FR2823753B1 - Nouveau procede de synthese de la (3as)-5,5-dioxo-2,3,3a, 4-tetrahydro-1h-pyrrolo [2,1-c] [1,2,4] benzothiadiazine - Google Patents

Nouveau procede de synthese de la (3as)-5,5-dioxo-2,3,3a, 4-tetrahydro-1h-pyrrolo [2,1-c] [1,2,4] benzothiadiazine

Info

Publication number
FR2823753B1
FR2823753B1 FR0105226A FR0105226A FR2823753B1 FR 2823753 B1 FR2823753 B1 FR 2823753B1 FR 0105226 A FR0105226 A FR 0105226A FR 0105226 A FR0105226 A FR 0105226A FR 2823753 B1 FR2823753 B1 FR 2823753B1
Authority
FR
France
Prior art keywords
benzothiadiazine
pyrrolo
dioxo
tetrahydro
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0105226A
Other languages
English (en)
French (fr)
Other versions
FR2823753A1 (fr
Inventor
Elsa Foucher
Gilles Thominot
Jean Pierre Lecouve
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Priority to FR0105226A priority Critical patent/FR2823753B1/fr
Priority to MXPA02003639A priority patent/MXPA02003639A/es
Priority to NO20021768A priority patent/NO20021768L/no
Priority to EP02290946A priority patent/EP1251132B1/fr
Priority to AT02290946T priority patent/ATE269339T1/de
Priority to SI200230015T priority patent/SI1251132T1/xx
Priority to PT02290946T priority patent/PT1251132E/pt
Priority to DE60200627T priority patent/DE60200627T2/de
Priority to ES02290946T priority patent/ES2223031T3/es
Priority to DK02290946T priority patent/DK1251132T3/da
Priority to JP2002113278A priority patent/JP4011956B2/ja
Priority to EA200200378A priority patent/EA004927B1/ru
Priority to HU0201256A priority patent/HUP0201256A3/hu
Priority to NZ518422A priority patent/NZ518422A/xx
Priority to ARP020101386A priority patent/AR036871A1/es
Priority to BR0201307-0A priority patent/BR0201307A/pt
Priority to CA002382405A priority patent/CA2382405C/fr
Priority to AU34405/02A priority patent/AU782080B2/en
Priority to PL02353512A priority patent/PL353512A1/xx
Priority to ZA200203085A priority patent/ZA200203085B/xx
Priority to CNB021057907A priority patent/CN1169811C/zh
Priority to US10/125,192 priority patent/US6518422B2/en
Priority to KR10-2002-0021237A priority patent/KR100468066B1/ko
Publication of FR2823753A1 publication Critical patent/FR2823753A1/fr
Priority to HK03101848.9A priority patent/HK1049668B/xx
Application granted granted Critical
Publication of FR2823753B1 publication Critical patent/FR2823753B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FR0105226A 2001-04-18 2001-04-18 Nouveau procede de synthese de la (3as)-5,5-dioxo-2,3,3a, 4-tetrahydro-1h-pyrrolo [2,1-c] [1,2,4] benzothiadiazine Expired - Fee Related FR2823753B1 (fr)

Priority Applications (24)

