EP1874689B2 - Mineral salt gel compositions - Google Patents
Mineral salt gel compositions Download PDFInfo
- Publication number
- EP1874689B2 EP1874689B2 EP05736193.3A EP05736193A EP1874689B2 EP 1874689 B2 EP1874689 B2 EP 1874689B2 EP 05736193 A EP05736193 A EP 05736193A EP 1874689 B2 EP1874689 B2 EP 1874689B2
- Authority
- EP
- European Patent Office
- Prior art keywords
- salt
- gel composition
- composition according
- gelling agent
- salt gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 150000003839 salts Chemical class 0.000 title claims description 136
- 239000000203 mixture Substances 0.000 title claims description 94
- 229910052500 inorganic mineral Inorganic materials 0.000 title description 29
- 239000011707 mineral Substances 0.000 title description 29
- DHRRIBDTHFBPNG-UHFFFAOYSA-L magnesium dichloride hexahydrate Chemical compound O.O.O.O.O.O.[Mg+2].[Cl-].[Cl-] DHRRIBDTHFBPNG-UHFFFAOYSA-L 0.000 claims description 68
- 239000003349 gelling agent Substances 0.000 claims description 55
- 238000011282 treatment Methods 0.000 claims description 23
- 239000012141 concentrate Substances 0.000 claims description 16
- 239000002537 cosmetic Substances 0.000 claims description 14
- 230000001225 therapeutic effect Effects 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 12
- 206010052428 Wound Diseases 0.000 claims description 10
- 208000027418 Wounds and injury Diseases 0.000 claims description 10
- 244000078703 ectoparasite Species 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 10
- 206010061217 Infestation Diseases 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 229920002472 Starch Polymers 0.000 claims description 7
- 239000008107 starch Substances 0.000 claims description 7
- 235000019698 starch Nutrition 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 239000001341 hydroxy propyl starch Substances 0.000 claims description 6
- 235000013828 hydroxypropyl starch Nutrition 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 5
- 239000000654 additive Substances 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- 208000028454 lice infestation Diseases 0.000 claims description 5
- 229920003023 plastic Polymers 0.000 claims description 5
- 239000004033 plastic Substances 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 241000282414 Homo sapiens Species 0.000 claims description 3
- 239000003205 fragrance Substances 0.000 claims description 3
- 239000000049 pigment Substances 0.000 claims description 3
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 230000000845 anti-microbial effect Effects 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000003921 oil Substances 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- 239000000419 plant extract Substances 0.000 claims description 2
- 239000000341 volatile oil Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims 3
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 239000004088 foaming agent Substances 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 235000002639 sodium chloride Nutrition 0.000 description 124
- 239000000499 gel Substances 0.000 description 72
- 235000010755 mineral Nutrition 0.000 description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 23
- 210000003491 skin Anatomy 0.000 description 22
- 239000000243 solution Substances 0.000 description 15
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 11
- CSNNHWWHGAXBCP-UHFFFAOYSA-L magnesium sulphate Substances [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 11
- 159000000003 magnesium salts Chemical class 0.000 description 10
- 230000009286 beneficial effect Effects 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 239000011780 sodium chloride Substances 0.000 description 8
- 239000012267 brine Substances 0.000 description 7
- 239000013078 crystal Substances 0.000 description 7
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 7
- 238000003287 bathing Methods 0.000 description 6
- 229910001629 magnesium chloride Inorganic materials 0.000 description 6
- 229910001425 magnesium ion Inorganic materials 0.000 description 6
- 235000019341 magnesium sulphate Nutrition 0.000 description 6
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 5
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 5
- 239000012266 salt solution Substances 0.000 description 5
- 241000283690 Bos taurus Species 0.000 description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 241001674048 Phthiraptera Species 0.000 description 4
- 201000004681 Psoriasis Diseases 0.000 description 4
- 206010000496 acne Diseases 0.000 description 4
- 239000000428 dust Substances 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- -1 hydroxypropylmethyl Chemical class 0.000 description 4
- 239000011777 magnesium Substances 0.000 description 4
- 229960002337 magnesium chloride Drugs 0.000 description 4
- 229940091250 magnesium supplement Drugs 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000005065 mining Methods 0.000 description 4
- 239000005022 packaging material Substances 0.000 description 4
- 244000045947 parasite Species 0.000 description 4
- 239000011505 plaster Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 208000002874 Acne Vulgaris Diseases 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- JLYXXMFPNIAWKQ-GNIYUCBRSA-N gamma-hexachlorocyclohexane Chemical compound Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl JLYXXMFPNIAWKQ-GNIYUCBRSA-N 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 239000002917 insecticide Substances 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 229960002809 lindane Drugs 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 230000002035 prolonged effect Effects 0.000 description 3
- 239000013535 sea water Substances 0.000 description 3
- 208000017520 skin disease Diseases 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- 244000144927 Aloe barbadensis Species 0.000 description 2
- 235000002961 Aloe barbadensis Nutrition 0.000 description 2
- 206010003645 Atopy Diseases 0.000 description 2
- 208000032544 Cicatrix Diseases 0.000 description 2
- 206010012442 Dermatitis contact Diseases 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 241000607479 Yersinia pestis Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 235000011399 aloe vera Nutrition 0.000 description 2
- 230000002141 anti-parasite Effects 0.000 description 2
- 239000003096 antiparasitic agent Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000037336 dry skin Effects 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000005755 formation reaction Methods 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 210000002510 keratinocyte Anatomy 0.000 description 2
- 229940050906 magnesium chloride hexahydrate Drugs 0.000 description 2
- 230000035800 maturation Effects 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000001185 psoriatic effect Effects 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- 230000037387 scars Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 description 1
- 241000238876 Acari Species 0.000 description 1
- 241000167854 Bourreria succulenta Species 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical class C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 235000003880 Calendula Nutrition 0.000 description 1
- 240000001432 Calendula officinalis Species 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 235000009024 Ceanothus sanguineus Nutrition 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 208000005156 Dehydration Diseases 0.000 description 1
- 206010014143 Ectoparasitic Infestations Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 240000003553 Leptospermum scoparium Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 239000005949 Malathion Substances 0.000 description 1
- 235000013500 Melia azadirachta Nutrition 0.000 description 1
- 244000237986 Melia azadirachta Species 0.000 description 1
- 241000749985 Nites Species 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 244000044822 Simmondsia californica Species 0.000 description 1
- 235000004433 Simmondsia californica Nutrition 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- VXSIXFKKSNGRRO-MXOVTSAMSA-N [(1s)-2-methyl-4-oxo-3-[(2z)-penta-2,4-dienyl]cyclopent-2-en-1-yl] (1r,3r)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate;[(1s)-2-methyl-4-oxo-3-[(2z)-penta-2,4-dienyl]cyclopent-2-en-1-yl] (1r,3r)-3-[(e)-3-methoxy-2-methyl-3-oxoprop-1-enyl Chemical class CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)O[C@@H]1C(C)=C(C\C=C/C=C)C(=O)C1.CC1(C)[C@H](/C=C(\C)C(=O)OC)[C@H]1C(=O)O[C@@H]1C(C)=C(C\C=C/C=C)C(=O)C1 VXSIXFKKSNGRRO-MXOVTSAMSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000019693 cherries Nutrition 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 210000001520 comb Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 229940117173 croton oil Drugs 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- JXSJBGJIGXNWCI-UHFFFAOYSA-N diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate Chemical compound CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC JXSJBGJIGXNWCI-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000000887 hydrating effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 210000002664 langerhans' cell Anatomy 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- OTCKOJUMXQWKQG-UHFFFAOYSA-L magnesium bromide Chemical compound [Mg+2].[Br-].[Br-] OTCKOJUMXQWKQG-UHFFFAOYSA-L 0.000 description 1
- 229910001623 magnesium bromide Inorganic materials 0.000 description 1
- MJMDTFNVECGTEM-UHFFFAOYSA-L magnesium dichloride monohydrate Chemical compound O.[Mg+2].[Cl-].[Cl-] MJMDTFNVECGTEM-UHFFFAOYSA-L 0.000 description 1
- PALNZFJYSCMLBK-UHFFFAOYSA-K magnesium;potassium;trichloride;hexahydrate Chemical compound O.O.O.O.O.O.[Mg+2].[Cl-].[Cl-].[Cl-].[K+] PALNZFJYSCMLBK-UHFFFAOYSA-K 0.000 description 1
- 229960000453 malathion Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 208000029380 parasitic ectoparasitic infectious disease Diseases 0.000 description 1
- 238000009304 pastoral farming Methods 0.000 description 1
- 230000003038 pediculicidal effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- HYJYGLGUBUDSLJ-UHFFFAOYSA-N pyrethrin Natural products CCC(=O)OC1CC(=C)C2CC3OC3(C)C2C2OC(=O)C(=C)C12 HYJYGLGUBUDSLJ-UHFFFAOYSA-N 0.000 description 1
- 229940070846 pyrethrins Drugs 0.000 description 1
- 239000002728 pyrethroid Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000002278 reconstructive surgery Methods 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 229920006298 saran Polymers 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000037067 skin hydration Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Definitions
- the invention relates to salt gel compositions, methods for manufacture and use of the same.
