FR2963555A3 - Chemical composition, useful e.g. to treat epidermis, comprises a mixture of shea butter, sesame oil, avocado oil, bisabolol, mannitol, tocopheryl acetate, fructose, glucose, hyaluronic acid, and caffeine - Google Patents

Chemical composition, useful e.g. to treat epidermis, comprises a mixture of shea butter, sesame oil, avocado oil, bisabolol, mannitol, tocopheryl acetate, fructose, glucose, hyaluronic acid, and caffeine Download PDF

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FR2963555A3
FR2963555A3 FR1003242A FR1003242A FR2963555A3 FR 2963555 A3 FR2963555 A3 FR 2963555A3 FR 1003242 A FR1003242 A FR 1003242A FR 1003242 A FR1003242 A FR 1003242A FR 2963555 A3 FR2963555 A3 FR 2963555A3
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chemical composition
glucose
bisabolol
caffeine
fructose
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Gerard Alain Adam
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SEPHAR SOC D ETUDES PHARMA
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SEPHAR SOC D ETUDES PHARMA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Chemical composition comprises a mixture of shea butter, sesame oil, avocado oil, bisabolol, mannitol, tocopheryl acetate, fructose, glucose, hyaluronic acid, and caffeine as solution or suspension. An independent claim is included for a cosmetic and pharmaceutical formulation comprising the chemical composition in combination with the excipients. ACTIVITY : Dermatological; Metabolic; Vulnerary. MECHANISM OF ACTION : None given.

Description

-1- La présente invention a pour objet une nouvelle composition chimique, les préparations qui la contiennent $ ses applications dans le traitement des cellules vieillissantes en particulier dans les domai s de la dermatologie et de la cosmétologie. The subject of the present invention is a new chemical composition, the preparations which contain it for its applications in the treatment of aging cells, particularly in the fields of dermatology and cosmetology.

Dans les domaines de la cosmétologie et de la dermatologique, de plus en plus d'efforts ont été engagés pour permettre de préserver les cellules constituant le derme et l'épiderme afin de permettre à la peau de remplir ses fonctions naturelles que sont : le maintien de l'hydratation du corps humain, le milieu d'échange avec l'extérieur, ses fonctions d'élimination par la sudation et son rôle primaire de protection contre les infections 1 o bactériennes. In the fields of cosmetology and dermatology, more and more efforts have been made to preserve the cells constituting the dermis and epidermis to allow the skin to fulfill its natural functions that are: the hydration of the human body, the exchange medium with the outside, its function of elimination by sweating and its primary role of protection against bacterial infections.

Les cellules qui constituent le derme et l'épiderme se renouvellent régulièrement formant ainsi un équilibre entre les cellules nouvelles et les cellules anciennes qui sont éliminées par desquamation. Toutefois, la capacité d'un individu à générer de nouvelles cellules est 15 limitée et afin de préserver un capital cellulaire naturel, il est important de trouver des traitements permettant de prolonger le plus possible la durée de vie cellulaire au même titre que les autres fonctions de l'organisme telles que le système cardiovasculaire ou le système nerveux central. The cells that make up the dermis and the epidermis renew themselves regularly thus forming a balance between the new cells and the old cells which are removed by desquamation. However, the ability of an individual to generate new cells is limited and in order to preserve natural cellular capital, it is important to find treatments that extend cell life as much as other functions as much as possible. of the body such as the cardiovascular system or the central nervous system.

20 Par ailleurs, les rayons solaires, les régimes alimentaires appauvris, sont autant de facteurs qui conduisent à une déshydratation intense de la peau et un vieillissement prématuré. In addition, the sun's rays, depleted diets, are all factors that lead to intense dehydration of the skin and premature aging.

