FR2761884A1 - COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS CONTAINING LAPSANA EXTRACT - Google Patents
COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS CONTAINING LAPSANA EXTRACT Download PDFInfo
- Publication number
- FR2761884A1 FR2761884A1 FR9704525A FR9704525A FR2761884A1 FR 2761884 A1 FR2761884 A1 FR 2761884A1 FR 9704525 A FR9704525 A FR 9704525A FR 9704525 A FR9704525 A FR 9704525A FR 2761884 A1 FR2761884 A1 FR 2761884A1
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- Prior art keywords
- cosmetic
- lampsane
- compositions according
- extracts
- dermopharmaceutical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Cosmetics (AREA)
Abstract
Description
La lampsane ou Lapsana communis L. est une herbe que l'on ramasse au long des chemins des campagnes d'Europe. Au cours des siècles derniers, elle était utilisée chez les humains ou les bovins contre les gerçures et les crevasses, ou comme aliment pour lapin.The Lampsane or Lapsana communis L. is a grass that is collected along the paths of the countryside in Europe. For centuries, it has been used in humans or cattle for chapping and crevices, or as rabbit food.
L'objet du présent brevet réside dans la découverte que les extraits hydroglycoliques de la partie aérienne fleurie et sèche de cette plante possèdent des activités biochimiques utiles dans des applications cosmétiques et dermopharmaceutiques, à savoir, la capacité de protéger le collagène des effets délétères du radical OH', les cellules en culture contre ceux de l'eau oxygénée et d'inhiber les effets délétères de l'élastase leucocytaire humaine ou de ceux de la hyaluronidase.The object of the present patent resides in the discovery that the hydroglycolic extracts of the flowering and dry aerial part of this plant possess biochemical activities useful in cosmetic and dermopharmaceutical applications, namely, the capacity to protect collagen from the deleterious effects of the radical OH ', cells in culture against those of hydrogen peroxide and inhibit the deleterious effects of human leukocyte elastase or those of hyaluronidase.
Les extraits de Lapsana communis objets du présent brevet peuvent donc être utilisés dans le domaine de la cosmétique, notamment pour leurs activités citées ci-dessus qui leur confèrent des effets anti-vieillissement et antirides par la protection des constituants de base de la structure cutanée et donc, prolongent la souplesse et la fonction protectrice de la peau.The extracts of Lapsana communis which are the subject of this patent can therefore be used in the field of cosmetics, in particular for their activities mentioned above which give them anti-aging and anti-wrinkle effects by protecting the basic constituents of the skin structure and therefore, prolong the suppleness and the protective function of the skin.
La préparation des extraits peut se réaliser par macération, pendant 9 jours à la température de 15-20"C, de 30 grammes de broyat de la partie aérienne fleurie sèche avec 220 ml d'un mélange d'eau/Polyéthylène Glycol 400/Butylène Glycol (16/64/20%). Après filtration, on recueille environ 145 ml d'un extrait brun foncé que l'on décolore au moyen de quelques grammes de charbon activé suivie de deux filtrations sur papier. Le filtrat obtenu est limpide, de couleur jaune-orangé.The extracts can be prepared by maceration, for 9 days at a temperature of 15-20 "C, of 30 grams of ground material from the dry flowering aerial part with 220 ml of a mixture of water / Polyethylene Glycol 400 / Butylene Glycol (16/64/20%) After filtration, approximately 145 ml of a dark brown extract is collected which is discolored using a few grams of activated charcoal followed by two paper filtrations. The filtrate obtained is clear, yellow-orange in color.
En plus des solvants mentionnés ci-dessus (eau, Polyéthylène glycol 400,
Butylène Glycol seuls ou sous forme de mélange en proportions variées), il est possible d'utiliser d'autres solvants tels que la glycérine, I'éthanol, ainsi que des mélanges glycérine/eau, propylène glycol/eau, butylène glycol/eau, éthanol/eau.In addition to the solvents mentioned above (water, Polyethylene glycol 400,
Butylene Glycol alone or as a mixture in various proportions), it is possible to use other solvents such as glycerin, ethanol, as well as glycerin / water, propylene glycol / water, butylene glycol / water, ethanol / water.
