FR2829692A1 - Use of a mixture of vitamins, trace elements, amino acids, polyunsaturated fatty acids, antiradical agents and plant and/or animal extracts to produce capsules for promoting good metabolic function - Google Patents

Abstract

Use of a mixture of vitamins, trace elements, amino acids, polyunsaturated fatty acids, radical scavengers and plant and/or animal extracts to produce hard or soft gelatin capsules for promoting good metabolic function, is new.

Description

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Specific and selective concomitant contribution of six categories of substances in order to promote the maintenance in humans and animals of a physiological balance based on biochemistry, immunology, cell and tissue structures and their integrity. VITAMINS, OLIGOELEMENTS, AMINO ACIDS, POLYUNSATURATED FATTY ACIDS, REACTIVE OXYGENATED SPECIES DEACTIVATORS AND DEACTIVATORS and EXTRACTS of VEGETABLE or / and ANIMAL origin are six types of compounds used together in the form of mixtures specific. as substances intervening in a specific biochemical mechanism which allow a good metabolic functioning of the organism. Certain deficiencies lead to signs and pathological situations. Apart from drug treatment, additional daily administration during defined periods can prevent these deficiencies and certain dysfunctions.

Vitamins, trace elements and amino acids as substances involved in a defined physiological, biochemical and immunological mechanism, polyunsaturated fatty acids, fundamental constituents of cell membranes, sensor compounds of

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 free radicals and deactivators of reactive oxygen species involved in many pathologies and responsible for aging and cell destruction and plant extracts with complementary activities are recommended in the form of hard capsules and soft capsules administered jointly, are capable of promoting maintenance of a physiological balance which allows a good metabolic functioning of the organism, with a preventive aim and avoiding or delaying the appearance of various pathological signs.

Currently vitamins, minerals, trace elements, amino acids and fatty acids are used in different formulations; antioxidants which are not necessarily free radical scavengers are also used as anti-aging products. These various products currently used in isolation are each time only one element of a mechanism. The object of this invention is to provide all the elements of the same mechanism and of several biochemical mechanisms involving a combination of vitamins, trace elements and amino acids. In addition, polyunsaturated fatty acids, fundamental constituents of cell membranes, within which the biochemical mechanisms take place, and compounds which scavenge free radicals and deactivate oxygenated species are also used jointly; the structures of these polyunsaturated fatty acids are also protected by free radical scavengers. All of these constituents must be administered together with respect for the lipophilic and hydrophilic parts in order to guarantee maximum bioavailability. This administration is thus done by means of hard gelatin capsules and soft gelatin capsules, two dosage forms adapted to the objective.

 The free radical scavenging and deactivating reactive oxygen species compounds protect the organic structures and maintain the functioning of the organism. Indeed, free radicals and oxygenated species are involved in many pathologies and different effects of cell destruction.

 Polyunsaturated fatty acids, fundamental constituents of cell membranes, help make the cell "tight" to attackers and thus allow a certain fluidity which contributes to the availability of enzymes, membrane receptors.

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 Six types of compounds, at the authorized daily doses (RDA) or at the active doses, in the form of specific mixtures of vitamins, trace elements and amino acids, amino acids supplementing the amino acids of gelatin present in the capsules and in the capsules are used jointly in the context of one or more biochemical mechanisms involved in a specific physiological, biochemical and immunological activity. The vitamins, trace elements and associated amino acids chosen are those existing in a human or animal organism.

Many vitamins, essential organic elements in small quantities in the diet or during food supplements, are precursors of coenzymes. Some enzymes require the presence of an additional chemical compound called a cofactor. The cofactor can be either an inorganic ion, Fe2 +, Mg2 +, Mn2 +, Zn2 + ..., or a complex, organic or metalloorganic molecule called coenzyme. To be active, certain enzymes require both a coenzyme and one or more metal ions.

Vitamins, trace elements and amino acids are involved in certain biochemical mechanisms. Gelatin used in the dosage form hard capsule or soft capsule or in the form of an additive contains amino acids; Supplementation with specific amino acids can be carried out when the concentration in gelatin is insufficient.

Polyunsaturated fatty acids, compounds that scavenge free radicals and deactivate reactive oxygen species and extracts of plant and / or animal origins with complementary activities are used together.

The polyunsaturated fatty acids, fundamental constituents of cell membranes are for example chosen from the constituents of wheat germ oil, borage oil, cod liver oil, safflower oil, evening primrose oil, fish oil, all containing established fatty acids.

Polyunsaturated fatty acids are long chain fatty acids with 2 to 6 double bonds, easily oxidizable. There are two essential acids for humans, linoleic acid. and alphalinoleic acid, which can only be provided by food or by a specific external contribution. These two fatty acids are the precursors

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 biological of several others developed in the cell and classified into two families according to the position of their first double bond: omega 3 and omega 6.

