FR2761263A1 - SLIMMING COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS - Google Patents

SLIMMING COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS Download PDF

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FR2761263A1
FR2761263A1 FR9703740A FR9703740A FR2761263A1 FR 2761263 A1 FR2761263 A1 FR 2761263A1 FR 9703740 A FR9703740 A FR 9703740A FR 9703740 A FR9703740 A FR 9703740A FR 2761263 A1 FR2761263 A1 FR 2761263A1
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cosmetic
extracts
lipolytic activity
dermopharmaceutical compositions
activity according
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FR2761263B1 (en
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Daniel Greff
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Sederma SA
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Sederma SA
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Priority to FR9703740A priority Critical patent/FR2761263B1/en
Priority to PCT/FR1998/000379 priority patent/WO1998042306A1/en
Priority to AU67348/98A priority patent/AU6734898A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Cosmetics (AREA)

Abstract

The invention concerns the use of plant extracts selected among the genus Armeniacea, Actractylodis, Sinomenum, Bupleurum and Pharbitidis for their lipolytic activity used in cosmetics. The extracts, preferably obtained by hydroglycolitic or alcoholic maceration, are used for preparing cosmetic or dermopharmaceutical compositions for their lipolytic, slimming and toning properties.

Description

La médecine traditionnelle chinoise est basée sur 1' utilisation d un grand nombre de plantes, de leurs extraits, décoctions et macérats. Peu de ces préparations ont subi des études systématiques et contrôlées quant aux réelles activités, aux principes actifs responsables d éventuels effets curatifs ou préventifs.Traditional Chinese medicine is based on the use of a large number of plants, their extracts, decoctions and macerates. Few of these preparations have undergone systematic and controlled studies as to the real activities, the active ingredients responsible for any curative or preventive effects.

Lors de la recherche de nouveaux produits à efficacité cosmétique il a été découvert par la demanderesse que certaines plantes traditionnellement utilisées par voie orale pour des troubles divers (douleurs, faiblesse, infections) possèdent une activité cosmétique insoupçonnée : les extraits de ces plantes stimulent la lipolyse in vitro et in vivo et peuvent donc être utilisés dans le traitement cosmétique des surcharges graisseuses cutanées et de la cellulite.When researching new products with cosmetic efficacy, it has been discovered by the applicant that certain plants traditionally used by the oral route for various disorders (pain, weakness, infections) have an unexpected cosmetic activity: the extracts of these plants stimulate lipolysis in vitro and in vivo and can therefore be used in the cosmetic treatment of fatty skin overloads and cellulite.

L'industrie cosmétique est en permanence à la recherche de nouveaux ingrédients actifs possédant des activités lipolytiques pour les intégrer dans des produits dits amincissants. De nombreuses substances (molécules pures comme les dérives de xanthines; mélanges complexes comme certains extraits d algues, extraits tissulaires et autres) sont proposées et utilisées. Le marché demande néanmoins des nouveautés et des produits encore plus actifs.The cosmetic industry is constantly looking for new active ingredients with lipolytic activities to integrate them into so-called slimming products. Many substances (pure molecules such as xanthine derivatives; complex mixtures such as certain algae extracts, tissue extracts and others) are proposed and used. The market nevertheless demands new products and even more active products.

L'objet du présent brevet est la découverte que certains extraits obtenus à partir de ces plantes, principalement de la partie racine ou rhizome, possèdent des activités biochimiques utiles pour l'application cosmétique et dermopharmaceutique, à savoir : le pouvoir de stimuler la lipolyse des triglycérides dans les adipocytes.The object of this patent is the discovery that certain extracts obtained from these plants, mainly from the root or rhizome, have biochemical activities useful for cosmetic and dermopharmaceutical application, namely: the power to stimulate the lipolysis of triglycerides in adipocytes.

II s agit de plantes des genres suivants : Armeniacea, Atractylodis, Platicodon,
Sinomenum, Flemingia, Bupleurum, Pharbitidis et Coleus, en particulier des ressources suivantes: graines d ' Armeniacea Mume, rhizome d Atractilodys lancea et A. macrocephalis, racine de Platicody grandiflorum, racine et tige de Sinomenum acutum, racine de
Bupleurum chinense, de graine de Pharbitidis diversifolia, de racine Coleus forskohli, racine ou partie aérienne de Flemingia strobilifera.These are plants of the following genera: Armeniacea, Atractylodis, Platicodon,
Sinomenum, Flemingia, Bupleurum, Pharbitidis and Coleus, in particular from the following resources: seeds of Armeniacea Mume, rhizome of Atractilodys lancea and A. macrocephalis, root of Platicody grandiflorum, root and stem of Sinomenum acutum, root of
Bupleurum chinense, from Pharbitidis diversifolia seed, from Coleus forskohli root, root or aerial part of Flemingia strobilifera.

