FR2804429B1 - Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2804429B1
FR2804429B1 FR0001171A FR0001171A FR2804429B1 FR 2804429 B1 FR2804429 B1 FR 2804429B1 FR 0001171 A FR0001171 A FR 0001171A FR 0001171 A FR0001171 A FR 0001171A FR 2804429 B1 FR2804429 B1 FR 2804429B1
Authority
FR
France
Prior art keywords
preparing
novel
pharmaceutical compositions
compositions containing
containing same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0001171A
Other languages
English (en)
French (fr)
Other versions
FR2804429A1 (fr
Inventor
Jean Louis Peglion
Aimee Dessinges
Christophe Poitevin
Jean Paul Vilaine
Nicole Villeneuve
Catherine Thollon
Marie Pierre Bourguignon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Priority to FR0001171A priority Critical patent/FR2804429B1/fr
Priority to CNB011123346A priority patent/CN1298705C/zh
Priority to MXPA01000945A priority patent/MXPA01000945A/es
Priority to ES01400225T priority patent/ES2241757T3/es
Priority to EP01400225A priority patent/EP1122254B1/fr
Priority to US09/772,569 priority patent/US6323217B2/en
Priority to NZ509636A priority patent/NZ509636A/en
Priority to PT01400225T priority patent/PT1122254E/pt
Priority to AT01400225T priority patent/ATE294175T1/de
Priority to HU0100489A priority patent/HUP0100489A3/hu
Priority to DK01400225T priority patent/DK1122254T3/da
Priority to CA002332513A priority patent/CA2332513C/fr
Priority to EA200100090A priority patent/EA003096B1/ru
Priority to SI200130342T priority patent/SI1122254T1/xx
Priority to NO20010522A priority patent/NO320387B1/no
Priority to DE60110278T priority patent/DE60110278T2/de
Priority to BR0100234-1A priority patent/BR0100234A/pt
Priority to PL01345528A priority patent/PL345528A1/xx
Priority to AU16747/01A priority patent/AU774808B2/en
Priority to ZA200100864A priority patent/ZA200100864B/xx
Priority to JP2001022954A priority patent/JP3513493B2/ja
Priority to KR10-2001-0004591A priority patent/KR100463369B1/ko
Priority to ARP010100429A priority patent/AR027335A1/es
Publication of FR2804429A1 publication Critical patent/FR2804429A1/fr
Priority to HK02100331.6A priority patent/HK1039117B/zh
Application granted granted Critical
Publication of FR2804429B1 publication Critical patent/FR2804429B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
FR0001171A 2000-01-13 2000-01-31 Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2804429B1 (fr)

Priority Applications (24)

