FR2876909A1 - Cosmetic and/or pharmaceutical composition, to prevent or treat adipose overloads and cellulitis, comprises a combination of one or more xanthinic bases and chaulmoogra oil and/or its components - Google Patents

Abstract

Cosmetic and/or pharmaceutical composition (I) to prevent or treat adipose overloads and cellulitis, comprises a combination of one or more xanthinic bases (II) and chaulmoogra oil (III) and/or its components. ACTIVITY : Antilipemic. MECHANISM OF ACTION : None given.

Description

The present invention relates to a novel composition for use in

  therapeutic and cosmetic, and more particularly a new composition combining chaulmoogra oil and xanthine bases for the treatment of

  fat overload and cellulite.

  The skin consists of superficial layers, namely the epidermis, and deeper layers, the dermis and hypodermis, and each has specific properties allowing the whole to react and adapt to the conditions of its environment. The epidermis, which is composed of three types of cells, namely keratinocytes (90% of epidermal cells), melanocytes (2 to 3% of epidermal cells) and Langerhans cells, constitutes the outer layer and plays a role. fundamental to ensure the protection and maintenance of good trophicity. The dermis serves as a support for the epidermis and consists mainly of fibroblasts and an extracellular matrix essentially based on collagen and elastin. Collagen fibers contribute to the texture and tone of the skin and elastin is responsible for its elasticity. Other cells, such as macrophages and leucocytes, are also present in the dermis layer. The hypodermis, which is the deepest layer of the skin, contains lipid-producing fat cells so that the subcutaneous tissue makes a fat layer that protects the muscles, bones, and internal organs from shock.

  Adipocytes synthesize triglycerides by lipogenesis from free fatty acids and glycerol from glucose degradation. Fatty acids and glucose are brought to the body by food. Conversely, the triglycerides contained in adipocytes undergo lipolysis by the action of enzymes and release glycerol or glycerol esters as well as fatty acids which can in turn circulate in the body and / or be captured by adipocytes. where they are again transformed into triglycerides B1529fr by lipogenesis. Thus, in case of imbalance between lipogenesis and lipolysis, there can be an excessive accumulation of triglycerides which results in fat overload.

  Adipose overloads, or localized fat overloads, are defects that can affect the aesthetic appearance of the individual, and they also constitute abnormal physiological states in humans, but especially in women, where cellulite accumulations are always considered unsightly. These conditions, although different from obesity, usually require systemic treatment. Often, in the absence of therapeutic treatment, a cosmetic treatment is desired to fight against fat overload, and to mitigate the unsightly effects.

  Also, there is a continuing need to develop compositions that can provide a lipolytic effect useful in the treatment of fat overload, both cosmetically and therapeutically. The lipolytic effect of a substance can be evaluated by its ability to destock adipocyte lipids by increasing the intercellular concentration of cyclic AMP (cAMP). This increase is dependent on the saturation of neuropeptide Y receptors and α 2 adrenergic receptors. Indeed, when neuropeptide Y or prostanoids bind to their receptors, they induce a decrease in cAMP, which leads to a decrease in the activity of lipases, and an increase in the accumulation of adipocyte lipids. It can also be evaluated by the determination of the glycerol released in a culture medium of adipocytes.

  Many substances, especially of plant origin, have been proposed to try to fight against cellulite and fat overload and various compositions have been developed. They can be administered internally, for example orally or by injection, or more generally externally, especially by topical application.

  The compounds exerting a certain action by topical application are distributed between those which have a circulatory drainage action and those which act on the adipocyte. Thus, procyanidolic oligomers, derived from grape seeds, flavonoids, such as ruscus, red vine extracts, horse chestnut, witch hazel, have some drainage action. Caffeine, and various caffeine derivatives, act on the α 2 -adrenergic receptors of adipocyte membranes. In particular, caffeine can help reduce edema and water retention, increase lipolysis and limit the storage of fat. Among the caffeine derivatives, mention may be made of caffeine carboxylates, as in patent FR 2,639,541. Caffeine-based combinations have also been proposed, for example the combination of caffeine, and more generally of a xanthine base with Polygala tenuifolia, as in US Pat. No. 5,667,793, or with algae extracts as in the US Pat. FR 2,490,492.