- it relates to gel compositions based on MgCl 2 .6H 2 O (Bischofite) and the cosmetic and therapeutical uses thereof.
- Mineral salts are known to have a wide range of therapeutic and cosmetic properties. They can relieve skin ailments such as acne, eczema and psoriasis. Furthermore, they have positive cosmetic effects, like softening, hydrating and inflammation-suppressing effects. Particularly well known is the use of natural salt crystals from the Dead Sea. Dead Sea salts can help strengthen the immune system, detoxify, improve circulation, relieve aches and pains, soften and heal the skin, reduce fatigue, release tension, rejuvenate and revitalize. Bathing in the Dead Sea as treatment of skin diseases has been known for hundreds of years. The Dead Sea has an average salinity of 280 g/kg compared with the ocean's average 35 g/kg.
- Magnesium salts are quantitatively and qualitatively most important in Dead Sea water. The actual salt content depends on the regional location (water is flowing in by the River Jordan), the water depth, and various additional factors. Salt from the Dead Sea is sold in many countries.
- Magnesium ions also exhibit anti-inflammatory properties; a magnesium ion-containing ointment significantly inhibited the croton-oil-induced inflammation of the skin. Furthermore, beneficial effects of magnesium ions applied locally to the skin of patients with contact dermatitis have been reported ( Greiner J, Diezel W. Entzündungshemmendecardi von Magnesium-Ionen bei derenneekzem-Repress. Hautier 1990; 41: 602-605 .12)
- Epsom salt Another common bath salt is Epsom salt, which is made up of hydrated magnesium sulphate. Epsom salt baths are used for combating stress and alleviating muscular aches and pains. The high magnesium content in Epsom salt baths also facilitates the removal of acids through the skin.
- Therapeutic mineral salts are typically provided in the form of crystal-like granular or flaky products.
- the treatment with a beneficial or therapeutic mineral salt has thus far primarily involved bathing or immersing the affected body or skin parts in an aqueous solution of the salt.
- a granular form is advantageous for a rapid dissolution in water.
- Salt solutions thus do not allow to apply large amounts of salt per unit of skin surface. As a result, the cosmetic and/or therapeutic effectiveness of salts when used in solution is relatively low.
- a salt gel composition comprising MgCl 2 .6H 2 O in an amount at least 60 percent by weight (w%) and a gelling agent, wherein the gelling agent is present in an amount of at least 0.05% by weight for each 1% of liquid to be gelated in the composition.
- a salt gel is chemically and physically stable for extended periods of time. It allows to expose a body part to a high concentration of the beneficial magnesium salt for a prolonged period of time.
- the saltgel can be packaged in a tube, container or pump dispenser which is both user-friendly and protects the hygroscopic magnesium salt against excessive moist.
- MgCl 2 .6H 2 O is a salt hydrate that is also known as Bischofite.
- Bischofite is a crystalline salt hydrate left after evaporation of an ancient sea. Bischofite is are extremely hygroscopic; it melts in the open air. As a mineral, Bischofite is encountered as a glomeroblastic salt rock. Pure Bischofite crystals are aquatic-transparent, but may also be of white, rose and fallow colour depending on impurities. Bischofite is encountered on many continents, in formations differing in age including modern ones. There were discoveries of small deposits in Western Ukraine, Byelorussia and Ukraine.
- a gel comprising 60% of the magnesium salt is sufficiently concentrated to obtain satisfactory cosmetic or therapeutic effects
- a higher salt concentration is preferred.
- Particularly good results are obtained using a composition comprising at least 70w%, more preferably at least 80w% MgCl 2 .6H 2 O.
- the invention provides a stable salt gel composition which contains 85 w% MgCl 2 .6H 2 O.
- the gelling agent that is used to formulate a viscous Bischofite gel composition is preferably present in an amount of at least 0.5% by weight, more preferably at least 1 w% based on the Bischofite content of the composition.
- a composition of the invention comprises around 60% Bischofite and 3% gelling agent, both percentages being expressed to the total weight of the salt gel composition.
- around 1w% gelling agent is used relative to the Bischofite content, for example in a concentrated salt gel composition with 85% Bischofite and 1% gelling agent. The higher the salt content, the less gelling agent will be required to achieve the desired stabilized salt concentrate, because less free water is present.
- the gelling agent is present in the composition in an amount of at least around 0.06% for each 1% of liquid present in the composition to be gelated.
- the amount of gelling agent to be used will however not only depend on the salt content of the composition, but also on other factors, like the type of gelling agent and the desired viscosity.
- the gelling agent is present in an amount of 0.1%, 0.2%, 0.4%, 1%, 2%, 3% or more, for example 5%.
- the gelling agent is preferably present in amount of up to 8-10% for each percentage of liquid to be gelated, although this may depend on the type of gelator used.
- a highly viscous composition can be obtained which has a pad-like, semi-transparent appearance.
- a 80% Bischofite composition is prepared using at least 6% gelling agent.
- the term 'salt gel composition' as used herein is thus not limited to compositions with semi-solid, paste-like properties but also encompasses gel pads.
- gelling agents can be used to prepare a salt gel composition. Natural, i.e. non-toxic, gelling agents are of course preferred if the composition is to be used as cosmetic or therapeutic composition. Especially at high concentrations of salt, the use of non-ionic gelling agents is preferred as these are only minimally affected by salts.
- useful gelling agents to formulate a Bischofite gel are starch and cellulose derivatives, for example hydroxyethyl derivatives, hydroxypropylmethyl derivatives and hydroxypropyl derivatives. Hydroxypropyl derivatives were found to be particularly useful.
- the gelling agent is hydroxypropyl cellulose (HPC).
- HPC hydroxypropyl cellulose
- Hydroxypropyl starch is a derivative of natural starch, used primarily for fluid-loss control in drilling muds, drill-in, completion and workover fluids. Being non-ionic, it is only slightly affected by salinity and hardness in fluids.
- Linear and branched carbohydrate polymers in natural starch have three reactive OH groups on each glucose unit. During manufacture, these polymers are reacted with propylene oxide, adding hydroxypropyl (CH(OH)CH 2 CH 3 ) groups at the OH positions by an ether linkage.
- hydroxypropyl starch phosphate also known under the trade name StructureTM XL.