Application Number Priority Date Filing Date Title
FR0001171A FR2804429B1 (fr) 2000-01-31 2000-01-31 Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CNB011123346A CN1298705C (zh) 2000-01-31 2001-01-23 新的哌啶－4－磺酰胺化合物、其制备方法和含有它们的药物组合物
MXPA01000945A MXPA01000945A (es) 2000-01-31 2001-01-26 Compuestos nuevos de piperidin-4-sulfonamida, un proceso para su preparacion y composiciones farmaceuticas que los contienen.
SI200130342T SI1122254T1 (enExample) 2000-01-31 2001-01-30
US09/772,569 US6323217B2 (en) 2000-01-13 2001-01-30 Piperidine-4 sulphonamide compounds
NZ509636A NZ509636A (en) 2000-01-31 2001-01-30 New piperidine-4-sulphonamides compounds, a process for their preparation and pharmaceutical compositions containing them useful for treating disease caused by endothelial dysfunction
PT01400225T PT1122254E (pt) 2000-01-31 2001-01-30 Derivados de 4-sulfonamidas piperidina, processo para a sua preparacao e as composicoes farmaceuticas que os contem
AT01400225T ATE294175T1 (de) 2000-01-31 2001-01-30 4-sulfonamid-piperidin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
HU0100489A HUP0100489A3 (en) 2000-01-31 2001-01-30 New piperidine-4-sulphonamide compounds, process for their preparation and pharmaceutical compositions containing them
DK01400225T DK1122254T3 (da) 2000-01-31 2001-01-30 4-sulfonamidpiperidinderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
CA002332513A CA2332513C (fr) 2000-01-31 2001-01-30 Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EA200100090A EA003096B1 (ru) 2000-01-31 2001-01-30 Новые пиперидин-4-сульфонамидные производные, способ их получения и содержащие их фармацевтические композиции
ES01400225T ES2241757T3 (es) 2000-01-31 2001-01-30 Derivados 4-sulfonamida piperidina, su proceso de preparacion y composiciones farmaceuticas que los contienen.
NO20010522A NO320387B1 (no) 2000-01-31 2001-01-30 Piperidin-4-sulfonamidforbindelser, fremgangsmate ved deres fremstilling og farmasoytiske sammensetninger inneholdende dem, samt anvendelse av forbindelsene
DE60110278T DE60110278T2 (de) 2000-01-31 2001-01-30 4-Sulfonamid-Piperidin-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen
EP01400225A EP1122254B1 (fr) 2000-01-31 2001-01-30 Dérivés de 4-sulfonamides pipéridine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
PL01345528A PL345528A1 (en) 2000-01-31 2001-01-31 Novel piperidine-4-sulphonamide compounds, method of obtaining them and pharmacological compositions containing such compounds
AU16747/01A AU774808B2 (en) 2000-01-31 2001-01-31 New piperdine-4-sulphonamide compounds, a process for their preparation and pharmaceutical compositions containing them
ZA200100864A ZA200100864B (en) 2000-01-31 2001-01-31 Piperidine-4-sulphonamides compounds, a process for their preparation and pharmaceutical compositions containing them.
JP2001022954A JP3513493B2 (ja) 2000-01-31 2001-01-31 ピペリジン−４−スルホンアミド化合物、それらの調製方法及びそれらを含有する医薬組成物
KR10-2001-0004591A KR100463369B1 (ko) 2000-01-31 2001-01-31 피페리딘-4-설폰아미드 화합물, 이들의 제조 방법 및 이들을 함유하는 약제학적 조성물
BR0100234-1A BR0100234A (pt) 2000-01-31 2001-01-31 Compostos de piperidina-4-sulfonamida, processo para a sua preparação e composições farmacêuticas contendo os mesmos
ARP010100429A AR027335A1 (es) 2000-01-31 2001-01-31 Compuestos de piperidina-4-sulfonamida, proceso de preparacion de los mismos, y composiciones farmaceuticas que los contienen
HK02100331.6A HK1039117B (zh) 2000-01-31 2002-01-16 新的哌啶-4-磺酰胺化合物、其制备方法和含有它们的药物组合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0001171A FR2804429B1 (fr) 2000-01-31 2000-01-31 Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2804429A1 FR2804429A1 (fr) 2001-08-03
FR2804429B1 true FR2804429B1 (fr) 2003-05-09

Family

ID=8846469

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0001171A Expired - Fee Related FR2804429B1 (fr) 2000-01-13 2000-01-31 Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (24)

Country Link
US (1) US6323217B2 (enExample)
EP (1) EP1122254B1 (enExample)
JP (1) JP3513493B2 (enExample)
KR (1) KR100463369B1 (enExample)
CN (1) CN1298705C (enExample)
AR (1) AR027335A1 (enExample)
AT (1) ATE294175T1 (enExample)
AU (1) AU774808B2 (enExample)
BR (1) BR0100234A (enExample)
CA (1) CA2332513C (enExample)
DE (1) DE60110278T2 (enExample)
DK (1) DK1122254T3 (enExample)
EA (1) EA003096B1 (enExample)
ES (1) ES2241757T3 (enExample)
FR (1) FR2804429B1 (enExample)
HK (1) HK1039117B (enExample)
HU (1) HUP0100489A3 (enExample)
MX (1) MXPA01000945A (enExample)
NO (1) NO320387B1 (enExample)
NZ (1) NZ509636A (enExample)
PL (1) PL345528A1 (enExample)
PT (1) PT1122254E (enExample)
SI (1) SI1122254T1 (enExample)
ZA (1) ZA200100864B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ521978A (en) * 2000-04-28 2004-10-29 Acadia Pharm Inc Compounds that affect cholinergic receptors and are particularly muscarinic agonists
EP1535912A1 (en) * 2000-04-28 2005-06-01 Arcadia Pharmaceuticals Inc. Muscarinic agonists
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
AU2003284402A1 (en) * 2002-11-15 2004-06-15 Yamanouchi Pharmaceutical Co., Ltd. Antagonist to melanin-concentrating hormone receptor
JP2008507492A (ja) * 2004-07-23 2008-03-13 バイエル・クロツプサイエンス・エス・アー 殺菌剤としてのｎ−［２−（４−ピリジニル）エチル］ベンズアミド誘導体
ATE527258T1 (de) * 2004-07-28 2011-10-15 Takeda Pharmaceutical Pyrroloä2,3-cüpyridinverbindung, verfahren zu deren herstellung und anwendung
TW200630337A (en) * 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
ES2362617T3 (es) * 2005-02-25 2011-07-08 Kowa Company, Ltd. Proceso para la producción de haluro de 4-fluoroisoquinolin-5-sulfonilo o una de sus sales.
WO2007110449A1 (en) 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
TW200812963A (en) 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
US8791264B2 (en) 2006-04-13 2014-07-29 Purdue Pharma L.P. Benzenesulfonamide compounds and their use as blockers of calcium channels
CL2007003223A1 (es) * 2006-11-10 2008-01-11 Wyeth Corp Compuestos derivados de piperidinil 4-arilsulfonamidas n-sustituidas, que actuan como moduladores de la proteina sfrp-1; proceso para preparar los compuestos; co mposicion farmaceutica que comprende a dichos copmpuestos y uso de los compuestos para preparar medicamentos para el tratamiento de enfermedades.
WO2008124118A1 (en) * 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
US8765736B2 (en) 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
AR080375A1 (es) 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida
PL395470A1 (pl) 2011-06-29 2013-01-07 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Sulfonamidowe pochodne amin alicyklicznych do leczenia chorób osrodkowego ukladu nerwowego

