FR2490492A1 - Compsns. for treating cellulitis - contg. xanthine base and seaweed extract - Google Patents

Compsns. for treating cellulitis - contg. xanthine base and seaweed extract Download PDF

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Publication number
FR2490492A1
FR2490492A1 FR8020333A FR8020333A FR2490492A1 FR 2490492 A1 FR2490492 A1 FR 2490492A1 FR 8020333 A FR8020333 A FR 8020333A FR 8020333 A FR8020333 A FR 8020333A FR 2490492 A1 FR2490492 A1 FR 2490492A1
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Prior art keywords
xanthine
extract
base
theophylline
composition according
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Granted
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FR8020333A
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FR2490492B1 (en
Inventor
Jean-Pascal Billot
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Riker Laboratories Inc
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Riker Laboratories Inc
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Priority to FR8020333A priority Critical patent/FR2490492A1/en
Priority to BE0/206017A priority patent/BE890433A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/06Preparations for care of the skin for countering cellulitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Cosmetic compsns. for local treatment of cellulitis comprise creams, lotions, ointments or gels contg. at least one xanthine base (I) and a seaweed extract (II) in a suitable excipient. (I) is pref. theophylline and (II) can be a dry extract or an aq., alcoholic or water-glycol extract. The (II):(I) wt. ratio is pref. 1:1-10 and the concn. of (I) is pref. 1-10%. The excipient can be an o/w emulsion or an aq. or aq.-alcoholic gel. Combinations of (I) and (II) have a synergistic effect in reducing swelling, pain, etc..

Description

La présente invention concerne une composition cosmétique pour le traitement local de la cellulite. Cette composition est essentiellement caractérisée en ce qu'elle comprend, dans un excipient approprié, au moins un composé choisi dans la classe des xanthines et de l'extrait d'algues. The present invention relates to a cosmetic composition for the local treatment of cellulite. This composition is essentially characterized in that it comprises, in a suitable excipient, at least one compound selected from the class of xanthines and algae extract.

L'action des xanthines, comme par exemple l'action de la théophylline sur la lipolyse est connue comme jouant un rôle d'activation. Cette propriété a été suggérée et utilisée pour le traitement local de la cellulite (voir
Gallien : Encyclopédie Médico Chirurgicale - 25-199 B10-51977).
The action of xanthines, such as the action of theophylline on lipolysis, is known to play an activating role. This property has been suggested and used for the local treatment of cellulite (see
Gallien: Encyclopedia Surgical Medicine - 25-199 B10-51977).

De même, les extraits d'algues (extraits hydroglycoliques) possèdent des propriétés complémentaires : ils provoquent une vaso-dilatation, augmentent le métabolisme cellulaire et favorisent la résorption des exsudats (Gallien : Encyclopédie Médico Chirurgicale -25 199 B10-5- 1977). Similarly, extracts of algae (hydroglycolic extracts) have complementary properties: they cause vasodilatation, increase cellular metabolism and promote the resorption of exudates (Gallien: Encyclopedia Médico Chirurgicale -25 199 B10-5- 1977).

Or, la Demanderesse a constaté qu'en associant dans un excipient approprié convenant pour des applications topiques habituellement utilisées en cosmétologie ou en dermatologie, au moins une xanthine et un extrait d'algues, on obtenait un effet de synergie se traduisant par une exaltation des propriétés finales et par un effet global supérieur à celui correspondant à la simple somme ds effets pouvant être attribués à chacun des produits actifs sur les phénomènes du type cellulitique, lesquels se caractérisent par l'accumulation de graisse dans les adipocytes, la rétention hydrique par la substance fondamentale conjointement à une diminution des échanges cellulaires et un ralentissement circulatoire.Ces phénomènes de type cellulitique se manifestent au niveau de la silhouette par un empâtement localisé, un aspect inesthétique des téguments infiltrés (aspect peau d'orange) ainsi que par l'existence de douleurs spontanées variables sous forme de tension permanente ou de douleur à la palpation. However, the Applicant has found that by combining in a suitable excipient suitable for topical applications usually used in cosmetology or dermatology, at least one xanthine and an extract of algae, a synergistic effect is obtained resulting in an exaltation of properties and by an overall effect greater than that corresponding to the simple sum of the effects that can be attributed to each of the active products on the phenomena of the cellulite type, which are characterized by the accumulation of fat in the adipocytes, the fluid retention by the fundamental substance together with a decrease in cellular exchanges and a circulatory slowdown.These cellulite-type phenomena are manifested at the level of the silhouette by a localized impasto, an unsightly appearance of the infiltrated integuments (orange peel aspect) as well as by the existence variable spontaneous pain in the form of permanent tension or pain on palpation.

