerisré The water of Neris-les-Bains, the water of Allevar-les-Bains, the water of Digne, the water of Maizieres, the water of Neyrac-les-Bains Water, Water of Lons-le-Saunier, Water of EauxBonnes, Water of Rochefort, Water of Saint Christau, Water of Les Fumades, Terre water of Tercis-les-Bains, or water of Avene. The water may also include reconstituted thermal spring water, i.e. water containing trace elements such as zinc, copper, magnesium, etc. which reconstitute the properties of the thermal spring water.

The pH of the cosmetic composition is not limited, but is generally between 3.0 and 4.0, and in some embodiments between 3 and 3.5. The pH is determined by adding a base (organic or inorganic) such as ammonia or a primary, secondary or tertiary (poly)amine such as monoethanolamine, diethanolamine, triethanolamine, isopropanolamine or 1, It can be adjusted to the desired value by addition of 3-propanediamine, or alternatively by addition of an inorganic or organic acid, advantageously a carboxylic acid such as citric acid. It will be appreciated by the skilled artisan that pH is a measure of the hydrogen ion concentration of water which is determined by measuring the electrode potential using an electrode attached to a pH meter. It is further added that due to the inherent variability of pH measurements, the skilled artisan would expect a variability of at least 10% in the pH measurement of a composition as disclosed herein when measured in a typical laboratory using a typical pH meter. will understand

other ingredients

In various embodiments, the cosmetic composition also includes one or more additional ingredients such as, but not limited to, glycols, humectants, preservatives, surfactants, thickeners, active compounds, or combinations thereof. For the avoidance of doubt, the cosmetic composition may comprise one or more of any one of the additional ingredients. For example, the cosmetic composition may include one or more than one glycol, or one or more than one humectant, and the like. It will be appreciated that additional components, if present, are present in the carrier system in either an aqueous or oily phase.

The cosmetic composition includes, for example, a single-phase solution containing an aqueous phase, a multi-phase solution containing at least one aqueous phase, a water-in-oil emulsion, an oil-in-water emulsion, or an aqueous phase such as (but not limited to) a water-in-water silicone emulsion. It may be any suitable cosmetic composition such as, but not limited to, an emulsion. The cosmetic composition may be provided in the form of a product for application to keratin tissue, such as skin care products or hair care products (but not limited thereto), including hydroglycol solutions, micellar water, leave-on creams or lotions, It may be a product such as, but not limited to, a toner, cleanser or makeup remover.

In some embodiments, the cosmetic composition comprises one of the active compounds selected from the group consisting of vitamin E, carnosine, hyaluronic acid, panthenol, at least one sun filter, at least one hydroxy acid, and combinations thereof. or combinations thereof. In some embodiments, the active compound is alpha, beta selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, tartaric acid, citric acid, mandelic acid, lactobionic acid, gluconolactone, galactose, and combinations thereof. or polyhydroxy acids.

In various embodiments, the cosmetic composition further comprises one or more additives selected from emulsifiers, emollients, fragrances, pH adjusting agents, other cosmetically acceptable additives, or combinations thereof, wherein the cosmetic composition includes titanium dioxide, zinc oxide , tin oxide, iron oxide, mica, silica, iron ferrocyanide, alumina, silicate, synthetic fluorophlogopite, polyethylene, polypropylene, poly methyl methacrylate, talc, perlite, hectorite, bentonite, kaolin clay, pumice stone, nitride It is free or essentially free of powder and solid particles, including but not limited to boron, and combinations thereof. In some specific embodiments, the cosmetic composition excludes propylene glycol or butylene glycol.

Humectants/Glycols

According to the present disclosure, one or more humectants may be present in the cosmetic composition.

In some embodiments, the humectant is one or more polyols such as hexylene glycol, dipropylene glycol, glycerin, glycerol, glycols such as caprylyl glycol, butylene glycol, propylene Glycol, Isoprene Glycol, Polyethylene Glycol, Monoethylene Glycol, Diethylene Glycol, Triethylene Glycol, Diethylene Glycol, Hexylene Glycol, Glycol Ether, such as monopropylene, dipropylene and tripropylene glycol alkyl (C1-C4) ethers, squalene, triacetin, sugars such as glucose, xylitol, maltitol, sorbitol, sucrose pentaerythritol, inositol, pyrrolidone carboxylic acids , lactic acid, lithium chloride, acetamide MEA, sodium lactate, urea, dicyanamide, hyaluronic acid, aloe vera, honey, and seaweed extract.

