FR2952936B1 - Polymere de type acrylique ou methacrylique comprenant des greffons alpha-tocopherol - Google Patents

Polymere de type acrylique ou methacrylique comprenant des greffons alpha-tocopherol

Info

Publication number
FR2952936B1
FR2952936B1 FR0958413A FR0958413A FR2952936B1 FR 2952936 B1 FR2952936 B1 FR 2952936B1 FR 0958413 A FR0958413 A FR 0958413A FR 0958413 A FR0958413 A FR 0958413A FR 2952936 B1 FR2952936 B1 FR 2952936B1
Authority
FR
France
Prior art keywords
alpha
acrylic
type polymer
methacrylic type
active agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0958413A
Other languages
English (en)
Other versions
FR2952936A1 (fr
Inventor
You Ping Chan
Olivier Breyne
Alain Constancis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Flamel Technologies SA
Original Assignee
Flamel Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0958413A priority Critical patent/FR2952936B1/fr
Application filed by Flamel Technologies SA filed Critical Flamel Technologies SA
Priority to CA2781082A priority patent/CA2781082A1/fr
Priority to EP10805323A priority patent/EP2504370A1/fr
Priority to PCT/IB2010/055440 priority patent/WO2011064743A1/fr
Priority to AU2010325556A priority patent/AU2010325556B2/en
Priority to MX2012006042A priority patent/MX2012006042A/es
Priority to JP2012540532A priority patent/JP2013512301A/ja
Priority to CN2010800536856A priority patent/CN102648221A/zh
Priority to KR1020127013312A priority patent/KR20120099442A/ko
Priority to US12/955,076 priority patent/US20110129540A1/en
Publication of FR2952936A1 publication Critical patent/FR2952936A1/fr
Application granted granted Critical
Publication of FR2952936B1 publication Critical patent/FR2952936B1/fr
Priority to IL219491A priority patent/IL219491A0/en
Priority to ZA2012/03225A priority patent/ZA201203225B/en
Priority to CL2012001358A priority patent/CL2012001358A1/es
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
    • C08F220/30—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
    • C08F220/30—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety
    • C08F220/302—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety and two or more oxygen atoms in the alcohol moiety
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/58—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing oxygen in addition to the carbonamido oxygen, e.g. N-methylolacrylamide, N-(meth)acryloylmorpholine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Optics & Photonics (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Graft Or Block Polymers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne une nouvelle famille de polymères de type acrylique et/ou méthacrylique, comprenant des greffons alpha-tocophérol, aptes à former des nanoparticules dans un milieu aqueux et à pH neutre. Elle vise en outre l'utilisation de telles nanoparticules, associées de manière non covalente à un actif, notamment un actif de faible ou moyenne solubilité aqueuse, en vue de véhiculer, de solubiliser et/ou d'accroître la solubilisation aqueuse dudit actif.
FR0958413A 2009-11-26 2009-11-26 Polymere de type acrylique ou methacrylique comprenant des greffons alpha-tocopherol Expired - Fee Related FR2952936B1 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
FR0958413A FR2952936B1 (fr) 2009-11-26 2009-11-26 Polymere de type acrylique ou methacrylique comprenant des greffons alpha-tocopherol
CN2010800536856A CN102648221A (zh) 2009-11-26 2010-11-26 含α-生育酚接枝侧链的丙烯酸和/或甲基丙烯酸类聚合物
PCT/IB2010/055440 WO2011064743A1 (fr) 2009-11-26 2010-11-26 Polymere de type acrylique ou methacrylique comprenant des greffons alpha-tocopherol
AU2010325556A AU2010325556B2 (en) 2009-11-26 2010-11-26 Acrylic or methacrylic polymer including alpha-tocopherol grafts
MX2012006042A MX2012006042A (es) 2009-11-26 2010-11-26 Polimero de tipo acrilico o metacrilico que comprende injertos de alfa-tocoferol.
JP2012540532A JP2013512301A (ja) 2009-11-26 2010-11-26 α−トコフェロールグラフトを含むアクリル又はメタクリル系ポリマー
CA2781082A CA2781082A1 (fr) 2009-11-26 2010-11-26 Polymere de type acrylique ou methacrylique comprenant des greffons alpha-tocopherol
KR1020127013312A KR20120099442A (ko) 2009-11-26 2010-11-26 알파－토코페롤 그라프트를 포함하는 아크릴계 또는 메타크릴계 중합체
EP10805323A EP2504370A1 (fr) 2009-11-26 2010-11-26 Polymere de type acrylique ou methacrylique comprenant des greffons alpha-tocopherol
US12/955,076 US20110129540A1 (en) 2009-11-26 2010-11-29 Polymer of acrylic or methacrylic type comprising alpha-tocopherol grafts
IL219491A IL219491A0 (en) 2009-11-26 2012-04-30 Polymer of acrylic or methacrylic type comprising alpha-tocopherol grafts
ZA2012/03225A ZA201203225B (en) 2009-11-26 2012-05-04 Acrylicor methacrylic polymer including alpha-tocopherol agents
CL2012001358A CL2012001358A1 (es) 2009-11-26 2012-05-25 Polimero con esqueleto lineal de tipo acrilico y/o metacrilico al que estan ligados injertos de alfa-tocoferol, por medio de un espaciador formado en parte por la menos una funcion hidroloizable yn porque el reparto de dichos injertos al nivel de dichos esqueleto es aleatorio; procedimiento de preparacion; composicion.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0958413A FR2952936B1 (fr) 2009-11-26 2009-11-26 Polymere de type acrylique ou methacrylique comprenant des greffons alpha-tocopherol

