FR2858615B1 - Derives de l'acide butenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et application au traitement de la dyslipidemie, l'atherosclerose et du diabete - Google Patents

Derives de l'acide butenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et application au traitement de la dyslipidemie, l'atherosclerose et du diabete

Info

Publication number
FR2858615B1
FR2858615B1 FR0309610A FR0309610A FR2858615B1 FR 2858615 B1 FR2858615 B1 FR 2858615B1 FR 0309610 A FR0309610 A FR 0309610A FR 0309610 A FR0309610 A FR 0309610A FR 2858615 B1 FR2858615 B1 FR 2858615B1
Authority
FR
France
Prior art keywords
dyslipidemia
atherosclerosis
diabetes
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0309610A
Other languages
English (en)
Other versions
FR2858615A1 (fr
Inventor
Jean Jacques Zeiller
Herve Dumas
Dangremont Valerie Guyard
Isabelle Berard
Francis Contard
Daniel Guerrier
Gerard Ferrand
Yves Bonhomme
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
Merck Sante SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0309610A priority Critical patent/FR2858615B1/fr
Application filed by Merck Sante SAS filed Critical Merck Sante SAS
Priority to US10/566,995 priority patent/US7820847B2/en
Priority to EP04740992A priority patent/EP1658260A1/fr
Priority to AU2004263254A priority patent/AU2004263254B2/en
Priority to PCT/EP2004/007776 priority patent/WO2005014521A1/fr
Priority to JP2006522255A priority patent/JP4908211B2/ja
Priority to CA2534493A priority patent/CA2534493C/fr
Priority to ARP040102771A priority patent/AR045212A1/es
Publication of FR2858615A1 publication Critical patent/FR2858615A1/fr
Application granted granted Critical
Publication of FR2858615B1 publication Critical patent/FR2858615B1/fr
Priority to US12/821,384 priority patent/US8247448B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C07C69/736—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR0309610A 2003-08-04 2003-08-04 Derives de l'acide butenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et application au traitement de la dyslipidemie, l'atherosclerose et du diabete Expired - Fee Related FR2858615B1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FR0309610A FR2858615B1 (fr) 2003-08-04 2003-08-04 Derives de l'acide butenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et application au traitement de la dyslipidemie, l'atherosclerose et du diabete
EP04740992A EP1658260A1 (fr) 2003-08-04 2004-07-14 Derives d'acide butenoique, procedes de preparation de ces derives, compositions pharmaceutiques comprenant ces derives et utilisation de ces derives dans le traitement de la dyslipidemie, de l'atherosclerose et du diabete
AU2004263254A AU2004263254B2 (en) 2003-08-04 2004-07-14 Butenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and use for the treatment of dyslipidaemia, atherosclerosis and diabetes
PCT/EP2004/007776 WO2005014521A1 (fr) 2003-08-04 2004-07-14 Derives d'acide butenoique, procedes de preparation de ces derives, compositions pharmaceutiques comprenant ces derives et utilisation de ces derives dans le traitement de la dyslipidemie, de l'atherosclerose et du diabete
US10/566,995 US7820847B2 (en) 2003-08-04 2004-07-14 Butenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them and use for the treatment of dyslipidaemia, atherosclerosis and diabetes
JP2006522255A JP4908211B2 (ja) 2003-08-04 2004-07-14 ブテン酸誘導体、その調製方法、それらを含む薬剤組成物、および脂質代謝異常、アテローム性動脈硬化症および糖尿病の治療のための使用
CA2534493A CA2534493C (fr) 2003-08-04 2004-07-14 Derives d'acide butenoique, procedes de preparation de ces derives, compositions pharmaceutiques comprenant ces derives et utilisation de ces derives dans le traitement de la dyslipidemie, de l'atherosclerose et du diabete
ARP040102771A AR045212A1 (es) 2003-08-04 2004-08-04 Derivados de acido butenoico, procedimientos para su preparacion, composiciones farmaceuticas que los comprenden y uso para el tratamiento de dislipidemia, aterosclerosis y diabetes
US12/821,384 US8247448B2 (en) 2003-08-04 2010-06-23 Butenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and use for the treatment of dyslipidaemia, atherosclerosis and diabetes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0309610A FR2858615B1 (fr) 2003-08-04 2003-08-04 Derives de l'acide butenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et application au traitement de la dyslipidemie, l'atherosclerose et du diabete

Publications (2)

Publication Number Publication Date
FR2858615A1 FR2858615A1 (fr) 2005-02-11
FR2858615B1 true FR2858615B1 (fr) 2006-12-22

Family

ID=34073009

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0309610A Expired - Fee Related FR2858615B1 (fr) 2003-08-04 2003-08-04 Derives de l'acide butenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et application au traitement de la dyslipidemie, l'atherosclerose et du diabete

Country Status (8)

Country Link
US (2) US7820847B2 (fr)
EP (1) EP1658260A1 (fr)
JP (1) JP4908211B2 (fr)
AR (1) AR045212A1 (fr)
AU (1) AU2004263254B2 (fr)
CA (1) CA2534493C (fr)
FR (1) FR2858615B1 (fr)
WO (1) WO2005014521A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023110750A1 (fr) 2021-12-13 2023-06-22 Global Bioenergies Variants d'acyl-coa hydrolase

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS582202B2 (ja) * 1975-12-10 1983-01-14 ダイニツポンジヨチユウギク カブシキガイシヤ サツチユウザイ オヨビ ソノセイホウ
JP2001261612A (ja) * 2000-03-22 2001-09-26 Mitsui Chemicals Inc カテコールプロピオン酸誘導体およびそれを有効成分として含有する核内レセプター作動薬
FR2869610B1 (fr) * 2004-05-03 2006-07-28 Merck Sante Soc Par Actions Si Derives de l'acide pentenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et leurs applications therapeutiques

Also Published As

Publication number Publication date
JP2007501190A (ja) 2007-01-25
AR045212A1 (es) 2005-10-19
EP1658260A1 (fr) 2006-05-24
FR2858615A1 (fr) 2005-02-11
US20060178434A1 (en) 2006-08-10
US8247448B2 (en) 2012-08-21
AU2004263254B2 (en) 2010-03-18
US7820847B2 (en) 2010-10-26
JP4908211B2 (ja) 2012-04-04
CA2534493C (fr) 2012-08-28
CA2534493A1 (fr) 2005-02-17
US20100261789A1 (en) 2010-10-14
AU2004263254A1 (en) 2005-02-17
WO2005014521A1 (fr) 2005-02-17

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Date Code Title Description
ST Notification of lapse

Effective date: 20080430