The metabolism and bioavailability of polyunsaturated fatty acids are dependent on enzymes, deltésaturases, requiring zinc and magnesium. Deficiency of zinc, magnesium and vitamin B6 leads to poor activity of deltadesaturases.

The properties of fish oil have been demonstrated by the Greenlandic Eskimos, who eat large quantities of raw fish. This population is rarely affected by cardiovascular diseases. This protection is due to the presence in the flesh of cold sea poisons of two specific fatty acids EPA and DHA.

The six types of compounds are presented partly in hard capsules and partly in soft capsules administered jointly, in order to favor the maintenance of a physiological balance.

Free radicals are reactive forms of oxygen; these are mainly the superoxide anion (02 -), the hydroxyl radical (OH), lipid radicals, (ROO). These species are involved in many pathologies, and are responsible in particular for inflammatory manifestations, cell aging.

A free radical scavenging power can therefore prevent progression to a given pathology.

composés tocophéryles, des composés ascorbyliques, le glutathion, le p- carotène, t'a-carotène, te y-carotène, te Ô-carotène, des flavonoïdes, des produits contenant des dérivés de la chondroitine sulfate. The free radical sensors and deactivators of reactive oxygen species are chosen from enzymatic systems involving trace elements, superoxide dismutases such as, for example, cations of the copper, zinc, iron, manganese type, among the selenium which is a constituent part of the glutathione peroxidase and among non-enzymatic systems involving separately or in combination of

tocopheryl compounds, ascorbyl compounds, glutathione, p-carotene, t'a-carotene, te y-carotene, te Ô-carotene, flavonoids, products containing derivatives of chondroitin sulfate.

Various formulations of nonlimiting mixtures taken as examples appear in this description.

In Formulation N01 we find the copper, zinc, manganese cations, in Formulations N02 and N "6 we find the zinc cation, in Formulation? 3 we find the copper cation, in Formulation? 7 on

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 find the copper and zinc cations in the Formulation? 8 we find the zinc and manganese cations, 6-carotene acts as a non-stoichiometric trap for singlet oxygen; one molecule can inactivate hundreds of singlet oxygen molecules. The energy of singlet oxygen converts the trans form of 8-carotene to the cis isomer with return to the trans structure. The ss-carotene is present for example in Formulations N01, N05 and? 7.

Selenium is found, for example, in Formulations N01 and N "7.

l'extrait de Soja enrichi en isofiavones, l'extrait d'Echinacea angustifolia, l'extrait de Levure de bière, certains des extraits pouvant contenir des flavonoïdes. The plant extracts are for example chosen from Gingko biloba extract, Alfalfa extract, Sophora japonica extract, Ginseng extract, Gentian extract, Harpagophytum extract, Myrtle extract,

Soy extract enriched with isofiavones, Echinacea angustifolia extract, Brewer's yeast extract, some of the extracts which may contain flavonoids.

An in vitro study was made on the effect of Gingko biloba extracts on fibrinogenesis and on the stability of collagen fibrils. The fibrils are protected against the action of collagenase. This protective and stabilizing action of collagen is due to the flavonoic part of the extract, which increases the barrier function of the skin.

Alfalfa, alfalfa herb is rich in amino acids and vitamins (B1, B2, B6, C, E) and in 6-carotene elements which complement the different constituents of this mixture. It is known for its polyendocrine activity characterized by an L.H. inhibitory factor in order to reduce the transformation of testosterone into D.H.T.

Sophora extract enriched in rutin has a protective effect on the incidence of ischemic heart disease.

Ginseng is traditionally used in functional asthenia.

The extract stimulates the energy metabolism of oxygen in the muscles.

Gentian extract is involved in appetite; orally it is traditionally used to stimulate appetite.

Harpagophytum or devil's claw, contains monoterpene glucosides of the aucuboside type. It is known for the normalization of uric acid and joint pain. The extracts are assigned analgesic and antispasmodic properties.

Bilberry extract brings its activity in certain painful states.

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 Soy isoflavones are free radical scavengers. Associated with the other constituents of the antioxidant complex, they oppose lipid peroxidation. Numerous studies have shown a correlation between soy consumption and the balance of lipid functions; the lipid profile is improved by isoflavones. Soy extract lowers plasma cholesterol and LDL cholesterol.

Echinacea contains echinacosides that can inhibit the factors that trigger inflammation. Heteroglycans are recognized as immunostimulatory compounds.

groupe B (bol, B2, B5, B6, B12). Elle contient également des acides aminés, l'alanine, l'arginine, l'acide aspartique, l'acide glutamique, la glycine, la leucine, la méthionine, la proline, la sérine et la valine. La levure est traditionnellement préconisé dans les signes précurseurs de l'anémie, des syndromes nerveux et dans la régulation du métabolisme glucidique. Yeast is a vegetable food supplement rich in vitamins from

group B (bowl, B2, B5, B6, B12). It also contains amino acids, alanine, arginine, aspartic acid, glutamic acid, glycine, leucine, methionine, proline, serine and valine. Yeast is traditionally recommended in the warning signs of anemia, nervous syndromes and in the regulation of carbohydrate metabolism.