La base xanthique entrant dans la composition selon l'invention peut être une base xanthique choisie parmi les bases xanthiques connues telles que caféine, théobromine, aminophylline, théophylline, succiphyline, Adipophylline, etc., la base préférée étant la théophylline. The xanthine base used in the composition according to the invention may be a xanthine base chosen from known xanthine bases such as caffeine, theobromine, aminophylline, theophylline, succiphyline, adipophylline, etc., the preferred base being theophylline.

L'extrait d'algues peut être choisi parmi les extraits connus disponibles tels que les extraits secs, les extraits aqueux, alcooliques, hydroglycoliques, etc. The algae extract may be selected from known extracts available such as dry extracts, aqueous extracts, alcoholic, hydroglycolic, etc.

La proportion relative d'extrait d'algues par rapport à la base xanthique est avantageusement comprise (en parties en poids) entre 1:1 et 1:10 avec une concentration en base xanthique (dans la composition finale) comprise entre 1 et 10 %. The relative proportion of algae extract relative to the xanthine base is advantageously included (in parts by weight) between 1: 1 and 1:10 with a xanthine base concentration (in the final composition) of between 1 and 10% .

L'excipient peut être tout excipient destine à la réalisation de crèmes, de laits, d'onguents, de gels et sa formulation ne présente pas de difficultés pour l'homme de l'art. Ce sera de préférence un excipient favorisant une résorption efficace des matières actives à l'endroit même où l'on désire une action efficace tout en minimisant les risques d'effets systémiques.Comme exemples de types d'excipients pouvant être utilisés pour la formulation d'une composition selon l'invention, on citera les excipients du type huile dans eau contenant comme phase grasse des huiles
Qu matières grasses végétales, minérales ou animales.accepta- bles du point de vue cosmétologique ou dermatologique appartenant à la famille des acides gras compatibles, glycérides, vaseline, alcool gras ou bases grasses polyoxyéthylénées et analogues et, une phase aqueuse pouvant elle-même être mélangée en partie à un solvant miscible à l'eau tel que l'alcool éthylique, le diéthylèneglycol, la glycérine, etc.
The excipient may be any excipient for the production of creams, milks, ointments, gels and its formulation does not present difficulties for a person skilled in the art. It will preferably be an excipient promoting an effective resorption of the active ingredients at the place where it is desired an effective action while minimizing the risk of systemic effects. Examples of types of excipients that can be used for the formulation of d a composition according to the invention, mention may be made of excipients of the oil-in-water type containing, as fatty phase, oils
Vegetable, mineral or animal fats.which are cosmetologically or dermatologically acceptable belonging to the family of compatible fatty acids, glycerides, petrolatum, fatty alcohol or polyoxyethylenated fatty bases and the like, and an aqueous phase which may itself be partially mixed with a water-miscible solvent such as ethyl alcohol, diethylene glycol, glycerine, etc.

Ces formules pouvant être additionnées comme cela est très connu, d'autres ingrédients tels que parfums, agents de conservation, émollients, etc. On citera aussi les excipients du type gel aqueux ou hydroalcoolique avec un agent épaississant comme la carboxyméthylcellulose, le carboxypolyméthylène et analogues additionné ou non (comme cela est bien connu) d'un solvant, d'un agent dit surgraissant, d'un émollient, d'un parfum, d'un agent de conservation, etc.These formulas can be added as is well known, other ingredients such as perfumes, preservatives, emollients, etc. Mention may also be made of excipients of the aqueous or aqueous-alcoholic type with a thickening agent such as carboxymethylcellulose, carboxypolymethylene and the like, with or without addition (as is well known) of a solvent, a so-called superfatting agent, an emollient, a perfume, a preservative, etc.

La préparation d'une composition selon l'invention se fait en adoptant les méthodes usuelles connues.  The preparation of a composition according to the invention is done by adopting the usual known methods.