According to some embodiments, the glycol, if present, may be present in the cosmetic composition alone or in combination with at least one other glycol, each glycol having a weight, based on the weight of the composition, of the cosmetic composition. in the range of from about 0.1% to about 30%, or from about 5% to about 25%, or from about 10% to about 15% by weight based on, or any suitable combination, subcombination, range, or sub-combination thereof It can be present in a range of amounts. In some embodiments, the total amount of glycols is less than about 30%, for example the total amount is about 29.5%, or about 29%. As provided herein, some glycols when present alone in a cosmetic composition can make up at least about 8%, or at least about 8.5%, or at least about 9%, or at least about 9.5%, or at least about 10%, or present in an amount of at least about 10.5%.

Thus, in various embodiments, each glycol is present in a cosmetic composition according to the present disclosure, each alone and/or in combination as described in the paragraphs set forth above herein in an amount of about 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.5, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 to less than about 30 weight percent, including increments and ranges within and between them.

In some embodiments, the composition comprises a glycol selected from the group consisting of hexylene glycol, dipropylene glycol, pentylene glycol, propylene glycol, ethoxydiglycol, and combinations thereof. Contains kohl wetting agent. In some embodiments, the composition comprises ethoxydiglycol, propylene glycol and pentylene glycol, or hexylene glycol, pentylene glycol and dipropylene glycol, or dipropylene glycol , or hexylene glycol and dipropylene glycol. In some embodiments, the composition includes glycerin.

According to various embodiments, the amount of humectant present in the cosmetic composition is from about 1% to about 10%, or from about 1% to about 8%, or from about 1% to about 5% by weight of the composition. %, or in the range of about 2% to about 3% by weight, or any suitable combination, subcombination, range, or subrange thereof. However, one skilled in the art will understand that other scopes are within the scope of this invention.

Thus, any one or combination of humectants, if present, may be present by weight of the composition in an amount of about 1, 2, 3, 4, 5, 6, 7, 8, by weight of the cosmetic composition. 9, to about 10 weight percent, including increments and ranges within and between.

antiseptic

According to the present disclosure, one or more preservatives and/or antimicrobial agents may be present in the composition. Any preservatives commonly used in cosmetic formulations include, for example, preservatives acceptable for the cosmetic composition of the present specification such as phenoxyethanol, members of the paraben family such as methyl, ethyl, propyl, butyl or isobutyl parabens, 4-hydroxy benzoic acid, benzoic acid, sorbic acid, dehydroacetic acid, triclosan, benzyl alcohol, chlorophenesin or salicylic acid. In more concentrated amounts of solvents suitable for optional additives, specifically solvents suitable for antimicrobials and preservatives, members of the paraben family may be used as preservatives.

In some embodiments, the preservative may include one or more of a preservative selected from the group consisting of organic acids, parabens, formaldehyde donors, phenol derivatives, quaternary ammonium, alcohols, isothiazolinones, and combinations thereof. A preservative having antibacterial activity is optionally present in the cosmetic composition of the present invention. Examples of organic acid preservatives include, but are not limited to, sodium benzoate, potassium sorbate, benzoic and dehydroacetic acids, sorbic acid, and combinations thereof. A preferred organic acid preservative system comprises a mixture of sodium benzoate and potassium sorbate. Examples of paraben preservatives include, but are not limited to, alkyl para-hydroxybenzoates, wherein the alkyl radical has 1, 2, 3, 4, 5 or 6 carbon atoms, such as 1 to 4 carbon atoms, e.g. For example, methyl para-hydroxybenzoate (methylparaben), ethyl para-hydroxybenzoate (ethylparaben), propyl para-hydroxybenzoate (propylparaben), butyl para-hydroxybenzoate (butylparaben) and It has isobutyl para-hydroxybenzoate (isobutylparaben). Examples of formaldehyde donor preservatives include, but are not limited to, 1,3-dimethylol-5,5-dimethylhydantoin (DMDM hydantoin), imidazolidinyl urea, gluteraldehyde, and combinations thereof It doesn't work. Examples of quaternary ammonium preservatives include, but are not limited to, benzalkonium chloride, methen ammonium chloride, benzethonium chloride, and combinations thereof. Examples of alcohol preservatives include, but are not limited to, ethanol, benzyl alcohol, dichlorobenzyl alcohol, phenoxyethanol, and combinations thereof. Examples of isothiazolone preservatives include, but are not limited to, methylchloroisothiazolinone, methylisothiazolinone, and combinations thereof.

Other suitable preservatives include chloracetamide, triclosan and iodopropynyl butylcarbamate, pyridine derivatives (eg pyrithione and zinc pyrithione), chlorphenesin, phenyl mercury salts, phenoxyethanol, and other known including but not limited to preservative systems.

In some embodiments, the preservative comprises one or more preservatives, one or a combination of which is from about 0.001% to about 5%, or alternatively from about 0.05% to about 2.5% or alternatively, by weight of the composition. typically present at a concentration of about 0.1% to about 2.0% by weight.

