FR3088200B1 - Utilisation d'un compose organometallique en tant qu'agent de demethylation de l'adn - Google Patents

Utilisation d'un compose organometallique en tant qu'agent de demethylation de l'adn Download PDF

Info

Publication number
FR3088200B1
FR3088200B1 FR1860412A FR1860412A FR3088200B1 FR 3088200 B1 FR3088200 B1 FR 3088200B1 FR 1860412 A FR1860412 A FR 1860412A FR 1860412 A FR1860412 A FR 1860412A FR 3088200 B1 FR3088200 B1 FR 3088200B1
Authority
FR
France
Prior art keywords
organometal compound
dna demethylation
demethylation agent
agent
organometallic compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1860412A
Other languages
English (en)
Other versions
FR3088200A1 (fr
Inventor
Stephanie Grandemange
Antonio Monari
Philippe Gros
Pierre Francois Cartron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Universite de Lorraine
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Universite de Lorraine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM, Universite de Lorraine filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Priority to FR1860412A priority Critical patent/FR3088200B1/fr
Priority to CA3118628A priority patent/CA3118628A1/fr
Priority to US17/292,689 priority patent/US20220031652A1/en
Priority to EP19835442.5A priority patent/EP3880165A1/fr
Priority to PCT/FR2019/052689 priority patent/WO2020099777A1/fr
Publication of FR3088200A1 publication Critical patent/FR3088200A1/fr
Application granted granted Critical
Publication of FR3088200B1 publication Critical patent/FR3088200B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/58—Metal complex; Coordination compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne l'utilisation non-thérapeutique, en tant qu'agent de déméthylation de l'ADN, d'au moins un composé organométallique comprenant un atome de fer lié à deux groupes terpyridines. L'invention porte également sur un composé organométallique comprenant un atome de fer lié à deux groupes terpyridines pour son utilisation comme médicament.
FR1860412A 2018-11-12 2018-11-12 Utilisation d'un compose organometallique en tant qu'agent de demethylation de l'adn Active FR3088200B1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
FR1860412A FR3088200B1 (fr) 2018-11-12 2018-11-12 Utilisation d'un compose organometallique en tant qu'agent de demethylation de l'adn
CA3118628A CA3118628A1 (fr) 2018-11-12 2019-11-12 Utilisation d'un compose organometallique en tant qu'agent de demethylation de l'adn
US17/292,689 US20220031652A1 (en) 2018-11-12 2019-11-12 Use of an organometallic compound as a dna-demethylating agent
EP19835442.5A EP3880165A1 (fr) 2018-11-12 2019-11-12 Utilisation d'un compose organometallique en tant qu'agent de demethylation de l'adn
PCT/FR2019/052689 WO2020099777A1 (fr) 2018-11-12 2019-11-12 Utilisation d'un compose organometallique en tant qu'agent de demethylation de l'adn

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1860412A FR3088200B1 (fr) 2018-11-12 2018-11-12 Utilisation d'un compose organometallique en tant qu'agent de demethylation de l'adn

Publications (2)

Publication Number Publication Date
FR3088200A1 FR3088200A1 (fr) 2020-05-15
FR3088200B1 true FR3088200B1 (fr) 2021-02-26

Family

ID=65763592

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1860412A Active FR3088200B1 (fr) 2018-11-12 2018-11-12 Utilisation d'un compose organometallique en tant qu'agent de demethylation de l'adn

Country Status (5)

Country Link
US (1) US20220031652A1 (fr)
EP (1) EP3880165A1 (fr)
CA (1) CA3118628A1 (fr)
FR (1) FR3088200B1 (fr)
WO (1) WO2020099777A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115010653B (zh) * 2021-03-05 2023-11-24 江苏师范大学 一种金属双三联吡啶配体及一种含钌超分子化合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1463870A (fr) * 1964-08-05 1966-07-22 Unilever Nv Procédé de teinture de matières kératiniques
DE19852972A1 (de) * 1998-11-17 2000-05-18 Henkel Kgaa Färbemittel mit Übergangsmetallkomplexen
JP2008545624A (ja) * 2005-05-13 2008-12-18 チバ ホールディング インコーポレーテッド 金属錯体を含むケラチン繊維を着色するための方法
DE102012216381A1 (de) * 2012-09-14 2014-05-28 Beiersdorf Ag Verwendung von 4–(4–Hydroxyphenyl)–2–Butanon als demethylierendes Agens

Also Published As

Publication number Publication date
CA3118628A1 (fr) 2020-05-22
FR3088200A1 (fr) 2020-05-15
EP3880165A1 (fr) 2021-09-22
WO2020099777A1 (fr) 2020-05-22
US20220031652A1 (en) 2022-02-03

Similar Documents

Publication Publication Date Title
MA53172A (fr) Composés de sulfonimidamide en tant qu'inhibiteurs de l'activité de l'interleukine 1
MA52948B1 (fr) Composés
MA28269A1 (fr) Arylpyrazoles substitués servant d'agents parasiticides
MX2019003544A (es) Composiciones que comprenden un ligando de union al receptor cannabinoide.
MX2007006178A (es) Fenoles substituidos como agentes activos que inhiben la produccion del factor de crecimiento endotelial vascular.
MA53170A (fr) Composés de sulfonylurée en tant qu'inhibiteurs de l'activité de l'interleukine 1
PA8546301A1 (es) Resolucion de sal quiral
WO2002068384A3 (fr) (2-hydroxy)ethylthioureas utiles en tant que modulateurs des recepteurs adrenergiques alpha2b
MX340137B (es) Método y sistema para dividir llamadas de destino en un sistema elevador.
FR3088200B1 (fr) Utilisation d'un compose organometallique en tant qu'agent de demethylation de l'adn
MX2019002845A (es) Silanos y composiciones curables que comprenden dichos silanos.
MY148807A (en) Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof
WO2009124920A3 (fr) Concentré émulsifiable
ATE514633T1 (de) Ausgabesystem für komplementäre gleitmittelzusammensetzungen
PH12020551891A1 (en) New quinoline derivatives
MA53370B1 (fr) Procédé et intermédiaires pour la préparation de bilastine
MXPA02011039A (es) Combinaciones de productos activos fungicidas.
ES2094344T3 (es) Compuestos anti-virales.
WO2014062428A8 (fr) Procédés de synthèse de 2-amino-4,6-diméthoxybenzamide et d'autres composés de benzamide
WO2009018551A3 (fr) Composés thérapeutiques
FR3069775B1 (fr) 1,4 :3,6 dianhydrohexitols pour hydrater la peau
WO2021094505A8 (fr) Composés herbicides
BR112022008113A2 (pt) Formas sólidas de um modulador de receptor s1p
FR3097223B1 (fr) Adduits silylés, polymères silylés et compositions les comprenant
EP2183256A4 (fr) Composés thérapeutiques

Legal Events

Date Code Title Description
PLFP Fee payment

Year of fee payment: 2

PLSC Publication of the preliminary search report

Effective date: 20200515

PLFP Fee payment

Year of fee payment: 3

PLFP Fee payment

Year of fee payment: 4

PLFP Fee payment

Year of fee payment: 5

PLFP Fee payment

Year of fee payment: 6