The association of vitamin E, vitamin C and a flavonoid of the rutin type is interesting. Various in vitro and in vivo studies have concluded that the combination of these three compounds known for their antioxidant activity leads to significant synergy. Indeed, their action at the membrane level is improved as soon as the three are present. Vitamin E intervenes first in antioxidant reactions and as an inhibitor of lipoperoxidation by transforming into a tocopheryl radical. Vitamin C reacts with the tocopheryl radical by regenerating vitamin E and producing the very stable ascorbyl radical. Rutin acts at this level, potentiating anti-free radical activities and inhibiting the lipoperoxidation effects of these two vitamins.

Rutin is a flavonoid, a class of plant metabolites made up of polyphenolic molecules, found almost everywhere in the plant kingdom. These substances do not act on a specific enzyme, because they are substrates protectors. This synergistic mixture is present for example in Formulations N'Il, N "5, N06 and? 8.

It is the same for Formulations N03, N04 and? 7 where your rutin is replaced respectively by the natural constituents of extracts of Harpagophytum, Ginseng and Echinacea.

For Formulation N'2, free radical sensors, silicon, zinc

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 and methionine are adapted to the treated soil in order to facilitate bioavailability, the skin containing these three elements.

 Silicon exists in the form of derivatives of the silanolate type, in ether and in derivatives of silicic acid which can intervene in certain mechanisms for capturing reactive oxygenated species. It is present for example in formulations N 2, N 4, N 5 and N06.

Methionine, the sulfur amino acid, is a powerful free radical scavenger. It is for example present in the Formulations? 1,? 2 and? 5.

The animal extracts are for example chosen from a hydrolyzate of marine proteins rich in chondroitin sulfates. The latter is a powerful free radical scavenger. It is present for example in Formulations N08 and? 5.

The vitamins are chosen from ascorbyl compounds, tocopheryl compounds, vitamins A, vitamins D, vitamins 81 in the form, for example, of thiamine hydrochloride, vitamins B2 in the form, for example, of riboflavin, vitamins B3 in the form, for example. nicotinamide, vitamins B5 in the form, for example, of calcium pantothenate, vitamins B6 in the form, for example, of pyridoxine hydrochloride, vitamins B8 in the form, for example, of biotin, vitamins B9 in the form, for example, of folic acid, vitamins B12 in the form of, for example, cobalamins, vitamins K.

tocophéryle, le y-tocophéryle, le ô-tocophéryle, et les composés ascorbyliques, appelés vitamine C sont choisis par exemple parmi l'acide ascorbique, le palmitate d'ascorbyle, le stéarate d'ascorbyle, le phosphate . d'ascorbyle et de magnésium, l'ascorbyl-glucosyle. The tocopheryl compounds are chosen, for example, from atocopheryl, called Vitamin E, and its derivatives, atocopheryl succinate, α-tocopheryl palmitate, α-tocopheryl stearate, ss-

tocopheryl, y-tocopheryl, ô-tocopheryl, and ascorbyl compounds, called vitamin C are chosen for example from ascorbic acid, ascorbyl palmitate, ascorbyl stearate, phosphate. ascorbyl and magnesium, ascorbyl-glucosyl.

 For the trace elements they are preferably used in the form of organic cation salts; one can for example consider gluconate, pidolate, lactate, citrate, fumarate; they can also be used in the form of mineral salts such as for example chromium nitrate, corresponding oxides and hydroxides such as for example those of magnesium.

 The trace elements are chosen for example from gluconate of

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 calcium, magnesium gluconate, iron giuconate, copper gluconate, zinc gluconate, manganese gluconate, sodium gluconate, potassium gluconate, calcium lactate, iron gluconate and fumarate iron, copper citrate, zinc lactate, manganese citrate, sodium lactate and sodium citrate, potassium lactate, magnesium hydroxide, magnesium oxide, chromium in the form for example chromium nitrate nonahydrate. Colloidal silica, sodium selenite, boron in the form, for example, of boric acid are also used.

arginine, la L-cystéine et le chlorhydrate de L-cystéine, la L-cystine et le chlorhydrate de L cystine, la L-histidine et le chlorhydrate de L-histidine, la L-isoleucine et le chlorhydrate de L-isoleucine, la L-leucine et le chlorhydrate de L-leucine, la L-lysine et le chlorhydrate de L-lysine, la L-méthionine, la L-phénylalanine, la L-thréonine, le L-tryptophane, la L-tyrosine, la L-valine.

