FR2755976B1 - Nouveaux complexes d'acides nucleiques et de polymere substitue par des residus entrainant la destabilisation des membranes cellulaires - Google Patents

Nouveaux complexes d'acides nucleiques et de polymere substitue par des residus entrainant la destabilisation des membranes cellulaires

Info

Publication number
FR2755976B1
FR2755976B1 FR9613990A FR9613990A FR2755976B1 FR 2755976 B1 FR2755976 B1 FR 2755976B1 FR 9613990 A FR9613990 A FR 9613990A FR 9613990 A FR9613990 A FR 9613990A FR 2755976 B1 FR2755976 B1 FR 2755976B1
Authority
FR
France
Prior art keywords
destabilization
free
groups
cell membranes
nucleic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9613990A
Other languages
English (en)
French (fr)
Other versions
FR2755976A1 (fr
Inventor
Patrick Midoux
Michel Monsigny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IDM Immuno Designed Molecules
Original Assignee
IDM Immuno Designed Molecules
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9613990A priority Critical patent/FR2755976B1/fr
Application filed by IDM Immuno Designed Molecules filed Critical IDM Immuno Designed Molecules
Priority to CA002267833A priority patent/CA2267833A1/fr
Priority to ES97945903T priority patent/ES2225992T3/es
Priority to DE69730348T priority patent/DE69730348T2/de
Priority to PCT/FR1997/002022 priority patent/WO1998022610A1/fr
Priority to AU51239/98A priority patent/AU742818B2/en
Priority to IL128912A priority patent/IL128912A/en
Priority to AT97945903T priority patent/ATE274066T1/de
Priority to JP52325798A priority patent/JP2001504344A/ja
Priority to EP97945903A priority patent/EP0946744B1/fr
Priority to US09/297,519 priority patent/US6372499B1/en
Publication of FR2755976A1 publication Critical patent/FR2755976A1/fr
Application granted granted Critical
Publication of FR2755976B1 publication Critical patent/FR2755976B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
FR9613990A 1996-11-15 1996-11-15 Nouveaux complexes d'acides nucleiques et de polymere substitue par des residus entrainant la destabilisation des membranes cellulaires Expired - Fee Related FR2755976B1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR9613990A FR2755976B1 (fr) 1996-11-15 1996-11-15 Nouveaux complexes d'acides nucleiques et de polymere substitue par des residus entrainant la destabilisation des membranes cellulaires
JP52325798A JP2001504344A (ja) 1996-11-15 1997-11-10 核酸のトランスフェクションのための、細胞膜の脱安定化を引き起こす残基を有する新規なポリマー性複合体
DE69730348T DE69730348T2 (de) 1996-11-15 1997-11-10 Neue polymerische komplexe für die transfektion von nukleinsaüren, mit resten für destabilisierung der zellmembranen
PCT/FR1997/002022 WO1998022610A1 (fr) 1996-11-15 1997-11-10 Nouveaux complexes polymeriques pour la transfection d'acides nucleiques, avec des residus destabilisant des membranes cellulaires
AU51239/98A AU742818B2 (en) 1996-11-15 1997-11-10 Novel polymeric complexes for the transfection of nucleic acids, with residues causing the destabilisation of cell membranes
IL128912A IL128912A (en) 1996-11-15 1997-11-10 Complexes of nucleic acids with polymers substituted by residues which enable transfection of cells
CA002267833A CA2267833A1 (fr) 1996-11-15 1997-11-10 Nouveaux complexes polymeriques pour la transfection d'acides nucleiques, avec des residus destabilisant des membranes cellulaires
ES97945903T ES2225992T3 (es) 1996-11-15 1997-11-10 Nuevos complejos polimericos para la transfeccion de acidos nucleicos, con residuos que desestabilizan unas membranas celulares.
EP97945903A EP0946744B1 (fr) 1996-11-15 1997-11-10 Nouveaux complexes polymeriques pour la transfection d'acides nucleiques, avec des residus destabilisant des membranes cellulaires
US09/297,519 US6372499B1 (en) 1996-11-15 1997-11-10 Polymeric complexes for the transfection of nucleic acids, with residues causing the destabilisation of cell membranes
AT97945903T ATE274066T1 (de) 1996-11-15 1997-11-10 Neue polymerische komplexe für die transfektion von nukleinsaüren, mit resten für destabilisierung der zellmembranen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9613990A FR2755976B1 (fr) 1996-11-15 1996-11-15 Nouveaux complexes d'acides nucleiques et de polymere substitue par des residus entrainant la destabilisation des membranes cellulaires