  The xanthic bases consist of the three purine bases, namely caffeine, theophylline and theobromine. Xanthine is a compound derived from purine, having two contiguous rings, pyridinyl and glyoxalinyl, constituting a 2,6-dioxypurine. Xanthine can be obtained by reducing uric acid. Theobromine, theophylline and caffeine are methylated derivatives of xanthine which differ from each other by the position and number of methyl groups. Theobromine, or 3,7-dimethyl xanthine, is an alkaloid extracted from the cacao seed, Theobroma cacao; it is also found in small quantities in tea and coffee. Theophylline, or 1,3-dimethylxanthine, is an alkaloid extracted from the leaves of the tea tree, Thea sinensis. It can also be synthesized by methylation of xanthine. Caffeine, or 1,3,7-trimethyl xanthine, is an alkaloid extracted from tea tree leaves, and coffee beans. Caffeine can also be obtained from the seeds of kolatier, guarana and mate, as well as from the seeds of porangaba (Cordia salicifolia) of the boraginated family. It can also be synthesized by methylating theobromine and theophylline.

  However, xanthine bases, and in particular high concentration caffeine, are not always well supported by patients and may cause side effects, for example palpitations.

  Chaulmoogra oils have long been used in traditional medicine in Asia, particularly in India and China, for the treatment of leprosy, before the emergence of sulfonated drugs, including diaminodiphenylsulfone, and antituberculosis antibiotics such as than rifampicin and rifamycin. Hydnocarpic acid, one of the main constituents of chaulmoogra oil, has been shown to exhibit antimycobacterial activity by inhibiting the growth of certain mycobacteria, such as Mycobacterium leprae, as indicated by PL Jacobsen and L. Levy, Antimycobacterial Agents and Chemotherapy (1973) pp. 373-379.

  More recently, their use as a component of cosmetic compositions has been described, for example in patent FR 2 706 304 relating to compositions intended to harmonize the pigmentation of the skin, by virtue of the pigmentation effects of the achromic cutaneous zones, that is, ie, little or no pigmented, by migration of pigmentation from pigmented areas. Patent FR 2,518,402 describes a composition containing chaulmoogra oil that can be used in cosmetics for the normalization of sebaceous secretions and cutaneous microbial flora. The use of chaulmoogra oils in hair lotions intended to promote the regrowth of hair has also been described in patent BE 570.171.

  Chaulmoogra oils are mainly extracted from the seeds of woody plants in tropical regions belonging to the family Flacourtiaceae, including a tree of varieties such as Hydnocarpus wightiana and Tarakto-genos kurzii. These plants are mainly of Asian origin, including India, Vietnam and the Philippines, as well as Central and South America, including Brazil.

  The seeds from which are extracted the oils of chaulmoogra contain a high proportion of lipids, between 30 and 50% according to the species, as well as 15 to 20% of protides and 4 to 6% of mineral matter, as well as 1 to 3 % unsaponifiable, glycerides of unsaturated fatty acids with pentenic ring, consisting essentially of chaulmoogric acid, hydnocarpic acid and gorlic acid. It seems that these acids are responsible for the therapeutic antimycobacterial action in the traditional treatment of leprosy. It has been observed that the spatial structure of these acids is similar to the cyclopentanoperhydroxyphenantrene ring characteristic of sterols.

  The chaulmoogic, hydnocarpic and gorlic acids can be represented by the following general formulas, respectively: (12) ## STR5 ## Thus, these three acids comprise the same cyclopentenic ring carrying an acidic group at the end of a carbon chain - (CH 2) n - where n is 10 in the case of the acid

H

  hydnocarpic and 12 in the case of chaulmoogric acid, the same chain having a double bond in the case of gorlic acid. The contents of each of these three acids in chaulmoogra oils depend on the origin of the species.

  Esters of these acids, in particular methyl, ethyl and benzyl esters, have been synthesized with a view to improving their acceptability and tolerance. In the same way, it has been found that salts such as sodium chaulmoograte and sodium hydnocarpate exert a dissolving action on lecithins and cholesterol, which could explain their action on the waxy envelope of the bacilli of leprosy and tuberculosis.