The amino acids are chosen from L-arginine and L- hydrochloride

arginine, L-cysteine and L-cysteine hydrochloride, L-cystine and L cystine hydrochloride, L-histidine and L-histidine hydrochloride, L-isoleucine and L-isoleucine hydrochloride, L-leucine and L-leucine hydrochloride, L-lysine and L-lysine hydrochloride, L-methionine, L-phenylalanine, L-threonine, L-tryptophan, L-tyrosine, L -valine.

For flavonoids the choice is made among rutin, troxerutin, quercetin, cyanidin, malvidin, luteolinidin, pelargonin, myrtillin.

For Formulation N01 Anti-stress and anti-free radicals, vitamin B6 and the amino acids of gelatin, proline, glycine, tyrosine, alanine, hydroxyproline, histidine, supplemented with glycine and methionine are involved in energy production. Outside of muscle contraction, the energy of ATP produced by phosphorylating oxidations is stored in the form of creatine phosphate; methionine and glycine are precursors of creatine synthesis; Alanine is the substrate for hepatic neoglucogenesis; during long-term activity the muscles can also consume alanine; they promote the formation of peptide structures.

Vitamin B6 and magnesium increase the production of energy from the metabolism of sugars and lipids; the body needs energy to defend itself against aggression.

magnésium favorisent certains mécanismes biochimiques et 1 physiologiques perturbés lors du stress ou des conséquences de la vie. The joint use of different constituents, vitamin B6 with amino acids of the vitamin B6-zinc mixture, of the vitamin B6- mixture

magnesium promote certain biochemical and physiological mechanisms 1 disturbed during stress or the consequences of life.

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For Formulation N02 Skin, Hair and Nails Vitamin B6 and the amino acids of gelatin, proiine, gtycine. tyrosine, alanine, hydroxyproline, histidine, methionine supplements are part of alpha keratin and collagen; cysteine is synthesized from methionine which provides the sulfur atom and serine, an amino acid which is not essential. Zinc is an activator of keratogenesis and it inhibits Sa-reductase, an enzyme leading to dihydrotestosterone (D. H. T.), the excess of which is responsible for androgenetic alopecia and hyperseborrhea. Vitamin B6 potentiates the inhibitory action of zinc.

The mixture is useful in the presence of brittle nails. There is an increase in the bioavailability of zinc by! has vitamin B6.

The mixture of zinc, vitamin B5 and biotin with the amino acids have a regulating effect on seborrhea and a positive action on slowing down hair loss.

 For the formulation? 3 Regulation of chronic pain conditions tyrosine in the presence of ascorbate participates in the synthesis of catecholamines (nor-adrenaline and adrenaline from dopamine), melanins, thyroid hormones; one unit of tyrosine and two units of glycine are the three amino acids of the pentapeptic, endorphin type, physiological compound known for its analgesic properties. The joint use of different constituents, vitamin C with amino acids of gelatin and a hydrolyzate of marine proteins titrated in glycosaminoglycans, of the mixture of vitamin B6-vitamin B12-and of copper is favorable to good biochemical functioning, including disturbances can lead to painful conditions.

For Formulation N04 Fatigue-Asthenia-Recovery carnitine plays an important role in muscle contraction during prolonged effort. It intervenes favorably in functional asthenia. The physiological production of carnitine is done from lysine which is transformed into trimethyl-lysine and which under the influence of vitamin C gives ss-hydroxytrimethyl-lysine. The latter is transformed into y-butyrobetaine aldehyde then into y-butyrobetaine which under the influence of vitamin C gives a physiological carnitine. The latter promotes the entry of fatty acids into the mitochondria (carnitine shuttle). Magnesium participates in the synthesis of proteins and fatty acids to

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 energy storage.

For Formulation N5 Os-Cartilàge-Collagene the joint use of different constituents, vitamin C with amino acids of gelatin and a hydrolysate of marine proteins titrated in glycosaminoglycans, of the boron-magnesium-calcium mixture is beneficial for the structuring of bone, collagen, cartilage and for their physiological renewal. The synthesis of collagen from procollagen requires the hydroxylation of a certain number of amino acid molecules of the lysine and proline type. Vitamin C and ascorbic acid play a protective role against lysine hydroxylase and proline hydroxylase. Ascorbic acid is involved in the synthesis of collagen to repair damaged tissue.

For Formulation N06 Lipid and cholesterol metabolism vitamin B3 with magnesium and zinc has a hypotipememic action; in the presence of silicon deprivation, various disorders have been observed in humans involved in atherosclerosis. When the sum of synthesized cholesterol and that obtained from food exceeds the amount necessary for the synthesis of membranes, bile salts and steroids, pathological accumulations of cholesterol in the form of atheroma plaques in blood vessels can develop in humans leading to atherosclerosis. The amino acids in gelatin have been supplemented with glycine and arginine. A circulating lowered arginine level has been shown in the obese rat; it is reasonable to suggest that lower concentrations of arginine may be related to obesity. The metabolism of cholesterol is also linked to arginine. Glycine is a very polar small molecule; in the liver, it participates in detoxification reactions.