Publications (2)

Publication Number Publication Date
FR2755976A1 FR2755976A1 (fr) 1998-05-22
FR2755976B1 true FR2755976B1 (fr) 1999-01-15

Family

ID=9497684

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9613990A Expired - Fee Related FR2755976B1 (fr) 1996-11-15 1996-11-15 Nouveaux complexes d'acides nucleiques et de polymere substitue par des residus entrainant la destabilisation des membranes cellulaires

Country Status (11)

Country Link
US (1) US6372499B1 (https=)
EP (1) EP0946744B1 (https=)
JP (1) JP2001504344A (https=)
AT (1) ATE274066T1 (https=)
AU (1) AU742818B2 (https=)
CA (1) CA2267833A1 (https=)
DE (1) DE69730348T2 (https=)
ES (1) ES2225992T3 (https=)
FR (1) FR2755976B1 (https=)
IL (1) IL128912A (https=)
WO (1) WO1998022610A1 (https=)

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US6919076B1 (en) 1998-01-20 2005-07-19 Pericor Science, Inc. Conjugates of agents and transglutaminase substrate linking molecules
AU770963B2 (en) * 1998-12-02 2004-03-11 I.D.M. Immuno-Designed Molecules New oligomeric conjugates liable to transfer biological molecules into cells
AU7352200A (en) * 1999-09-01 2001-03-26 Regents Of The University Of California, The Novel natriuretic peptide receptors, interacting compounds and methods of regulating proliferation and/or survival of neurons
US7070807B2 (en) 1999-12-29 2006-07-04 Mixson A James Branched histidine copolymers and methods for using same
WO2001047496A1 (en) * 1999-12-29 2001-07-05 Mixson A James Histidine copolymer and methods for using same
JP5610659B2 (ja) * 2000-07-21 2014-10-22 ルバンス セラピュティックス インク．Ｒｅｖａｎｃｅ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 多成分生物学的輸送システム
FR2812658B1 (fr) * 2000-08-01 2005-04-15 De Bruno Vandiere Procede d'analyse d'acides nucleiques
US7465708B2 (en) 2002-11-25 2008-12-16 Mixson A James Branched cationic copolymers and methods for antimicrobial use
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
JP2007527431A (ja) 2004-03-03 2007-09-27 ルバンス セラピュティックス 局所的診断及び治療用の輸送のための組成物及び方法
US7740861B2 (en) * 2004-06-16 2010-06-22 University Of Massachusetts Drug delivery product and methods
US20060040879A1 (en) * 2004-08-21 2006-02-23 Kosak Kenneth M Chloroquine coupled nucleic acids and methods for their synthesis
AU2005284727A1 (en) * 2004-09-17 2006-03-23 University Of Massachusetts Compositions and their uses for lysosomal enzyme deficiencies
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
US20060211004A1 (en) 2005-02-15 2006-09-21 Ilsley Diane D Methods and compositions for determining non-specific cytotoxicity of a transfection agent
ZA200707352B (en) 2005-03-03 2009-04-29 Revance Therapeutics Inc Compositions and methods for topical application and transdermal delivery of botulinum toxins
ATE526991T1 (de) * 2005-10-24 2011-10-15 Univ Massachusetts Zusammensetzungen und ihre verwendungen für die gentherapeutische behandlung von knochenerkrankungen
EP2222283A2 (en) * 2007-10-29 2010-09-01 University of Massachusetts Yeast cell wall protein (ycwp) encapsulated multilayered nanoparticles for nucleic acid delivery (sirna)
FR2928373B1 (fr) * 2008-03-05 2010-12-31 Centre Nat Rech Scient Polymere derive de la polyethylenimine lineaire pour le transfert de gene.
US8815818B2 (en) 2008-07-18 2014-08-26 Rxi Pharmaceuticals Corporation Phagocytic cell delivery of RNAI
EP2342340A1 (en) 2008-09-22 2011-07-13 Rxi Pharmaceuticals Corporation Rna interference in skin indications
WO2010078536A1 (en) 2009-01-05 2010-07-08 Rxi Pharmaceuticals Corporation Inhibition of pcsk9 through rnai
US20120277155A1 (en) 2011-02-25 2012-11-01 Medtronic, Inc. Therapy for kidney disease and/or heart failure
EP2750697A4 (en) 2011-09-02 2015-03-25 Medtronic Inc CHIMERIC NATRIURETIC PEPTIDE COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF
US9162191B2 (en) * 2012-11-15 2015-10-20 Board Of Trustees Of The University Of Alabama Imidazole-containing polymer membranes and methods of use
CN102949729B (zh) * 2012-11-20 2014-06-18 中国科学院宁波材料技术与工程研究所 主动靶向型小干扰核糖核酸输送载体及其制备方法
US12544344B2 (en) 2017-04-19 2026-02-10 Phio Pharmaceuticals Corp. Topical delivery of nucleic acid compounds
AR122446A1 (es) * 2020-04-29 2022-09-14 Medimmune Llc Composiciones y métodos para suministrar agentes farmacéuticamente activos
US20240050582A1 (en) * 2021-03-08 2024-02-15 Universiteit Gent Conjugates including multiple saccharidic chains on a linear protein and uses in mammals feed