  Chaulmoogra oils also contain fatty acids such as palmitic, oleic, palmitoleic, stearic, myristic, and traces of alepric and aleprylic acid.

  Applicant studies on cell receptors and protection of dendritic cells have now unexpectedly demonstrated that chaulmoogra oil has a lipolytic effect verified by its action on cultured human adipocytes, resulting in competition. this oil, applied externally, vis-à-vis neuropeptide Y and a2 adrenergic receptors, and that lipolytic effect could potentiate that of xanthine bases, especially caffeine.

  The subject of the present invention is therefore a novel cosmetic and / or pharmaceutical composition combining one or more xanthine bases, in particular caffeine, and chaulmoogra oil and / or at least one of its components, intended for the treatment and prevention of fat overload and cellulite.

  The invention also relates to the combined use of xanthine bases, in particular caffeine, and chaulmoogra oil, or its essential components such as chaulmoogric, hydnocarpic and gorlic acids, as well as their salts and esters. for the preparation of a cosmetic composition for the treatment of fat overload and cellulite.

  The subject of the invention is also the combined use of xanthine bases, in particular caffeine, and of chaulmoogra oil, and / or of its essential components such as chaulmoogric, hydnocarpic and gorlic acids, as well as their salts and esters, for the preparation of a lipolytic drug for the treatment of fat overload and cellulitis.

  The subject of the invention is also a process for the cosmetic treatment of the skin, more particularly for preventing or reducing fat overload and cellulite, by applying a composition based on chaulmoogra oil and xanthine bases on the the skin requiring such treatment.

  The xanthine bases used in the present invention are caffeine, theophylline and theobromine, alone or in combination, and preferably caffeine.

  Experiments have shown that the lipolytic activity of chaulmoogra oil is mainly due to the chaulmoogric, hydnocarpic and gorlic acids it contains. The invention therefore extends to the use of xanthine bases in combination with chaulmoogra oil and / or chaulmoogric, hydnocarpic and gorlic acids, as well as their salts or esters, such as, for example, their methyl esters, ethyl or benzyl, as well as sodium or potassium salts, and for example sodium or potassium chaulmoograte and sodium hydnocarpate.

  Experiments have shown that the combination of xanthine bases, in particular caffeine, and chaulmoogra oil gives a lipolytic effect which is clearly greater than that of each of the constituents, used alone.

  Thus, it has been demonstrated that by using a composition comprising 0.5% of chaulmoogra oil and 0.4% of caffeine, the proportion of glycerol released into the culture medium, during evaluation tests of the lipolytic effect in the adipocytes, is 40% whereas it is only 30% with caffeine alone.

  The chaulmoogra oils used in the compositions of the present invention can be extracted from the seeds of plants of varieties such as Hydnocarpus wightiana, Tarakto-genos kurzii, Hydnocarpus alpina, Hydnocarpus anthelmintica, Hydnocarpus cauliflora, Hydnocarpus dawnensis, Hydnocarpus heterophylla, Hydnocarpus hutchinsonii, Hydnocarpus ovoidea, Hydnocarpus subfalcata, Hydnocarpus venenata, Hydnocarpus verrucosa, Hydnocarpus woodii, Hydnocarpus calvipetala, Hydnocarpus ilicifolia, Hydnocarpus octandra, Gynocardia odorata, Oncoba echinata, Caloncoba glauca, Caloncoba welwitschii, Carpotroche brasiliensis, Carpotroche amazonica, Asteriastigma macrocarpa, Mayna odorata and Lindakeria dentata.

  The effectiveness of the combination of xanthine bases and chaulmoogra oil according to the present invention was verified on tests for evaluating the lipolytic effect by releasing glycerol in a culture medium of human adipocytes. This activity is indeed significant of a lipolytic effect resulting in a hydrolysis of total lipids in glycerol and free fatty acids.

  Preparation of human adipocytes in culture Adipocytes are obtained by taking adipose tissue from plastic surgery (whole skin), stored at room temperature in a suitable preservation medium and then finely cut and placed in HBSS buffer at pH 7, 4. A solution of collagenase type II (1 mg / ml in HBSS buffer pH 7.4) is added to the tube containing the adipose tissue fragments (4 volumes of collagenase per 1 volume of tissue) and the whole is incubated at 37 C for 40 minutes under constant stirring, without carbon dioxide. This first step releases the adipocytes from the conjunctival gangue and vascular stroma.