- Structure XL is commercially available from National Starch and Chemical Company, a member of the ICI Group. It has been used in personal care emulsions, were it can aid in emulsion stabilization, aesthetics enhancement and viscosity build.
- An emulsion containing STRUCTURE XL has a good stability over a broad temperature range (-30°C up to 50°C). It also makes the formulation easy to apply to the skin. STRUCTURE XL is readily cold water dispersible so that no pre-mixes are needed.
- STRUCTURE XL allows to formulate over a wide pH range with high amounts of salts and a large variety of raw materials. According to the supplier, STRUCTURE XL is stable in the presence of up to 20% of mono- and divalent salts. The recommended concentrations according to the supplier to improve emulsion stability range from about 3% to 7.5%, while significant viscosity effects were reportedly observed at concentrations > 7.5%. The present inventors surprisingly observed that STRUCTURE XL can be used to formulate a stable gel comprising much higher concentrations of Bischofite; 1w% STRUCTURE XL was capable of stabilizing a salt gel comprising 80w% MgCl 2 .6H 2 O.
- a concentrated magnesium chloride gel of the invention can be used for several purposes, ranging from personal care use (such as cosmetic or therapeutic use) to industrial and agricultural applications.
- the invention also encompasses the use of a Bischofite gel as dust absorber or dust suppressor. Due to the presence of the gelling agent in the salt composition, the suppressive action is improved and better controllable.
- the gelling agent somewhat reduces the hygroscopic action of the Bischofite (the salt is surrounded by the agent) which results in a prolonged dust suppressing effect. Also, the gelling agent 'glues' the Bischofite to the sand or dust particles.
- a mineral salt gel composition as provided herein finds its use in animal feed.
- the salt gel is more easily mixed with other components of the animal feed compared to existing sources of MgCl 2 , e.g. pure Bischofite.
- the bitter taste of pure Bischofite is somewhat masked
- the concentrated salt gel forms the basis.
- one or more additional ingredients can of course be present in the salt gel.
- the salt gel is a cosmetic composition.
- the presence of a high concentration magnesium chloride hexahydrate can have beneficial effects on the skin.
- the salt gel composition may further comprise other substances that contribute to the attractiveness and/or cosmetic properties of the composition. Examples of substances that may be added to the salt composition include fragrances, e.g.
- the invention provides a mineral scrub gel on the basis of Bischofite.
- an exfoliating substance is included in the gel, for instance coarse sea salt crystals, sugar, ground apricot- or cherry pits or crushed olive pits or a salt with known therapeutical and/or cosmetic properties, for example (Dead) sea salt crystals.
- Useful exfoliating salt additives include particles of those salts which do not dissolve in the mineral gel of the invention, for instance sodium chloride, carnallite and magnesium sulphate.
- a mineral scrub gel may for example comprise 70- 85% Bischofite and 1-2.5% of the gelling agent Structure XL.
- Another aspect of the present invention relates to the treatment of ecto-parasitic infestations, in particular lice (pediculosis).
- lice pestsitic infestations
- Conventional approaches to combat pediculosis typically involve the use of chemical insecticides, such as DDT, hexachlorocyclohexane (HCH), malathion, pyrethrins, permethrins, and the like.
- DDT hexachlorocyclohexane
- HSH hexachlorocyclohexane
- malathion pyrethrins
- permethrins and the like.
- Lice resistant to DDT and HCH have been observed in Canada, the USA and Europe.
- the salt composition of the invention kills target pests by virtue of its strong hygroscopic properties. Of course, this mode of killing is very unlikely to induce resistance.
- the active ingredient is not toxic. Rather, the salt gel composition can be conveniently applied to the scalp (or any other infested area) for prolonged periods without causing any harm or irritation.
- the salt gel can be massaged into the hair to thoroughly coat the hair.
- the gel formulation sticks to the hair and avoids excessive dripping or spilling, even during prolonged periods of time. Subsequently, a plastic cap can be put over the head.
- the salt paste can be simply rinsed off the hair and scalp with water.
- the dead parasites and, if present, their eggs can be combed out using a special comb. It was found that this treatment is more than 90% effective, not only against lice but also against nits and unhatched eggs in every stage of development.
- the salt has a softening and smoothening effect on the hair, thereby further enhancing the detachment of nites from the hair. Furthermore, minor infections or small wounds which may be present in the treated area will be exposed to the beneficial effects of Bischofite.
- a salt gel composition of the invention is advantageously used to combat ecto-parasites, i.e. parasites which live on the outer surface of its host.
- the treatment may be repeated after some time (e.g. 7-10 days) following the first treatment.
- the host can be any organism suffering from an ecto-parasite infestation, including human beings and cattle.
- the major cattle ectoparasites are ticks and biting flies. Their bites cause irritations, preventing the cattle from grazing, and can also lead to secondary infections and infestations.
- As bloodsuckers, these parasites will also cause anaemia when present in high numbers, weakening the animals and even killing younger ones. Even more important, several of these bloodsucking parasites also act as vectors, meaning that they transmit various very debilitating or lethal diseases to their host.
- the content of the mineral salt and gelling agent in an anti-parasitic gel composition according to the invention can vary, depending on several factors such as the mode of application, the type of gelling agent, the subject to be treated (human or animal) and the ectoparasite to be killed. In one embodiment, it comprises at least 60% Bischofite, preferably at least 70% Bischofite.
- an anti-parasitic salt gel composition comprising around 85% Bischofite and 1.5% of a hydroxypropyl starch gelling agent (e.g. Structure XL).
- a mineral salt gel composition is provided which is less viscous (e.g. comprising 70-85% Bischofite and around 1% gelling agent) and allows application to the subject to be treated by way of spraying. This form of application is particularly advantageous for the treatment of cattle.
- Pediculicidal compositions comprising salts have been described in US 6,607,716 .
- the suggested amounts of effective salt range from 1 to 50 weight percent, with a preferred range of 5 to 20 w%, more preferred 10w%.
- the preferred salt in US 6,607,716 is sodium chloride.
- Concentrated salt compositions with at least 60w% MgCl 2 .6H 2 O as provided herein were not disclosed.
- Still a further aspect of the invention relates to the therapeutic use of salt gel pads of the invention.
- magnesium salts have anti-inflammatory and bacteriostatic effects and stimulate the rapid natural closure of wounds.
- the moist salt pad keeps wound or scars moist and soft, while the magnesium chloride can exert its wide range of beneficial effects.
- a flexible salt gel pad comprising magnesium chloride of the invention is thus advantageously used as dressing for wounds, including chronic wounds and burn wounds, and for the local treatment of symptoms associated with (inflammatory) skin disorders, such as psoriasis.
- a salt gel pad may also be used in the area of plastic and reconstructive surgery.
- the salt gel pad is preferably contacted directly with the affected area. If a prolonged exposure to the salt is desired, it is practical to immobilize the pad. This can be done with a plaster, bandage, or the like.
- the plaster or bandage may be used as a separate article or it may be an integral part of the pad. The latter can be achieved during the production of the pad, by contacting the salt gel composition while still in a liquid form with a plaster, bandage or the like.
- the size and shape of the pad can vary. It will generally have a thickness of between 0.3 and 2 centimetre.
- the salt gel not only has beneficial effects on its own based on the magnesium salt but it also provides an excellent matrix for the release of other therapeutic or cosmetic substances.
- the gel pad may also comprise additional ingredients that are of benefit to the user, for example additional anti-inflammatory or anti-microbial compounds, and/or factors which enhance wound healing, for instance aloe vera.
- a mineral gel composition of the invention is typically prepared in two main stages. In the first stage, a salt concentrate is obtained. During the second stage, the salt concentrate is stabilized with a gelling agent.
- the salt concentrate can be prepared using either a solid or liquid starting material, or a mixture thereof.