L'avantage de ces extraits de plantes réside dans un ratio favorable d'activité biologique sur matière sèche (et couleur associée), ce qui est souvent problématique en phytothérapie cosmétique. Les extraits sont stables, sans forte odeur et facilement utilisés dans tout type de produit cosmétique. The advantage of these plant extracts lies in a favorable ratio of biological activity on dry matter (and associated color), which is often problematic in cosmetic phytotherapy. The extracts are stable, without strong odor and easily used in any type of cosmetic product.

Des extraits d'autres espèces des genres cités sont décrits dans la littérature et dans certains brevets, mais dans ces extraits on ne décrit pas les activités cosmétiques lipolytiques que nous avons trouvées dans les plantes citées.Extracts from other species of the genera mentioned are described in the literature and in certain patents, but in these extracts the lipolytic cosmetic activities that we have found in the plants mentioned are not described.

Les solvants d'extraction pour la préparation des extraits objets du présent brevet peuvent être choisis parmi l'eau, le propylène glycol, le butylène glycol, la glycérine, le polyéthylène glycol, les éthers méthyliques ou éthyliques des diglycols, les polyols cycliques, les diglycols éthoxylés ou propoxylées ainsi que les alcanols méthanol, éthanol, propanol, butanol, isopropanol et isobutanol ou tout mélange de ces solvants.The extraction solvents for the preparation of the extracts which are the subject of this patent can be chosen from water, propylene glycol, butylene glycol, glycerin, polyethylene glycol, methyl or ethyl ethers of diglycols, cyclic polyols, ethoxylated or propoxylated diglycols as well as the methanol, ethanol, propanol, butanol, isopropanol and isobutanol alkanols or any mixture of these solvents.

A titre d exemple nous citons un procédé d extraction pour illustrer I invention: 100 g de racine d ' Atractylodis lancea sont broyés, puis extraits à épuisement par macération à chaud dans 500 ml d éthanol. Après séparation des plantes et du solvant, on filtre l'extrait sur charbon actif, puis on évapore L'méthanol à sec.By way of example, we cite an extraction process to illustrate the invention: 100 g of Atractylodis lancea root are ground, then extracted to exhaustion by hot maceration in 500 ml of ethanol. After separation of the plants and the solvent, the extract is filtered over activated carbon, then the methanol is evaporated to dryness.

Parallèlement 100 g de racine broyée sont macérés (30 heures) dans un mélange de polyéthylène glycol et d eau (50/50 p/p), puis séparés par filtration. Le résidu sec de l'extraction éthanolique est repris dans l'extrait hydroglycolique à une proportion variant entre 1/10 et 1/1000, préférablement entre 1/20 et 1/100. Ceci constitue l'extrait total qui peut être utilisé dans une formule cosmétique ou dermopharmaceutique destinée à I ' application topique pour les soins de la peau, en particulier pour réduire la couche graisseuse des adipocytes de la hanche et/ou des cuisses.In parallel, 100 g of ground root are macerated (30 hours) in a mixture of polyethylene glycol and water (50/50 w / w), then separated by filtration. The dry residue from ethanolic extraction is taken up in the hydroglycolic extract in a proportion varying between 1/10 and 1/1000, preferably between 1/20 and 1/100. This constitutes the total extract which can be used in a cosmetic or dermopharmaceutical formula intended for topical application for skin care, in particular for reducing the fatty layer of adipocytes of the hip and / or thighs.

L'exemple de fabrication de l'extrait donné n'est pas limitatif. Les améliorations, optimisations et modifications du procédé envisageables sont évidentes pour l'homme de l'art. A la place de la macération simple, on peut employer des techniques à contre courant, la décoction, la lixiviation, I'extraction à l'aide d'ultrasons, de micro-ondes.The example of manufacture of the given extract is not limiting. The conceivable improvements, optimizations and modifications of the process are obvious to those skilled in the art. Instead of simple maceration, countercurrent techniques can be used, decoction, leaching, extraction using ultrasound, microwaves.

L'activité biochimique la plus intéressante des extraits de plantes citées est le pouvoir stimulateur de la libération des acides gras et du glycérol à partir des triglycérides contenus dans les adipocytes.The most interesting biochemical activity of the plant extracts mentioned is the stimulating power of the release of fatty acids and glycerol from the triglycerides contained in the adipocytes.