For the Formulation? 7 Boosting immunity vitamin B6 with copper, magnesium and zinc plays a role in multiple metabolisms, particularly in that of amino acids. It interferes with macromolecules. It plays a role in immune reactions. It has a beneficial action against asthma in adults (decrease in frequency and severity) and plays a role in immune functions. Leucine, a branched and relatively rigid amino acid, plays a pivotal role in the establishment of the tertiary structure of proteins. Leucine, a ketoforming amino acid, is catabolized into

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 ss-hydroxy-ss-methylglutaryl-coenzyme A intervening at the level of the tissue affections. ' The barrier against bacterial or viral infections in the intestine and lung consists of a glucoprotein where threonine is one of the major amino acid constituents; arginine plays an important role in the immune system; the nitric oxide formed by metabolic transformation of arginine regulates the interactions of macrophages and the adhesion of lymphocytes and their activation.

Within the framework of Formulation N08 Carbohydrate metabolism amino acids such as glycine, amino acid with the simplest structure and cysteine, sulfur amino acid, in association with the amino acids of gelatin and those of yeast under the impact of vitamin 81 participate in the production of precursors of the Krebs cycle. Glycogenic amino acids (alanine, arginine, cysteine, glutamic acid, glycine, histidine, methionine, proline, serine, valine), a glycogenic and ketogenic amino acid (tyrosine) and a ketogenic amino acid (leucine) are present in this formulation. Outside of muscle contraction, the energy of ATP produced by phosphorylating oxidations is stored in the form of creatine phosphate; during muscle contraction, ATP is regenerated: creatine phosphate reacts with ADP to give ATP and creatine. Three amino acids are precursors of creatine synthesis: glycine, arginine and methionine. Zinc and chromium have an impact on the use and tolerance of circulating glucose and on the activity of insulin. In addition, vitamin B2 and vitamin B3 from brewer's yeast supplemented with vitamins B2 and B3 are involved in redox reactions of carbohydrate metabolism.

A synergistic mixture chosen for capsules of Formula N01 Anti-stress and anti-free radicals contains pyridoxine hydrochloride, ascorbic acid, calcium D-gluconate (2/1) monohydrate, magnesium Dgluconate (2 / 1) dihydrate, zinc D-gluconate (2/1), copper D-gluconate (2/1), manganese D-gluconate (2/1) dihydrate, sodium selenite, gelatin supplemented with glycine and methionine and for capsules of the Anti-stress and anti-free radical formulation the polyunsaturated fatty acids of wheat germ oil, the natural tocopherol concentrate, the enriched Sophora japonica extract

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 in rutin, p carotene, dry extract of Gingko biloba.

A synergistic mixture chosen for capsules of the Formula? 2 Skin, Hair and Nails contains nicotinamide, calcium pantothenate, pyridoxine hydrochloride, biotin, zinc D-gluconate (2/1), colloidal silica, gelatin supplemented with methionine and Alfalfa and for capsules of the Skin, Hair and Nails Formula polyunsaturated fatty acids from borage oil.

A synergistic mixture is chosen for capsules of the Formula? 3 Regulation of chronic pain states contains thiamine hydrochloride, nicotinamide, pyridoxine hydrochloride, vitamin B12, folic acid, Dg copper giuconate (2/1), gelatin supplemented with tyrosine, harpagophytum and capsules of the Formulation Regulation of chronic painful conditions polyunsaturated fatty acids from borage oil, hydrolyzate of marine proteins rich in chondroitin sulfates, ascorbyl palmitate and blueberry extract at 25%.

A synergistic mixture chosen for capsules of the Formula? 4 Fatigue-Asthenia-Recovery contains thiamine hydrochloride, calcium pantothenate, vitamin B12, nicotinamide, ascorbic acid, folic acid, magnesium D-gluconate (2/1) dihydrate, oxide magnesium, zinc D-gluconate (2/1), copper D-gluconate (2/1), colloidal silica, gentian extract, standardized Ginseng extract, lysine and valine and for capsules of the Fatigue-Asthenia-Recovery Formulation polyunsaturated fatty acids from safflower oil.

A synergistic mixture chosen for capsules of the Formula? 5 Os- Cartilage-Collagene contains ascorbic acid, calcium D-gluconate (2/1) monohydrate, magnesium D-gluconate (2/1) dihydrate, colloidal silica, boric acid, proline and lysine and for capsules of the Os-Cartilage-Collagen Formula polyunsaturated fatty acids from cod liver oil, hydrolysate of marine proteins rich in chondroitin sulfates, natural tocopherols, enriched Sophora japonica extract in rutin, ss carotene.