Cet exemple d'obtention d'extrait n'est pas limitatif. II est possible de réaliser des extraits de Lapsana communis par d'autres procédés comme, par exemple, la simple décoction, la lixiviation, I'extraction au moyen d'ultrasons ou de microondes ou enfin au moyen de techniques à contre courant.This example of obtaining an extract is not limiting. It is possible to produce extracts of Lapsana communis by other methods such as, for example, simple decoction, leaching, extraction by means of ultrasound or microwaves or finally by means of counter-current techniques.
Les analyses par chromatographie liquide haute pression (HPLC) de ces extraits révèlent la présence de différents types d'acides hydroxy-cinnamiques parmi lesquels dominent : I'acide chicorique, I'acide chlorogénique, I'acide 3,5 dicaféylquinique..... The analyzes by high pressure liquid chromatography (HPLC) of these extracts reveal the presence of different types of hydroxy-cinnamic acids among which dominate: chicoric acid, chlorogenic acid, 3,5 dicafeylquinic acid ... .
Par rapport à d'autres polyphénols usuellement utilisés en cosmétique, ces acides hydroxy-cinnamiques présentent de nombreux avantages comme, par exemple, une meilleure solubilité et donc une meilleure disponibilité, une stabilité satisfaisante comparée à celles des tanins, une très faible coloration et une innocuité démontrée quotidiennement par les grandes quantités de café torréfié, de fruits (pommes, poires, cerises, myrtilles) et légumes frais (chicorée, artichaut) qui sont consommées dans le monde et qui contiennent chacun au moins l'une de ces molécules.Compared with other polyphenols commonly used in cosmetics, these hydroxy-cinnamic acids have many advantages such as, for example, better solubility and therefore better availability, satisfactory stability compared to those of tannins, very low coloration and safety demonstrated daily by the large quantities of roasted coffee, fruit (apples, pears, cherries, blueberries) and fresh vegetables (chicory, artichoke) which are consumed worldwide and which each contain at least one of these molecules.
Enfin, aucun effet irritant, cytotoxique, génotoxique ou mutagène n'a été reporté à ce jour.Finally, no irritant, cytotoxic, genotoxic or mutagenic effects have been reported to date.
Ces extraits possèdent de fortes activités protectrices, cellulaires ou extracellulaires, contre les activités délétères des radicaux libres et d'enzymes comme l'élastase et la hyaluronidase qui seront rapidement démontrées par les exemples suivants.These extracts have strong protective activities, cellular or extracellular, against the deleterious activities of free radicals and enzymes such as elastase and hyaluronidase which will be quickly demonstrated by the following examples.
Dans une première série d'essais, une solution de collagène est mis en présence d'un système générateur d'ion OHt, espèce radicalaire de l'oxygène particulièrement réactive. La dénaturation du collagène est objectivée par le suivi de la variation de l'absorbance au moyen d'un spectrophotomètre.In a first series of tests, a collagen solution is placed in the presence of an OHt ion generating system, a radical species of oxygen which is particularly reactive. The denaturation of collagen is objectified by monitoring the change in absorbance using a spectrophotometer.
En présence de l'extrait de Lampsane, aux concentrations de 0.1 et 0.3%, on observe des protections de respectivement 62+2% et 89+3% par rapport au contrôle effectué sans extrait.In the presence of the Lampsane extract, at concentrations of 0.1 and 0.3%, protections of 62 + 2% and 89 + 3% respectively are observed compared to the control carried out without extract.
Une deuxième série d'expériences a démontré que les extraits de Lampsane, utilisés à la concentration de 0,5% et 1,0%, étaient capables de protéger une culture cellulaire de fibroblastes humains contre une agression d'une durée de 60 minutes par une autre sorte de forme radicalaire de l'oxygène: I'eau oxygénée à la concentration de 0,4.10~3%. A second series of experiments demonstrated that the extracts of Lampsane, used at the concentration of 0.5% and 1.0%, were capable of protecting a cell culture of human fibroblasts against aggression lasting 60 minutes by another kind of radical form of oxygen: hydrogen peroxide at the concentration of 0.4.10 ~ 3%.