Un exemple d'une étude in vitro illustre cet effet:
Des adipocytes humains (obtenus à partir de morceaux de peau prélevés lors de la chirurgie plastique) sont mis en suspension dans un milieu de survie. Le métabolisme lipolytique de base est suivi par le dosage de glycérol et d'acides gras libérés dans le temps. An example from an in vitro study illustrates this effect:
Human adipocytes (obtained from pieces of skin removed during plastic surgery) are suspended in a survival medium. The basic lipolytic metabolism is followed by the dosage of glycerol and fatty acids released over time.

On ajoute ensuite différentes concentrations d'extraits préparés selon le procédé décrit précédemment ou un procédé similaire ; après un temps d'incubation plus ou moins long, on constate l'augmentation du métabolisme lipolytique par une augmentation de la quantité de glycérol et d'acides gras libérés dans le milieu. Un témoin positif de stimulation est constitué par la théophylline.Then added different concentrations of extracts prepared according to the method described above or a similar method; after a more or less long incubation time, there is an increase in lipolytic metabolism by an increase in the amount of glycerol and of fatty acids released in the medium. A positive stimulation control consists of theophylline.

Les résultats obtenus sont les suivants:
Augmentation du relargage de glycérol
Extrait d' Atractylodis lancea 137%
Extrait de Sinomeni diversifolia 243%
Théophylline 95%
Ces exemples ne sont pas limitatifs. Selon le type de procédé d'extraction employé, la quantité de plante mise en jeu, la concentration d'extrait utilisée dans le milieu cellulaire, l'activité lipolytique peut varier de +10 à +2000%. Il s'avère que l'addition de caféine, de théophylline ou d'autres dérivés de xanthine potentialisent encore I activité lipolytique.The results obtained are as follows:
Increased release of glycerol
Extract of Atractylodis launched 137%
Sinomeni diversifolia extract 243%
Theophylline 95%
These examples are not limitative. Depending on the type of extraction process used, the amount of plant involved, the concentration of extract used in the cell environment, the lipolytic activity can vary from +10 to + 2000%. It turns out that the addition of caffeine, theophylline or other xanthine derivatives further potentiates lipolytic activity.

En même temps, on constate que ces extraits possèdent une activité in vivo (application topique) non seulement amincissante (mise en évidence par échographie aux ultrasons dans une étude clinique sur 20 personnes), mais également raffermissante. L'étude au CutomètreR (Courage et Khazaka) permet de mesurer l'élasticité et la tonicité de la peau, d'où l'on peut déduire le paramètre "fermeté". On observe une augmentation significative de la fermeté de la peau à la suite d ' un traitement prolongé avec les extraits de ces plantes.At the same time, we note that these extracts have an in vivo activity (topical application) not only slimming (demonstrated by ultrasound ultrasound in a clinical study on 20 people), but also firming. The CutometerR study (Courage and Khazaka) allows the elasticity and tone of the skin to be measured, from which the "firmness" parameter can be deduced. A significant increase in the firmness of the skin is observed following a prolonged treatment with the extracts of these plants.

Les extraits ainsi obtenus peuvent être employés dans les produits cosmétiques et dermopharmaceutiques de toute sorte. De telles compositions présentent des activités amincissantes (réduction de l'épaisseur de la couche adipeuse des cuisses et/ou des hanches), raffermissantes (augmentation de la fermeté cutanée) et restructurantes (diminution de l'aspect "cellulite" = "peau d'orange"). The extracts thus obtained can be used in cosmetic and dermopharmaceutical products of all kinds. Such compositions have slimming activities (reduction of the thickness of the fatty layer of the thighs and / or hips), firming (increase in skin firmness) and restructuring (reduction of the "cellulite" = "skin" appearance. orange").

Les extraits de plantes objets du présent brevet peuvent être utilisés dans toute forme galénique employée en cosmétique : émulsions H/E et E/H, laits, lotions, gels, pommades, huiles pour le corps, savons, sticks, sprays, sans que cette liste soit limitative. The plant extracts which are the subject of this patent can be used in any galenic form used in cosmetics: O / W and W / O emulsions, milks, lotions, gels, ointments, body oils, soaps, sticks, sprays, without this list is exhaustive.

II est possible d'incorporer les extraits de plantes décrits dans des vecteurs cosmétiques comme les liposomes, les chylomicrons, les macro-, micro- et nanoparticules ainsi que les macro-, micro- et nanocapsules, de les absorber sur des polymères organiques poudreux, les talcs, bentonites et autres supports minéraux. It is possible to incorporate the plant extracts described in cosmetic vectors such as liposomes, chylomicrons, macro-, micro- and nanoparticles as well as macro-, micro- and nanocapsules, to absorb them on powdery organic polymers, talcs, bentonites and other mineral supports.