  After incubation, the cells are recovered by filtration on a nylon filter and the adipocytes thus isolated are separated by flotation. After removal of the subnant by suction, the adipocyte suspension is washed with a KBR isotonic buffer to remove any trace of collagenase. After addition of 3.5% BSA, the pH is adjusted to 7.5 and the buffer is filtered (0.22 μm filter).

  The human adipocytes in culture are distributed in several batches incubated for 1 hour with stirring. Lot 1 is a negative control that does not contain any product and without treatment. Lot # 2 is a positive control that is treated with only 0.4% caffeine. Lots 3, 4 and 5 respectively contain 0.5%, 1% and 5% by weight of chaulmoogra oil in the first test (Table 1), and the same concentrations of chaulmoogra oil supplemented with caffeine. 0.4% in the second test (Table 2).

  Enzymatic determination of glycerol The enzymatic determination of glycerol consists in measuring the oxidation of the reduced form of nicotinamideadeninedinucleotide (NADH) by measuring the optical density (OD) at 385 nm. Indeed, the amount of NADH oxidized during the reaction of glycerol conversion to pyruvate and lactate is proportional to the total concentration of glycerol.

  Under the action of three enzymes (glycerokinase, pyruvate kinase and lactate dehydrokinase) the following three reactions occur: 1) glycerol reacts with ATP to give glycerol-3-phosphate and ADP; 2) ADP reacts with phosphoenolpyruvate to release pyruvate and ATP; 3) Finally, pyruvate reacts with NADH-H to provide lactate-NAD.

  A glycilglycine buffer (pH 7.4) containing NADH (0.83 mg), ATP (2 mg), magnesium sulfate (1 mg) and phosphoenolpyruvate (1 mg) is used. the enzyme suspension consists of pyruvate kinase (240 μ) and lactate dehydrogenase (220 μ). Glycerokinase (34 μ) is used in suspension.

  The method consists in mixing all the elements of reactions 2) and 3) above, in the presence and in the absence of adipocyte culture media (with and without the product to be tested), and measuring the OD (A1), and in a second step to start the reaction 1) by adding glycerokinase. The resulting OD is then measured at 385 nm (A2). The difference in OD is obtained from the differences in OD for the product to be tested on the one hand, and for the control on the other hand.

  Table 1 of the results indicated below shows that chaulmoogra oil, used alone, has a lower lipolytic effect than caffeine at the doses tested.

Table 1

  glycerol (mg / l) increase% Control (lot # 1) 52.8 4.2 Positive control (caffeine 68.5 5.5 + 30% to 0.4%) Chaulmoogra oil at 55.7 5, 7 + 6% 0.5% (lot 3) Chaulmoogra oil at 64.8 3.9 + 23% 1% (lot 4) Chaulmoogra oil at 66.7 4.4 + 27% 5% (lot 5) These results show that the lipolytic effect of chaulmoogra oil, at concentrations of 1 and 5%, is slightly lower than that of caffeine.

Table 2

  glycerol (mg / 1) increase% Control (lot no. 1) 52.8 4.2 Positive control (caffeine at 68.5 5.5 + 30% 0.4%) Chaulmoogra oil 0.5% 73, 9 6 , 1 + 40% + caffeine 0.4% (lot 3) Chaulmoogra oil 1% 69.9 4.1 + 33% + caffeine 0.4% (lot 4) Chaulmoogra oil 5% 68.4 5.3 + 30% + caffeine 0.4% (lot 5) These results highlight the lipolytic effect of the combination of caffeine and chaulmoogra oil according to the invention, from the concentration of 0.5% by weight. weight of chaulmoogra oil for a concentration of 0.4% of caffeine. This lipolytic effect is particularly clear because the increase in the level of glycerol released in the culture medium of human adipocytes is 40%, which shows that the lipolytic effect of caffeine has been potentiated by the presence of chaulmoogra.

  The weight ratio of the xanthan bases, especially caffeine, to chaulmoogra oil is generally between 1: 0.5 and 1: 5 and preferably between 1: 1 and 1: 1.5, and preferably neighbor of 1: 1.25.