Application Number Priority Date Filing Date Title
FR0105226A FR2823753B1 (fr) 2001-04-18 2001-04-18 Nouveau procede de synthese de la (3as)-5,5-dioxo-2,3,3a, 4-tetrahydro-1h-pyrrolo [2,1-c] [1,2,4] benzothiadiazine
MXPA02003639A MXPA02003639A (es) 2001-04-18 2002-04-10 Proceso nuevo para la sintesis de (3as)-5, 5-dioxo-2, 3, 3a-4- tetrahidro-1h-pirrolo[2, 1c][1, 2, 4] benzotiadiazina.
NO20021768A NO20021768L (no) 2001-04-18 2002-04-15 Fremgangsmåte for den syntese av (3aS)-5,5-diokso-2,3,3a,4- tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzotiadiazin
AT02290946T ATE269339T1 (de) 2001-04-18 2002-04-16 Verfahren zur herstellung von (3as)-5,5-dioxo-2,3,3a,4-tetrahydro-1h-pyrrolo( ,1-c)(1,2, 4)benzothiadiazin
SI200230015T SI1251132T1 (en) 2001-04-18 2002-04-16 Synthesis of (3aS)-5,5-dioxo-2,3,3a,4-tetrahydro-1H-pyrrolo(2,1-c)(1,2,4)benzothiadiazine
PT02290946T PT1251132E (pt) 2001-04-18 2002-04-16 Processo de sintese da (3as)-5,5-dioxo-2,3,3a,4-tetra-hidro-1h-pirrolo(2,1-c)(1,2,4) benzotiadiazina
DE60200627T DE60200627T2 (de) 2001-04-18 2002-04-16 Verfahren zur Herstellung von (3aS)-5,5-Dioxo-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazin
ES02290946T ES2223031T3 (es) 2001-04-18 2002-04-16 Procedimiento para la sintesis de (3as)-5,5-dioxo-2,3,3a,4-tetrahidro-1h-pirrolo(2,1-c)(1,2,4)benzotiadiazina.
DK02290946T DK1251132T3 (da) 2001-04-18 2002-04-16 Fremgangsmåde til syntese af (3aS)-5,5-dioxo-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]-benzothiadiazin
JP2002113278A JP4011956B2 (ja) 2001-04-18 2002-04-16 （３ａＳ）−５，５−ジオキソ−２，３，３ａ，４−テトラヒドロ−１Ｈ−ピロロ〔２，１−ｃ〕〔１，２，４〕ベンゾチアジアジンの新規な合成方法
EP02290946A EP1251132B1 (fr) 2001-04-18 2002-04-16 Procédé de synthèse de la (3aS)-5,5-dioxo-2,3,3a,4-tétrahydro-1H-pyrrolo (2,1-c)(1,2,4)benzothiadiazine
NZ518422A NZ518422A (en) 2001-04-18 2002-04-17 Process for the synthesis of (3aS)-5,5-dioxo-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine
EA200200378A EA004927B1 (ru) 2001-04-18 2002-04-17 СПОСОБ СИНТЕЗА (3aS)-5,5-ДИОКСО-2,3,3a,4-ТЕТРАГИДРО-1H-ПИРРОЛО[2,1-c][1,2,4]БЕНЗОТИАДИАЗИНА
ARP020101386A AR036871A1 (es) 2001-04-18 2002-04-17 Procedimiento para la sintesis industrial de (3as)-5,5 dioxo-2,3,3a,4-tetrahidro-1h-pirrolo[2,1-c][1,2,4]benzotiadiazina
BR0201307-0A BR0201307A (pt) 2001-04-18 2002-04-17 Processo para a sìntese de (3as)-5,5-dioxo-2,3,3a,4-tetrahidro-1h-pirrolo[2,1-c][1,2, 4]benzotiadiazina
HU0201256A HUP0201256A3 (en) 2001-04-18 2002-04-17 Novel process for the synthesis of (3as)-5,5-dioxo-2,3,3a,4-tetrahiydro-1h-pyrrolo[2,1-c][1,2,4]benzothiadiazine
AU34405/02A AU782080B2 (en) 2001-04-18 2002-04-18 New process for the synthesis of (3aS)-5,5-dioxo-2,3,3a,4-tetrahydro-1H- pyrrolo(2,1-c)(1,2,4)benzothiadiazine
PL02353512A PL353512A1 (en) 2001-04-18 2002-04-18 Novel method of synthesising (3a,s)-5,5-dioxo-2,3,3a,4-tetrahydro-1h-pyrrole[2,1-c][1,2,4]benzothiadiazine
ZA200203085A ZA200203085B (en) 2001-04-18 2002-04-18 Process for the synthesis of (3AS)-5,5-DIOXO-2,3,3A,4-tetrahydro-1H-pyrrolo [2,1-C][1,2,4]benzothiadiazine.
CA002382405A CA2382405C (fr) 2001-04-18 2002-04-18 Nouveaux procedes de synthese de la (3as)-5,5-dioxo-2,3,3a,4-tetrahydro-1h-pyrrolo[2,1-c][1,2,4]benzothiadiazine
CNB021057907A CN1169811C (zh) 2001-04-18 2002-04-18 合成(3aS)-5,5-二氧代-2,3,3a,4-四氢-1H-吡咯并[2,1-c][1,2,4]苯并噻二嗪的新方法
US10/125,192 US6518422B2 (en) 2001-04-18 2002-04-18 Process for the synthesis of (3aS)-5,5-dioxo-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4] benzothiadiazine
KR10-2002-0021237A KR100468066B1 (ko) 2001-04-18 2002-04-18 （３ａＳ）-５,５-디옥소-２,3,３ａ,４-테트라히드로-１Ｈ-피롤로〔２,１-ｃ〕〔１,２,４〕벤조티아디아진의 합성 방법
HK03101848.9A HK1049668B (en) 2001-04-18 2003-03-14 New process for the synthesis of (3as)-5,5-dioxo-2,3,3a,4-tetrahydro-1h-pyrrolo[2,1-c][1,2,4]benzothiadiazine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0105226A FR2823753B1 (fr) 2001-04-18 2001-04-18 Nouveau procede de synthese de la (3as)-5,5-dioxo-2,3,3a, 4-tetrahydro-1h-pyrrolo [2,1-c] [1,2,4] benzothiadiazine

Publications (2)