La concentration d'utilisation de ces extraits peut varier entre 0.1 et 30% (p/p), préférentiellement entre 0.5 et 10% dans le produit fini.The concentration of use of these extracts can vary between 0.1 and 30% (w / w), preferably between 0.5 and 10% in the finished product.

Les extraits de plantes objets du brevet peuvent être combinés dans les compositions cosmétiques avec tout autre ingrédient habituellement utilisé en cosmétique: lipides d'extraction et/ou de synthèse, polymères gélifiants et viscosants, tensioactifs et émulsifiants, principes actifs hydro- ou liposolubles, extraits d'autres plantes, extraits tissulaires, extraits marins. La combinaison avec d'autres agents stimulant la lipolyse tels que la caféine, la théophylline, les dérivés de xanthine en général, est particulièrement avantageuse pour réaliser 1' invention. The plant extracts which are the subject of the patent can be combined in cosmetic compositions with any other ingredient usually used in cosmetics: extraction and / or synthetic lipids, gelling and viscosifying polymers, surfactants and emulsifiers, water- or liposoluble active principles, extracts other plants, tissue extracts, marine extracts. The combination with other lipolysis stimulating agents such as caffeine, theophylline, xanthine derivatives in general, is particularly advantageous for carrying out the invention.

Claims (9)