Il existe bien des causes exogènes et des causes endogènes qui entraînent une déshydratation rapide des cellules de l'épiderme et des tissus de soutien (tissus conjonctifs) 25 et qui aboutit à la formation d'une peau plus fine qui a, au fil des ans, de plus en plus de mal a remplir ses fonctions de base. Le maintien d'un niveau normal d'hydratation des cellules de l'épiderme est condition essentielle pour que la peau remplisse ses fonctions naturelles qui sont à la fois des fonctions physiques et des fonctions organiques. 30 Parmi les fonctions physiques de la peau on peut citer : la régulation de la température corporelle, la formation d'un film hydrolipidique protecteur, les sensations tactiles et thermiques,.. Parmi les fonctions organiques on peut citer la synthèse de certaines hormones comme la vitamine D3, les échanges gazeux, l'élimination de toxines,.. -2- Un niveau de l'eau intracellulaire trop bas entraîne une souffrance cellulaire et une perte des capacités métaboliques des cellules et donc de leur capacité à produire de l'énergie. There are many exogenous causes and endogenous causes that result in rapid dehydration of epidermal cells and supporting tissues (connective tissues) and result in the formation of a finer skin that has, over the years , more and more difficult to fulfill its basic functions. The maintenance of a normal level of hydration of the cells of the epidermis is essential condition for the skin to fulfill its natural functions which are at the same time physical functions and organic functions. Among the physical functions of the skin, mention may be made of: the regulation of body temperature, the formation of a protective hydrolipidic film, the tactile and thermal sensations, etc. Among the organic functions, mention may be made of the synthesis of certain hormones such as Vitamin D3, gaseous exchange, elimination of toxins, etc. -2- An intracellular water level that is too low causes cellular suffering and a loss of the cells' metabolic capacities and therefore their capacity to produce energy. .

L'objet de la présente invention est une nouvelle composition permettant de corriger les 5 mécanismes intracellulaires et extracellulaires défaillants afin de préserver et de maintenir un niveau élevé d'hydratation des tissus du derme et de l'épiderme. The object of the present invention is a novel composition for correcting defective intracellular and extracellular mechanisms to preserve and maintain a high level of hydration of dermal and epidermal tissues.

La demanderesse a maintenant trouvé de manière surprenante une nouvelle composition dénommée NBE 80 (Nutritive Body Enhancer 80) agissant à la fois sur le métabolisme 10 interne des cellules en fabriquant de l'eau intracellulaire à partir sucres indispensables à la régulation du cycle de Krebs (cycle de la glycolyse) et sur le maintien d'un niveau d'hydratation naturel et donc permettant un accroissement de la durée de vie cellulaire. Ainsi le maintien de l'hydratation est assuré par les actifs contenus dans le NBE 80 lequel agit selon deux mécanismes bien distincts complémentaires et synergiques. Le premier 15 mécanisme mis en jeu consiste à apporter aux cellules du derme les nutriments essentiels que sont les sucres (glucose) dans les cellules, lesquels nutriments, après catabolisme dans le cycle de Krebs fournit de l'eau in situ. Le second mécanisme mis en jeu par les actifs du NBE 80 consiste à maintenir l'hydratation ainsi obtenue dans les cellules et d'empêcher une élimination trop rapide de l'eau ainsi obtenue par biosynthèse. 20 Par ailleurs, les épidermes ayant subi des stress exogènes développent une réaction de type inflammatoire avec libération de médiateurs de l'inflammation tels que les cytokines, histamine, PGE2 (prostaglandine E2), LDH I (lactate DeHydrogénase), Ill a (Interleukine 1-a.) lesquels se propagent à d'autres cellules en créant une véritable réaction en chaîne 25 laquelle s'accompagne d'une vasodilatation réactionnelle. The Applicant has now surprisingly found a new composition called NBE 80 (Nutritive Body Enhancer 80) acting both on the internal metabolism of cells by making intracellular water from sugars essential for the regulation of the Krebs cycle ( cycle of glycolysis) and on the maintenance of a natural level of hydration and thus allowing an increase in the cell life. Thus the maintenance of hydration is ensured by the assets contained in the NBE 80 which acts according to two distinct and complementary mechanisms synergistic. The first mechanism involved is to provide the cells of the dermis with the essential nutrients that are sugars (glucose) in the cells, which nutrients after catabolism in the Krebs cycle provide water in situ. The second mechanism involved by the assets of NBE 80 is to maintain the hydration thus obtained in the cells and prevent too rapid elimination of the water thus obtained by biosynthesis. Furthermore, exogenously stressed epidermals develop an inflammatory-type reaction with release of inflammatory mediators such as cytokines, histamine, PGE2 (prostaglandin E2), LDH I (lactate DeHydrogenase), Illa (Interleukin 1 -a.) which propagate to other cells creating a true chain reaction which is accompanied by a reaction vasodilatation.