  According to the present invention, the content of xanthine base, more particularly caffeine, may be between 0.1 and 8%, and preferably between 0.5 and 5% by weight, while the oil content of chaulmoogra, or in acids or salts or esters is generally between 0.1 and 15%, and preferably between 1 and 8% relative to the total weight of the composition, to provide the best lipolytic effects.

  In the case of relatively high contents of caffeine and of chaulmoogra oil, it may be advantageous to use a medium comprising an aqueous phase having a dielectric constant of approximately 60, for example by means of a medium having an alcoholic degree ( for example ethyl) about 30%.

  Xanthic bases, especially caffeine, and chaulmoogra oil can be used advantageously in a form encapsulated in liposomes.

  According to a known technique in the manufacture of cosmetic compositions, the liposomes are constituted by small hollow spheres, generally less than 500 nm in diameter, whose wall is formed of a double layer of lipids such as glucolipids or phospholipids. They can be obtained for example by ultrasonic treatment of a mixture of an aqueous solute and lipids.

  Lipids (phospholipids or glucolipids) are reorganized in a configuration where the energy of the whole is minimal, therefore thermodynamically the most stable. Liposomes are used in the cosmetics industry to deliver compounds into cells when the vesicle fuses with the plasma membrane.

  According to a preferred embodiment of the invention, at least part of the caffeine and chaulmoogra oil is encapsulated in liposome-type vesicles, and the weight ratio of caffeine to chaulmoogra oil, preferably close to 1.25, is provided by appropriate vectorization in liposomes.

  The compositions according to the present invention are preferably topically administrable. In conventional terminology, topical administration refers to any method of applying the substance or composition directly to the skin on the area requiring treatment.

  In accordance with the present invention, the topically administrable composition may advantageously contain, in addition to the basic components described above, one or more other substances known to have beneficial effects on the skin, and more particularly tocopherol, vitamin A (retinol), retinoic acid, bactericidal agents, as well as plant extracts known to promote the thinning effect such as oily extracts of green tea and green coffee or an alcoholic extract of ivy.

  Some of these extracts, in particular the glycolic extract of ivy (hederagenin), have the advantage of facilitating the penetration of the composition of the invention through the epidermis and the dermis. Other compounds known to facilitate the penetration of the active ingredients of cosmetic compositions through the epidermis are, for example, ethoxydiglycol and saponosides of the hederagenin type.

  The cosmetic and pharmaceutical compositions in accordance with the present invention are preferably intended for topical administration, and therefore contain carriers and excipients commonly used in compositions of this type, such as O / W or W / O emulsions, creams, gels or lotions. In the case of emulsions, the fatty phase may represent between 10 and 60% of the weight of the composition, the aqueous phase between 10 and 80% and the emulsifier between 2 and 20%, the remainder being constituted by the components above and the other components listed below.

  The composition may also contain various substances and excipients chosen according to their known properties and the intended dosage form. Thus, preservatives, emulsifiers, viscosifiers, thickeners, gelling agents, antioxidants, moisturizers, surfactants, perfumes, oils, lipids, a specific solvent and the like can be incorporated into the composition. only water and various additives to improve the physical properties of the composition.

  The emulsifier may be selected from high molecular weight carboxyvinyl polymers (eg, Carbopol), polysorbates (eg, Tween 20 or Polysorbate 80), sorbitan esters, and especially a monostearate, a tristearate, a monopalmitate, and a sorbitan laurate. Other emulsifying agents may also be used, such as various stearic or palmitic acid derivatives, and for example PEG 100 stearate, mono- or diglycerides of stearic or palmitic acid, self-emulsifiable propylene glycol stearate, or alternatively polyglyceryl-2-sesquioleate, polyoxyethylene cetyl ether, a siloxane polyglucoside, or an emulsifiable silicone.

  Nonionic emulsifying mixtures such as Protegin X may also be used.

  The viscosifying agents used in the compositions of the invention may be chosen from various polymers of acrylic acid, a cellulose gum, a silica, carboxyvinyl polymers, an aluminum and magnesium silicate, and it is possible, for example, to use silica. colloidal sold under the trademark Aerosil 200 or a crosslinked polyacrylic acid such as Carbopol 940.