D'autres caractéristiques et avantages de l'invention ressortiront plus clairement de la description qui va suivre. Other features and advantages of the invention will emerge more clearly from the description which follows.

Pour montrer l'intérêt et les résultats inattendus résultant de l'association dans une composition selon l'invention d'une base xanthique et d'extrait d'algues, on a réalisé à partir d'un même excipient du type huile dans eau, une crème contenant 2 % d'extrait d'algues, une crème avec 10 % de théophylline micro-cristalline et une crème avec 10 e de théophylline micro-cristalline + 2 % d'extrait d'algues. On a procédé à une prise de 5 mensurations sur des sujets (atteints de cellulite) avant - et après traitement (application de la crème une fois par jour pendant I mois), à savoir - Tour de cheville - Tour de mollet : 10 cm en dessous de la pointe de la
rotule au repos, sur sujet allongé.
To show the interest and the unexpected results resulting from the combination in a composition according to the invention of a xanthic base and of algae extract, it was realized from the same excipient of the oil-in-water type, a cream containing 2% algae extract, a cream with 10% micro-crystalline theophylline and a cream with 10 th theophylline micro-crystalline + 2% algae extract. Five measurements were taken on subjects (with cellulite) before - and after treatment (application of the cream once a day for one month), namely - Ankle - Calf circumference: 10 cm below the tip of the
patella at rest, on elongated subject.

- Tour ce cuisse : 20 et 30 cm au-dessus de la pointe de
la rotule au repos - Tour de haut de
cuisse : à l'exacte verticale de la racine du
membre.
- This thigh turn: 20 and 30 cm above the tip of
the patella at rest - Tower of high
thigh: at the exact vertical of the root of the
member.

Une diminution de plus de 2 cm est considérée comme un bon ou un excellent résultat. A decrease of more than 2 cm is considered a good or excellent result.

La palpation attentive permet par contre une appréciation clinique objective de l'importance des accolements aux plans profonds, de l'importance de l'élément douleur et de l'importance de la rétention d'eau. On the other hand, careful palpation allows an objective clinical assessment of the importance of deep-plane connections, the importance of the pain element and the importance of water retention.

Ces crèmes constituaient le seul traitement à l'exlusion de toute autre thérapeutique diététicomédicamenteuse. These creams were the only treatment to exclude any other dietary-drug therapy.

Les résultats obtenus ont été les suivants
Crème aux algues (essais sur 10 patients).
The results obtained were as follows
Seaweed cream (tests on 10 patients).

Les résultats tant au point de vue des critères de mensurations que de celui de la palpation, n'ont pu être considérés comme bons et excellents, c'est-à-dire que, dans tous les cas, la diminution des mensurations a été inférieure à 2 cm ou nulle et que la palpation n'a pas montré d'amélioration significative. The results in terms of both measurement and palpation criteria could not be considered as good and excellent, that is, in all cases, the decrease in measurements was inferior. at 2 cm or none and palpation showed no significant improvement.

Crème à la théophylline seule (10 patients) 20 % d'excellents résultats (diminution de mensura
tison 3 cm) 30 % de bons résultats (diminution de mensuration > 2 cm) 10 % de résultats médiocres (diminution de mensura
tions < 2 cm) 40 % de résultats nuls.
Cream theophylline alone (10 patients) 20% excellent results (decrease in mensura
3 cm) 30% good results (decreased measurement> 2 cm) 10% poor results (decreased mensuration
<2 cm) 40% of zero results.

Crème théophylline + extraits d'algues - 2 expérimentations distinctes s 46 et 25 cas.Theophylline cream + algae extracts - 2 separate experiments 46 and 25 cases.

Première expérimentation - Excellents et bons résultats 77 % (diminution de mensura
tison )2 cm) - Résultats médiocres et nuls : 23 %
Deuxième expérimentation - Excellents et bqns résultats : 80 % - Résultats médiocres et nuls : 20 %
Les différents cas traités étaient classés dans les types de cellulites habituellement rencontrées : héréditaires (circulatoire, culotte de zouave, prédiabétique), circulatoires pures (capillaires ou veineuses), en culottes de cheval, abdominales avec composante génitale, psychosomatiques, avec les différents degrés de sévérité - phase I, II ou III (voir J. ~Moron, Guide pratique des volontés,
Maloine S.A. Edition).
First experiment - Excellent and good results 77% (decrease of mensura
2 cm) - mediocre and invalid results: 23%
Second experiment - Excellent and very good results: 80% - Poor and invalid results: 20%
The different cases treated were classified in the types of cellulite usually encountered: hereditary (circulatory, Zouave, prediabetic), pure circulatory (capillaries or venous), in saddlebags, abdominal with genital component, psychosomatic, with different degrees of severity - phase I, II or III (see J. ~ Moron, Practical Guide of Wills,
Maloine SA Edition).

