FR2773798B1 - Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2773798B1
FR2773798B1 FR9800424A FR9800424A FR2773798B1 FR 2773798 B1 FR2773798 B1 FR 2773798B1 FR 9800424 A FR9800424 A FR 9800424A FR 9800424 A FR9800424 A FR 9800424A FR 2773798 B1 FR2773798 B1 FR 2773798B1
Authority
FR
France
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
tricyclic compounds
novel tricyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9800424A
Other languages
English (en)
French (fr)
Other versions
FR2773798A1 (fr
Inventor
Michel Langlois
Allainmat Monique Mathe
Carole Jellimann
Jean Andrieux
Caroline Bennejean
Pierre Renard
Philippe Delagrange
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9800424A priority Critical patent/FR2773798B1/fr
Application filed by ADIR SARL filed Critical ADIR SARL
Priority to PT98959957T priority patent/PT1047664E/pt
Priority to HK01104169.6A priority patent/HK1033455B/xx
Priority to JP2000540110A priority patent/JP2002509130A/ja
Priority to DK98959957T priority patent/DK1047664T3/da
Priority to US09/600,373 priority patent/US6423870B1/en
Priority to AT98959957T priority patent/ATE267163T1/de
Priority to CA002318381A priority patent/CA2318381C/fr
Priority to CNB988131374A priority patent/CN1247528C/zh
Priority to HU0100283A priority patent/HUP0100283A3/hu
Priority to DE69824046T priority patent/DE69824046T2/de
Priority to EP98959957A priority patent/EP1047664B1/fr
Priority to PCT/FR1998/002694 priority patent/WO1999036392A1/fr
Priority to AU15676/99A priority patent/AU739488B2/en
Priority to ES98959957T priority patent/ES2221999T3/es
Priority to ZA9811380A priority patent/ZA9811380B/xx
Priority to NZ505323A priority patent/NZ505323A/xx
Priority to PL98341837A priority patent/PL195664B1/pl
Priority to BR9815081-2A priority patent/BR9815081A/pt
Publication of FR2773798A1 publication Critical patent/FR2773798A1/fr
Priority to NO20003604A priority patent/NO20003604L/no
Application granted granted Critical
Publication of FR2773798B1 publication Critical patent/FR2773798B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/20—Acenaphthenes; Hydrogenated acenaphthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/28—Phenalenes; Hydrogenated phenalenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)
FR9800424A 1998-01-16 1998-01-16 Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2773798B1 (fr)

Priority Applications (20)

Application Number Priority Date Filing Date Title
FR9800424A FR2773798B1 (fr) 1998-01-16 1998-01-16 Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP98959957A EP1047664B1 (fr) 1998-01-16 1998-12-11 Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2000540110A JP2002509130A (ja) 1998-01-16 1998-12-11 新しい三環系化合物、その製造方法及びこれらを含む医薬組成物
DK98959957T DK1047664T3 (da) 1998-01-16 1998-12-11 Tricykliske forbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
US09/600,373 US6423870B1 (en) 1998-01-16 1998-12-11 Tricyclic compounds, preparation method and pharmaceutical compositions containing same
AT98959957T ATE267163T1 (de) 1998-01-16 1998-12-11 Tricyclische verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
HK01104169.6A HK1033455B (en) 1998-01-16 1998-12-11 Novel tricyclic compounds, preparation method and pharmaceutical compositions containing same
CNB988131374A CN1247528C (zh) 1998-01-16 1998-12-11 新颖的三环化合物、其制备方法及含有它们的药物组合物
HU0100283A HUP0100283A3 (en) 1998-01-16 1998-12-11 Novel tricyclic compounds, preparation method and pharmaceutical compositions containing same
DE69824046T DE69824046T2 (de) 1998-01-16 1998-12-11 Tricyclische verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
PT98959957T PT1047664E (pt) 1998-01-16 1998-12-11 Novos compostos triciclicos processo para a sua preparacao e as composicoes farmaceuticas que os contem
CA002318381A CA2318381C (fr) 1998-01-16 1998-12-11 Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PL98341837A PL195664B1 (pl) 1998-01-16 1998-12-11 Nowe związki tricykliczne, sposób ich otrzymywania, zawierające te związki kompozycje farmaceutyczne oraz ich zastosowanie
ES98959957T ES2221999T3 (es) 1998-01-16 1998-12-11 Nuevos compuestos triciclicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ZA9811380A ZA9811380B (oth) 1998-01-16 1998-12-11
NZ505323A NZ505323A (en) 1998-01-16 1998-12-11 Phenalenyl, acenaphthyl and other tricyclic compounds
AU15676/99A AU739488B2 (en) 1998-01-16 1998-12-11 New tricyclic compounds, a process for their preparation and pharmaceutical compositions containing them
BR9815081-2A BR9815081A (pt) 1998-01-16 1998-12-11 Compostos tricìclicos, um processo para a sua preparação e composições farmacêuticas contendo-os
PCT/FR1998/002694 WO1999036392A1 (fr) 1998-01-16 1998-12-11 Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
NO20003604A NO20003604L (no) 1998-01-16 2000-07-13 Nye tricykliske forbindelser, fremgangsmÕte ved deres fremstilling og farmasøytiske sammensetninger inneholdende dem