La composition du NBE 80, grâce à ses constituants limite les réactions inflammatoires tout en favorisant la microcirculation sanguine avec pour résultats une diminution de la stase sanguine et donc une augmentation de l'apport des nutriments au coeur des cellules, 30 une augmentation de l'apport en oxygène dans les tissus et dans les cellules et une augmentation du drainage lymphatique permettant ainsi une meilleure élimination des médiateurs inflammatoires. -3- Le NBE 80 objet de la présente invention trouve donc ses applications dans la réhydratation des tissus déshydratés et le maintien de l'hydratation , la protection des cellules de l'épiderme contre les stress oxydatifs de nature inflammatoire et la correction du métabolisme de cellules ischémiées et donc dans des désordres dermatologiques tels que les peaux séchées nécessitant le rétablissement de l'équilibre hydrolytique. The composition of NBE 80, thanks to its constituents, limits the inflammatory reactions while promoting the microcirculation of the blood with the result of a decrease in blood stasis and therefore an increase of the nutrient supply to the heart of the cells, an increase of oxygen supply in the tissues and cells and an increase in lymphatic drainage thus allowing better elimination of inflammatory mediators. The NBE 80 object of the present invention therefore finds its applications in the rehydration of dehydrated tissues and the maintenance of hydration, the protection of epidermal cells against oxidative stress of an inflammatory nature and the correction of the metabolism of ischemic cells and therefore in dermatological disorders such as dried skin requiring the restoration of hydrolytic balance.

La présente invention a pour objet une nouvelle composition contenant dans des proportions bien définies un mélange de beurre de karité, huile de sésame, huile d'avocat, bisabolol, mannitol, acétate de tocophéryl, fructose, glucose, acide hyaluronique, caféine et escine. The present invention relates to a novel composition containing in a well defined proportions a mixture of shea butter, sesame oil, avocado oil, bisabolol, mannitol, tocopheryl acetate, fructose, glucose, hyaluronic acid, caffeine and escine.

Les agents agissant sur la production d'eau intracellulaire sont bien connus individuellement pour leurs propriétés pharmacologiques mais l'effet de la combinaison donne des effets inattendus. Agents acting on intracellular water production are well known individually for their pharmacological properties but the effect of the combination gives unexpected effects.

La présente invention concerne également les préparations cosmétiques et pharmaceutiques contenant le NBE 80 seul ou foiinulé de façon conque avec des excipients notoires permettant une application sur le derme en l'absence de toute réaction de type allergique. Ainsi les préparations également objet de l'invention peuvent en outre contenir de façon indicative mais non limitative des excipients tels que les agents complexants, les gélifiants, les solvants, les parfums, les charges, les agents bactéricides, les absorbeurs d'odeurs, les matières colorantes ou matifiantes. The present invention also relates to cosmetic and pharmaceutical preparations containing NBE 80 alone or faithfully in conque with known excipients allowing application to the dermis in the absence of any allergic-type reaction. Thus, the preparations which are also the subject of the invention may further contain, in an indicative but nonlimiting manner, excipients such as complexing agents, gelling agents, solvents, perfumes, fillers, bactericidal agents, odor absorbers, dyestuffs or mattifying materials.

