FR2723682A1 - Absorbable nutritional supplement for children and adolescents, to ensure daily micronutrient intake - Google Patents

Absorbable nutritional supplement for children and adolescents, to ensure daily micronutrient intake Download PDF

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Publication number
FR2723682A1
FR2723682A1 FR9410269A FR9410269A FR2723682A1 FR 2723682 A1 FR2723682 A1 FR 2723682A1 FR 9410269 A FR9410269 A FR 9410269A FR 9410269 A FR9410269 A FR 9410269A FR 2723682 A1 FR2723682 A1 FR 2723682A1
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Prior art keywords
vitamin
pref
nutritional supplement
natural
excipient
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FR9410269A
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French (fr)
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FR2723682B1 (en
Inventor
Jean Paul Curtay
Christian Boiron
Jacky Abecassis
Bernard Baume
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Boiron SA
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Boiron SA
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10Carbonates; Bicarbonates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15Vitamins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16Inorganic salts, minerals or trace elements
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Inorganic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Absorbable nutritional supplement based on vitamins and mineral salts to ensure a daily micronutrient intake, comprises calcium carbonate; zinc citrate; beta -carotene; a mixt. of vitamins B1, B2, B5, B6, B8, B9, B12 and PP; vitamin E; vitamin C; and an excipient. The excipient pref. comprises dextrose, microcrystalline cellulose, colloidal silica and magnesium stearate. The vitamin E and beta -carotene are natural. The compsn. pref. comprises 65.86682 % (pref. 110 mg) calcium carbonate, 17.95 % (pref. 30 mg) vitamin C, 9.55 % (pref. 16 mg) zinc citrate, 2.99 % (pref. 5 mg) vitamin PP, 1.2 % (pref. 2 mg) natural vitamin E, 0.30 % (pref. 0.5 mg) natural beta -carotene, 1.2 % (pref. 2 mg) vitamin B5, 0.36 % (pref. 0.6 mg) vitamin B6, 0.3 % (pref. 0.5 mg) vitamin B2, 0.24 % (pref. 0.4 mg) vitamin B1, 0.04 % (pref. 67 mu g) vitamin B9, 0.003 % (pref. 50 mu g) vitamin B8 and 0.00018 % (pref. 0.3 mu g) vitamin B12 and excipient to 300 mg.

Description

COMPLEMENT NUTRITIONNEL ABSORBABLE POUR L'EOUILIBRE OUOTIDIEN DE L'ENFANT ET L'ADOLESCENT.ABSORBABLE NUTRITIONAL SUPPLEMENT FOR EARLY HEARING OF CHILDREN AND ADOLESCENTS.

L'invention vise un complément nutritionnel absorbable destiné à amener à l'organisme de l'enfant et l'adolescent les apports quotidiens nécessaires en nutriments pour préserver et maintenir au mieux sa forme. Il favorise un développement physique et intellectuel harmonieux. The invention relates to an absorbable nutritional supplement intended to bring to the body of the child and the adolescent the daily intakes necessary in nutrients to preserve and maintain its form as well as possible. It promotes harmonious physical and intellectual development.

Par "complément nutritionnel", on désigne un ensemble absorbable formant une supplémentation en micronutriments qui, complétant l'alimentation quotidienne, permet de renforcer l'organisme dans son ensemble. By "nutritional supplement" is meant an absorbable whole forming a micronutrient supplementation which, supplementing the daily diet, makes it possible to strengthen the organism as a whole.

L'invention permet de couvrir les besoins quotidiens de l'enfant et de l'adolescent en micronutriments et en vitamines, pour compenser les insuffisances dues notamment à une alimentation déséquilibrée et au rythme de la vie. Comme on le sait, ces insuffisances peuvent à la longue entrainer des désordres plus ou moins graves. The invention makes it possible to cover the daily needs of the child and the adolescent in micronutrients and vitamins, to compensate for the insufficiencies due in particular to an unbalanced diet and to the rhythm of life. As we know, these shortcomings can in the long run lead to more or less serious disorders.

L'invention pallie ces inconvénients. Elle consiste en un complément nutritionnel absorbable per-os à base de sels minéraux et de vitamines, pour assurer l'apport quotidien en micronutriments, qui se caractérise en ce qu'il comprend
- du carbonate de calcium;
- du citrate de zinc;
- du béta-carotène;
- un mélange de vitamines B1, B2, B5, B6, B8, B9, B12 et PP;
- de la vitamine C;
- de la vitamine E;
- et un excipient.
The invention overcomes these drawbacks. It consists of an absorbable per-bone nutritional supplement based on mineral salts and vitamins, to ensure the daily intake of micronutrients, which is characterized in that it comprises
- calcium carbonate;
- zinc citrate;
- beta-carotene;
- a mixture of vitamins B1, B2, B5, B6, B8, B9, B12 and PP;
- vitamin C;
- vitamin E;
- and an excipient.