Les résultats ci-dessus font donc ainsi bien apparaître une potentialisation de la théophylline par l'extrait d'algues.  The above results thus clearly show a potentiation of theophylline by the algae extract.

Les exemples suivants sont donnés à titre illustratif de compositions conformes à l'invention, les pourcentage étant exprimés en % en poids. The following examples are given by way of illustration of compositions in accordance with the invention, the percentages being expressed in% by weight.

EXEMPLE 1
(%) - Acide stéarique 19 - Alcool cétylique 0,5 - Triéthanolamine 1,1 - Glycérine 5 - Conservateurs 0,2 - Extrait hydroglycolique d'algues 2 - Succiphyline 5 - Eau distillée q.s.p. 100 %
EXEMPLE 2 (%) - Myglyol 812* 1 - Glycérine 4 - Carbopol 934** 1 - Triéthylamine q.s.pour pH = 6,5 - Softigen*** 1 - Conservateurs 0,2 - Théophylline 3 - Extrait hydroglycolique d'algues 2 - Isopropanol/eau (65/35 v/v) q.s.p. 100 % * Triglycérides d'acides gras saturés de C8
à C12 ** Carboxypolyméthylène Glycérides semi-synthétiques d'acides gras
en C8-C12.
EXAMPLE 1
(%) - Stearic acid 19 - Cetyl alcohol 0,5 - Triethanolamine 1,1 - Glycerin 5 - Preservatives 0,2 - Hydrogolic algae extract 2 - Succiphyline 5 - Distilled water qs 100%
EXAMPLE 2 (%) - Myglyol 812 * 1 - Glycerin 4 - Carbopol 934 ** 1 - Triethylamine qfor pH = 6.5 - Softigen *** 1 - Preservatives 0.2 - Theophylline 3 - Hydroglycolic algae extract 2 - Isopropanol / water (65/35 v / v) qs 100% * Triglycerides of saturated C8 fatty acids
to C12 ** Carboxypolymethylene Semi-synthetic glycerides of fatty acids
in C8-C12.

EXEMPLE 3
(%) - Labrafil 2130 CS* 13 - Polystate B 13 - Conservateurs 0,2 - Succiphylline 10 - Extrait hydroglycolique d'algues 5 - Eau q.s.p. 100 % * Triglycérides palmito-stéarique polyoxy
éthylénés.
EXAMPLE 3
(%) - Labrafil 2130 CS * 13 - Polystate B 13 - Preservatives 0.2 - Succiphylline 10 - Hydrogolic algae extract 5 - Water qs 100% * Polyoxy palmitostearic triglycerides
ethylenes.

* Mono, di-stéarate de polyoxyéthylèneglycol 300
Pour la préparation des compositions du type de celles des exemples 1 et 3, les phases aqueuses chaudes contenant les conservateurs et l'extrait d'algues sont ajoutés sous agitation aux phases grasses préalablement fondues. La base xanthique est ajoutée sous forme micromisée à l'excipient ainsi préparé après refroidissement, puis la crème est homogénéisée
Pour la préparation de compositions du type de celle de l'exemple 2, la base xanthique, l'extrait d'algues et les conservateurs sont préalablement dissous dans le mélange hydroalcoolique puis la solution obtenue est utilisée pour faire gonfler l'agent épaississant, à savoir le
Carbopol 934. Le pH est alors ajusté pour obtenir une consistance de gel.
* Mono, polyoxyethylene glycol di-stearate 300
For the preparation of the compositions of the type of those of Examples 1 and 3, the hot aqueous phases containing the preservatives and the algae extract are added with stirring to the previously melted fatty phases. The xanthine base is added in micromized form to the excipient thus prepared after cooling, and then the cream is homogenized
For the preparation of compositions of the type of that of Example 2, the xanthine base, the algae extract and the preservatives are dissolved beforehand in the hydroalcoholic mixture, and the solution obtained is then used to swell the thickening agent. know the
Carbopol 934. The pH is then adjusted to obtain a gel consistency.