Thus, any one or combination of preservatives, if present, may be present, based on the total weight of the composition, in an amount of about 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4, to about 5% by weight (within and between Increments and ranges).

Surfactants

According to the present disclosure, various non-limiting embodiments of cosmetic compositions may optionally include at least one surfactant. And according to the present disclosure, various non-limiting embodiments of cosmetic compositions including, but not limited to, for example a vitamin E ingredient such as tocopherol may optionally include at least one surfactant. In some embodiments, the cosmetic composition does not include oil. In some embodiments, the cosmetic composition does not include a surfactant. In some embodiments, the cosmetic composition includes at least one oil, such as tocopherol, along with at least one surfactant. In some embodiments, the cosmetic composition includes at least one oil along with more than one surfactant. In some embodiments, the cosmetic composition comprises at least one oil without any surfactant, wherein the total amount of oil present does not inhibit forming the cosmetic composition as a clear single phase solution.

The at least one surfactant may be a nonionic, cationic, anionic, or amphoteric surfactant. The at least one surfactant is polyoxyethylene sorbitan monolaurate, laureth-23, polyoxyethylated octyl phenol, 3-((3-cholamidopropyl) dimethylammonio)-1 propane sulfonate, sodium dilauramidoglutamide lysine, cholate, deoxycholate, sodium dodecylsulfate, TWEEN-80, and combinations thereof. At least one surfactant may exclude esters. The at least one surfactant may be present in the cosmetic composition in an amount ranging from about 1% to about 5% by weight of the cosmetic composition.

In some specific embodiments, the at least one surfactant, if present, comprises one or a combination of polyoxyethylene sorbitan monolaurate and laureth-23.

In various embodiments, the at least one surfactant, when present, comprises about 1% to about 5% by weight of the cosmetic composition, in some embodiments about 1% to about 2% by weight of the cosmetic composition, in some embodiments form from about 3% to about 6%, in some embodiments from about 3% to about 4.5% by weight, or any suitable combination, subcombination, range, or subrange thereof. In some embodiments, laureth-23 is present in about 1% to about 5% by weight of the cosmetic composition, in some embodiments about 3% to about 4.5% by weight of the cosmetic composition, or any suitable combination; may exist in subcombinations, ranges, or subranges. In some embodiments, the polyoxyethylene sorbitan monolaurate is from about 1% to about 5% by weight of the cosmetic composition, in some embodiments from about 1% to about 2% by weight of the cosmetic composition, or may be present in any suitable combination, subcombination, range, or subrange. In some embodiments, the cosmetic composition includes more than one surfactant. However, one skilled in the art will understand that other scopes are within the scope of this invention.

Thus, in various embodiments, each of the at least one surfactant, when present, is present in a composition according to the present disclosure in an amount of about 1, 2, 3, 4, to about 5 weight percent (including increments and ranges within and between) ) can exist.

polymer thickener

According to various embodiments, the composition may include one or more polymeric thickeners. In some embodiments, the one or more thickeners can be selected from one or more of natural gums and synthetic polymers, for example, the thickeners can be starches (corn, rice, tapioca, potato), gums (xanthan carrageenan, gellan, sclerotium) , tarabiotech fermented product). In some specific embodiments, the thickener is an acrylate/C10-30 alkyl acrylate crosspolymer, carbomer, xanthan gum, hydroxypropyl guar, ceratonia siliqua (carob) gum, ammonium polyacryloyldimethyl taurate, ammonium acryloyldimethyltaurate/steareth-25 methacrylate crosspolymer, and polyacrylate crosspolymer-6.

In some embodiments, the polymeric thickener is Carbomer, Acrylates/C10-30 Alkyl Acrylates Crosspolymer, Polyacrylates Crosspolymer-6, Microcrystalline Cellulose (and) Cellulose Gum, Xanthan Gum, Sodium Carboxymethyl Starch, Sclere Rothium Gum (and) Xanthan Gum, Xanthan Gum (and) Ceratonia Silicua (Carob) Gum (50/50), Dehydroxanthan Gum, Hydroxypropyl Starch Phosphate, Sclerotium Gum (and) Xanthan Gum (75/ 25), sclerotium gum, xanthan gum (and) sclerotium gum (and) lecithin (and) pullulan, and combinations thereof.

In some embodiments, the composition may include two or more polymeric thickeners. The amount of each of the at least one polymeric thickener, when present, is from about 0.01% to about 2%, or from about 0.01% to about 1.5%, or from about 0.3% to about 1.2% by weight of the composition, based on the weight of the composition. , or any suitable combination, subcombination, range, or subrange thereof. However, one skilled in the art will understand that other scopes are within the scope of this invention.