Les exemples ci après de composition selon l'invention sont donnés à titre d'illustration et sans caractère limitatif. Les quantités sont données en poids par rapport au poids total de la solution ou de la suspension sauf mention contraire. The following examples of composition according to the invention are given by way of illustration and without limitation. The amounts are given by weight relative to the total weight of the solution or suspension unless otherwise specified.

Exemplel : Composition selon l'invention : Les pourcentages en masse des solutions ou suspensions de la composition du NBE 80 sont donnés à titre indicatif et sans caractère limitatif : Beuure de Karité : 2.0 Huile de sésame : 2.0 Huile d'avocat : 1.0 Bisabolol : 0.5 Mannitol : 0.3815 Tocophéryl acétate : 0.3 Fructose : 0.075 5 Glucose : 0.07 Acide hyaluronique : 0.02 Caféine : 0.01 Escine (extrait aesculus hippocastanum) ! 0.0025 Exemplel: Composition according to the invention: The percentages by mass of the solutions or suspensions of the composition of NBE 80 are given as an indication and without limitation: Shea Butter: 2.0 Sesame oil: 2.0 Avocado oil: 1.0 Bisabolol: 0.5 Mannitol: 0.3815 Tocopheryl acetate: 0.3 Fructose: 0.075 5 Glucose: 0.07 Hyaluronic acid: 0.02 Caffeine: 0.01 Escine (Aesculus hippocastanum extract)! 0.0025

10 Exemple 2 : Effet sur l'hydratation cutanée. Example 2: Effect on cutaneous hydration.

L'effet du NBE 80 a été mis en évidence sur un modèle in vivo chez des patients volontaires de sexe féminin en utilisant la méthode de mesure de l'hydratation cutanée au Cornéomètre. 15 Chaque patiente est son propre témoin et les mesures sont effectuées sur une zone traitée (par exemple jambe droite) avec les produits à étudier et sur une zone symétrique non traitée (par exemple jambe gauche). Les résultats expriment le pourcentage d'augmentation du niveau d'hydratation d'une zone en fonction de l'autre. 20 Les produits étudiés ont été mis en solution puis incorporés dans une crème inerte. Les différentes crèmes ainsi obtenues ont été appliquées pendant 2 heures puis la peau a été nettoyée et les mesures ont été effectuées au coméomètre. Les quantités appliquées sont, pour tous les produits, de 2mg par cm2. Les mesures au cornéomètre ont été 25 effectuées 2 heures, 5 heures et 8 heures après le nettoyage de la peau et en comparaison avec les zones témoins pour chaque patiente. Les crèmes testées contiennent les solutions suivantes : Solution témoin : eau distillée Sol R : solution de NBE 80 selon l'exemple 1 30 Témoins : Sol 1 : Hyaluronate de sodium 1% Sol 2 : Glycéryl polyméthacrylates 0,1% stabilisé avec du butylene glycol : 2% Résultats exprimés en différence de pourcentage d'hydratation par rapport au témoin (eau distillée) -5- La significativité des résultats est calculée selon le Test de Student (NS : Non Significatif, HS : Hautement significatif) 2 heure après le nettoyage : Sol R (NBE 80) 48% (HS : p<0,001) Sol 1 : 25% (HS) Sol 2 : 18% (HS : p<0,001) 5 heures après le nettoyage : Sol R (NBE 80) : 38% (HS : p<0,001) Sol 1 : 10% (NS) Sol 2 : 8% (NS) 8 heures après le nettoyage : Sol R (NBE 80): 30% (S: p<0,01) Sol 1 : 6% (NS) Sol 2 : 5% (NS) Ainsi les résultats obtenus montrent que l'application de NBE 80 entraîne une hydratation significative et durable par rapport aux autres solutions testées. Cette rémanence de l'effet qui prouve une synergie inattendue est expliquée par la complémentarité des mécanismes d'action pharmacologique des substances formant la composition du NBE 80. De façon tout aussi inattendue, l'hydratation obtenue avec le NBE 80 persiste plus de 8 heures de façon significative alors que les autres substances ont cessé de produire leur effet. The effect of NBE 80 was demonstrated on an in vivo model in female volunteers using the corneal moisture measurement method. Each patient is her own control and the measurements are made on a treated area (eg right leg) with the products to be studied and on an untreated symmetrical area (eg left leg). The results express the percentage increase in the level of hydration of one zone as a function of the other. The studied products were dissolved and then incorporated in an inert cream. The different creams thus obtained were applied for 2 hours then the skin was cleaned and the measurements were made with the cometometer. The quantities applied are, for all products, 2 mg per cm 2. Corneometer measurements were taken 2 hours, 5 hours and 8 hours after skin cleansing and in comparison with control areas for each patient. The creams tested contain the following solutions: Control solution: distilled water Sol R: solution of NBE 80 according to Example 1 Controls: Sol 1: Sodium hyaluronate 1% Sol 2: Glyceryl polymethacrylates 0.1% stabilized with butylene glycol : 2% Results expressed as difference in percentage of hydration relative to the control (distilled water) -5- The significance of the results is calculated according to the Student's Test (NS: Not Significant, HS: Highly significant) 2 hours after cleaning : Sol R (NBE 80) 48% (HS: p <0.001) Sol 1: 25% (HS) Sol 2: 18% (HS: p <0.001) 5 hours after cleaning: Sol R (NBE 80): 38 % (HS: p <0.001) Soil 1: 10% (NS) Soil 2: 8% (NS) 8 hours after cleaning: Sol R (NBE 80): 30% (S: p <0.01) Sol 1 : 6% (NS) Sol 2: 5% (NS) Thus the results obtained show that the application of NBE 80 causes a significant and lasting hydration compared to the other solutions tested. This remanence of the effect which proves an unexpected synergy is explained by the complementarity of the pharmacological action mechanisms of the substances forming the composition of NBE 80. In an equally unexpected way, the hydration obtained with NBE 80 persists for more than 8 hours. significantly while other substances have ceased to produce their effect.