Ces compositions ont donné d'excellents à bons résultats dans le traitement de cellulites. These compositions have given excellent results in the treatment of cellulites.

I1 va de soi que la présente invention n"a été décrite qu'à titre purement explicatif et nullement limitatif et que toute modification utile pourra y être apportée sans sortir de son cadre tel que défini par les revendications ciaprès.  It goes without saying that the present invention has been described only as a purely explanatory and non-limiting and that any useful modification can be made without departing from its scope as defined by the claims below.

Claims (5)

REVENDICATIONS 1. Composition cosmétique pour le traitement local de la cellulite se présentant sous forme de crème, lait, onguent, gel, caractérisée par le fait qu'elle comprend dans un excipient approprié, au moins une base xanthique et de l'extrait d'algues. 1. Cosmetic composition for the local treatment of cellulite in the form of cream, milk, ointment, gel, characterized in that it comprises in a suitable excipient, at least one xanthine base and algae extract . 2. Composition selon l > a revendication 1, caractérisée par le fait que la base xanthique est choisie parmi les bases xanthiques connues telles que caféine, théobromine, aminophylline, théophylline, succiphylline, etc., la base préférée étant la théophylline. 2. Composition according to claim 1, characterized in that the xanthine base is chosen from known xanthine bases such as caffeine, theobromine, aminophylline, theophylline, succiphylline, etc., the preferred base being theophylline. 3. Composition selon la revendication 1 ou 2, caractérisépar le fait que l'extrait d'algues est un extrait sec, un extrait aqueux, alcoolique ou hydroglycolique. 3. Composition according to claim 1 or 2, characterized in that the algae extract is a dry extract, an aqueous extract, alcoholic or glycolic. 4. Composition selon l'une quelconque des revendications 1 à 3, caractérisée par le fait que la proportion relative d'extrait d'algues par rapport à la base xanthique est avantageusement comprise (en parties en poids) entre 1:1 et 1:10 avec une concentration en base xanthique (dans la composition finale) comprise entre et 10 %. 4. Composition according to any one of claims 1 to 3, characterized in that the relative proportion of algae extract relative to the xanthine base is advantageously included (in parts by weight) between 1: 1 and 1: With a xanthine base concentration (in the final composition) of between 10% and 10%. 5. Composition selon l'une quelconque des revendications 1 à 4, caractérisée par le fait que l'excipient est du type émulsion huile dans l'eau ou du type gel aqueux ou hydroalcoolique.  5. Composition according to any one of claims 1 to 4, characterized in that the excipient is of the oil-in-water emulsion type or of the aqueous or hydroalcoholic gel type.
FR8020333A 1980-09-22 1980-09-22 Compsns. for treating cellulitis - contg. xanthine base and seaweed extract Granted FR2490492A1 (en)

Priority Applications (2)

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FR8020333A FR2490492A1 (en) 1980-09-22 1980-09-22 Compsns. for treating cellulitis - contg. xanthine base and seaweed extract
BE0/206017A BE890433A (en) 1980-09-22 1981-09-21 COSMETIC COMPOSITION FOR THE LOCAL TREATMENT OF CELLULITE

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FR8020333A FR2490492A1 (en) 1980-09-22 1980-09-22 Compsns. for treating cellulitis - contg. xanthine base and seaweed extract

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FR2490492B1 FR2490492B1 (en) 1983-07-08

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Cited By (16)

