FR2789269A1 - Dietetic composition, useful for preventing cancer of intestine and colon, comprises food fiber and red fruit extract containing anthocyanosides - Google Patents

Abstract

Dietetic composition (A) comprises a mixture of food fiber (I) and at least one extract (II) of red fruit, containing anthocyanosides (III). An Independent claim is also included for a method for preparing (A) by direct mixing of (I) and (II) at ambient temperature.

Description

i DIETETIC COMPOSITION BASED ON FRUIT EXTRACT (S)

  RED, MANUFACTURING METHOD AND USE OF SAID COMPOSITION

  The subject of the invention is a dietary composition based on extract (s) of red fruit. It also relates to the manufacturing process, as well as

  the use of said composition.

  In the following description and in the claims, the term “red fruits” means elderberries (Sambucus nigra), blackcurrant berries (Ribes

  nigrum), currants (Ribes rubrum), blackberries (Morus nigra), grapes, and more particularly blueberries (Vaccinium myrtillus and other species of the genus Vaccinium), although this list is not exhaustive.15 It is known that red fruits are rich in pigments called anthocyanosides, which have been proven to have properties on the blood circulatory system. They in fact exhibit a vasomotor action originating from a restoration or an increase in ionic fluxes at the level of cell membranes and more particularly from a modification of the calcium flux. In addition, they improve microvascular functioning by acting in particular on the

  permeability of the capillaries, the increase being in this way one of the first manifestations of the inflammatory process.

  Furthermore, it is known that anthocyanosides exert an inhibitory action with respect to elastase, a proteolytic enzyme which can intervene in the

  breakdown of connective tissue and collagen.

  Finally, it has also been shown that anthocyanosides have a

  significant antioxidant, anti-platelet and anti-radical activity.

  These properties have been recognized for the treatment of disorders relating to the retinal circulation, but also in the treatment of functional disorders of capillary fragility and visual disorders of vascular origin.35 These properties have also been used in the treatment of hesperanopia and myopia, in the pharmaceutical specialties 2 marketed under the brands DIFRAREL 100 and DIFRAREL E by

LEURQUIN MEDIOLANUM Laboratories.

  Based on the recognized properties of anthocyanosides, the Applicant has found that extracts of red fruits containing anthocyanosides can be judiciously mixed with short-chain dietary fibers, each of these two components having a synergistic effect and being capable of acting in particular as preventive factors for cancerous proliferation in the intestine and the colon.10 More specifically, the invention relates to a dietary composition based on extract (s) of red fruit characterized in that it comprises a mixture * of dietary fiber,

  * at least one red fruit extract containing anthocyanosides.

  According to a first characteristic of the invention, the dietary fibers are chosen from the group comprising inulin and oligosaccharides, alone or

in mixture.

  The oligosaccharides are obtained by fractional hydrolysis of natural polysaccharides and in particular of inulin, or of lactose in the case of galacto-

  oligosaccharides. Advantageously, the oligosaccharides are chosen from the group

  including fructo-oligosaccharides (FOS), oligo-fructoses and galacto-oligosaccharides.

  More precisely, oligosaccharides are composed of 2 to 7 molecules and are divided into three main classes: * fructo-oligosaccharides (FOS) are composed of 1 to 3 molecules of fructose linked to a molecule of sucrose; * oligo-fructoses are composed of 2 to 6 molecules of fructose linked to a glucose molecule or 2 to 6 molecules of fructose linked to a reducing fructose; * galacto-oligosaccharides are composed of 2 to 5 molecules of

  galactose, linked to a glucose molecule.

  The properties of these fibers have been widely described. In particular, they are attributed a role in increasing intestinal motility, because these low molecular weight fibers are not digested in the small intestine, but are assimilated in the terminal part of the colon. In addition, their short chain structure has the advantage of not causing any irritation of the intestinal wall.

  likely to result in the release of free radicals.

  Advantageously, the oligosaccharides chosen are fructo-

oligosaccharides.

  Indeed, it is known that FOS restore the intestinal microbial balance by increasing the bifidogenic flora. In addition, the bifidogenic flora restored by the consumption of FOS causes a decrease in the intestinal pH, a factor which seems favorable to the prevention of colon cancer. In addition, FOS have selective retention properties of certain minerals (calcium, zinc, copper) and

  controlled assimilation of triacyl glycerols and phospholipids in the blood.

  The synergistic effect of anthocyanosides and FOS can therefore be identified.