In some embodiments, the total amount of polymeric thickener in the composition, when present, is from about 0.01% to about 5%, or from about 0.02% to about 2%, or from about 0.03% to about 5% by weight of the composition. 1.5%, or from about 0.1% to about 0.2%, or any suitable combination, subcombination, range, or subrange thereof. However, one skilled in the art will understand that other scopes are within the scope of this invention.

Thus, the one or more polymeric thickeners, when present, in an amount of about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, 3.5, 4.0, 4.5 to about 5.0 weight percent, including increments and ranges within and between ) exists.

optional active compound

According to the present disclosure, embodiments of the cosmetic composition may include one or more additional compounds selected from active compounds, specifically keratin tissue actives such as, but not limited to, skin actives. In some embodiments, the optional active compound may be selected from the group consisting of vitamins, such as vitamin E, carnosine, hyaluronic acid, panthenol, at least one sun filter, at least one hydroxy acid, and combinations thereof. there is. In some embodiments, the active compound is alpha, beta selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, tartaric acid, citric acid, mandelic acid, lactobionic acid, gluconolactone, galactose, and combinations thereof. or polyhydroxy acids. For the avoidance of doubt, the cosmetic composition may contain one or more of any one of the optional active compounds. For example, the cosmetic composition may include one or more than one hydroxy acid, one or more than one vitamin, and the like.

Vitamin E includes alpha-tocopherol, beta-tocopherol, delta-tocopherol, gamma-tocopherol, and alpha-tocotrienol, beta-tocotrienol, delta-tocotrienol, gamma-tocotrienol, and It may be selected from the group consisting of derivatives. Salts or derivatives of tocopherols are, for example, pharmaceutically acceptable compounds such as acetates, sulfates, succinates, nicotinates, palmitates, allophanates, phosphates, quinones, or halogenated derivatives, esters, or stereoisomers. includes The present invention includes the use of vitamin E derivatives with substitutions, additions, and other alterations in the 6-chromanol ring and/or side chain, provided that the derivative retains the antioxidant activity of vitamin E. Additional tocopherols can be constructed by conjugating to the side chains or ring structures of various other moieties, such as those containing oxygen, nitrogen, sulfur and/or phosphorus. Tocopherol derivatives can also be prepared by modifying the length of the side chains found in tocopherols such as alpha-, beta-, delta- and gamma-tocopherols. Tocopherols may also differ in ring structure and side chain stereochemistry and degree of saturation. Additional tocopherol derivatives, including prodrugs, can be prepared by conjugation of sugars or other moieties to side-chain or ring structures. Tocopherols are without limitation stereoisomers (eg, + and - stereoisomers of alpha-tocopherol; (+/-) indicates a racemic mixture) or structurally distinct mixtures of tocopherols (eg, alpha-plus gamma -tocopherol). For example, tocopherol can be obtained, for example, from Roche (Nutley, NJ).

In some embodiments, the additional active agent may also include at least one hydroxy acid selected from alpha, beta or polyhydroxy acids. Thus, in various embodiments, the hydroxy acid may be selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, tartaric acid, citric acid, mandelic acid, lactobionic acid, gluconolactone, galactose, and combinations thereof. there is.

In some embodiments, the additional active agent is also mangiferin, baicalin, resveratrol, tannic acid, polyphenols, amino acids and derivatives thereof, imidazole, carnosine derivatives, carotenoids, carotenes (e.g., α-carotene, β-carotene, and lycopene). ), vitamin A, coenzyme Q10, bioflavonoids, glutathione, plant extracts (eg, rosemary extract, olive leaf extract), green tea extract, and combinations thereof. .

In some specific embodiments, the cosmetic composition comprises a combination of active compounds present in the cosmetic composition comprising tocopherol, panthenol, hyaluronic acid, hydroxy acid, carnosine, or combinations thereof.

Generally, each optional active compound is present in the cosmetic composition in an amount of from about 0.1% to about 30%, in some embodiments from about 0.5% to about 30%, in some embodiments from about 0.5% by weight, based on the weight of the cosmetic composition. % to about 15% by weight, in some embodiments from about 0.1% to about 1% by weight, in some embodiments from about 1% to about 2% by weight, or any suitable combination, subcombination, or range thereof; or as a subrange.

Vitamin E and its derivatives, including but not limited to, tocopherol, are in the cosmetic composition in an amount of about 0.5% to about 2%, in some embodiments, about 0.5% to about 1%, in some embodiments, by weight of the cosmetic composition. form in an amount from about 1% to about 2.0% by weight, or any suitable combination, subcombination, range, or subrange thereof.

Carnosine, hyaluronic acid, and panthenol are present in the cosmetic composition in an amount of about 0.1% to about 5%, in some embodiments, about 0.1% to about 3%, and in some embodiments, about 0.5% by weight, based on the weight of the cosmetic composition. to about 1.0 weight percent, or any suitable combination, subcombination, range, or subrange thereof.

