FR2767825A1 - Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht°1,2-b!-1, 4-oxazines disubstituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht°1,2-b!-1, 4-oxazines disubstituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Download PDF

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Publication number
FR2767825A1
FR2767825A1 FR9710852A FR9710852A FR2767825A1 FR 2767825 A1 FR2767825 A1 FR 2767825A1 FR 9710852 A FR9710852 A FR 9710852A FR 9710852 A FR9710852 A FR 9710852A FR 2767825 A1 FR2767825 A1 FR 2767825A1
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FR
France
Prior art keywords
ppm
formula
compound
trans
meaning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR9710852A
Other languages
English (en)
French (fr)
Inventor
Jean Louis Peglion
Jean Christophe Harmange
Mark Millan
Francoise Lejeune
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Servier de Medecine Translationnelle SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Priority to FR9710852A priority Critical patent/FR2767825A1/fr
Priority to NZ331637A priority patent/NZ331637A/xx
Priority to CN98119987A priority patent/CN1088064C/zh
Priority to NO19984007A priority patent/NO311218B1/no
Priority to CA002246482A priority patent/CA2246482C/fr
Priority to BR9803933-4A priority patent/BR9803933A/pt
Priority to US09/144,025 priority patent/US6025356A/en
Priority to PL328285A priority patent/PL194533B1/pl
Priority to HU9801951A priority patent/HU226059B1/hu
Priority to ZA987963A priority patent/ZA987963B/xx
Priority to PT98402155T priority patent/PT899267E/pt
Priority to ES98402155T priority patent/ES2189108T3/es
Priority to DK98402155T priority patent/DK0899267T3/da
Priority to EP98402155A priority patent/EP0899267B1/fr
Priority to DE69810034T priority patent/DE69810034T2/de
Priority to JP24691098A priority patent/JP4417451B2/ja
Priority to AU83024/98A priority patent/AU740928C/en
Priority to AT98402155T priority patent/ATE229513T1/de
Publication of FR2767825A1 publication Critical patent/FR2767825A1/fr
Priority to HK99105446.1A priority patent/HK1020340B/xx
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR9710852A 1997-09-01 1997-09-01 Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht°1,2-b!-1, 4-oxazines disubstituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Pending FR2767825A1 (fr)

Priority Applications (19)