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9800424A FR2773798B1 (fr) 1998-01-16 1998-01-16 Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2773798A1 FR2773798A1 (fr) 1999-07-23
FR2773798B1 true FR2773798B1 (fr) 2001-02-02

Family

ID=9521844

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9800424A Expired - Fee Related FR2773798B1 (fr) 1998-01-16 1998-01-16 Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (19)

Country Link
US (1) US6423870B1 (oth)
EP (1) EP1047664B1 (oth)
JP (1) JP2002509130A (oth)
CN (1) CN1247528C (oth)
AT (1) ATE267163T1 (oth)
AU (1) AU739488B2 (oth)
BR (1) BR9815081A (oth)
CA (1) CA2318381C (oth)
DE (1) DE69824046T2 (oth)
DK (1) DK1047664T3 (oth)
ES (1) ES2221999T3 (oth)
FR (1) FR2773798B1 (oth)
HU (1) HUP0100283A3 (oth)
NO (1) NO20003604L (oth)
NZ (1) NZ505323A (oth)
PL (1) PL195664B1 (oth)
PT (1) PT1047664E (oth)
WO (1) WO1999036392A1 (oth)
ZA (1) ZA9811380B (oth)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025355A (en) * 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
GB9726569D0 (en) * 1997-12-16 1998-02-11 Univ Southampton Neuroprotective agents
DE10133927A1 (de) * 2001-07-12 2003-01-23 Bayer Ag Benzodioxinothiophene, deren Herstellung und Verwendung
DE60208683T2 (de) * 2001-08-01 2006-11-02 Basell Polyolefine Gmbh Verfahren zur herstellung von heterocyclischen pentalen derivaten
AU2007342806A1 (en) * 2006-12-28 2008-07-17 Takeda Pharmaceutical Company Limited Tricyclic compound and pharmaceutical use thereof
FR2934857B1 (fr) * 2008-08-05 2010-08-27 Servier Lab Nouveau procede de synthese de l'agomelatine
TW202220965A (zh) 2020-08-06 2022-06-01 美商塔朵根公司 用於心理疾患或心理增強之２－胺基茚滿化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9407919D0 (en) * 1994-04-21 1994-06-15 Glaxo Group Ltd Chemical compounds
WO1996008466A1 (en) 1994-09-12 1996-03-21 Takeda Chemical Industries, Ltd. Benzocycloalkene compounds, their production and use
FR2725985B1 (fr) * 1994-10-21 1996-11-15 Adir Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2732964B1 (fr) * 1995-04-14 1997-05-16 Adir Nouveaux amides tricycliques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2734815B1 (fr) * 1995-05-31 1997-07-04 Adir Nouveaux composes arylalkyl (thio) carboxamides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
SK283970B9 (sk) * 1996-03-08 2004-10-05 Takeda Chemical Industries Ltd Tricyklické zlúčeniny, spôsob výroby a farmaceutický prípravok ich obsahujúci

Also Published As

Publication number Publication date
HUP0100283A2 (hu) 2002-04-29
CN1247528C (zh) 2006-03-29
PT1047664E (pt) 2004-08-31
EP1047664B1 (fr) 2004-05-19
WO1999036392A1 (fr) 1999-07-22
AU739488B2 (en) 2001-10-11
BR9815081A (pt) 2000-10-17
HK1033455A1 (en) 2001-08-31
ATE267163T1 (de) 2004-06-15
EP1047664A1 (fr) 2000-11-02
FR2773798A1 (fr) 1999-07-23
CA2318381C (fr) 2007-04-17
US6423870B1 (en) 2002-07-23
DK1047664T3 (da) 2004-09-13
HUP0100283A3 (en) 2002-05-28
DE69824046T2 (de) 2005-06-30
CN1285817A (zh) 2001-02-28
NO20003604L (no) 2000-09-12
NO20003604D0 (no) 2000-07-13
JP2002509130A (ja) 2002-03-26
PL195664B1 (pl) 2007-10-31
AU1567699A (en) 1999-08-02
ES2221999T3 (es) 2005-01-16
ZA9811380B (oth) 1999-06-14
PL341837A1 (en) 2001-05-07
DE69824046D1 (de) 2004-06-24
NZ505323A (en) 2002-10-25
CA2318381A1 (fr) 1999-07-22

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse

Effective date: 20060929