  The gelling agents or thickeners may be chosen for example from polyacrylamides, acrylates such as Pemulen, cellulose derivatives such as hydroxypropyl cellulose, or natural gums.

  The moisturizing agents used may be chosen for example from a polyol, sorbitol, maltitol, pentaerythritol, glyceryl polyacrylates and polymethacrylates, glycerol or glycerol derivatives. It is also possible to add emollients such as alkyl malate, isohexadecane, capric or caprylic acid triglycerides, etc. The usual preservatives of the technique of dermatological or cosmetological compositions can be used in the invention, and for example benzoic acid and an alkyl phydroxybenzoate such as methyl and propyl p-hydroxybenzoates (Methylparaben and Propylparaben), a alcohol such as phenoxyethanol or chlorphenesine or imidazolidinyl urea.

  The constituents of the fatty phase, that is to say the oils and lipids, can be chosen from jojoba oil, corn oil, liquid petroleum jelly, hydrogenated coconut oil, Safflower oil, saturated fatty acid glycerides, stearic acid, palmitic acid, octyl stearate, glyceryl palmitate, octyl palmitate, capric and caprylic acid triglyceride, 2 octyldodecanol, polyethylene glycol, 2-ethylhexyl adipate, or silicone oils such as methyl phenyl polysiloxane, dimethicone, cyclomethicone, cyclomethicone / dimethicone copolyol, phenyl dimethicone.

  The composition may also contain a solvent chosen according to the components used and the intended form of administration. The solvent may be, for example, water, and preferably deionized water, or a specific solvent such as propylene glycol, a diethylene glycol ether, or an alcohol, in particular ethanol.

  The pH of the composition is preferably between 5.5 and 7.5, and may be adjusted, depending on the compositions, by the addition of an acid such as citric acid or a base such as hydroxide. sodium.

  The composition according to the present invention may be presented in the forms conventionally used for topical application, that is to say in the form of gel, lotion, emulsion (in particular cream or milk), mask or ointment, or else transdermal patches. containing common and compatible pharmaceutically acceptable excipients and carriers.

  These forms of topical administration are prepared by the known techniques, and for example, in the case of a cream, by dispersion of a fatty phase in an aqueous phase to obtain an oil-in-water emulsion, or conversely to prepare a water-in-oil emulsion. In the case of creams, it is preferred to use lamellar structure emulsions containing little or no ethoxylated products. The oil of chaulmoogra is preferably preheated before being incorporated in the fatty phase, while the caffeine is introduced into the aqueous or alcoholic phase.

  By way of example, it is possible to prepare topical compositions in accordance with the invention in the form of slimming creams, milks or slimming gels, which can be used in one or more daily applications, the duration of the treatment being generally of the order of one to three months.

  The examples of caffeine and chaulmoogra oil compositions given below illustrate the invention without limiting its scope. Unless otherwise indicated, parts and percentages are by weight.

Example 1

  A slimming gel based on a combination of caffeine and chaulmoogra oil having the composition indicated below is prepared according to the usual techniques: liposomes of chaulmoogra oil (corresponding to 0.5% of chaulmoogra oil) 0 caffeine liposomes (corresponding to 0.4% caffeine) 10.0 glycerin 4.0 methyl silanol mannuronate 5.0 carboxyvinyl polymer 1.0 tromethamine 1.2 cinnamon distilled water 20.0 distilled water buds fir 5.0 chilli distilled water 1.0 preservative Demineralized water 0.1 qs 100,00 This slimming gel is used topically, once a day on the areas of the skin to be treated, for a period of 6 to 8 weeks. The first effects can be observed from the end of the 2nd week. The tests carried out on a group of 20 volunteers made it possible to observe a significant decrease of fatty cellulite. A reduction of 0.2 to 2.5 cm of round of thigh is observed at the end of the 4th week of treatment, and 0.5 to 3 cm at the end of the 6th week in 70% of the volunteers following the treatment.