A synergistic mixture chosen for capsules of the Formula N06 Lipid and cholesterol metabolism contains nicotinamide, ascorbic acid, magnesium D-gluconate (2/1) dihydrate, -ie D-zinc giuconate (2/1 ), colloidal silica, gelatin supplemented with arginine and

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 in glycine, the extract of Sophora japonica enriched in rutin and capsules of the Lipid and Cholesterol Metabolism Formula polyunsaturated fatty acids of evening primrose oil and fish oil, soy isoflavones at 10% and the concentrate of natural tocopherols.

A synergistic mixture chosen for capsules of the Formula? 7 Boosting immunity contains calcium pantothenate, pyridoxine hydrochloride, ascorbic acid, magnesium D-gluconate (2/1) dihydrate and magnesium oxide, zinc D-gluconate (2 / 1), copper D-gluconate (2/1), sodium selenite, gelatin supplemented with leucine, threonine and arginine and capsules of the Formula Boosting immunity of polyunsaturated fatty acids in oil of evening primrose, the concentrate of natural tocopherols, p carotene and the extract of Echinacea angustifolia.

A synergistic mixture chosen for capsules of the Formula? 8 Carbohydrate metabolism contains thiamine hydrochloride, riboflavin, nicotinamide, ascorbic acid, biotin, magnesium D-gluconate (2/1) dihydrate, manganese D-gluconate (2/1) dihydrate, Zinc D-gluconate (2/1), chromium nitrate nonahydrate, gelatin enriched with cysteine and glycine and capsules of the Carbohydrate Metabolism Formula polyunsaturated fatty acids from fish oil, brewer's yeast, concentrate of natural tocopherols and Sophora japonica extract enriched in rutin The treatment is carried out in the form of periodic cures of 2 hard capsules per day and 4 soft capsules per day allowing the administration of effective doses of the six types of constituents, the gelatin capsules and capsules used as active ingredients. The presentation of a treatment formulation can for example be a jar of capsules and two jars of capsules per package, each treatment corresponding to a dose of one unit in the morning and one unit in the evening.

The structures of polyunsaturated fatty acids are protected for each formulation by mixtures of free radical scavengers or deactivators of reactive oxygen species. As an example - the polyunsaturated fatty acids of borage oil of Formula 2 are protected by the vitamin E contained in this oil and by zinc, a constituent of superoxide dismutase; - polyunsaturated fatty acids from borage oil of Formula 3

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 are protected by the hydrolyzate of marine proteins rich in chondroitin sulfates, ascorbyle palmitate and the constituents of blueberry extract at 25%; - the polyunsaturated fatty acids of evening primrose oil and fish oil of Formula 6 are protected by 10% soy isoflavones and by the concentrate of natural tocopherols.

foie de morue de la Formulation ? 5, de l'huile d'onagre de la Formulation ? 7. Ce mélange est en faveur d'une bonne biodisponibilité. 6-carotene in the form of natural carotene ss at 20% on vegetable oil and vitamin E in the form of a concentrate of natural tocopherols are very lipophilic compounds; they mix well with the polyunsaturated fatty acids of wheat germ oil, Formulation NIl, oil of

Cod liver of the Formula? 5, Evening Primrose Oil from the Formula? 7. This mixture is in favor of good bioavailability.

Silicon is involved in the biochemistry of macromolecules such as glycosaminoglycans, collagen and elastin. In the presence of silicon deprivation, various disorders have been observed in humans involved in atherosclerosis, ostearthritis, osteoporosis. Vitamin B9 is involved in the metabolism of certain amino acids, protein synthesis, synthesis of purine and pyrimidine bases.

There is also interactivity between trace elements and oils. In the book "Micronutrition in biology and chemical practice" by P.

Moreau (Ed. Lavoisier TEC and DOC), it is mentioned that in addition to a treatment for fatty diabetes, a balance of nutritional intake must be sought: "thus a low intake (approximately 600 mg per day of fish oil ) with an intake of chromium (50 to 200 pg of chromium t! i) can considerably help to improve the state of diabetes "The combination of polyunsaturated fatty acids and certain trace elements is necessary for physiological activity. Polyunsaturated fatty acids are not used or stored in a fixed form. They change by gaining one, then two and possibly more double bonds thanks to enzymes, deltadésaturases; this evolution corresponds to a desaturation. The role of certain trace elements is essential. Some desaturases are iron enzymes, in addition to zinc, probably as a cofactor. Copper is also involved. Both enzymes work poorly when there is a zinc deficiency. Phospholipase activity is closely linked to the presence of zinc and to

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 conversely, the incorporation of polyunsaturated long chain fatty acids cannot be carried out in the absence of zinc. The metabolism of polyunsaturated fatty acids of the two series n-6 and n-3 is totally dependent on the presence of zinc. The indirect deficiencies linked to a poor activity of delta-6 desaturase by a deficiency in zinc, magnesium, vitamins B6 and B8 or by excess of inhibiting factors (stress, saturated or trans fatty acid, senescence, fast sugars) show the necessary complementarity of the various constituents.