En d'autres termes, l'invention concerne une composition spécifique de sels minéraux particuliers et de vitamines particulières, qui permet d'assurer les apports quotidiens complémentaires souhaités chez l'enfant et l'adolescent. In other words, the invention relates to a specific composition of particular mineral salts and of particular vitamins, which makes it possible to ensure the daily supplements desired in children and adolescents.

Le calcium favorise l'optimisation du capital osseux atteint à la fin de la croissance chez l'adolescent, et partant réduit le risque de déminéralisation future chez la jeune femme. Calcium promotes the optimization of bone capital reached at the end of growth in adolescents, and therefore reduces the risk of future demineralization in young women.

Le zinc
- est indispensable au bon fonctionnement des cellules et à la
croissance des tissus;
- est essentiel aux systèmes de défenses anti-infectieuses et joue
un rôle important dans l'immunité.
Zinc
- is essential for the proper functioning of the cells and the
tissue growth;
- is essential to anti-infectious defense systems and plays
an important role in immunity.

- est nécessaire à la synthèse des protéines, notamment la
kératine qui forme les cheveux et les ongles.
- is necessary for protein synthesis, especially
keratin which forms hair and nails.

Le citrate de zinc possède un excellent rapport absorption/efficacité. Zinc citrate has an excellent absorption / efficiency ratio.

En pratique, le bétacarotène utilisé est le bétacarotène naturel. Ce composé est un précurseur de la vitamine A. Il permet à l'organisme de synthétiser de la vitamine A en fonction de ses besoins. C'est également un anti-oxydant aux propriétés particulières, capable de neutraliser les radicaux libres résultant en particulier de l'exposition au soleil.  In practice, the betacarotene used is natural betacarotene. This compound is a precursor of vitamin A. It allows the body to synthesize vitamin A according to its needs. It is also an antioxidant with special properties, capable of neutralizing free radicals resulting in particular from exposure to the sun.

Les vitamines B et PP sont essentielles à
- la bonne assimilation des nutriments (protéines, lipides,
glucides) apportés par l'alimentation,
- la production de l'énergie,
- la synthèse des neurotransmetteurs dont dépendent les capacités
de concentration et de mémorisation.
Vitamins B and PP are essential to
- the proper assimilation of nutrients (proteins, lipids,
carbohydrates) provided by food,
- energy production,
- the synthesis of neurotransmitters on which the capacities depend
of concentration and memorization.

La vitamine E utilisée est de préférence la vitamine E naturelle. Elle diminue le risque de dommages pulmonaires provoqués par la pollution, et de dommages musculaires crées par l'effort. Elle joue un rôle d'antioxydant protecteur des graisses. The vitamin E used is preferably natural vitamin E. It reduces the risk of lung damage caused by pollution, and muscle damage created by exertion. It acts as a protective antioxidant for fats.

La vitamine C joue un rôle essentiel dans
- l'énergie physique et psychique,
- les défenses immunitaires,
- la protection contre les toxiques (tabac, vapeurs d'essence,
nitrates, pesticides ...),
- la solidité de la trame osseuse,
- la santé des gencives,
- la réduction de la durée et de l'intensité des épisodes
infectieux.
Vitamin C plays an essential role in
- physical and psychic energy,
- immune defenses,
- protection against toxic substances (tobacco, petrol vapors,
nitrates, pesticides ...),
- the strength of the bone structure,
- gum health,
- reduction in the duration and intensity of episodes
infectious.

La combinaison de la vitamine C, de la vitamine E et du bétacarotène provoque une synergie qui exacerbe les actions antioxydantes de chacun de ces trois composants.  The combination of vitamin C, vitamin E and betacarotene causes a synergy that exacerbates the antioxidant actions of each of these three components.

Les excipients sont avantageusement constitués par un mélange de dextrose, de cellulose micro-cristalline, de silice colloïdale utilisée pour ses propriétés anti-agglomérantes lors de la fabrication des comprimés, et enfin de stéarate de magnésium connu comme agent lubrifiant de compression. The excipients are advantageously constituted by a mixture of dextrose, microcrystalline cellulose, colloidal silica used for its anti-caking properties during the manufacture of the tablets, and finally magnesium stearate known as a compressive lubricating agent.