- the solid starting material can be salt flakes comprising MgCl 2 .6H 2 O, for example Bischofite salt flakes.
- water and salt flakes are combined in a container and the mixture is heated while stirring until all the salt flakes are dissolved.
- a mixture of 85% Bischofite in is heated to about 109°C. Mixtures with a lower or higher Bischofite concentration may be heated to other temperatures to cause melting of the salt flakes. These temperatures can be easily determined imperically. Heating of the salt/water mixture can be performed by any means, for instance electrically, using steam or using hot oil.
- the mixture is allowed to cool to a temperature below 40 °C under constant stirring.
- the container can be placed in a bath with cold water. The stirring ensures that the crystals which form at the walls of the container upon cooling are scraped off the wall, allowing new crystals to form at the cold wall. Also, this avoids the formation of large salt crystals such that the final gel composition has a fine structure.
- the liquid starting material for preparing a salt concentrate can be a salt melt or a mixture of a salt solution to which a salt melt is added.
- a solution of Bischofite at a known concentration for example prepared from flakes or from a concentrated brine, is brought in a stirred container, preferably a double-walled metal container which can be actively cooled.
- a Bischofite melt prepared by heating Bischofite to a temperature at which a homogenous melt is obtained which contains no solid Bischofite, is added to the solution in a controlled fashion while stirring and cooling the mixture.
- the rate at which the melt is added to the solution should be low enough to avoid boiling of the mixture and high enough to prevent too fast crystallization to occur.
- a salt solution with at least 60w%, preferably at least 65% Bischofite is preferred because this ensures a controlled and efficient mixing with the added melt while avoiding that the mixture comes to a boil.
- said aqueous solution is a brine of crude Bischofite which is obtained from the earth using solution mining.
- solution mining water is pumped into the underground salt cavern to extract salt.
- the salt mixes with the water to form a brine solution. This solution is then easily pumped to the surface.
- the brine solution is heated in an evaporator to evaporate water and to obtain a concentrated (e.g. 85 w%) Bischofite melt.
- the salt melt is then transferred to a crystallizer (e.g. a stirred double-walled metal container) where it is cooled down to form a crystalline salt concentrate.
- This crystalline salt concentrate is ready for further mixing with gelling agent.
- This variant method is particularly attractive for large scale preparations, for example starting from freshly mined Bischofite brine.
- a gelling agent is added while stirring.
- the gelling agent is preferably added to the salt concentrate as a powder.
- the salt/ gelling agent mixture is allowed to 'mature" for at least several hours, e.g. 12 hours or even more. This ensures that the gelling agent has come into maximal contact with the free water molecules. For instance, if a starch-based gelling agent is used a maximal swelling of the starch moieties is achieved during the maturation period. Following the maturation period, the composition is generally stirred again to obtain a homogenous and stable salt gel composition.
- the invention provides a method for preparing a salt gel composition according to any of the previous claims, comprising the steps of: a) providing a starting composition comprising MgCl 2 .6H 2 O in a dissolved and/or molten form; b) cooling said starting composition to a temperature at which the gelling agent has adequate gelling properties while stirring to obtain a salt concentrate comprising the desired amount of MgCl 2 .6H 2 O; c) mixing said salt concentrate with a suitable amount of gelling agent; d) allowing the mixture obtained in step c) to mature; and e) homogenizing the matured mixture obtained in step d), optionally while adding one or more further ingredients.
- the temperature at which the gelling agents has sufficient gelling properties depends of various factors, in particular the type of gelling agent use.
- the gelling agent Structure XL can be used as a gelling agent in the range of -30°C to 50°C. In that case, the mixture is preferably cooled to a temperature below 50°C, such as 40°C or lower.
- other temperatures may be suitable. These can be empirically determined by a person skilled in the art.
- the salt gel composition is ready for packaging in the desired package material.
- Various types of packaging materials may be used.
- the packaging material is provided with a resealable closure. This is user-friendly and also prevents unwanted moist access to the strongly hygroscopic salt concentrate.
- Examples of useful packaging material for paste-like salt gel compositions include a tube (e.g. 100-500 ml) with a screw cap or click-on cap.
- the tube is preferably made of a flexible plastic.
- Other examples are containers of any sort or shape with a screw cap or click-on cap.
- packaging materials with a dispenser system are preferred.
- the gel pads can be sealed in a moisture resistant, e.g. plastic, wrapping.
- kits for the treatment of an ecto-parasite infestation comprising a Bischofite-based salt gel composition according to the invention.
- the composition can be present in any type of container or tube.
- a kit of the invention is for example a kit for the treatment of a lice infestation.
- the kit may contain additional useful items, such as a plastic hair cap, a comb and/or instructions for use.
- Example 1 MINERAL GEL for disinfection of the skin comprising 65% Bischofite and 3% Structure XL as gelling agent.
- This form of the mineral gel is comparable with conventional disinfecting soap gels in terms of viscosity and application range.
- the disinfecting properties can be ascribed to the Bischofite. Washing the skin (e.g. hands) with the salt gel of relatively low viscosity can disinfect the skin. Following treatment with the salt gel, it can be easily rinsed off the skin with water.
- the mineral salt gel may also comprise a fragrance and pigment to increase the attractiveness of the gel.
- Example 2 MINERAL GEL for the treatment of skin disorders comprising 85% Bischofite and 1 à 2 % Structure XL
- Mineral salts in this type of gel formulation allow for a very convenient application of the salt to the skin.
- the mineral can be applied as a gel packing.
- the gel may be massaged lightly onto the skin.
- the amount of gel to be used can vary. Generally speaking, a layer of several millimetres will be sufficient to exert the beneficial therapeutic effects of the Bischofite.
- the mineral gel has no scrub-like properties exfoliating the skin but can soak off dead skin cells. Thereby, the skin becomes more susceptible to the caring, healing and clearing properties of Bischofite.
- This type of gel is suitably used for the treatment of acne.
- the Bischofite mineral cleanses the infected skin. dehydrates and drains the pores, thus preventing new pimples from forming. Possible scars due to the inflammation will heal more efficiently.
- the salt gel may be covered with Saran-wrap following application onto the skin.
- Example 3 MINERAL PAD (gel pad) comprising 85% Bischofite and 3-5% Structure XL.
- the minerals are formulated into a thick, highly viscous dosage form which sticks to the site of application. Following application of the pad to the desired site it may be pressed onto the skin into a thinner pad which sticks for even longer periods of time.
- the pad may be covered with a bandage or plaster, e.g. to allow for more freedom to move while the minerals can exert their effects on the skin.
- the gel pad is suitably used for the treatments of small wounds or to combat acne.
- the mineral salts can be easily rinsed off with water after completion of the treatment.
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Description
- The invention relates to salt gel compositions, methods for manufacture and use of the same. In particular, it relates to gel compositions based on MgCl2.6H2O (Bischofite) and the cosmetic and therapeutical uses thereof.
- Mineral salts are known to have a wide range of therapeutic and cosmetic properties. They can relieve skin ailments such as acne, eczema and psoriasis. Furthermore, they have positive cosmetic effects, like softening, hydrating and inflammation-suppressing effects. Particularly well known is the use of natural salt crystals from the Dead Sea. Dead Sea salts can help strengthen the immune system, detoxify, improve circulation, relieve aches and pains, soften and heal the skin, reduce fatigue, release tension, rejuvenate and revitalize. Bathing in the Dead Sea as treatment of skin diseases has been known for hundreds of years. The Dead Sea has an average salinity of 280 g/kg compared with the ocean's average 35 g/kg. It is rich in magnesium, calcium, potassium, and bromine and is depleted in sodium, sulphate, and carbonate ions. Magnesium salts are quantitatively and qualitatively most important in Dead Sea water. The actual salt content depends on the regional location (water is flowing in by the River Jordan), the water depth, and various additional factors. Salt from the Dead Sea is sold in many countries.