Example 2

  A slimming cream based on a combination of caffeine and chaulmoogra oil having the composition indicated below is prepared according to the usual techniques: chaulmoogra oil 2.5 caffeine 2.0 glycerin 2.0 trisodium EDTA 0.1 butylene glycol 4.0 xanthan gum 0.2 cetearyl glucoside 4.0 cetyl alcohol 1.0 tristearin 0.8 acetyl glycol stearate 0.8 phenyl dimethicone 1.0 cyclopentasiloxane 4.0 tocopherol 0.7 sodium acrylate copolymer / dimethyl acryloyl laurate 0.5 isohexadecane 0.3 Polysorbate 80 0.8 preservatives 0.8 fragrances 0.1 Demineralized water qs 100.00

Example 3

  A slimming gel based on the combination of caffeine and chaulmoogra oil having the composition indicated below is prepared according to the usual techniques: chaulmoogra oil 1.0 caffeine 0.5 theophylline 0.2 PEG 400 2.0 glycerine 2.0 96% ethyl alcohol 20.0 carboxtvinyl polymer 0.5 potassium hydroxide 0.3 octyldocecanol 1.0 decyl oleate 1.0 ammonium acryloyl dimethyl laurate / VP copolymer 0.7 lauryl methicone copolyol 0.5 Tween 20 0 , 5 ivy glycolic extract 2.0 perfumes 0.1 Demineralized water qs 100.00

Example 4

  A slimming cream based on a combination of caffeine and chaulmoogra oil having the composition indicated below is prepared according to the usual techniques: chaulmoogra oil 2,5 macadamia oil 2,0 hazelnut oil 3,0 octyl dodecanol 3.0 Tween 60 3.5 Span 60 2.5 butyl alcohol 0.5 behenyl alcohol 1.5 Demineralized water qs 100.00 caffeine 1.5 theobromine 0.5 trisodium EDTA 0.1 carboxyvinyl polymer 0.3 ethoxy diglycol 5.0 tromethamine 0.5 glycerin 2.0 escin 0.3 96% ethyl alcohol 5.0 preservatives 0.6 perfumes 0.2

Claims (13)

  Cosmetic and / or pharmaceutical composition for the treatment and prevention of fat overload and cellulite, characterized in that it comprises in combination one or more xanthine bases and chaulmoogra oil and / or at least one of its components.   2. Composition according to claim 1, characterized in that the components of the oil of chaulmoogra are chaulmoogric, hydnocarpic and gorlic acids, as well as their salts and esters.   3. Composition according to claim 2, characterized in that it comprises one or more xanthine bases in combination with the salts or esters of chaulmoogric, hydnocarpic and gorlic acids.   4. Composition according to Claim 3, characterized in that the salts and esters are chosen from methyl, ethyl or benzyl esters, as well as sodium or potassium salts.   5. Composition according to any one of the preceding claims, characterized in that the weight ratio of xanthan bases to chaulmoogra oil is between 1: 0.5 and 1: 5.   6. Composition according to any one of the preceding claims, characterized in that the oil content of chaulmoogra, or acids or salts or esters is between 0.1 and 15% by weight, and the content of xanthine base between 0 , 1 and 8% by weight relative to the total weight of the composition.   7. Composition according to claim 6, characterized in that the oil content of chaulmoogra, or acids or salts or esters is between 1 and 8% by weight relative to the total weight of the composition.   8. Composition according to any one of the preceding claims, characterized in that the xanthine base and the oil of chaulmoogra, or its acids or esters, are in the form of liposomes.   9. Composition according to any one of the preceding claims, characterized in that the xanthine bases are caffeine, theophylline and theobromine, alone or in combination.   10. Composition according to claim 9, characterized in that the xanthine base is caffeine.   11. Combined use of one or more xanthic bases and chaulmoogra oil, and / or its essential components such as chaulmoogric, hydnocarpic and gorlic acids, as well as their salts and esters, for the preparation of a cosmetic composition for the treatment of fat overload and cellulite.   12. Combined use of one or more xanthine bases and chaulmoogra oil, and / or its essential components such as chaulmoogric, hydnocarpic and gorlic acids, and their salts and esters, for the preparation of a medicament lipolytic effect for the treatment of fat overload and cellulite.   13. A method of cosmetic treatment of the skin, to prevent or reduce adipose overload and cellulite, by applying a composition based on xanthine bases and chaulmoogra oil on the skin area requiring such treatment.