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
GB1316990A (en) * 1970-09-17 1973-05-16 Roche Products Ltd Imidazolyl derivatives
US5166320A (en) * 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
JP2827287B2 (ja) * 1988-07-05 1998-11-25 武田薬品工業株式会社 水溶性薬物含有徐放型マイクロカプセル
US5354844A (en) * 1989-03-16 1994-10-11 Boehringer Ingelheim International Gmbh Protein-polycation conjugates
DE59010432D1 (de) * 1989-03-16 1996-09-05 Boehringer Ingelheim Int Genetische Einheiten zur Inhibierung der Funktion von RNA
EP0563249B1 (en) * 1990-12-19 1997-04-23 Advanced Magnetics Incorporated Targeting of therapeutic agents using polysaccharides
DE4104186A1 (de) * 1991-02-12 1992-08-13 Genentech Inc Neue, ueber endozytose in hoehere eukaryotische zellen aufnehmbare, nukleinsaeure enthaltende komplexe
EP0610441A4 (en) * 1991-10-29 1996-01-10 Clover Cons Ltd CROSSLINKABLE POLYSACCHARIDES, POLYCATIONS AND LIPIDS CAN BE USED TO ENCODE AND DISPENSE MEDICINAL PRODUCTS.
WO1993019768A1 (en) * 1992-04-03 1993-10-14 The Regents Of The University Of California Self-assembling polynucleotide delivery system
US5733762A (en) * 1994-04-28 1998-03-31 I.D.M. Immuno-Designed Molecules Complexes of nucleic acid and polymer, their process of preparation and their use for the transfection of cells
FR2719316B1 (fr) * 1994-04-28 1996-05-31 Idm Nouveaux complexes d'acide nucléique et de polymère, leur procédé de préparation et leur utilisation pour la transfection de cellules.
US6030941A (en) * 1996-05-01 2000-02-29 Avi Biopharma, Inc. Polymer composition for delivering substances in living organisms

Also Published As

Publication number Publication date
WO1998022610A1 (fr) 1998-05-28
EP0946744A1 (fr) 1999-10-06
IL128912A0 (en) 2000-02-17
DE69730348D1 (de) 2004-09-23
IL128912A (en) 2006-06-11
CA2267833A1 (fr) 1998-05-28
EP0946744B1 (fr) 2004-08-18
US6372499B1 (en) 2002-04-16
AU742818B2 (en) 2002-01-10
ATE274066T1 (de) 2004-09-15
DE69730348T2 (de) 2005-09-01
AU5123998A (en) 1998-06-10
FR2755976A1 (fr) 1998-05-22
JP2001504344A (ja) 2001-04-03
ES2225992T3 (es) 2005-03-16

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