- Biochemical effects of magnesium salt therapy have been evidenced in vitro and in vivo. In vitro studies have shown that magnesium bromide and magnesium chloride inhibit the well-known excessive proliferation of psoriatic keratinocytes. Increased levels of magnesium and calcium ions, which may play a role in cell proliferation and differentiation, have been described in psoriatic keratinocytes and after sodium laurylsulfate-induced irritation.
- Spasov et al. (Bull Exp Biol Med. 2001;131(2):132-5) reported that local treatment with a Bischofite-containing drug (polykatan™) with up to 95% MgCl2.6H2O, promoted healing of infected skin wounds of rats. Washing the wounds with a 10% polykatan solution showed a bacteriostatic effect against a variety of opportunistic micro organisms. Furthermore, the rate of wound healing was enhanced when wounds were treated with the magnesium salt solution as compared to a NaCl solution isotonic to polykatan solution or to untreated controls. Magnesium ions also exhibit anti-inflammatory properties; a magnesium ion-containing ointment significantly inhibited the croton-oil-induced inflammation of the skin. Furthermore, beneficial effects of magnesium ions applied locally to the skin of patients with contact dermatitis have been reported (Greiner J, Diezel W. Entzündungshemmende Wirkung von Magnesium-Ionen bei der Kontaktekzem-Reaktion. Hautarzt 1990; 41: 602-605.12)
- Magnesium ions inhibit the antigen-presenting capacity of Langerhans' cells, most important for sensitization and elicitation of allergic reactions; contributing to the efficacy of Dead Sea salt in the treatment of inflammatory skin diseases. At the Dead Sea, bathing in the salt water is usually combined with ultraviolet (UV) irradiation. Although such a combination is effective, the benefit of the bathing aspect has been emphasized by Even-Paz et al.,(Dead Sea sun versus Dead Sea water in the treatment of psoriasis. J Dermatol Treat 1996; 7: 83-86). The authors found improvement in psoriasis patients who only bathed in Dead Sea water. Proksch et al. (Int J Dermatol. 2005; 44(2):151-7) examined the effect of bathing in a Dead Sea salt solution especially rich in magnesium ions on biophysical characteristics in atopic dry skin. It was found that bathing in a magnesium-rich Dead Sea salt solution improves skin barrier function, enhances skin hydration, and reduces inflammation in atopic dry skin.
- Another common bath salt is Epsom salt, which is made up of hydrated magnesium sulphate. Epsom salt baths are used for combating stress and alleviating muscular aches and pains. The high magnesium content in Epsom salt baths also facilitates the removal of acids through the skin.
- Therapeutic mineral salts are typically provided in the form of crystal-like granular or flaky products. The treatment with a beneficial or therapeutic mineral salt has thus far primarily involved bathing or immersing the affected body or skin parts in an aqueous solution of the salt. A granular form is advantageous for a rapid dissolution in water. The smaller the salt's granule size is, the faster it dissolves in the bath. However, it will be understood that when using dissolved salts, the salt will be significantly diluted and the (skin) surface to be treated is only exposed to minor amounts of the beneficial salt. Salt solutions thus do not allow to apply large amounts of salt per unit of skin surface. As a result, the cosmetic and/or therapeutic effectiveness of salts when used in solution is relatively low. Furthermore, because of the rapid dissolution of granular mineral salts in water, these salts are inefficient and cumbersome to handle for application of and unsuitable for use under the shower. Following application of salt granules onto the body, the salts easily dissolve in the water emerging from the shower. Moreover, a substantial proportion of the granules falls down and is rinsed away before having been in contact with the body.
- Therefore, it is an object of the present invention to provide a salt formulation that allows for a convenient application of a therapeutic or cosmetic mineral salt, in particular magnesium salt, in a concentrated form.
- Surprisingly, it has been found that the objects set are achieved.by the provision of a salt gel composition comprising MgCl2.6H2O in an amount at least 60 percent by weight (w%) and a gelling agent, wherein the gelling agent is present in an amount of at least 0.05% by weight for each 1% of liquid to be gelated in the composition. Such a salt gel is chemically and physically stable for extended periods of time. It allows to expose a body part to a high concentration of the beneficial magnesium salt for a prolonged period of time. Furthermore, the saltgel can be packaged in a tube, container or pump dispenser which is both user-friendly and protects the hygroscopic magnesium salt against excessive moist.
- MgCl2.6H2O (magnesium chloride hexahydrate) is a salt hydrate that is also known as Bischofite. Bischofite is a crystalline salt hydrate left after evaporation of an ancient sea. Bischofite is are extremely hygroscopic; it melts in the open air. As a mineral, Bischofite is encountered as a glomeroblastic salt rock. Pure Bischofite crystals are aquatic-transparent, but may also be of white, rose and fallow colour depending on impurities. Bischofite is encountered on many continents, in formations differing in age including modern ones. There were discoveries of small deposits in Western Ukraine, Byelorussia and Kazakhstan. All the discoveries were represented by thin (3 to 7 m) non-extended layers. Most notable potassium and magnesium salt deposits are found in Carlsbad, New Mexico; the Paradox Basin in Colorado and Utah; deposits in Strassfurt, Germany; the Perm Basin, Russia and the Williston Basin in Saskatchewan, Canada. Another natural source of Bischofite is the region around Veendam, The Netherlands. NEDMAG INDUSTRIES Mining and Manufacturing B.V. mines the Bischofite salt from the Zechstein salts near Veendam with a unique solution mining method.
- Whereas a gel comprising 60% of the magnesium salt is sufficiently concentrated to obtain satisfactory cosmetic or therapeutic effects, a higher salt concentration is preferred. Particularly good results are obtained using a composition comprising at least 70w%, more preferably at least 80w% MgCl2.6H2O. For example, the invention provides a stable salt gel composition which contains 85 w% MgCl2.6H2O.
- The gelling agent that is used to formulate a viscous Bischofite gel composition is preferably present in an amount of at least 0.5% by weight, more preferably at least 1 w% based on the Bischofite content of the composition. For example, a composition of the invention comprises around 60% Bischofite and 3% gelling agent, both percentages being expressed to the total weight of the salt gel composition. In another embodiment, around 1w% gelling agent is used relative to the Bischofite content, for example in a concentrated salt gel composition with 85% Bischofite and 1% gelling agent. The higher the salt content, the less gelling agent will be required to achieve the desired stabilized salt concentrate, because less free water is present. As a general rule of thumb, approximately 0.06% of gelling agent is required to prepare a stable gel composition from a composition with 1% (by volume) of "free" water. For example, a brine with 64% MgCl2.H2O (30% MgCl2) contains 46% water. Accordingly, approximately 2.8-3.0% of gelling agent should be used. Likewise, a 85% Bischofite brine with only 15% free water only requires around 0.9-1.0% of gelling agent. Thus, according to the invention the gelling agent is present in the composition in an amount of at least around 0.06% for each 1% of liquid present in the composition to be gelated. The amount of gelling agent to be used will however not only depend on the salt content of the composition, but also on other factors, like the type of gelling agent and the desired viscosity. For example, the gelling agent is present in an amount of 0.1%, 0.2%, 0.4%, 1%, 2%, 3% or more, for example 5%. The gelling agent is preferably present in amount of up to 8-10% for each percentage of liquid to be gelated, although this may depend on the type of gelator used. At a gelling agent concentration of more than approximately 0.3 w% for each percentage of free water , a highly viscous composition can be obtained which has a pad-like, semi-transparent appearance. In one embodiment, a 80% Bischofite composition is prepared using at least 6% gelling agent. The term 'salt gel composition' as used herein is thus not limited to compositions with semi-solid, paste-like properties but also encompasses gel pads.