Dans ces conditions opératoires, la mortalité cellulaire des expériences contrôles est de 45+3% alors qu'en présence de 1% d'un extrait de Lampsane, cette mortalité tombe à 11+2%, ce qui démontre un effet protecteur de 75%.Under these operating conditions, the cell mortality of the control experiments is 45 + 3% whereas in the presence of 1% of an extract of Lampsane, this mortality drops to 11 + 2%, which demonstrates a protective effect of 75% .
Une troisième série d'expériences a consisté à incuber une suspension d'élastine et une solution d'élastase humaine, en présence ou en l'absence d'extrait à tester.A third series of experiments consisted in incubating a suspension of elastin and a solution of human elastase, in the presence or in the absence of extract to be tested.
Dans ces conditions, en présence d'un extrait de Lampsane à la concentration de 1%, on observe une inhibition de la dégradation de l'élastine de 70+4% par rapport à celle obtenue en l'absence de cet extrait. Under these conditions, in the presence of an extract of Lampsane at a concentration of 1%, an inhibition of the degradation of the elastin of 70 + 4% is observed compared to that obtained in the absence of this extract.
Enfin, dans une quatrième série d'expériences, le même type de protocole que cidessus était mis en oeuvre mais en utilisant la hyaluronidase et son substrat,
I'acide hyaluronique. Après 20 minutes d'incubation, en présence d'un extrait de
Lampsane, à la concentration de 3%, on observe une inhibition de la dégradation de l'acide hyaluronique de 44+3% par rapport à celle obtenue en l'absence d'extrait.Finally, in a fourth series of experiments, the same type of protocol as above was implemented but using hyaluronidase and its substrate,
Hyaluronic acid. After 20 minutes of incubation, in the presence of an extract of
Lampsane, at a concentration of 3%, an inhibition of the degradation of hyaluronic acid of 44 + 3% is observed compared to that obtained in the absence of extract.
Les extraits de Lampsane décrits dans ce brevet, peuvent donc être utilisés dans des produits cosmétiques et dermopharmaceutiques de toute sorte.The Lampsane extracts described in this patent can therefore be used in cosmetic and dermopharmaceutical products of all kinds.
De par leurs activités démontrées ci-dessus, de telles préparations présentent des effets anti-vieillissement et antirides, et protègent les constituants de base de la structure cutanée contre les agressions des radicaux libres de l'oxygène et prolongent la souplesse et la fonction protectrice de la peau.By virtue of their activities demonstrated above, such preparations have anti-aging and anti-wrinkle effects, and protect the basic constituents of the skin structure against attack by free oxygen radicals and prolong the flexibility and protective function of the skin.
Les extraits de Lampsane décrits dans ce brevet peuvent être utilisés dans toute forme galénique employée en cosmétique ou dermopharmacie: émulsions H/E et
E/H, laits, lotions, polymères gélifiants et viscosants, tensioactifs et émulsifiants, pommades, lotions capillaires, shampooings, savons, sticks et crayons, sprays, huiles corporelles, sans que cette liste soit limitative.The Lampsane extracts described in this patent can be used in any galenical form used in cosmetics or dermopharmacy: O / W emulsions and
W / O, milks, lotions, gelling and viscosifying polymers, surfactants and emulsifiers, ointments, hair lotions, shampoos, soaps, sticks and pencils, sprays, body oils, without this list being exhaustive.
II est possible d'incorporer les extraits de Lampsane décrits dans ce brevet dans des vecteurs cosmétiques comme les liposomes, les chylomicrons, les macro-, micro- et nanoparticules ainsi que les macro-, micro- et nanocapsules, de les absorber sur des polymères organiques poudreux, les talcs, bentonites et autres supports minéraux. It is possible to incorporate the Lampsane extracts described in this patent into cosmetic vectors such as liposomes, chylomicrons, macro-, micro- and nanoparticles as well as macro-, micro- and nanocapsules, to absorb them on polymers powdery organic, talcs, bentonites and other mineral supports.
Les extraits de Lampsane peuvent être combinés dans les compositions cosmétiques avec tout autre ingrédient habituellement utilisé en cosmétique: lipides d'extraction et/ou de synthèse, polymères gélifiants et viscosants, tensioactifs et émulsifiants, principes actifs hydro- ou liposolubles, extraits d'autres plantes, extraits tissulaires, extraits marins.Lampsane extracts can be combined in cosmetic compositions with any other ingredient usually used in cosmetics: extraction and / or synthetic lipids, gelling and viscosifying polymers, surfactants and emulsifiers, water- or fat-soluble active ingredients, extracts from other plants, tissue extracts, marine extracts.
