FR2864447A1 - Dermal or dermatological composition, useful for treating e.g. muscle pain and eczema, comprises flowers of Hypericum and olive oil - Google Patents

Dermal or dermatological composition, useful for treating e.g. muscle pain and eczema, comprises flowers of Hypericum and olive oil Download PDF

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Publication number
FR2864447A1
FR2864447A1 FR0315618A FR0315618A FR2864447A1 FR 2864447 A1 FR2864447 A1 FR 2864447A1 FR 0315618 A FR0315618 A FR 0315618A FR 0315618 A FR0315618 A FR 0315618A FR 2864447 A1 FR2864447 A1 FR 2864447A1
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dermal
olive oil
john
mixture
dermatological preparation
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FR2864447B1 (en
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Jean Marie Crispu
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/38Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Organic Chemistry (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Dermal or dermatological composition (A) comprises a mixture of (1) flowers of St. John's wort (Hypericum) and (2) olive oil. An independent claim is also included for a method of preparing (A). ACTIVITY : Analgesic; Antiallergic; Dermatological; Antipruritic; Antiseborrheic; Vulnerary. No details of tests for these activities are given. MECHANISM OF ACTION : None given.

Description

Préparation dermique et dermatologique à large champ d'action, et sonDermal and dermatological preparation with broad field of action, and its

procédé d'obtention.obtaining process.

La présente invention concerne une préparation dermique et dermatologique à large champ d'action, se présentant sous forme de pommade, d'onguent, de lotion, ou autres formes galéniques contenant comme ingrédients actifs de l'huile d'olive et des fleurs de millepertuis ou Hypericum. L'invention vise également le procédé d'obtention de cette préparation.  The present invention relates to a dermal and dermatological preparation with a broad field of action, in the form of an ointment, ointment, lotion or other galenic forms containing as active ingredients olive oil and St. John's Wort flowers. or Hypericum. The invention also relates to the process for obtaining this preparation.

La préparation selon l'invention exerce une action curative dans le traitement des traumatismes musculaires et ligamenteux tels que entorses, courbatures, etc, des affections articulaires et lombaires (ex. sciatique) , ainsi que des troubles dermiques d'origines diverses (allergie, parasite, maladie, piqûre d'insecte, rayonnement, etc) tels que les brûlures superficielles, les coups de soleil, les prurits localisés, les tâches de vieillesse, l'acné, les boutons, l'eczéma ou autres dermatoses, les dermatites. Elle facilite en outre, la cicatrisation des plaies superficielles.  The preparation according to the invention has a curative action in the treatment of muscular and ligamentous traumas such as sprains, body aches, etc., articular and lumbar disorders (eg sciatica), as well as dermal disorders of various origins (allergy, parasite). , disease, insect bite, radiation, etc.) such as superficial burns, sunburn, localized itching, age spots, acne, pimples, eczema or other dermatoses, dermatitis. It also facilitates the healing of superficial wounds.

La préparation dermique et dermatologique selon l'invention est remarquable en ce qu'elle ne nécessite pour son obtention que deux seuls ingrédients: l'huile d'olive et les fleurs de millepertuis ou Hypericum, sans adjonction d'un quelconque produit chimique. II s'agit donc d'un produit parfaitement naturel.  The dermal and dermatological preparation according to the invention is remarkable in that it requires for its production only two ingredients: olive oil and St. John's wort flowers or Hypericum, without the addition of any chemical. It is therefore a perfectly natural product.

Suivant le procédé de l'invention, on procède d'abord au mélange de l'huile d'olive et des fleurs de millepertuis, à l'aide de tous matériels appropriés connus en soi.  According to the process of the invention, the olive oil is first mixed with St. John's Wort flowers, using any appropriate material known per se.

De préférence, les fleurs de millepertuis auront été prélevées sur des plants sauvages poussant sur terrain sec, puis rincées à l'eau claire, égouttées, séchées et découpées.  Preferably, St. John's Wort flowers will have been collected from wild plants growing on dry ground, then rinsed with clear water, drained, dried and cut.

Selon un mode de réalisation avantageux de l'invention, 45 grammes de fleurs de millepertuis sont nécessaires pour un litre d'huile d'olive.  According to an advantageous embodiment of the invention, 45 grams of St. John's wort flowers are required for one liter of olive oil.

Le mélange huile d'olive - fleurs de millepertuis est ensuite placé dans un récipient adéquat pour macération, par exemple un bocal en verre, et exposé à l'air libre et à température ambiante de préférence pendant une période d'environ trois mois.  The olive oil - St. John's wort flower mixture is then placed in a suitable maceration container, for example a glass jar, and exposed to free air and at room temperature preferably for a period of about three months.

II est très important de souligner que le mélange huile d'olive - fleurs de millepertuis doit être placé à l'air libre et à température ambiante afin que toutes les conditions soient réunies pour que se développe une moisissure naturelle à la surface du mélange, durant la période de macération. La présence de cette moisissure est en effet indispensable pour l'efficacité de la préparation selon l'invention.  It is very important to emphasize that the olive oil - St. John's wort flower mix should be placed in the open air and at room temperature so that all the conditions are in place for a natural mold to grow on the surface of the mixture during the period of maceration. The presence of this mold is indeed essential for the effectiveness of the preparation according to the invention.