Carnosine is present in the cosmetic composition in an amount of about 0.10% to about 1%, in some embodiments, about 0.20% to about 0.5%, in some embodiments, about 0.20% to about 0.25% by weight, based on the weight of the cosmetic composition. or in any suitable combination, subcombination, range, or subrange thereof.

Hyaluronic acid is present in the cosmetic composition in an amount of about 0.01% to about 1%, in some embodiments, about 0.01% to about 0.1%, and in some embodiments, about 0.05% to about 0.07% by weight, based on the weight of the cosmetic composition. , or any suitable combination, subcombination, range, or subrange thereof.

Panthenol is present in the cosmetic composition in an amount of from about 0.1% to about 1%, in some embodiments, from about 0.1% to about 0.5%, in some embodiments, from about 0.2% to about 0.4%, by weight of the cosmetic composition, based on the weight of the cosmetic composition; in some embodiments from about 0.2% to about 0.25% by weight, or any suitable combination, subcombination, range, or subrange thereof.

The hydroxy acid is present in the cosmetic composition in an amount of from about 0.25% to about 10%, in some embodiments from about 0.5% to about 8%, and in some embodiments from about 1% to about 5% by weight of the cosmetic composition, based on the weight of the cosmetic composition. , in some embodiments from about 0.25% to about 0.5%, or any suitable combination, subcombination, range, or subrange thereof.

Thus, in various embodiments, the optional active compound, when present, is present in a composition according to the present disclosure, and each individual component is present in an amount of about 0.01, 0.02, including increments and ranges therebetween, as described hereinabove. 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28 to about 30 weight percent.

optional additives

The composition may also contain at least one additive used in the field of cosmetics which does not affect the properties of the composition according to the present invention, such as emulsifiers, emollients, fragrances, pH adjusting agents (citric acid, sodium chloride; neutralizing agents or pH adjusting agents (e.g. triethylamine (TEA) and sodium hydroxide), and combinations thereof), other cosmetically acceptable additives such as but not limited to pearlescent agents, silica, and colorants; essential oil; fruit extracts such as Pyrus Malus (apple) fruit extract, and Aloe Barbadensis leaf juice powder. While optional additives are given as examples, it will be appreciated that other optional ingredients compatible with cosmetic applications known in the art may be used.

According to various embodiments, the amount of one or more additives present in the composition, alone or in combination, may be from about 0.001% to about 20%, or from about 0.005% to about 0.005% by weight, based on the total weight of the composition, in a composition according to the present disclosure. about 0.01%, or about 0.01% to about 0.1%, or about 0.15% to about 5%, or about 0.40% to about 4%, or about 0.5% to about 2.5%, or from about 1% to about 2% by weight, or any suitable combination, subcombination, range, or subrange thereof.

Thus, any one or combination of the additives may be present by weight of the composition, each one or combination of about 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03 , 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10 , 11, 12, 13, 14, 15, 16, 17, 18, 19 to about 20 weight percent, including increments and ranges within and between them.

While optional additives are given as examples, it will be appreciated that other suitable optional ingredients compatible with cosmetic applications known in the art may be used. It will be appreciated by those skilled in the art that any optional additives are present only in such an extent and amount that they do not materially adversely affect the basic and novel characteristic(s) of the claimed disclosure. Thus, in some embodiments that include optional additives, such optional additives will not substantially adversely affect the solubility of the skin active agent in the cosmetic composition. And, in some embodiments that include optional additives, these optional additives will not substantially adversely affect the cosmetic composition forming the single phase solution.

In some specific embodiments, the cosmetic composition may include optional additives such as phenoxyethanol, terephthalylidene dicamphor sulfonic acid, trisodium ethylenediamine disuccinate, sodium citrate, sodium chloride, hydroxyacetophenone sodium benzo ate, potassium sorbate, citric acid, caprylyl glycol, trisodium ethylenediamine disuccinate, or combinations thereof. In some embodiments, phenoxyethanol is present in the cosmetic composition as a preservative in the range of about 0.5% to about 2%, and in some embodiments in the range of about 1% to about 2%.

According to various embodiments, when present in a cosmetic composition according to the present disclosure, the amount of the one or more actives and additives, alone or in combination, is from about 0.001% to about 20%, in some embodiments, about 20% by weight, based on the total weight of the cosmetic composition. 0.05% to about 0.01% by weight, in some embodiments from about 0.01% to about 0.1% by weight, in some embodiments from about 0.15% to about 5% by weight, in some embodiments from about 0.40% to about 4% by weight , in some embodiments from 0.5% to about 2.5% by weight, in some embodiments from about 0.1% to about 0.5% by weight, in some embodiments from about 1% to about 2% by weight, or any suitable combination, may exist in subcombinations, ranges, or subranges. However, one skilled in the art will understand that other scopes are within the scope of this invention.