Application Number Priority Date Filing Date Title
FR9710852A FR2767825A1 (fr) 1997-09-01 1997-09-01 Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht°1,2-b!-1, 4-oxazines disubstituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
NZ331637A NZ331637A (en) 1997-09-01 1998-08-31 Trans 9-substituted 3,4,4a,5,6,10b-hexahydro-4(alkyl, alkenyl or alkynyl)-2h-naphth[1,2-b]-1,4-oxazine derivatives and medicaments
CN98119987A CN1088064C (zh) 1997-09-01 1998-08-31 萘并噁嗪衍生物、其制备方法及含有它们的药物组合物
NO19984007A NO311218B1 (no) 1997-09-01 1998-08-31 Nye disubstituerte trans-3,4,4a,5,6,10b-heksahydro-2H- naft[1,2-b]-1,4-oksaziner, en fremgangsmåte ved deres fremstillingog farmasöytiske sammensetninger inneholder disse
CA002246482A CA2246482C (fr) 1997-09-01 1998-08-31 Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht [1,2-b]-1,4-oxazines disubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BR9803933-4A BR9803933A (pt) 1997-09-01 1998-08-31 Trans-3,4,4a,5,6,10b-hexahidro-2h-nafto [1,2-b]-1,4-oxazinas dissubstituìdas, um processo para sua preparação e composições farmacêuticas que as contêm
US09/144,025 US6025356A (en) 1997-09-01 1998-08-31 Disubstituted trans-3,4,4a,5,6,10b-hexahydro-2H-naphth[1,2-b]-1,4-oxazines
PL328285A PL194533B1 (pl) 1997-09-01 1998-08-31 Nowe dipodstawione trans-3,4,4a,5,6,10b-heksahydro-2H-nafto[1,2-b]-1,4-oksazyny oraz zawierające je kompozycje farmaceutyczne
HU9801951A HU226059B1 (en) 1997-09-01 1998-08-31 Novel disubstituted trans-3,4,4a,5,6,10b-hexahydro-2h-naphto[1,2-b][1,4]oxazine derivatives, process for producing them and pharmaceutical compositions containing them
ZA987963A ZA987963B (en) 1997-09-01 1998-09-01 Disubstituted trans-3,4,4a,5,6,10b-haxahydro-2H-naphth(1,2-b)-1,4-oxazines a process for their preparation and pharmaceutical compositions containing them
PT98402155T PT899267E (pt) 1997-09-01 1998-09-01 Novas trans-3,4,4a,5,6,10b-hexa-hidro-2h-naft(1,2b)-1,4-oxazinas di-substituidas processo para a sua preparacao e as composicoes farmaceuticas que as contem
ES98402155T ES2189108T3 (es) 1997-09-01 1998-09-01 Nuevas oxazinas dissustituidas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen.
DK98402155T DK0899267T3 (da) 1997-09-01 1998-09-01 Disubstituerede trans-3,4,4a,5,6,10b-hexahydro-2H-napht[1,2-b]-1,4-oxiner, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger indeholdende disse
EP98402155A EP0899267B1 (fr) 1997-09-01 1998-09-01 Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2H-napht(1,2-b)-1,4-oxazines disubstituées, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
DE69810034T DE69810034T2 (de) 1997-09-01 1998-09-01 Disubstituierte trans-3,4,4a,5,6,10b-Hexahydro-2H-napht(1,2-b)-1,4-Oxazine, Verfahren zu deren Herstellung und diese enthaltende pharmazeutigsche Zusammensetzungen
JP24691098A JP4417451B2 (ja) 1997-09-01 1998-09-01 新規な二置換ｔｒａｎｓ−３，４，４ａ，５，６，１０ｂ−ヘキサヒドロ−２Ｈ−ナフト〔１，２−ｂ〕−１，４−オキサジン、それらの製造方法及びそれらを含有する医薬組成物
AU83024/98A AU740928C (en) 1997-09-01 1998-09-01 New disubstituted trans-3,4,4a,5,6,10b-hexahydro-2H-naphth (1,2-b)-1,4-oxazines, a process for their preparation and pharmaceutical compositions containing them
AT98402155T ATE229513T1 (de) 1997-09-01 1998-09-01 Disubstituierte trans-3,4,4a,5,6,10b-hexahydro-2h-napht(1,2-b)- ,4-oxazine, verfahren zu deren herstellung und diese enthaltende pharmazeutigsche zusammensetzungen
HK99105446.1A HK1020340B (en) 1997-09-01 1999-11-25 New disubstituted trans-3,4,4a,5,6,10b-hexahydro-2h-naphth (1,2-b)-1,4-oxazines, a process for their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9710852A FR2767825A1 (fr) 1997-09-01 1997-09-01 Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht°1,2-b!-1, 4-oxazines disubstituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
FR2767825A1 true FR2767825A1 (fr) 1999-03-05

Family

ID=9510643

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9710852A Pending FR2767825A1 (fr) 1997-09-01 1997-09-01 Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht°1,2-b!-1, 4-oxazines disubstituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (18)