Exemple 3 : Exemple de formulation pharmaceutique ou cosmétique de NBE 80. Cet exemple est donné à titre indicatif et sans caractère limitatif. Example 3 Example of a Pharmaceutical or Cosmetic Formulation of NBE 80. This example is given for information only and without limitation.

Les pourcentages de la composition sont donnés en poids par rapport au poids total (pour 100g) Eau : 66.226200 Glycérine : 5.0 Isononyl isononanoate : 0.5 Cetearyl alcool : 3.2 Propylène glycol : 3.0 Beurre de karité : 2.5 Triticum vulgare geai' oil : 2.0 Huile de sésame : 2.0 -6- Hydrogenated polydecène : 2.0 Cyclopentasiloxane ; 1.3 Huile d'avocat : 1.0 Cetearyl glucoj4e : 0.8 Cyclohexasiloxane : 0.7 Glyceryl stearate : 0.5 Bisabolol : 0.5 Peg-100 : 0.5 Hexylene glycol : 0.46 Mannitol: 0.3815 Phenoxyethanol : 0.3 65 Polyacrylamide : 0.3 Parful : 0.3 Imidazolidinyl urea : 0.3 Tocopheryl acétate : 0.3 Methylparaben :0.2855 C12-c14 isoparaffin : 0.24 Cetyl alcohol : 0.2 Amonium glycyrrhizate : 0.1 20 Butylparaben : 0.0775 Fructose : 0.075 Glucose : 0.07 Propylparaben : 0.0627 Laureth-7 : 0.06 25 Tetrasodium edta : 0.05 Polyquatemium-&( 0.05 Ethylparaben : 0.02 Sodium hyaluronate : 0.02 Triethanolamine : 0.016 30 Cafeine : 0.01 Urée : 0.01 Alanine : 0.01 Zinc gluconate : 0.006 Escine (extrait aesculus hippocastanum) : 0,0025 -7- Acide aspartique : 0.001 Acide glutamique : 0.001 5 The percentages of the composition are given by weight relative to the total weight (per 100 g) Water: 66.226200 Glycerin: 5.0 Isononyl isononanoate: 0.5 Cetearyl alcohol: 3.2 Propylene glycol: 3.0 Shea butter: 2.5 Triticum vulgare oil: 2.0 Oil of sesame: 2.0 -6- Hydrogenated polydecene: 2.0 Cyclopentasiloxane; 1.3 Avocado oil: 1.0 Cetearyl glucoj4e: 0.8 Cyclohexasiloxane: 0.7 Glyceryl stearate: 0.5 Bisabolol: 0.5 Peg-100: 0.5 Hexylene glycol: 0.46 Mannitol: 0.3815 Phenoxyethanol: 0.3 65 Polyacrylamide: 0.3 Parful: 0.3 Imidazolidinyl urea: 0.3 Tocopheryl acetate: 0.3 Methylparaben: 0.2855 C12-c14 isoparaffin: 0.24 Cetyl alcohol: 0.2 Ammonium glycyrrhizate: 0.1 20 Butylparaben: 0.0775 Fructose: 0.075 Glucose: 0.07 Propylparaben: 0.0627 Laureth-7: 0.06 25 Tetrasodium edta: 0.05 Polyquatemium - & (0.05 Ethylparaben: 0.02 Sodium hyaluronate: 0.02 Triethanolamine: 0.016 30 Caffeine: 0.01 Urea: 0.01 Alanine: 0.01 Zinc gluconate: 0.006 Escine (aesculus hippocastanum extract): 0.0025 -7- Aspartic acid: 0.001 Glutamic acid: 0.001 5