  It indeed seems interesting to combine the anti-free radical and antioxidant activity of anthocyanosides with the capacity of FOS to restore the intestinal microbial balance and to lower the intestinal pH. The dietary composition of the invention can thus be advantageously used, without being limiting, in the prevention of cancerous proliferation of the intestine and the colon.

  The extract of red fruits used in the dietary composition of the invention is advantageously an extract of blueberries.

  In practice, this extract of blueberries can come in all forms

  conventional dry, and in particular in powder form.

  Of course, the bilberry extract may have undergone any purification process known to those skilled in the art, so as to increase its titer in anthocyanosides. 35

  Advantageously, extracts of blueberries titrated from 0 to 100% in anthocyanoside monomers or from 0 to 100% in catecho- complex will be used.

  anthocyanin. In an advantageous form, the dietary composition of the invention comprises between 0.1 and 30% by weight of red fruit extract. For a concentration of less than 0.1% by weight of extract, there is no synergistic effect between the anthocyanosides contained in the extract and the

dietary fiber.

  For a concentration greater than 30% by weight of extract, the synergistic effect obtained remains constant, an overdose therefore brings no benefit.

  It should be noted that the bilberry extract and the FOS are advantageously in any dry form, which guarantees optimal stability of

  each of the compounds, and thus their activity.

  The invention also relates to the method for manufacturing the

  composition according to which at room temperature, the red fruit extract and the dietary fibers are mixed.

  Before mixing, the anthocyanosides and the FOS are sieved. A mixture of powders is then obtained, which can be packaged in all dry forms,

  in sachets for example, or be subjected to a compression step, so as to obtain tablets.

  The invention and the advantages which result therefrom will emerge more clearly from the following exemplary embodiments.

  Two dietary formulations are prepared in accordance with the invention, the

composition is as follows.

Example I

  Composition at 4% - 40 mg of blueberry extract - 1 g of fructo-oligosaccharides or inulin

Example 2

  Composition at 15% - 40 mg of blueberry extract - 2 g of fructo-oligosaccharides or inulin In the two examples, the two powders are sieved beforehand. The anthocyanosidic extract of blueberries is sieved over a cutoff threshold of 180 microns. As far as they are concerned, the FOS are screened on a cutoff threshold of

710 micrometers.

  First, a premix is made by mixing all of the blueberry extract with half the amount of FOS. The final mixture is

  obtained by mixing the premix with the second half of FOS.

  The mixture thus obtained is then packaged in the form of sealed bags. The mixing and packaging conditions, under controlled humidity and below 10%, are the essential factors to guarantee stability

of the product, and therefore its activity.

  The advantages of the invention appear clearly from the description.

  Note in particular the synergistic effect of a red fruit extract rich in anthocyanosides and dietary fibers, compounds which are positioned in particular as factors favorable to the prevention of proliferation

  intestinal and colon cancer.

  Note also the simplicity of the manufacturing process of the

composition object of the invention.

Claims (9)

  1 / Dietetic composition based on extract (s) of red fruit characterized in that it comprises in mixture: * dietary fibers,   * at least one red fruit extract containing anthocyanosides.   2 / dietetic composition according to claim 1, characterized in that the dietary fibers are chosen from the group comprising inulin and   oligosaccharides, alone or in mixture.   3 / dietetic composition according to claim 2, characterized in that the oligosaccharides are chosen from the group comprising fructo-   oligosaccharides (FOS), oligo-fructoses and galactooligosaccharides. 15   4 / dietetic composition according to one of the preceding claims, characterized in that the red fruit extract is in powder form.   / Dietetic composition according to claim 3, characterized in   that it comprises between 0.1 and 30% by weight of red fruit extract.   6 / Dietetic composition according to one of the preceding claims, characterized in that the red fruit extract is an extract of blueberries.   7 / A method of manufacturing the dietary composition object of one of claims 1 to 6, characterized in that one mixes directly, at temperature   ambient, red fruit extract and dietary fiber.   8 / manufacturing process according to the preceding claim, characterized in that each of the two powders of red fruit extract and fibers is sieved food before mixing.   9 / The manufacturing method according to claim 8, characterized in that the   mixture is then packaged in the form of sachets.   / Method according to claims 7 to 9, characterized in that the mixture   and packaging are carried out under controlled humidity.   11 / Use of the dietary composition which is the subject of claims 1 to 6   for the prevention of cancerous proliferation of the intestine and the colon. APPLICANT: FERLUX   REPRESENTATIVE: LAURENT CABINET and CHARRAS