Thus, any one or combination of active agents and additives may be present, each one or combination of about 0.001, 0.005, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.01, 0.02, 0.03 , 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10 , 11, 12, 13, 14, 15, 16, 17, 18, 19 to about 20 weight percent, including increments and ranges within and between them.

formulation

The cosmetic composition of the present invention may be used for the production of cosmetic preparations, or dermatological preparations, more particularly topical treatment preparations, which may be formulated, for example, into single phase solution compositions, cosmetic serums, or aerosols. Topical application to a surface can be, for example, a surface such as a mucous membrane or skin.

The following examples according to the invention are provided by way of illustration and without limitation. The name is either a chemical name or an INCI name. Amounts of active ingredients are given in weight percent based on a raw material composition containing 100% of the listed ingredients unless otherwise stated herein.

Example

Example 1: Inventive composition:

Various representative embodiments of the compositions and articles of the present invention are illustrated herein.

Example 2: Demonstration of metal chelation/blockade

The former when a solution of Fe(II) or Cu(II) is added to a solution of ferulic acid and phytic acid alone, in combination (ferulic acid+phytic acid), and together with ascorbic acid (ferulic acid+phytic acid+ascorbic acid) A paramagnetic resonance (EPR) test was performed. Chelation/coordination of metals was observed over time.

In the test, 10 microliters of Fe(II) or Cu(II) stock solutions (5000 or 500 ppm) were combined with 90 microliters of phytic acid solution. EPR was measured versus time and colorimetric measurements were made to measure residual free metal.

EPR testing showed that ferulic acid chelates Cu(II) very well. When phytic acid was tested using EPR, Fe(II) was determined to be strongly chelated. Additionally, phytic acid oxidized Fe(II) to Fe(III). In the presence of ascorbic acid and phytic acid, 90% of Fe(II) is oxidized to Fe(III) by ascorbic acid. The remaining Fe(II) is chelated and oxidized to Fe(III) by phytic acid. That is, the association of ascorbic acid, ferulic acid and phytic acid solves the chelation of Fe and Cu to inhibit any oxidation reaction catalyst by these transition metals. Regarding biological pathways and oxidative stress, Fe(III) produces fewer free radicals than Fe(II), so this chelation/oxidation is essential.

In some specific embodiments, an antioxidant solution of ferulic acid or phytic acid with added metal in metal to antioxidant ratios of 1:1 and 1:10 removes metal ions, characterized by clustering/removal of free metal ions. It is observed to provide Referring now to Table 4, the results show the reduction of metal ions by ferulic acid and phytic acid.

As shown in Table 4, ferulic acid chelates copper, reducing the amount of copper ions by about 60% at a ratio of 1:1 to metal, and about the same (60%) at a ratio of 10:1 (ferulic acid to metal). %) is reduced. And phytic acid chelates to form aggregates with iron, reducing the amount of iron ions by about 90% at a ratio of 1:1 with metal, and by about 65% at a ratio of 10:1 (phytic acid to metal). . The data further indicate that ferulic acid has no appreciable effect on iron ions and that phytic acid effectively reduces copper (II) but does not chelate it.

Example 3: Metal Removal by Cosmetic Composition

In some specific embodiments, it is observed that cosmetic compositions comprising both ferulic acid and phytic acid, according to the present disclosure, provide removal of metal ions added to the composition. Referring now to Table 5, the results show reduction of metal ions by ferulic acid and phytic acid as evidenced by the measured residual metal ions.

As shown in Table 5, compositions according to the present disclosure exhibit free metal ion removal of about 60% for copper and about 80% for iron.

Together, Tables 4 and 5 each show that phytic acid clearly and unexpectedly chelates iron but not copper, and that ferulic acid clearly and unexpectedly chelates copper but not iron. These two acids in combination with vitamin C together give the best overall results as shown in Table 5.

Although the present disclosure has been described with reference to the disclosed embodiments, those skilled in the art will understand that various changes may be made and equivalents may be substituted for elements without departing from the scope of the present disclosure. Additionally, many modifications may be made to adapt a particular situation or material to the teachings of this disclosure without departing from its essential scope. Thus, while this disclosure is not limited to the particular embodiment disclosed as the best mode contemplated for carrying out the disclosure, it is intended that the disclosure include all embodiments falling within the scope of the appended claims.

As used herein, “a” (English articles “a” and “an”) means one or more when applied to any feature of an embodiment of the present disclosure set forth in the specification and claims. Use of the singular does not limit meaning to a single feature unless the limitation is specifically stated. “The” before a singular or plural noun or noun phrase can have a singular or plural meaning, indicating a specific specified feature or specific specified features, depending on the context in which it is used. The adjective "any" means one, some, or all, regardless of quantity.