Publications (2)

Publication Number Publication Date
FR2952936A1 FR2952936A1 (fr) 2011-05-27
FR2952936B1 true FR2952936B1 (fr) 2011-11-25

Family

ID=42103880

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0958413A Expired - Fee Related FR2952936B1 (fr) 2009-11-26 2009-11-26 Polymere de type acrylique ou methacrylique comprenant des greffons alpha-tocopherol

Country Status (13)

Country Link
US (1) US20110129540A1 (fr)
EP (1) EP2504370A1 (fr)
JP (1) JP2013512301A (fr)
KR (1) KR20120099442A (fr)
CN (1) CN102648221A (fr)
AU (1) AU2010325556B2 (fr)
CA (1) CA2781082A1 (fr)
CL (1) CL2012001358A1 (fr)
FR (1) FR2952936B1 (fr)
IL (1) IL219491A0 (fr)
MX (1) MX2012006042A (fr)
WO (1) WO2011064743A1 (fr)
ZA (1) ZA201203225B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2433248B1 (es) * 2012-05-07 2015-03-10 Consejo Superior Investigacion Copolimeros anfifilicos portadores de alfa-tocoferol con propiedades antitumorales
ES2721675B2 (es) * 2018-02-02 2020-02-06 Nanomateriales Y Polimeros S L Procedimiento de obtencion de particulas polimericas funcionalizadas
ES2735638B2 (es) * 2018-06-18 2021-01-18 Alodia Farm S L Copolimeros y terpolimeros acrilicos funcionales autoasociados y su uso como vehiculos de compuestos bioactivos

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2680749A (en) * 1951-12-01 1954-06-08 Eastman Kodak Co Water-soluble tocopherol derivatives
US6123928A (en) * 1992-12-21 2000-09-26 Biophysica, Inc. Sunblocking polymers and their novel formulations
KR100195291B1 (ko) 1997-07-12 1999-06-15 서경배 비이온성 비타민
FR2786098B1 (fr) * 1998-11-20 2003-05-30 Flamel Tech Sa Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s), suspension colloidale les comprenant et leurs procedes de fabrication
FR2830447B1 (fr) 2001-10-09 2004-04-16 Flamel Tech Sa Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques
FR2840614B1 (fr) 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
KR20080003322A (ko) * 2005-02-24 2008-01-07 엘란 파마 인터내셔널 리미티드 도세탁셀 및 이의 유사체의 나노입자 배합물
RU2499607C2 (ru) * 2006-09-19 2013-11-27 Басф Се Косметические препараты на основе молекулярно впечатанных полимеров
US20110150837A1 (en) * 2009-12-23 2011-06-23 Flamel Technologies Amphiphilic polymer functionalized by methionine

Also Published As

Publication number Publication date
JP2013512301A (ja) 2013-04-11
FR2952936A1 (fr) 2011-05-27
WO2011064743A1 (fr) 2011-06-03
MX2012006042A (es) 2012-10-03
EP2504370A1 (fr) 2012-10-03
ZA201203225B (en) 2013-01-30
AU2010325556B2 (en) 2013-07-11
IL219491A0 (en) 2012-06-28
AU2010325556A1 (en) 2012-05-24
CA2781082A1 (fr) 2011-06-03
KR20120099442A (ko) 2012-09-10
CL2012001358A1 (es) 2012-10-12
CN102648221A (zh) 2012-08-22
US20110129540A1 (en) 2011-06-02

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20150731