La concentration d'utilisation de ces extraits de Lampsane peut varier entre 0.01 et 50% (p/p), préférentiellement entre 0.5 et 10%, en poids, dans le produit fini. The concentration of use of these Lampsane extracts can vary between 0.01 and 50% (w / w), preferably between 0.5 and 10%, by weight, in the finished product.
Claims (12)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9704525A FR2761884A1 (en) | 1997-04-10 | 1997-04-10 | COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS CONTAINING LAPSANA EXTRACT |
PCT/FR1998/000475 WO1998044905A1 (en) | 1997-04-10 | 1998-03-10 | Cosmetic or dermopharmaceutical compositions containing an extract of lapsana |
AU68411/98A AU6841198A (en) | 1997-04-10 | 1998-03-10 | Cosmetic or dermopharmaceutical compositions containing an extract of lapsana |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9704525A FR2761884A1 (en) | 1997-04-10 | 1997-04-10 | COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS CONTAINING LAPSANA EXTRACT |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2761884A1 true FR2761884A1 (en) | 1998-10-16 |
Family
ID=9505840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9704525A Withdrawn FR2761884A1 (en) | 1997-04-10 | 1997-04-10 | COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS CONTAINING LAPSANA EXTRACT |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU6841198A (en) |
FR (1) | FR2761884A1 (en) |
WO (1) | WO1998044905A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2778560A1 (en) * | 1998-05-12 | 1999-11-19 | Oreal | Composition for improving exfoliation of skin, stimulating epidermic regeneration and/or treating intrinsic and/or extrinsic cutaneous aging |
WO2002056856A1 (en) * | 2001-01-22 | 2002-07-25 | Codif International S.A. | Cosmetic product |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2884718B1 (en) * | 2005-04-22 | 2007-06-22 | Clarins Soc Par Actions Simpli | COSMETIC COMPOSITION FOR COMBINING THE CUTANEOUS CONSEQUENCES OF POLLUTION |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03190809A (en) * | 1989-12-21 | 1991-08-20 | Shiseido Co Ltd | Skin external preparation |
-
1997
- 1997-04-10 FR FR9704525A patent/FR2761884A1/en not_active Withdrawn
-
1998
- 1998-03-10 WO PCT/FR1998/000475 patent/WO1998044905A1/en active Application Filing
- 1998-03-10 AU AU68411/98A patent/AU6841198A/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03190809A (en) * | 1989-12-21 | 1991-08-20 | Shiseido Co Ltd | Skin external preparation |
Non-Patent Citations (4)
Title |
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DATABASE WPI Section Ch Week 9139, Derwent World Patents Index; Class B04, AN 91-286062, XP002052547 * |
E. M. KIRKPATRICK: "CHAMBERS 20TH CENTURY DICTIONARY", 1983, CHAMBERS, EDINBURGH, XP002052545 * |
G. GARNIER ET AL.: "RESSOURCES MEDICINALES DE LA FLORE FRANCAISE", 1961, VIGOT FRERES, PARIS, XP002052546 * |
H. MARZELL: "WÖRTERBUCH DER DEUTSCHEN PFLANZENNAMEN", 1972, S. HIRZEL, LEIPZIG, XP002052544 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2778560A1 (en) * | 1998-05-12 | 1999-11-19 | Oreal | Composition for improving exfoliation of skin, stimulating epidermic regeneration and/or treating intrinsic and/or extrinsic cutaneous aging |
EP0962223A1 (en) * | 1998-05-12 | 1999-12-08 | L'oreal | Use of cinnamic acid and it's derivatives to stimulate desquamation of the skin and compositions containing it |
WO2002056856A1 (en) * | 2001-01-22 | 2002-07-25 | Codif International S.A. | Cosmetic product |
FR2819718A1 (en) * | 2001-01-22 | 2002-07-26 | Codif Internat Sa | COSMETIC PRODUCT |
Also Published As
Publication number | Publication date |
---|---|
WO1998044905A1 (en) | 1998-10-15 |
AU6841198A (en) | 1998-10-30 |
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