- Several types of gelling agents (sometimes also referred to as binders) can be used to prepare a salt gel composition. Natural, i.e. non-toxic, gelling agents are of course preferred if the composition is to be used as cosmetic or therapeutic composition. Especially at high concentrations of salt, the use of non-ionic gelling agents is preferred as these are only minimally affected by salts. Examples of useful gelling agents to formulate a Bischofite gel are starch and cellulose derivatives, for example hydroxyethyl derivatives, hydroxypropylmethyl derivatives and hydroxypropyl derivatives. Hydroxypropyl derivatives were found to be particularly useful.
- In one embodiment, the gelling agent is hydroxypropyl cellulose (HPC). In another embodiment, use is made of hydroxypropyl starch, preferably in an amount of 1-5% by weight based on the salt hydrate. Hydroxypropyl starch is a derivative of natural starch, used primarily for fluid-loss control in drilling muds, drill-in, completion and workover fluids. Being non-ionic, it is only slightly affected by salinity and hardness in fluids. Linear and branched carbohydrate polymers in natural starch have three reactive OH groups on each glucose unit. During manufacture, these polymers are reacted with propylene oxide, adding hydroxypropyl (CH(OH)CH2CH3) groups at the OH positions by an ether linkage.
- Another preferred gelling agent is hydroxypropyl starch phosphate, also known under the trade name Structure™ XL. Structure XL is commercially available from National Starch and Chemical Company, a member of the ICI Group. It has been used in personal care emulsions, were it can aid in emulsion stabilization, aesthetics enhancement and viscosity build. An emulsion containing STRUCTURE XL has a good stability over a broad temperature range (-30°C up to 50°C). It also makes the formulation easy to apply to the skin. STRUCTURE XL is readily cold water dispersible so that no pre-mixes are needed. Because of its nonionic character and broad compatibility, STRUCTURE XL allows to formulate over a wide pH range with high amounts of salts and a large variety of raw materials. According to the supplier, STRUCTURE XL is stable in the presence of up to 20% of mono- and divalent salts. The recommended concentrations according to the supplier to improve emulsion stability range from about 3% to 7.5%, while significant viscosity effects were reportedly observed at concentrations > 7.5%. The present inventors surprisingly observed that STRUCTURE XL can be used to formulate a stable gel comprising much higher concentrations of Bischofite; 1w% STRUCTURE XL was capable of stabilizing a salt gel comprising 80w% MgCl2.6H2O.
- A concentrated magnesium chloride gel of the invention can be used for several purposes, ranging from personal care use (such as cosmetic or therapeutic use) to industrial and agricultural applications. For example, the invention also encompasses the use of a Bischofite gel as dust absorber or dust suppressor. Due to the presence of the gelling agent in the salt composition, the suppressive action is improved and better controllable. The gelling agent somewhat reduces the hygroscopic action of the Bischofite (the salt is surrounded by the agent) which results in a prolonged dust suppressing effect. Also, the gelling agent 'glues' the Bischofite to the sand or dust particles. In another aspect, a mineral salt gel composition as provided herein finds its use in animal feed. The gel is more easily mixed with other components of the animal feed compared to existing sources of MgCl2, e.g. pure Bischofite. In addition, if incorporated in the food as a gel, the bitter taste of pure Bischofite is somewhat masked
In every application, the concentrated salt gel forms the basis. Depending on the application one or more additional ingredients can of course be present in the salt gel. In one embodiment, the salt gel is a cosmetic composition. The presence of a high concentration magnesium chloride hexahydrate can have beneficial effects on the skin. The salt gel composition may further comprise other substances that contribute to the attractiveness and/or cosmetic properties of the composition. Examples of substances that may be added to the salt composition include fragrances, e.g. etheric oils, pigments, plant extracts like tea tree, neem, aloe vera, calendula, jojoba and the like. In a particular aspect, the invention provides a mineral scrub gel on the basis of Bischofite. To that end, an exfoliating substance is included in the gel, for instance coarse sea salt crystals, sugar, ground apricot- or cherry pits or crushed olive pits or a salt with known therapeutical and/or cosmetic properties, for example (Dead) sea salt crystals. Useful exfoliating salt additives include particles of those salts which do not dissolve in the mineral gel of the invention, for instance sodium chloride, carnallite and magnesium sulphate. A mineral scrub gel may for example comprise 70- 85% Bischofite and 1-2.5% of the gelling agent Structure XL. - Another aspect of the present invention relates to the treatment of ecto-parasitic infestations, in particular lice (pediculosis). These infestations are a common problem among children. They are often spread from shared hats, combs, lockers, closets and other unavoidable contacts in school. Infestations can easily spread to other children and family members by touching or via shared clothing. Conventional approaches to combat pediculosis typically involve the use of chemical insecticides, such as DDT, hexachlorocyclohexane (HCH), malathion, pyrethrins, permethrins, and the like. Not only is the use of these toxic and unpleasant chemical insecticides highly undesirable, they also induce resistance in the target pest against the insecticides. Lice resistant to DDT and HCH have been observed in Canada, the USA and Europe.
- The present inventors surprisingly observed that a concentrated Bischofite gel is advantageously used to treat infestation of lice fleas and similar ectoparasites. The salt composition of the invention kills target pests by virtue of its strong hygroscopic properties. Of course, this mode of killing is very unlikely to induce resistance. Furthermore, the active ingredient is not toxic. Rather, the salt gel composition can be conveniently applied to the scalp (or any other infested area) for prolonged periods without causing any harm or irritation. The salt gel can be massaged into the hair to thoroughly coat the hair. The gel formulation sticks to the hair and avoids excessive dripping or spilling, even during prolonged periods of time. Subsequently, a plastic cap can be put over the head. After about an hour, the maximum amount of time it typically takes to kill the ecto-parasites, the salt paste can be simply rinsed off the hair and scalp with water. The dead parasites and, if present, their eggs can be combed out using a special comb. It was found that this treatment is more than 90% effective, not only against lice but also against nits and unhatched eggs in every stage of development. The salt has a softening and smoothening effect on the hair, thereby further enhancing the detachment of nites from the hair. Furthermore, minor infections or small wounds which may be present in the treated area will be exposed to the beneficial effects of Bischofite.
- Thus, a salt gel composition of the invention is advantageously used to combat ecto-parasites, i.e. parasites which live on the outer surface of its host. The treatment may be repeated after some time (e.g. 7-10 days) following the first treatment. The host can be any organism suffering from an ecto-parasite infestation, including human beings and cattle. The major cattle ectoparasites are ticks and biting flies. Their bites cause irritations, preventing the cattle from grazing, and can also lead to secondary infections and infestations. As bloodsuckers, these parasites will also cause anaemia when present in high numbers, weakening the animals and even killing younger ones. Even more important, several of these bloodsucking parasites also act as vectors, meaning that they transmit various very debilitating or lethal diseases to their host.
- The content of the mineral salt and gelling agent in an anti-parasitic gel composition according to the invention can vary, depending on several factors such as the mode of application, the type of gelling agent, the subject to be treated (human or animal) and the ectoparasite to be killed. In one embodiment, it comprises at least 60% Bischofite, preferably at least 70% Bischofite. For example, provided is an anti-parasitic salt gel composition comprising around 85% Bischofite and 1.5% of a hydroxypropyl starch gelling agent (e.g. Structure XL). In another embodiment, a mineral salt gel composition is provided which is less viscous (e.g. comprising 70-85% Bischofite and around 1% gelling agent) and allows application to the subject to be treated by way of spraying. This form of application is particularly advantageous for the treatment of cattle.