REVENDICATIONS 1) Compositions cosmétiques ou dermopharmaceutiques à activité lipolytique1) Cosmetic or dermopharmaceutical compositions with lipolytic activity caractérisées en ce qu'elles contiennent un ou plusieurs extraits de plantes characterized in that they contain one or more plant extracts choisies parmi les genres Armeniacea, Atractylodis, Platicodon, chosen from the genera Armeniacea, Atractylodis, Platicodon, Sinomenum, Bupleurum, Pharbitidis, Coleus et Flemingia. Sinomenum, Bupleurum, Pharbitidis, Coleus and Flemingia. 2) Compositions cosmétiques ou dermopharmaceutiques à activité lipolytique2) Cosmetic or dermopharmaceutical compositions with lipolytic activity selon la revendication 1 caractérisées en ce qu'elles contiennent un ou according to claim 1 characterized in that they contain one or plusieurs extraits obtenus à partir d'une ou plusieurs des ressources several extracts obtained from one or more of the resources suivantes: graines d ' Armeniacea Mume, rhizome d ' Atractilodys lancea et following: seeds of Armeniacea Mume, rhizome of Atractilodys lancea and A. macrocephalis, racine de Platicody grandiflorum, racine et tige de A. macrocephalis, Platicody grandiflorum root, root and stem Sinomenum acutum, racine de de Bupleurum chinense, de graine de Sinomenum acutum, root of Bupleurum chinense, seed of Pharbitidis diversifolia, de racine Coleus forskohli, racine ou partie aérienne Pharbitidis diversifolia, from Coleus forskohli root, root or aerial part de Flemingia strobilifera. of Flemingia strobilifera. 3) Compositions cosmétiques ou dermopharmaceutiques à activité lipolytique3) Cosmetic or dermopharmaceutical compositions with lipolytic activity selon la revendication 2 caractérisées en ce que les extraits des plantes according to claim 2 characterized in that the plant extracts citées sont obtenus grâce à une extraction de la matière sèche au moyen cited are obtained by extracting the dry matter using des techniques de macération, de lixiviation, de décoction, d'extraction à maceration, leaching, decoction, extraction techniques contre courant, d'extraction à l'aide d'ultrasons, de micro-ondes. against current, extraction using ultrasound, microwave. 4) Compositions cosmétiques ou dermopharmaceutiques à activité lipolytique4) Cosmetic or dermopharmaceutical compositions with lipolytic activity selon la revendication 3 caractérisées en ce que le solvant d'extraction est according to claim 3 characterized in that the extraction solvent is choisi parmi le groupe constitué par: I'eau, le propylène glycol, les alcanols chosen from the group consisting of: water, propylene glycol, alkanols méthanol, éthanol, propanol, butanol, isopropanol et isobutanol, le butylène methanol, ethanol, propanol, butanol, isopropanol and isobutanol, butylene glycol, la glycérine, le polyéthylène glycol, les éthers méthyliques ou glycol, glycerin, polyethylene glycol, methyl ethers or éthyliques des diglycols, les polyols cycliques, les diglycols éthoxylés ou ethyl diglycols, cyclic polyols, ethoxylated diglycols or propoxylées ou tout mélange de ces solvants. propoxylates or any mixture of these solvents. 5) Compositions cosmétiques ou dermopharmaceutiques à activité lipolytique5) Cosmetic or dermopharmaceutical compositions with lipolytic activity selon l'une quelconque des revendications de 1 à 4 caractérisées en ce according to any one of claims 1 to 4, characterized in that que la concentration des extraits de plantes citées dans le produit fini est that the concentration of the plant extracts mentioned in the finished product is comprise entre 0.1 et 30% (p/p), préférentiellement entre 0.5 et 10% en between 0.1 and 30% (w / w), preferably between 0.5 and 10% in poids de la composition totale.  weight of the total composition. 6) Compositions cosmétiques ou dermopharmaceutiques à activité lipolytique6) Cosmetic or dermopharmaceutical compositions with lipolytic activity selon l'une quelconque des revendications de 1 à 5 caractérisées en ce according to any one of claims 1 to 5, characterized in that que les extraits des plantes citées sont utilisés dans toute forme galénique that the extracts from the plants mentioned are used in all dosage forms employée en cosmétique ou dermopharmacie à savoir: les émulsions H/E used in cosmetics or dermopharmacy, namely: O / W emulsions et E/H, laits, lotions, gels, pommades, huiles pour le corps, savons, sticks, and W / O, milks, lotions, gels, ointments, body oils, soaps, sticks, sprays. sprays. 7) Compositions cosmétiques ou dermopharmaceutiques à activité lipolytique7) Cosmetic or dermopharmaceutical compositions with lipolytic activity selon l'une quelconque des revendications de 1 à 6 caractérisées en ce according to any one of claims 1 to 6, characterized in that que les extraits des plantes citées sont incorporés dans des vecteurs that the extracts from the plants mentioned are incorporated into vectors cosmétiques comme les liposomes, les chylomicrons, les macro-, micro cosmetics like liposomes, chylomicrons, macro-, micro et nanoparticules ainsi que les macro-, micro- et nanocapsules, ou and nanoparticles as well as macro-, micro- and nanocapsules, or absorbés sur des polymères organiques poudreux, les talcs, bentonites et absorbed on powdery organic polymers, talcs, bentonites and autres supports minéraux. other mineral supports. 8) Compositions cosmétiques ou dermopharmaceutiques à activité lipolytique8) Cosmetic or dermopharmaceutical compositions with lipolytic activity selon l'une quelconque des revendications de 1 à 7 caractérisées en ce according to any one of claims 1 to 7, characterized in that que les extraits de plantes citées sont combinés dans les compositions that the plant extracts mentioned are combined in the compositions cosmétiques avec tout autre ingrédient habituellement utilisé en cosmetics with any other ingredient usually used in cosmétique: lipides d'extraction et/ou de synthèse, polymères gélifiants et cosmetic: extraction and / or synthetic lipids, gelling polymers and viscosants, tensioactifs et émulsifiants, principes actifs hydro- ou viscosants, surfactants and emulsifiers, hydro- or active ingredients liposolubles, extraits de plantes, extraits tissulaires, extraits marins, autres fat-soluble, plant extracts, tissue extracts, marine extracts, others agents stimulant la lipolyse tels que la caféine, la théophylline, les dérivés lipolysis stimulating agents such as caffeine, theophylline, derivatives de xanthine en général. of xanthine in general. 9) Compositions cosmétiques ou dermopharmaceutiques à activité lipolytique9) Cosmetic or dermopharmaceutical compositions with lipolytic activity selon l'une quelconque des revendications de 1 à 8 caractérisées en ce according to any one of claims 1 to 8, characterized in that que les extraits des plantes citées sont utilisés dans les applications that the extracts from the plants mentioned are used in the applications cosmétiques pour les soins de la peau, particulièrement le traitement cosmetics for skin care, especially treatment amincissant des surcharges pondérales des cuisses et des hanches, le slimming overweight thighs and hips, the traitement de la cellulite, le raffermissement cutané.  cellulite treatment, skin tightening.
FR9703740A 1997-03-25 1997-03-25 SLIMMING COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS Expired - Lifetime FR2761263B1 (en)

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FR9703740A FR2761263B1 (en) 1997-03-25 1997-03-25 SLIMMING COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS
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ITMI20040214A1 (en) * 2004-02-10 2004-05-10 Aboca S P A COSMETIC COMPOSITIONS CONTAINING ASSOCIATIONS OF BULPEURUM SPECIES AND SAGE MILTHIORRIZA EXTRACTS FOR THE REDUCTION AND CONTAINMENT OF CELLULITE BALLPEASTS

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