A intervalles réguliers, c'est-à-dire environ une fois par semaine, le mélange huile d'olive fleurs de millepertuis est agité ou brassé pour bien incorporer la moisissure développée en surface au mélange.  At regular intervals, that is, about once a week, the St. John's wort olive oil mixture is shaken or stirred to thoroughly incorporate the surface-grown mold into the mixture.

Après une période de trois mois pendant laquelle les étapes de macération et de brassage se sont succédées, la préparation selon l'invention est prête à être utilisée.  After a period of three months during which maceration and stirring steps have followed one another, the preparation according to the invention is ready to be used.

Elle peut alors être conditionnée dans tous récipients appropriés fermés pour assurer sa conservation.  It can then be packaged in all appropriate closed containers to ensure its preservation.

La préparation dermique et dermatologique selon l'invention a été testée 25 efficacement pour traiter notamment les entorses, les tâches de vieillesse, les brûlures superficielles, les muscles douloureux, et les démangeaisons.  The dermal and dermatological preparation according to the invention has been effectively tested to treat, in particular, sprains, age spots, superficial burns, sore muscles, and itching.

Elle peut aussi être utilisée pour traiter toutes les affections de la peau (dermatose, dermatite, etc.), ainsi que les douleurs d'origine lombaires, musculaires, articulaires, ligamentaires et faciliter la cicatrisation des plaies superficielles, sans aucun effet secondaire.  It can also be used to treat all skin conditions (dermatitis, dermatitis, etc.), as well as lumbar, muscular, articular, ligamentous pain and facilitate the healing of superficial wounds, without any side effects.

L'application se fait sur la région à traiter avec un léger massage pour étaler et faire 5 pénétrer la préparation dans la peau.  The application is made on the region to be treated with a light massage to spread and to penetrate the preparation into the skin.

Claims (7)

REVENDICATIONS 1. Préparation dermique et dermatologique, caractérisée en ce qu'elle est composée d'un mélange de fleurs de millepertuis ou Hypericum et d'huile d'olive.  1. Dermal and dermatological preparation, characterized in that it is composed of a mixture of St. John's Wort flowers or Hypericum and olive oil. 2. Préparation dermique et dermatologique selon la revendication 1, caractérisée en ce qu'elle est composée d'un mélange de fleurs de millepertuis et d'huile d'olive, et de la moisissure développée en surface dudit mélange durant une période de macération.  2. Dermal and dermatological preparation according to claim 1, characterized in that it is composed of a mixture of St. John's Wort flowers and olive oil, and the mold developed on the surface of said mixture during a period of maceration. 3. Préparation dermique et dermatologique selon la revendication 1 ou 2, caractérisée en ce que la proportion des composés est de 45 grammes de fleurs de millepertuis pour un litre d'huile d'olive.  3. Dermal and dermatological preparation according to claim 1 or 2, characterized in that the proportion of the compounds is 45 grams of St. John's Wort flowers per liter of olive oil. 4. Préparation dermique et dermatologique selon l'une quelconque des revendications 1 à 3, caractérisée en ce que les fleurs de millepertuis sont prélevées sur des plants sauvages poussant sur terrain sec.  4. Dermal and dermatological preparation according to any one of claims 1 to 3, characterized in that the flowers of St. John's Wort are taken from wild plants growing on dry ground. 5. Procédé d'obtention de la préparation dermique et dermatologique selon l'une quelconque des revendications 2 à 4, caractérisé en ce que l'on procède d'abord au mélange de l'huile d'olive et des fleurs de millepertuis, préalablement rincées à l'eau claire, égouttées, séchées puis découpées; on place ensuite le mélange obtenu dans un récipient adéquat pour macération et on l'expose à l'air libre et à température ambiante de préférence pendant une période d'environ trois mois pendant laquelle, à intervalles réguliers, ledit mélange est agité ou brassé pour bien incorporer la moisissure naturelle développée en surface du mélange  5. Process for obtaining the dermal and dermatological preparation according to any one of claims 2 to 4, characterized in that the first step is to mix the olive oil and St. John's wort flowers, previously rinsed with clear water, drained, dried and then cut; the resulting mixture is then placed in a suitable container for maceration and exposed in the open air and at room temperature preferably for a period of about three months during which, at regular intervals, said mixture is stirred or stirred for well incorporate the natural mold developed on the surface of the mixture 6. Préparation dermique et dermatologique selon l'une quelconque des 30 revendications 1 à 4 ou fabriquée selon le procédé d'obtention de la revendication 5, caractérisée par son utilisation thérapeutique pour les traitement des affections, troubles et lésions dermiques.6. Dermal and dermatological preparation according to any one of claims 1 to 4 or manufactured according to the process for obtaining claim 5, characterized by its therapeutic use for the treatment of disorders, disorders and dermal lesions. 7. Préparation dermique et dermatologique selon l'une quelconque des revendications 1 à 4 ou fabriquée selon le procédé d'obtention de la revendication 5, caractérisée par son utilisation pour le traitement des affections et traumatismes musculaires, ligamentaires, articulaires et lombaires.  7. Dermal and dermatological preparation according to any one of claims 1 to 4 or manufactured according to the process for obtaining claim 5, characterized by its use for the treatment of diseases and injuries muscle, ligament, joint and lumbar.
FR0315618A 2003-12-31 2003-12-31 DERMATOLOGICAL PREPARATION WITH BROAD FIELD OF ACTION AND METHOD OF OBTAINING THE SAME Expired - Fee Related FR2864447B1 (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009016247A1 (en) 2007-08-01 2009-02-05 Moses S.R.L. Method for preparing a hypericum extract in neem oil and a substance so obtained
US7879344B2 (en) 2006-06-29 2011-02-01 Kimberly-Clark Worldwide, Inc. Transdermal delivery of oleocanthal for relief of inflammation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1456275A (en) * 1973-01-18 1976-11-24 Saljic J Process of preparing an ointment
EP0769250A1 (en) * 1995-10-04 1997-04-23 SCHMIDT, Karlheinz, Prof. Dr. Dr. Milk based foodstuff and its use
DE19712729A1 (en) * 1997-03-26 1998-10-01 Franz Marschall Medicament e.g. for healing wounds, infections or insect bites
EP1197219A1 (en) * 2000-10-12 2002-04-17 Jukunda Naturarzneimittel Dr. Ludwig Schmitt GmbH & Co. KG Process for the preparation of oil of St. John's wort