* Cited by examiner, † Cited by third party
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FR2554344A1 (en) * 1983-11-07 1985-05-10 Pf Cosmetique Cosmetic composition with slimming and anticellulite action
FR2556217A1 (en) * 1983-12-09 1985-06-14 Biosculpture FATTY ANTI-OVERLOAD COSMETIC COMPOSITIONS AND IONOPHORESIS HUMAN BODY APPLICATION
FR2617401A1 (en) * 1987-06-30 1989-01-06 Oreal COSMETIC CELLULITIVE ACTION AND SLIMMING COMPOSITION HAVING THE ACTIVE INGREDIENT 1-HYDROXYALKYXANTHINE
FR2624010A1 (en) * 1987-12-07 1989-06-09 Fabre Pierre Cosmetique TOPICAL HETEROGENEOUS COMPOSITIONS BASED ON CAFFEINE MICROGRANULES AND / OR DERIVATIVES THEREOF, USEFUL AS SLIMMING AND / OR IN THE TREATMENT OF CELLULITE, AS WELL AS THEIR PREPARATION
FR2639541A1 (en) * 1988-11-29 1990-06-01 Fabre Pierre Cosmetique TOPICAL SLIMMERS CONTAINING CARBOXYLIC CARBOXYLIC DERIVATIVES DERIVED FROM ORGANIC BASES AND PREPARATIONS USEFUL IN THE TREATMENT OF CELLULITE
ES2049661A1 (en) * 1992-10-09 1994-04-16 Imbeal S A Lab Anti-cellulite compsn - contains mixt seaweed, algae, ivy and broom, with preservative in a substrate of fatty material and water
EP0629397A1 (en) * 1993-06-15 1994-12-21 LABORATOIRES Dr. N.G. PAYOT Cosmetic or pharmaceutical composition for topical application active against free radicals
GB2305603A (en) * 1995-09-26 1997-04-16 Allied Medical Group Topical cooling gels for reducing excess body fat
WO1997042928A1 (en) * 1996-05-14 1997-11-20 Lvmh Recherche Topical slimming composition
FR2876909A1 (en) * 2004-10-22 2006-04-28 Nuxe Sa Lab Cosmetic and/or pharmaceutical composition, to prevent or treat adipose overloads and cellulitis, comprises a combination of one or more xanthinic bases and chaulmoogra oil and/or its components
WO2006045932A2 (en) * 2004-10-22 2006-05-04 Laboratoire Nuxe Novel use of chaulmoogra oil and guggulipids in therapeutics and cosmetics
FR2879098A1 (en) * 2004-12-14 2006-06-16 Courtage Et De Diffusion Codif Use of algae extract to stimulate the oxygen uptake by the cells having lipolytic effect to produce ATP molecules
FR2911068A1 (en) * 2007-01-09 2008-07-11 Daniel Jouvance Rech S Et Crea Composition containing a unicellular alga of the genus Asterionella, plus caffeine and theobromine, used in cosmetic slimming formulations for topical application
WO2012140351A2 (en) 2011-04-11 2012-10-18 Laboratoire Nuxe Caffeine and triacanthine composition for treating excess fat
WO2012140352A2 (en) 2011-04-11 2012-10-18 Laboratoire Nuxe Gleditsia composition for treating excess fat
EP2968107A4 (en) * 2013-03-15 2016-08-17 Mary Kay Inc Cosmetic compositions and uses thereof

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Publication number Priority date Publication date Assignee Title
FR2377805A1 (en) * 1977-01-24 1978-08-18 Holzmann David NEW COMPOSITION ESPECIALLY FOR THE TREATMENT OF CELLULITE

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FR2377805A1 (en) * 1977-01-24 1978-08-18 Holzmann David NEW COMPOSITION ESPECIALLY FOR THE TREATMENT OF CELLULITE

Cited By (29)