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956382A (en) * 1987-02-07 1990-09-11 Pfizer Inc. Sulfonamide anti-arrhythmic agents
US4857301A (en) * 1987-09-25 1989-08-15 Schering Corporation Sulfonamide compounds, compositions and method of use
FR2679906B1 (fr) * 1991-07-31 1995-01-20 Adir Nouvelles (isoquinolein-5 yl) sulfonamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
AU6971794A (en) * 1993-05-26 1994-12-20 Smithkline Beecham Laboratoires Pharmaceutiques Novel compounds
FR2716679B1 (fr) * 1994-02-25 1996-04-05 Adir Nouvelles sulfonamides substituées, leur procédé de préparation et les compositions pharmaceutiques les renfermant.
HN1997000027A (es) * 1996-12-06 1997-06-05 Pfizer Prod Inc Derivados de 6-fenil piridil - 2 amina

Also Published As

Publication number Publication date
EA200100090A2 (ru) 2001-08-27
EP1122254B1 (fr) 2005-04-27
AU774808B2 (en) 2004-07-08
PL345528A1 (en) 2001-08-13
NO20010522D0 (no) 2001-01-30
KR20010078210A (ko) 2001-08-20
DE60110278T2 (de) 2006-02-16
JP2001233874A (ja) 2001-08-28
ZA200100864B (en) 2001-08-08
JP3513493B2 (ja) 2004-03-31
NZ509636A (en) 2001-09-28
DE60110278D1 (de) 2005-06-02
HK1039117B (zh) 2007-09-07
EP1122254A3 (fr) 2001-11-28
HU0100489D0 (en) 2001-04-28
US20010034352A1 (en) 2001-10-25
PT1122254E (pt) 2005-07-29
CN1298705C (zh) 2007-02-07
SI1122254T1 (enExample) 2005-08-31
AU1674701A (en) 2001-08-02
CA2332513A1 (fr) 2001-07-31
BR0100234A (pt) 2001-08-28
MXPA01000945A (es) 2002-06-04
EA003096B1 (ru) 2002-12-26
HK1039117A1 (en) 2002-04-12
US6323217B2 (en) 2001-11-27
NO320387B1 (no) 2005-11-28
ES2241757T3 (es) 2005-11-01
NO20010522L (no) 2001-08-01
HUP0100489A2 (hu) 2002-05-29
FR2804429A1 (fr) 2001-08-03
EA200100090A3 (ru) 2001-10-22
DK1122254T3 (da) 2005-08-29
KR100463369B1 (ko) 2004-12-23
AR027335A1 (es) 2003-03-26
CN1314345A (zh) 2001-09-26
HUP0100489A3 (en) 2002-10-28
ATE294175T1 (de) 2005-05-15
CA2332513C (fr) 2005-11-29
EP1122254A2 (fr) 2001-08-08

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