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1456275A (en) * 1973-01-18 1976-11-24 Saljic J Process of preparing an ointment
EP0769250A1 (en) * 1995-10-04 1997-04-23 SCHMIDT, Karlheinz, Prof. Dr. Dr. Milk based foodstuff and its use
DE19712729A1 (en) * 1997-03-26 1998-10-01 Franz Marschall Medicament e.g. for healing wounds, infections or insect bites
EP1197219A1 (en) * 2000-10-12 2002-04-17 Jukunda Naturarzneimittel Dr. Ludwig Schmitt GmbH & Co. KG Process for the preparation of oil of St. John's wort

Non-Patent Citations (6)

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Title
"FINAL REPORT ON THE SAFETY ASSESSMENT OF HYPERICUM PERFORATUM EXTRACT AND HYPERICUM PERFORATUM OIL", INTERNATIONAL JOURNAL OF TOXICOLOGY, TAYLOR AND FRANCIS, WASHINGTON, DC,, US, vol. 20, no. SUPPL 2, 2001, pages 31 - 39, XP009016121, ISSN: 1091-5818 *
HAGENSTROM, U.: "Oleum hyperici. II. Galenics of St. John 's Wort", SCIENTIA PHARMACEUTICA , 23, 83-8 CODEN: SCPHA4; ISSN: 0036-8709, 1955, XP009033702 *
HOELZL J ET AL: "COMPARISON OF THE HYPERICIN AND PEROXIDE CONCENTRATION OF COMMERCIAL AND SELF-PRODUCED OLEUM HYPERICI AND ITS EFFECT ON SEROTONIN UPTAKE", PLANTA MEDICA, THIEME, STUTTGART, DE, vol. 55, no. 7, 1989, pages 601 - 602, XP001056676, ISSN: 0032-0943 *
KULEVANOVA, SVETLANA ET AL: "Determination of total flavonoids and quercetin in Hyperici herba and its aqueous, aqueous-ethanolic and oil extracts", ACTA PHARMACEUTICA (ZAGREB) , 50(1), 29-37 CODEN: ACPHEE; ISSN: 1330-0075, 2000, XP009033700 *
MAISENBACHER P ET AL: "ANALYSIS AND STABILITY OF HYPERICI OLEUM", PLANTA MEDICA, THIEME, STUTTGART, DE, vol. 58, 1992, pages 351 - 354, XP000964768, ISSN: 0032-0943 *
MALAMAS M ET AL: "The tradition of medicinal plants in Zagori, Epirus (northwestern Greece).", JOURNAL OF ETHNOPHARMACOLOGY. OCT 1992, vol. 37, no. 3, October 1992 (1992-10-01), pages 197 - 203, XP001182601, ISSN: 0378-8741 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7879344B2 (en) 2006-06-29 2011-02-01 Kimberly-Clark Worldwide, Inc. Transdermal delivery of oleocanthal for relief of inflammation
WO2009016247A1 (en) 2007-08-01 2009-02-05 Moses S.R.L. Method for preparing a hypericum extract in neem oil and a substance so obtained
US8211481B2 (en) 2007-08-01 2012-07-03 Moses S.R.L. Method for preparing a hypericum extract in neem oil and a substance so obtained

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