* Cited by examiner, † Cited by third party
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FR2554344A1 (en) * 1983-11-07 1985-05-10 Pf Cosmetique Cosmetic composition with slimming and anticellulite action
FR2556217A1 (en) * 1983-12-09 1985-06-14 Biosculpture FATTY ANTI-OVERLOAD COSMETIC COMPOSITIONS AND IONOPHORESIS HUMAN BODY APPLICATION
EP0147282A2 (en) * 1983-12-09 1985-07-03 Biosculpture International Anti-adipose cosmetic compositions and their use in body treatment by ionophoresis
EP0147282A3 (en) * 1983-12-09 1987-06-24 Biosculpture International Anti-adipose cosmetic compositions and their use in body treatment by ionophoresis
BE1001278A3 (en) * 1987-06-30 1989-09-12 Oreal Cosmetic.
FR2617401A1 (en) * 1987-06-30 1989-01-06 Oreal COSMETIC CELLULITIVE ACTION AND SLIMMING COMPOSITION HAVING THE ACTIVE INGREDIENT 1-HYDROXYALKYXANTHINE
US5053433A (en) * 1987-06-30 1991-10-01 Societe Anonyme Dite: L'oreal Cosmetic composition with anticellulitic and slimming action, in which the active principle is a 1-hydroxyalkylxanthine
EP0323294A1 (en) * 1987-12-07 1989-07-05 Pierre Fabre Cosmetique Heterogeneous topical composition with a slimming and/or anti-cellulitis activity, containing a salt of caffeine-carboxylic-acid microgranules, and their preparation
FR2624010A1 (en) * 1987-12-07 1989-06-09 Fabre Pierre Cosmetique TOPICAL HETEROGENEOUS COMPOSITIONS BASED ON CAFFEINE MICROGRANULES AND / OR DERIVATIVES THEREOF, USEFUL AS SLIMMING AND / OR IN THE TREATMENT OF CELLULITE, AS WELL AS THEIR PREPARATION
FR2639541A1 (en) * 1988-11-29 1990-06-01 Fabre Pierre Cosmetique TOPICAL SLIMMERS CONTAINING CARBOXYLIC CARBOXYLIC DERIVATIVES DERIVED FROM ORGANIC BASES AND PREPARATIONS USEFUL IN THE TREATMENT OF CELLULITE
EP0371874A1 (en) * 1988-11-29 1990-06-06 Pierre Fabre Cosmetique Topical slimming agents containing caffein carboxylic acids neutralised by organic bases, and preparations for the treatment of cellulitis
ES2049661A1 (en) * 1992-10-09 1994-04-16 Imbeal S A Lab Anti-cellulite compsn - contains mixt seaweed, algae, ivy and broom, with preservative in a substrate of fatty material and water
EP0629397A1 (en) * 1993-06-15 1994-12-21 LABORATOIRES Dr. N.G. PAYOT Cosmetic or pharmaceutical composition for topical application active against free radicals
FR2706305A1 (en) * 1993-06-15 1994-12-23 Payot Laboratoires Dr Ng Cosmetic or pharmaceutical anti-free radical composition for topical application.
GB2305603A (en) * 1995-09-26 1997-04-16 Allied Medical Group Topical cooling gels for reducing excess body fat
WO1997042928A1 (en) * 1996-05-14 1997-11-20 Lvmh Recherche Topical slimming composition
FR2748659A1 (en) * 1996-05-14 1997-11-21 Lvmh Rech TOPICAL SLIMMING COMPOSITION
FR2876909A1 (en) * 2004-10-22 2006-04-28 Nuxe Sa Lab Cosmetic and/or pharmaceutical composition, to prevent or treat adipose overloads and cellulitis, comprises a combination of one or more xanthinic bases and chaulmoogra oil and/or its components
WO2006045932A2 (en) * 2004-10-22 2006-05-04 Laboratoire Nuxe Novel use of chaulmoogra oil and guggulipids in therapeutics and cosmetics
WO2006045932A3 (en) * 2004-10-22 2006-08-31 Nuxe Lab Novel use of chaulmoogra oil and guggulipids in therapeutics and cosmetics
FR2879098A1 (en) * 2004-12-14 2006-06-16 Courtage Et De Diffusion Codif Use of algae extract to stimulate the oxygen uptake by the cells having lipolytic effect to produce ATP molecules
FR2911068A1 (en) * 2007-01-09 2008-07-11 Daniel Jouvance Rech S Et Crea Composition containing a unicellular alga of the genus Asterionella, plus caffeine and theobromine, used in cosmetic slimming formulations for topical application
WO2012140351A2 (en) 2011-04-11 2012-10-18 Laboratoire Nuxe Caffeine and triacanthine composition for treating excess fat
WO2012140352A2 (en) 2011-04-11 2012-10-18 Laboratoire Nuxe Gleditsia composition for treating excess fat
EP2968107A4 (en) * 2013-03-15 2016-08-17 Mary Kay Inc Cosmetic compositions and uses thereof
US9463155B2 (en) 2013-03-15 2016-10-11 Mary Kay Inc. Cosmetic compositions and uses thereof
US10299994B2 (en) 2013-03-15 2019-05-28 Mary Kay Inc. Cosmetic compositions and uses thereof
US11135139B2 (en) 2013-03-15 2021-10-05 Belaj Innovations Llc Cosmetic compositions and uses thereof
US11723845B2 (en) 2013-03-15 2023-08-15 Mary Kay Inc. Cosmetic compositions and uses thereof

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FR2490492B1 (en) 1983-07-08
BE890433A (en) 1982-03-22

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