As used herein, “at least one” means one or more, and thus includes mixtures/combinations as well as individual components.

The transitional terms "comprising", "consisting essentially of" and "consisting of", when used in the appended claims, in their original and as amended form, provide that the claim(s) contain additional claim elements or steps not recited. Defines the claim scope for what is excluded from the scope of The term "comprising" is intended to be inclusive or open-ended and does not exclude any additional, unrecited elements, methods, steps or materials. The term "consisting of" excludes any element, step or material other than those specified in the claim, and in the latter case, impurities normally associated with the specified material(s). The term "consisting essentially of" limits the scope of the claim to those that do not materially affect the specified element, step or material(s) and the basic and novel characteristic(s) of the claimed disclosure. All materials and methods described herein embodying the present disclosure may be more specifically defined by any of the transitional terms “comprising,” “consisting essentially of, and “consisting of” in alternative embodiments.

The terms “free” and “free” indicate that the cosmetic composition is typically free of 0% by weight, based on the total weight of the cosmetic composition, of a reliably measurable excluded substance. The term "essentially free" means that although it is preferred that the excluded material is not present in the cosmetic composition, the cosmetic composition of the present invention may have an extremely small amount of the excluded material provided that such amount does not materially affect the beneficial properties of the cosmetic composition. means there is Specifically, “essentially free” means that the excluded material may be present in the cosmetic composition in an amount of less than about 0.1% by weight based on the total weight of the cosmetic composition.

In working examples, or other than where otherwise indicated, all numbers expressing quantities of ingredients and/or reaction conditions are to be understood as being modified by the term "about" which in all instances means within 10% of the indicated number (e.g. For example, "about 10%" means between 9 and 11% and "about 2%" means between 1.8% and 2.2%).

All percentages and ratios are calculated on a weight basis unless otherwise indicated. All percentages are calculated based on total composition unless otherwise indicated. Generally, unless expressly stated otherwise herein, "weight" or "amount" as used herein in relation to a percentage amount of an ingredient refers to the amount of raw material comprising the ingredient, wherein the ingredient is the active ingredient It can be described herein as accounting for 100% or less of Thus, the weight percentage of active agent in the composition is expressed as the amount of raw material containing the active agent used and may or may not reflect the final percentage of active agent, where the final percentage of active agent depends on the weight percentage of active agent in the raw material. .

The terms "weight percent" and "weight percent" may be used interchangeably and may be used interchangeably, except where specified in relation to a phase or system that is a constituent of a composition, article or material, for example, a composition, article or material. It means weight percentage based on the total weight of. All ranges and amounts given herein are intended to include subranges and amounts using the disclosed points as endpoints. Thus, a range of "1% to 10%", such as 2% to 8%, such as 3% to 5%, is "1% to 8%", "1% to 5%", "2% to 10%", etc. It is intended to include the range of. All numbers, amounts, ranges, etc., whether explicitly stated or not, are intended to be qualified with the term "about." Similarly, a range given as “about 1% to 10%” is intended to have the term “about” modifying both the 1% and 10% endpoints. It is also understood that when an amount of an ingredient is given, it is intended to mean the amount of active material unless specifically stated otherwise.

Although numerical ranges and parameters that give a broad scope of the present disclosure are approximations, unless otherwise indicated, the numerical values given in the specific examples are reported as accurately as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements. However, the following examples serve to illustrate embodiments of the present disclosure without limiting in nature.

All publications and patent applications mentioned in this specification are incorporated herein by reference for any and all purposes as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference herein. . In case of inconsistency between this disclosure and any publication or patent application incorporated herein by reference, the present disclosure controls.

Claims (20)