Claims (3)

REVENDICATIONS1- Composition chimique caractérisée en ce qu'elle contient, en solution ou en suspension, un mélange de beurre de karité, huile de sésame, huile d'avocat, bisabolol, mannitol, autate de tocophéryle, fructose, glucose, acide hyaluronique, et caféine CLAIMS1- A chemical composition characterized in that it contains, in solution or suspension, a mixture of shea butter, sesame oil, avocado oil, bisabolol, mannitol, tocopheryl autate, fructose, glucose, hyaluronic acid, and caffeine 2- Formulation pharmaceutique et cosmétique caractérisée en ce qu'elle contient la composition chimique selon la revendication 1 en association avec des excipients pharmacologiquement ou cosmétiquement acceptables 10 2- Pharmaceutical and cosmetic formulation characterized in that it contains the chemical composition according to claim 1 in association with pharmacologically or cosmetically acceptable excipients 10 3- Utilisation de la composition selon la revendication 1 pour la fabrication d'un produit pour le traitement des troubles de l'épiderme consécutifs à la déshydratation excessive de la peau et ou à une dénutrition excessive et pour la prévention des désordres métaboliques induits par des agents pro-inflammatoires tels que le traitement des brûlures. 15 3- Use of the composition according to claim 1 for the manufacture of a product for the treatment of disorders of the epidermis consecutive to excessive dehydration of the skin and or excessive undernutrition and for the prevention of metabolic disorders induced by pro-inflammatory agents such as burn treatment. 15
FR1003242A 2010-08-03 2010-08-03 Chemical composition, useful e.g. to treat epidermis, comprises a mixture of shea butter, sesame oil, avocado oil, bisabolol, mannitol, tocopheryl acetate, fructose, glucose, hyaluronic acid, and caffeine Pending FR2963555A3 (en)

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FR1003242A FR2963555A3 (en) 2010-08-03 2010-08-03 Chemical composition, useful e.g. to treat epidermis, comprises a mixture of shea butter, sesame oil, avocado oil, bisabolol, mannitol, tocopheryl acetate, fructose, glucose, hyaluronic acid, and caffeine

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3610863A4 (en) * 2017-03-31 2020-12-16 CAC Corporation Agent for enhancing skin barrier, medicinal composition, medicated cosmetic and beauty care method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3610863A4 (en) * 2017-03-31 2020-12-16 CAC Corporation Agent for enhancing skin barrier, medicinal composition, medicated cosmetic and beauty care method

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