Country Link
US (1) US6025356A (cg-RX-API-DMAC7.html)
EP (1) EP0899267B1 (cg-RX-API-DMAC7.html)
JP (1) JP4417451B2 (cg-RX-API-DMAC7.html)
CN (1) CN1088064C (cg-RX-API-DMAC7.html)
AT (1) ATE229513T1 (cg-RX-API-DMAC7.html)
AU (1) AU740928C (cg-RX-API-DMAC7.html)
BR (1) BR9803933A (cg-RX-API-DMAC7.html)
CA (1) CA2246482C (cg-RX-API-DMAC7.html)
DE (1) DE69810034T2 (cg-RX-API-DMAC7.html)
DK (1) DK0899267T3 (cg-RX-API-DMAC7.html)
ES (1) ES2189108T3 (cg-RX-API-DMAC7.html)
FR (1) FR2767825A1 (cg-RX-API-DMAC7.html)
HU (1) HU226059B1 (cg-RX-API-DMAC7.html)
NO (1) NO311218B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ331637A (cg-RX-API-DMAC7.html)
PL (1) PL194533B1 (cg-RX-API-DMAC7.html)
PT (1) PT899267E (cg-RX-API-DMAC7.html)
ZA (1) ZA987963B (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0130219D0 (en) * 2001-12-18 2002-02-06 Pfizer Ltd Compounds for the treatment of sexual dysfunction
EP1534679A4 (en) * 2002-08-30 2007-06-06 Biostratum Inc INHIBITORS OF POST-AMADORI ADVANCED GLYCATION ENDPRODUCTS
JP2006523674A (ja) * 2003-04-18 2006-10-19 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 慢性閉塞性肺疾患（ｃｏｐｄ）のための組合せ治療法
FR2906249B1 (fr) * 2006-09-26 2008-12-19 Servier Lab Composes tetracycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2098511A1 (en) 2008-03-07 2009-09-09 Solvias AG Process for preparing compounds containing a hydronaphtalene structure with an unsymmetrically substituted benzene ring
WO2009156458A1 (en) * 2008-06-27 2009-12-30 H. Lundbeck A/S Novel phenolic and catecholic amines and prodrugs thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0080115A2 (en) * 1981-11-20 1983-06-01 Merck & Co. Inc. Hexahydronaphth(1,2-b)-1,4-oxazines, process for their preparation and pharmaceutical formulation containing them
US4540691A (en) * 1984-04-13 1985-09-10 Nelson Research & Development Co. Dopamine agonists and use thereof
WO1991019719A1 (en) * 1990-06-15 1991-12-26 Whitby Research, Inc. Substituted naphthoxazines useful as dopaminergics
US5486611A (en) * 1989-07-13 1996-01-23 The Upjohn Company Carboxamido-(1,2N)-carbocyclic-2-aminotetralin derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4420480A (en) * 1981-11-20 1983-12-13 Merck & Co., Inc. Hexahydronaphth[1,2-b]-1,4-oxazines

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0080115A2 (en) * 1981-11-20 1983-06-01 Merck & Co. Inc. Hexahydronaphth(1,2-b)-1,4-oxazines, process for their preparation and pharmaceutical formulation containing them
US4540691A (en) * 1984-04-13 1985-09-10 Nelson Research & Development Co. Dopamine agonists and use thereof
US5486611A (en) * 1989-07-13 1996-01-23 The Upjohn Company Carboxamido-(1,2N)-carbocyclic-2-aminotetralin derivatives
WO1991019719A1 (en) * 1990-06-15 1991-12-26 Whitby Research, Inc. Substituted naphthoxazines useful as dopaminergics

Also Published As

Publication number Publication date
ES2189108T3 (es) 2003-07-01
HU9801951D0 (en) 1998-11-30
DE69810034T2 (de) 2003-08-14
HK1020340A1 (en) 2000-04-14
PL194533B1 (pl) 2007-06-29
HUP9801951A2 (hu) 2000-02-28
HUP9801951A3 (en) 2000-04-28
CN1222516A (zh) 1999-07-14
JP4417451B2 (ja) 2010-02-17
CN1088064C (zh) 2002-07-24
HU226059B1 (en) 2008-04-28
DK0899267T3 (da) 2003-03-10
NO984007L (no) 1999-03-02
PL328285A1 (en) 1999-03-15
JPH11130759A (ja) 1999-05-18
CA2246482A1 (fr) 1999-03-01
AU8302498A (en) 1999-03-11
EP0899267B1 (fr) 2002-12-11
BR9803933A (pt) 2001-04-24
NO311218B1 (no) 2001-10-29
NO984007D0 (no) 1998-08-31
ATE229513T1 (de) 2002-12-15
AU740928B2 (en) 2001-11-15
ZA987963B (en) 1999-03-04
PT899267E (pt) 2003-04-30
CA2246482C (fr) 2002-11-26
NZ331637A (en) 1999-07-29
US6025356A (en) 2000-02-15
DE69810034D1 (de) 2003-01-23
AU740928C (en) 2002-05-16
EP0899267A1 (fr) 1999-03-03

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