As a cosmetic composition,
(a) i. ferulic acid; and
ii. phytic acid
A metal chelation system comprising a;
(b) ascorbic acid; and
(c) a carrier system comprising an aqueous phase
Containing, cosmetic composition. The cosmetic composition according to claim 1, wherein the cosmetic composition exhibits removal of free metal ions from materials in contact with the cosmetic composition, and the removal of free metal ions ranges from at least about 40% to at most about 99%. The cosmetic composition according to claim 1, wherein the carrier system further comprises one or more additional components, each present in an aqueous phase or a second phase. The cosmetic composition according to claim 3, wherein the second phase is an oil phase. 4. The cosmetic composition of claim 3, wherein the one or more additional ingredients include one or more of glycols, humectants, preservatives, surfactants, thickeners, active compounds, or combinations thereof. The cosmetic composition according to claim 1, wherein the cosmetic composition is one of a single-phase solution including an aqueous phase, a multi-phase solution including at least one additional phase, and an emulsion including an oil phase. The cosmetic composition according to claim 1, wherein the cosmetic composition is a product for keratin tissue selected from a hydroglycol solution, micellar water, cream, lotion, toner, cleanser or makeup remover. The cosmetic composition according to claim 1, wherein the cosmetic composition is a leave-on or rinse-off formulation. The cosmetic composition according to claim 1, wherein the ascorbic acid is present in the cosmetic composition in an amount of about 5% by weight to about 30% by weight based on the weight of the composition. The cosmetic composition according to claim 9, wherein the ascorbic acid is present in a ratio of water to ascorbic acid in the range of about 3:1 to about 10:1 based on the weight of the cosmetic composition. The cosmetic composition according to claim 1, wherein the ferulic acid is present in the cosmetic composition in an amount of about 0.2% to about 5% by weight based on the weight of the composition. The cosmetic composition according to claim 1, wherein the phytic acid is present in the cosmetic composition in an amount of about 0.25% by weight to about 10% by weight based on the weight of the composition. 2. The method of claim 1 wherein ferulic acid is present in the range of about 0.2% to about 5% by weight of the composition; phytic acid is present in the range of about 0.25% to about 10%; Ascorbic acid is present in the range of about 5% to about 30%, all amounts by weight, cosmetic composition. The cosmetic composition according to claim 1, wherein the cosmetic composition contains an active compound selected from the group consisting of vitamin E, carnosine, hyaluronic acid, panthenol, at least one sun filter, at least one hydroxy acid, and combinations thereof. A cosmetic composition comprising one or a combination thereof. 15. The method of claim 14, wherein the active compound is alpha selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, tartaric acid, citric acid, mandelic acid, lactobionic acid, gluconolactone, galactose, and combinations thereof. , A cosmetic composition selected from the group consisting of beta or polyhydroxy acids. The method of claim 1, wherein the carrier system is propylene glycol, dipropylene glycol, pentylene glycol, hexylene glycol, ethoxydiglycol, propylene glycol and ethoxydiglycol Combinations of Cole; a combination of pentylene glycol, hexylene glycol and dipropylene glycol; And a glycol selected from the group consisting of a combination of dipropylene glycol and hexylene glycol, or a combination thereof, a cosmetic composition. As a cosmetic composition,
(a) i. ferulic acid; and
ii. One or a combination of phytic acid and chlorogenic acid
A metal chelation system comprising a;
(b) ascorbic acid; and
(c) comprising an aqueous phase and more than one additional ingredient, each present in the aqueous phase or second phase, said one or more additional ingredients being glycols, humectants, preservatives, surfactants, thickeners, active compounds, or Carrier systems comprising one or more of their combinations
Including,
The cosmetic composition (i) propylene glycol, dipropylene glycol, pentylene glycol, hexylene glycol, ethoxydiglycol, propylene glycol and ethoxydiglycol in the aqueous phase Combinations of Cole; a combination of pentylene glycol, hexylene glycol and dipropylene glycol; and a glycol selected from the group consisting of a combination of dipropylene glycol and hexylene glycol or a combination thereof, (ii) a multi-phase solution comprising at least one additional phase. , or (iii) an emulsion comprising an oil phase,
The cosmetic composition exhibits the removal of free metal ions from materials in contact with the cosmetic composition, and the removal of free metal ions ranges from at least about 40% to about 99% at most, the cosmetic composition. 18. The method of claim 17 wherein ferulic acid is present in the range of about 0.2% to about 5% by weight of the composition; phytic acid is present in the range of about 0.25% to about 10%; Ascorbic acid is present in the range of about 5% to about 30%, all amounts by weight, cosmetic composition. As a method of providing a cosmetic composition,
(a) i. ferulic acid; and
ii. phytic acid
Providing a metal chelating system comprising;
(b) providing ascorbic acid;
(c) (i) the award; and
(ii) one or more additional ingredients including one or more of glycols, humectants, preservatives, surfactants, thickeners, active compounds, or combinations thereof; and
(iii) optionally one or more additives that are emulsifiers, emollients, fragrances, pH adjusting agents, other cosmetically acceptable additives, or combinations thereof.
Providing a carrier system comprising; and
(d) combining said metal chelating system and said ascorbic acid in said aqueous phase of said carrier system with said one or more additional ingredients and optionally one or more additives to provide a cosmetic composition, wherein each of said metal chelating system The acid of is solubilized in the cosmetic composition, providing the cosmetic composition
A method for providing a cosmetic composition comprising a. 20. The method of claim 19, wherein the carrier system is propylene glycol, dipropylene glycol, pentylene glycol, hexylene glycol, ethoxydiglycol, propylene glycol and ethoxydiglycol Combinations of Cole; a combination of pentylene glycol, hexylene glycol and dipropylene glycol; And a glycol selected from the group consisting of a combination of dipropylene glycol and hexylene glycol, or a combination thereof, a cosmetic composition.