- Pediculicidal compositions comprising salts have been described in
US 6,607,716 . The suggested amounts of effective salt range from 1 to 50 weight percent, with a preferred range of 5 to 20 w%, more preferred 10w%. The preferred salt inUS 6,607,716 is sodium chloride. Concentrated salt compositions with at least 60w% MgCl2.6H2O as provided herein were not disclosed.
Still a further aspect of the invention relates to the therapeutic use of salt gel pads of the invention. As mentioned above, magnesium salts have anti-inflammatory and bacteriostatic effects and stimulate the rapid natural closure of wounds. The moist salt pad keeps wound or scars moist and soft, while the magnesium chloride can exert its wide range of beneficial effects. A flexible salt gel pad comprising magnesium chloride of the invention is thus advantageously used as dressing for wounds, including chronic wounds and burn wounds, and for the local treatment of symptoms associated with (inflammatory) skin disorders, such as psoriasis. A salt gel pad may also be used in the area of plastic and reconstructive surgery. The salt gel pad is preferably contacted directly with the affected area. If a prolonged exposure to the salt is desired, it is practical to immobilize the pad. This can be done with a plaster, bandage, or the like. The plaster or bandage may be used as a separate article or it may be an integral part of the pad. The latter can be achieved during the production of the pad, by contacting the salt gel composition while still in a liquid form with a plaster, bandage or the like. The size and shape of the pad can vary. It will generally have a thickness of between 0.3 and 2 centimetre. The salt gel not only has beneficial effects on its own based on the magnesium salt but it also provides an excellent matrix for the release of other therapeutic or cosmetic substances. Thus, the gel pad may also comprise additional ingredients that are of benefit to the user, for example additional anti-inflammatory or anti-microbial compounds, and/or factors which enhance wound healing, for instance aloe vera. - A mineral gel composition of the invention is typically prepared in two main stages. In the first stage, a salt concentrate is obtained. During the second stage, the salt concentrate is stabilized with a gelling agent. The salt concentrate can be prepared using either a solid or liquid starting material, or a mixture thereof.
- The solid starting material can be salt flakes comprising MgCl2.6H2O, for example Bischofite salt flakes. In one embodiment, water and salt flakes are combined in a container and the mixture is heated while stirring until all the salt flakes are dissolved. In one embodiment, a mixture of 85% Bischofite in is heated to about 109°C. Mixtures with a lower or higher Bischofite concentration may be heated to other temperatures to cause melting of the salt flakes. These temperatures can be easily determined imperically. Heating of the salt/water mixture can be performed by any means, for instance electrically, using steam or using hot oil. Thereafter, the mixture is allowed to cool to a temperature below 40 °C under constant stirring. The container can be placed in a bath with cold water. The stirring ensures that the crystals which form at the walls of the container upon cooling are scraped off the wall, allowing new crystals to form at the cold wall. Also, this avoids the formation of large salt crystals such that the final gel composition has a fine structure.
- The liquid starting material for preparing a salt concentrate can be a salt melt or a mixture of a salt solution to which a salt melt is added. In one embodiment, a solution of Bischofite at a known concentration, for example prepared from flakes or from a concentrated brine, is brought in a stirred container, preferably a double-walled metal container which can be actively cooled. A Bischofite melt, prepared by heating Bischofite to a temperature at which a homogenous melt is obtained which contains no solid Bischofite, is added to the solution in a controlled fashion while stirring and cooling the mixture. The rate at which the melt is added to the solution should be low enough to avoid boiling of the mixture and high enough to prevent too fast crystallization to occur. In this respect, the use of a salt solution with at least 60w%, preferably at least 65% Bischofite is preferred because this ensures a controlled and efficient mixing with the added melt while avoiding that the mixture comes to a boil.
In a variant of the above method, it is also possible to start with an aqueous salt solution which is heated in a controlled manner to evaporate excess water and to prepare a salt melt with a desired salt content. In one embodiment, said aqueous solution is a brine of crude Bischofite which is obtained from the earth using solution mining. In solution mining, water is pumped into the underground salt cavern to extract salt. Here, the salt mixes with the water to form a brine solution. This solution is then easily pumped to the surface. The brine solution is heated in an evaporator to evaporate water and to obtain a concentrated (e.g. 85 w%) Bischofite melt. The salt melt is then transferred to a crystallizer (e.g. a stirred double-walled metal container) where it is cooled down to form a crystalline salt concentrate. This crystalline salt concentrate is ready for further mixing with gelling agent. This variant method is particularly attractive for large scale preparations, for example starting from freshly mined Bischofite brine. - Following the preparation of a salt concentrate using cooling and crystallization to < 40°C, a gelling agent is added while stirring. The gelling agent is preferably added to the salt concentrate as a powder. To obtain a stable salt gel composition, it is preferred that the salt/ gelling agent mixture is allowed to 'mature" for at least several hours, e.g. 12 hours or even more. This ensures that the gelling agent has come into maximal contact with the free water molecules. For instance, if a starch-based gelling agent is used a maximal swelling of the starch moieties is achieved during the maturation period. Following the maturation period, the composition is generally stirred again to obtain a homogenous and stable salt gel composition. It this point in the procedure one or more additives (see above) may be added to the composition. Herewith, the invention provides a method for preparing a salt gel composition according to any of the previous claims, comprising the steps of: a) providing a starting composition comprising MgCl2.6H2O in a dissolved and/or molten form; b) cooling said starting composition to a temperature at which the gelling agent has adequate gelling properties while stirring to obtain a salt concentrate comprising the desired amount of MgCl2.6H2O; c) mixing said salt concentrate with a suitable amount of gelling agent; d) allowing the mixture obtained in step c) to mature; and e) homogenizing the matured mixture obtained in step d), optionally while adding one or more further ingredients. The temperature at which the gelling agents has sufficient gelling properties depends of various factors, in particular the type of gelling agent use. For example, the gelling agent Structure XL can be used as a gelling agent in the range of -30°C to 50°C. In that case, the mixture is preferably cooled to a temperature below 50°C, such as 40°C or lower. For other types of gelling agents, other temperatures may be suitable. These can be empirically determined by a person skilled in the art.
The salt gel composition is ready for packaging in the desired package material. Various types of packaging materials may be used. Preferably, the packaging material is provided with a resealable closure. This is user-friendly and also prevents unwanted moist access to the strongly hygroscopic salt concentrate. Examples of useful packaging material for paste-like salt gel compositions include a tube (e.g. 100-500 ml) with a screw cap or click-on cap. The tube is preferably made of a flexible plastic. Other examples are containers of any sort or shape with a screw cap or click-on cap. For large scale applications, packaging materials with a dispenser system are preferred. The gel pads can be sealed in a moisture resistant, e.g. plastic, wrapping. - Furthermore, the invention provides a kit for the treatment of an ecto-parasite infestation comprising a Bischofite-based salt gel composition according to the invention. The composition can be present in any type of container or tube. A kit of the invention is for example a kit for the treatment of a lice infestation. The kit may contain additional useful items, such as a plastic hair cap, a comb and/or instructions for use.
- The invention is illustrated by the Examples below.
- This form of the mineral gel is comparable with conventional disinfecting soap gels in terms of viscosity and application range. However, in the mineral salt gel the disinfecting properties can be ascribed to the Bischofite. Washing the skin (e.g. hands) with the salt gel of relatively low viscosity can disinfect the skin. Following treatment with the salt gel, it can be easily rinsed off the skin with water. The mineral salt gel may also comprise a fragrance and pigment to increase the attractiveness of the gel.