Claims (21)

CLAIMS 1) Use of a mixture of: - vitamins - trace elements - amino acids - polyunsaturated fatty acids - compounds that scavenge free radicals and deactivate reactive oxygen species, protecting the structures of polyunsaturated fatty acids, - extracts of plant and / or animal origin with complementary activities for the manufacture of a composition in the form of hard gelatin (hydrophilic) capsules or soft gelatin (lipophilic) capsules administered jointly, to promote the maintenance of a physiological balance allowing a good metabolic functioning of the organism, the lipophilic mixture of the soft capsules and hydrophilic of the capsules allowing respectively a maximum bioavailability of their constituents. 2) Use according to claim 1 characterized in that the polyunsaturated fatty acids, fundamental constituents of cell membranes are for example chosen from the constituents of wheat germ oil, borage oil, liver oil cod, safflower oil, evening primrose oil, fish oil, all containing established fatty acids. 3) Use according to claim 1 characterized in that the free radical sensors and deactivators of reactive oxygen species are chosen from enzymatic systems involving the trace elements of superoxide dismutases such as for example cations of the copper, zinc, iron type, manganese. 4) Use according to claim 1 characterized in that the free radical sensors and deactivators of reactive oxygen species are chosen from the selenium constituent part of glutathione peroxidase. 5) Use according to claim 1 characterized in that the free radical sensors and deactivators of reactive oxygen species are chosen from non-enzymatic systems involving separately or in combination of tocopheryl compounds, ascorbylic compounds, glutathione, p- carotene, a-carothene, te y-carothene, te 5-carotene, flavonoids, products containing derivatives of chondroitin sulfate. 6) Use according to claim 1 characterized in that the composition additionally contains plant extracts, for example chosen from the extract of

 Gingko biloba, Alfalfa extract, Sophora japonica extract, Ginseng extract, Gentian extract, Harpagophytum extract, Bilberry extract, soy extract enriched with isoflavones , the extract of Echinacea angustifolia, <Desc / Clms Page number 17>  Brewer's yeast extract, some of the extracts which may contain flavonoid derivatives. 7) Use according to claim 1 characterized in that the composition additionally contains animal extracts, for example chosen from a hydrolyzate of marine proteins rich in chondroitin sulfates. 8) Use according to claim 1 characterized in that the vitamins are chosen from ascorbyl compounds, tocopheryl compounds, vitamins A, vitamins D, vitamins 81 in the form, for example, of thiamine hydrochloride, vitamins B2 in the form of example of riboflavin, vitamins B3 in the form for example of nicotinamide, vitamins B5 in the form of for example calcium pantothenate, vitamins B6 in the form of for example pyridoxine hydrochloride, vitamins B8 in the form of for example biotin, vitamins B9 in the form for example of folic acid, the vitamins B12 in the form for example of cobalamins, the vitamins K. 9) Use according to claims let 8 characterized in that the tocopheryl compounds are chosen for example from a - tocopheryl, called Vitamin E, te p-tocopheryte, te y-tocopheryte, te 8-tocopheryte, te succinate a - tocopheryl, a-tocopheryl palmitate, a-tocopheryl stearate. 10) Use according to claims 1 and 8 characterized in that the ascorbyl compounds, called vitamin C are chosen for example from ascorbic acid, ascorbyl palmitate, ascorbyl stearate, ascorbyl phosphate and magnesium , ascorbylglucosyle. 11) Use according to claim 1 characterized in that the trace elements are chosen for example from calcium gluconate, magnesium gluconate, iron gluconate, copper gluconate, zinc gluconate, manganese gluconate, sodium gluconate, gluconate potassium, calcium lactate, iron gluconate and iron fumarate, copper citrate, zinc lactate, manganese citrate, sodium lactate and sodium citrate, potassium lactate, magnesium hydroxide, magnesium oxide, colloidal silica, sodium selenite, boron in the form for example of boric acid, chromium in the form for example of chromium nitrate nonahydrate. 12) Use according to claim 1 characterized in that the amino acids are chosen from L-arginine and L-arginine hydrochloride, L-cysteine and L-cysteine hydrochloride, L-cystine and L hydrochloride -cystine, the L-histidine and L-histidine hydrochloride, L-isoleucine and hydrochloride

 of L-isoleucine, L-leucine and L-leucine hydrochloride, L-lysine and L-lysine hydrochloride, L-methionine, L-phenylalanine, L-threonine, L-tryptophan, L-tyrosine, L-valine. <Desc / Clms Page number 18>  cyanidine, malvidine, luteolinidine, pelargonin, myrtillin.