Publication Number Publication Date
FR2823753A1 FR2823753A1 (fr) 2002-10-25
FR2823753B1 true FR2823753B1 (fr) 2004-07-16

Family

ID=8862416

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0105226A Expired - Fee Related FR2823753B1 (fr) 2001-04-18 2001-04-18 Nouveau procede de synthese de la (3as)-5,5-dioxo-2,3,3a, 4-tetrahydro-1h-pyrrolo [2,1-c] [1,2,4] benzothiadiazine

Country Status (23)

Country Link
US (1) US6518422B2 (enExample)
EP (1) EP1251132B1 (enExample)
JP (1) JP4011956B2 (enExample)
KR (1) KR100468066B1 (enExample)
CN (1) CN1169811C (enExample)
AR (1) AR036871A1 (enExample)
AT (1) ATE269339T1 (enExample)
AU (1) AU782080B2 (enExample)
BR (1) BR0201307A (enExample)
CA (1) CA2382405C (enExample)
DE (1) DE60200627T2 (enExample)
DK (1) DK1251132T3 (enExample)
EA (1) EA004927B1 (enExample)
ES (1) ES2223031T3 (enExample)
FR (1) FR2823753B1 (enExample)
HU (1) HUP0201256A3 (enExample)
MX (1) MXPA02003639A (enExample)
NO (1) NO20021768L (enExample)
NZ (1) NZ518422A (enExample)
PL (1) PL353512A1 (enExample)
PT (1) PT1251132E (enExample)
SI (1) SI1251132T1 (enExample)
ZA (1) ZA200203085B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2856065B1 (fr) * 2003-06-13 2005-08-19 Servier Lab Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US20060014887A1 (en) * 2004-07-19 2006-01-19 3M Innovative Properties Company Method of hydrolyzing a dispersion of ionic fluoropolymer
FR2879201B1 (fr) * 2004-12-10 2007-02-16 Servier Lab Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2230094B1 (de) 2009-03-20 2013-12-11 Kremstal Türenwerk GmbH Verfahren für das Beschichten von Plattenwerkstoffen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3294791A (en) * 1966-03-14 1966-12-27 American Home Prod Tetrahydro-2, 5-methano-1, 2, 5-benzothiadiazepine 1, 1-dioxide
US3471483A (en) * 1967-11-09 1969-10-07 American Home Prod 1 - substituted - 2,3,3a - 4 - tetrahydro - 1h-pyrrolo(2,1 - c)(1,2,4)benzothiadiazine,5,5-dioxide
JPH06192272A (ja) * 1992-12-24 1994-07-12 Japan Tobacco Inc 新規なトリアゾロベンゾチアジアジン及びトリアゾロベンゾチアジアゼピン誘導体
FR2722502B1 (fr) * 1994-07-12 1996-08-23 Adir Nouveau derive de benzothiadiazine, son procede depreparation et les compositions pharmaceutiques qui le contiennent
FR2812291B1 (fr) * 2000-07-28 2002-12-13 Adir Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
EP1251132B1 (fr) 2004-06-16
KR20020081148A (ko) 2002-10-26
CN1381455A (zh) 2002-11-27
BR0201307A (pt) 2003-06-10
DE60200627T2 (de) 2005-07-14
NZ518422A (en) 2002-12-20
CN1169811C (zh) 2004-10-06
PL353512A1 (en) 2002-10-21
ZA200203085B (en) 2002-11-25
NO20021768D0 (no) 2002-04-15
JP2003012674A (ja) 2003-01-15
CA2382405C (fr) 2007-03-06
DK1251132T3 (da) 2004-10-25
HUP0201256A2 (hu) 2002-12-28
FR2823753A1 (fr) 2002-10-25
NO20021768L (no) 2002-10-21
PT1251132E (pt) 2004-09-30
SI1251132T1 (en) 2004-10-31
HU0201256D0 (enExample) 2002-06-29
AU782080B2 (en) 2005-06-30
MXPA02003639A (es) 2004-11-12
AU3440502A (en) 2002-10-24
US20020161222A1 (en) 2002-10-31
EA004927B1 (ru) 2004-10-28
ATE269339T1 (de) 2004-07-15
HUP0201256A3 (en) 2004-11-29
US6518422B2 (en) 2003-02-11
JP4011956B2 (ja) 2007-11-21
ES2223031T3 (es) 2005-02-16
KR100468066B1 (ko) 2005-01-24
AR036871A1 (es) 2004-10-13
EP1251132A1 (fr) 2002-10-23
EA200200378A3 (ru) 2002-12-26
CA2382405A1 (fr) 2002-10-18
DE60200627D1 (de) 2004-07-22
HK1049668A1 (en) 2003-05-23
EA200200378A2 (ru) 2002-10-31

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Effective date: 20061230