- Mineral salts in this type of gel formulation allow for a very convenient application of the salt to the skin. The mineral can be applied as a gel packing. The gel may be massaged lightly onto the skin. The amount of gel to be used can vary. Generally speaking, a layer of several millimetres will be sufficient to exert the beneficial therapeutic effects of the Bischofite. The mineral gel has no scrub-like properties exfoliating the skin but can soak off dead skin cells. Thereby, the skin becomes more susceptible to the caring, healing and clearing properties of Bischofite.
- This type of gel is suitably used for the treatment of acne. The Bischofite mineral cleanses the infected skin. dehydrates and drains the pores, thus preventing new pimples from forming. Possible scars due to the inflammation will heal more efficiently.
- In case a long-term treatment of skin with a mineral salt gel is desired, the salt gel may be covered with Saran-wrap following application onto the skin.
- In the mineral pad, the minerals are formulated into a thick, highly viscous dosage form which sticks to the site of application. Following application of the pad to the desired site it may be pressed onto the skin into a thinner pad which sticks for even longer periods of time. The pad may be covered with a bandage or plaster, e.g. to allow for more freedom to move while the minerals can exert their effects on the skin. The gel pad is suitably used for the treatments of small wounds or to combat acne. The mineral salts can be easily rinsed off with water after completion of the treatment.
Claims (17)
- A salt gel composition comprising at least 60% by weight of MgCl2.6H2O (Bischofite) and a gelling agent, wherein the gelling agent is present in an amount of at least 0.05% by weight for each 1% of liquid to be gelated in the composition.
- A salt gel composition according to claim 1, wherein said gelling agent is a non-ionic derivative of starch or cellulose.
- A salt gel composition according to claim 2, wherein the gelling agent is a hydroxypropyl starch.
- A salt gel composition according to claim 3, wherein the gelling agent is hydroxypropyl starch phosphate (Structure™ XL).
- A salt gel composition according to any of the previous claims, further comprising at least one additive, preferably a cosmetic or therapeutic additive.
- A salt gel composition according to claim 5, wherein said additive is selected from group consisting of an exfoliating substance, a fragrance, a pigment, a salt, an anti-microbial substance, an anti-inflammatory substance, a plant extract, foaming agent and an oil, such as an etheric oil.
- A salt gel composition according to any of the previous claims, wherein the gelling agent is present in an amount of at least 0.3% by weight for each 1% of liquid to be gelated in the composition, such that the composition has the form of a gel pad.
- Method for preparing a salt gel composition according to any of the previous claims, comprising the steps of:a) providing a starting composition comprising MgCl2.6H2O in a dissolved and/or molten form;b) cooling said starting composition to a temperature at which the gelling agent displays gelling properties while stirring to obtain a salt concentrate comprising the desired amount of MgCl2.6H2O;c) mixing said salt concentrate with a suitable amount of gelling agent;d) allowing the mixture obtained in step c) to mature; ande) homogenizing the matured mixture obtained in step d), optionally while adding one or more further ingredients.
- Method for preparing a salt gel composition in the form of a gel pad, comprising the method of claim 8, wherein the gelling agent is added to the salt concentrate in an amount of at least 0.3% by weight for each 1% of liquid to be gelated in the concentrate.
- Use of a salt gel composition according to any one of claims 1 to 7 as a cosmetic substance.
- Salt gel composition according to any one of claims 1 to 7, for use as a dermatological composition.
- Salt gel composition according to any one of claims 1 to 7, for use in a method of treatment of an inflammatory disease.
- Salt gel composition according to any one of claims 1 to 7, for use in a method of treatment of wounds..
- Salt gel composition according to any one of claims 1 to 7, for use in a method of treatment of an ecto-parasite infestation in an animal, preferably a human.
- Salt gel composition according to claim 14, wherein said ectoparasite infestation is a lice infestation.
- Kit for the treatment of an ecto-parasite infestation comprising a salt gel composition according to any one of claims 1 to 7.
- Kit according to claim 16 for the treatment of a lice infestation, further comprising a plastic hair cap, a comb and/or instructions for use.
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US20100003315A1 (en) * | 2008-07-02 | 2010-01-07 | Willeford Kenneth L | Method and Composition for the Treatment of Skin Conditions |
US8551461B2 (en) | 2008-12-09 | 2013-10-08 | L'oreal | Moisturizing and shine-imparting emulsion lip compositions |
EP2355785A4 (en) | 2008-12-09 | 2014-08-13 | Oréal Sa L | Transfer-resistant emulsion containing a surfactant |
WO2010068894A2 (en) | 2008-12-11 | 2010-06-17 | L'oreal S.A. | Non-sticky, hydrating and moisturizing aqueous lip gloss composition |
US8597621B2 (en) | 2008-12-16 | 2013-12-03 | L'oreal | Shine-imparting hydrating and moisturizing emulsion lipstick composition |
WO2010077940A2 (en) | 2008-12-16 | 2010-07-08 | Hy Si Bui | Water-insoluble reaction product of a polyamine and an oil-soluble high carbon polar modified polymer |
US8475816B2 (en) | 2008-12-16 | 2013-07-02 | L'oreal S.A. | Emulsion lipstick composition |
US9308396B2 (en) | 2008-12-16 | 2016-04-12 | L'oreal | Transfer-resistant and long wear foundation in emulsion form containing oil absorbing powders |
EP2398444A4 (en) * | 2009-02-18 | 2015-06-17 | Sea Qiq As | Mixture of inorganic compounds, preparations containing the mixture and use of the mixture |
US8663667B2 (en) | 2009-06-29 | 2014-03-04 | L'oreal | Refreshing cream foundation in gel form |
BRPI1002597A2 (en) | 2009-06-29 | 2012-03-13 | L'oreal S.A. | COMPOSITION THAT UNDERSTAND AT LEAST ONE MODIFIED POLAR POLYMER SOLUBLE IN OIL |
BRPI1003281A2 (en) | 2009-06-29 | 2012-02-28 | L'oreal S.A. | COMPOSITION AND METHOD FOR MAKING UP A KERATINIC SUBSTRATE |
BRPI1002598A2 (en) | 2009-06-29 | 2012-03-13 | L'oreal S.A. | COMPOSITION AND METHOD FOR MAKING UP EYELASHES |
EP2322248B1 (en) | 2009-06-29 | 2017-12-27 | L'oreal S.A. | Composition comprising a polyol and an oil-soluble polar modified polymer |
EP2305210A3 (en) | 2009-06-29 | 2011-04-13 | L'oreal S.A. | Composition comprising a sugar silicone surfactant and an oil-soluble polar modified polymer |
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US8747868B2 (en) | 2010-12-30 | 2014-06-10 | L'oreal | Reaction product of a polar modified polymer and an alkoxysilane and a composition containing the reaction product |
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US10980830B2 (en) | 2017-05-03 | 2021-04-20 | George C. Kuefner | Systems and methods for treating skin conditions with magnesium ion compositions |
CN109553098B (en) * | 2018-09-04 | 2023-03-14 | 四川大学 | Method for preparing macroporous-mesoporous carbon with high specific surface area by using salt template and application |
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JP2824460B2 (en) * | 1988-03-11 | 1998-11-11 | 株式会社ビーエムジー | Adhesive PVA hydrogel composition |
US5326432A (en) * | 1992-08-07 | 1994-07-05 | Evans Bryan D | Method of producing magnesium chloride hexahydrate and other alkaline earth salts |
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FR2795081A1 (en) * | 1999-06-18 | 2000-12-22 | Oreal | Solid aqueous gel for use in make-up products for skin, mucous membranes and keratin fibers, comprises hydrophilic gelling agent and at least starch or its derivatives |
WO2001003742A1 (en) * | 1999-07-12 | 2001-01-18 | Suntory Limited | Drug composition for topical administration |
JP2002053470A (en) * | 2000-08-09 | 2002-02-19 | Isako Mura | Skin care preparation, bathing agent, cosmetic and head hair protecting agent |
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