 13) Use according to claims 5 and 6 characterized in that the flavonoids are chosen from rutin, troxerutin, quercetin,  14) Use of a composition according to claims 1 to 13 containing a synergistic mixture of: - pyridoxine hydrochloride - ascorbic acid - calcium D-gluconate (2/1) monohydrate - 0- magnesium gluconate (2 / 1) dihydrate - from 0- zinc gluconate (2/1) - from 0- copper gluconate (2/1) - from D- manganese gluconate (2/1) dihydrate - sodium selenite - acids polyunsaturated fat from wheat germ oil - from natural tocopherol concentrate - from Sophora japonica extract enriched with rutin - from p-carotene - from dry extract of Ginkgo biloba The gelatin of the capsules being supplemented with glycine and methionine to obtain an anti-stress and anti-free radical formulation.  15) Use of a composition according to claims 1 to 13 containing a synergistic mixture of: - nicotinamide - calcium pantothenate - pyridoxine hydrochloride - biotin - zinc D-gluconate (2/1) - colloidal silica - Alfalga - polyunsaturated fatty acids from borage oil The gelatin capsules are supplemented with methionine to obtain a formulation for the skin, hair and nails.  16) Use of a composition according to claims 1 to 13 containing a synergistic mixture of: - thiamine hydrochloride - nicotinamide - pyridoxine hydrochloride - vitamin B 12 - folic acid - copper D- gluconate (2 / 1) - harpagophytum - polyunsaturated fatty acids from borage oil - hydrolyzate of marine proteins rich in chondroitin sulfates - ascorbyl palmitate <Desc / Clms Page number 19> The gelatin of the capsules being supplemented with tyrosine to obtain a formulation for regulating chronic painful states.  - blueberry extract 25% 17) Use of a composition according to claims 1 to 13 containing a synergistic mixture of: - thiamine hydrochloride - calcium pantothenate - vitamin B12 - nicotinamide - ascorbic acid - folic acid - D-gluconate magnesium (2/1) dihydrate - magnesium oxide - zinc D-gluconate (2/1) - copper D-gluconate (2/1) - colloidal silica - gentian extract - d standardized extract of Ginseng - - polyunsaturated fatty acids from safflower oil The gelatin of the capsules being supplemented with lysine and valine to obtain

 a formulation to fight against fatigue and asthenia. The gelatin of the capsules being supplemented with proline and lysine to obtain a formulation for improving the condition of the bones, cartilage and collagen. 1 18) Use of a composition according to one of claims 1 to 13 containing a synergistic mixture of: - ascorbic acid - calcium D-gluconate (2/1) monohydrate - magnesium D-gluconate (2/1) dihydrate - colloidal silica - boric acid - proline - lysine - polyunsaturated fatty acids from cod liver oil - hydrolyzate of marine proteins rich in chondroitin sulfates - natural tocopherols - extracts of Sophora japonica enriched in rutin - p-carotene 19) Use of a composition according to claims 1 to 13 containing a synergistic mixture of: - nicotinamide - ascorbic acid - magnesium D-gluconate (2/1) dihydrate - zinc D-gluconate (2/1 ) - colloidal silica - extracts of Sophora japonica enriched in rutin <Desc / Clms Page number 20> The gelatin of the capsules being supplemented with arginine and glycine to obtain a formulation stimulating the metabolism of lipids and cholesterol.  - polyunsaturated fatty acids from evening primrose oil and fish oil - soy isoflavones at 10% - natural tocopherol concentrate

20) Use of a composition according to claims 1 to 13 containing a synergistic mixture of: - calcium pantothenate - pyridoxine hydrochloride - ascorbic acid - magnesium D-gluconate (2/1) dihydrate - oxide magnesium

 - zinc D-gluconate (2/1) - copper D-gluconate (2/1) - sodium selenite - polyunsaturated fatty acids from evening primrose oil The gelatin of the capsules being supplemented with leucine, threonine and arginine,

 to obtain an immunity boosting formulation. The gelatin of the capsules being supplemented with cysteine and glycine, to obtain a formulation stimulating the carbohydrate metabolism. 1 21) Use of a composition according to claims 1 to 13 containing a synergistic mixture of: - thiamine hydrochloride - riboflavin - nicotinamide - ascorbic acid - biotin - magnesium D-gluconate (2/1) dihydrate - 0- manganese gluconate (2/1) dihydrate - 0- zinc gluconate (2/1) - chromium nitrate nonahydrate - polyunsaturated fatty acids from fish oil - brewer's yeast - concentrate of natural tocopherols - extract of Sophora japonica enriched with rutin