Dans une forme d'exécution pratique, le complément nutritionnel conforme à l'invention sous forme de comprimés de trois cents (300) milligrammes contient en poids et en pourcent en poids de principes actifs:
- 110 mg, soit 65,86682 % de carbonate de calcium
- 30 mg, soit 17,95% de vitamine C
- 16 mg, soit 9,55% de citrate de zinc
- 5 mg, soit 2,99% de vitamine PP
- 2 mg, soit 1,2% de vitamine E naturelle
-0,5 mg, soit 0,30% de bétacarotène naturel
-2mg,soit 1,2% de vitamine B5
-0,6 mg, soit 0,36% de vitamine B6
-0,5 mg, soit 0,30% de vitamine B2
-0,4 mg, soit 0,24% de vitamine B1
- 67 Rg, soit 0,04% de vitamine B9
- 50 Rg, soit 0,003% de vitamine B8
- 0,3 Fg, soit 0,00018% de vitamine B12
- et le complément en masse à 300 mg d'un excipient formé par un
mélange de dextrose, cellulose microcristalline, silice colloïdale et de
stéarate de magnésium.
In a practical embodiment, the nutritional supplement according to the invention in the form of tablets of three hundred (300) milligrams contains by weight and in percent by weight of active ingredients:
- 110 mg, i.e. 65.86682% calcium carbonate
- 30 mg, or 17.95% of vitamin C
- 16 mg, i.e. 9.55% zinc citrate
- 5 mg, or 2.99% of vitamin PP
- 2 mg, i.e. 1.2% natural vitamin E
-0.5 mg, i.e. 0.30% natural betacarotene
-2mg, i.e. 1.2% vitamin B5
-0.6 mg, i.e. 0.36% vitamin B6
-0.5 mg, i.e. 0.30% vitamin B2
-0.4 mg, i.e. 0.24% vitamin B1
- 67 Rg, or 0.04% of vitamin B9
- 50 Rg, or 0.003% of vitamin B8
- 0.3 Fg, or 0.00018% of vitamin B12
- and the mass supplement to 300 mg of an excipient formed by a
mixture of dextrose, microcrystalline cellulose, colloidal silica and
magnesium stearate.

Pour garantir l'intégrité des différents composés, on effectue avantageusement la formulation en deux phases, respectivement une phase humide puis une phase sèche qui intègre les principes actifs fragiles, dont notamment les vitamines.  To guarantee the integrity of the various compounds, the formulation is advantageously carried out in two phases, respectively a wet phase and then a dry phase which incorporates the fragile active principles, including in particular the vitamins.

Le complément nutritionnel conforme à l'invention peut être absorbé sous forme de poudre, de gélules, de granules, mais de préférence sous forme de comprimés. The nutritional supplement according to the invention can be absorbed in the form of powder, capsules, granules, but preferably in the form of tablets.

Ce complément nutritionnel, sous forme de comprimés de 300 mg, peut être avalé tous les jours, à la fin du petit déjeuner, à raison de
-un comprimé pour les enfants de 4 à 9 ans,
- deux comprimés pour les enfants et adolescents de 10 à 15 ans.
This nutritional supplement, in the form of tablets of 300 mg, can be swallowed every day, at the end of breakfast, at a rate of
-a tablet for children from 4 to 9 years old,
- two tablets for children and adolescents from 10 to 15 years old.

Le complément se caractérise par la bonne compatibilité des composants entre eux et leur synergie d'action, ce qui contribue avantageusement chez l'enfant et l'adolescent:
- à favoriser une croissance équilibrée;
- à améliorer la forme physique et intellectuelle;
- et à stimuler les défenses immunitaires.
The complement is characterized by the good compatibility of the components with each other and their synergy of action, which advantageously contributes to children and adolescents:
- to promote balanced growth;
- to improve physical and intellectual fitness;
- and to stimulate the immune defenses.

Claims (6)

REVENDICATIONS 1/ Complément nutritionnel absorbable per-os à base de sels minéraux et de vitamines, pour assurer l'apport quotidien en micronutriments, caractérisé en ce qu'il comprend: 1 / Oral absorbable nutritional supplement based on mineral salts and vitamins, to ensure the daily intake of micronutrients, characterized in that it comprises: - du carbonate de calcium; - calcium carbonate; - du citrate de zinc; - zinc citrate; - du béta-carotène;  - beta-carotene; - un mélange de vitamines B1, B2, B5, B6, B8, B9, B12 et PP; - a mixture of vitamins B1, B2, B5, B6, B8, B9, B12 and PP; - de la vitamine E; - vitamin E; - de la vitamine C; - vitamin C; - et un excipient - and an excipient 2/ Complément nutritionnel selon la revendication 1, caractérisé en ce que l'excipient est constitué par un mélange de dextrose, de cellulose micro-cristalline, de silice colloïdale et de stéarate de magnésium. 2 / nutritional supplement according to claim 1, characterized in that the excipient consists of a mixture of dextrose, microcrystalline cellulose, colloidal silica and magnesium stearate. 3/ Complément nutritionnel selon les revendications 1 ou 2, caractérisé en ce que la vitamine E est de la vitamine E naturelle. 3 / Nutritional supplement according to claims 1 or 2, characterized in that vitamin E is natural vitamin E. 4/ Complément nutritionnel selon l'une des revendications 1 à 3, caractérisé en ce que le bétacarotène est du bétacarotène naturel.  4 / Nutritional supplement according to one of claims 1 to 3, characterized in that the betacarotene is natural betacarotene. 5/ Complément nutritionnel selon l'une des revendications 1 à 4, caractérisé en ce qu'il comprend, en pourcent en poids de principes actifs: 5 / nutritional supplement according to one of claims 1 to 4, characterized in that it comprises, in percent by weight of active ingredients: - 65,86682 % de carbonate de calcium - 65.86682% calcium carbonate - 17,95% de vitamine C - 17.95% vitamin C - 9,55% de citrate de zinc - 9.55% zinc citrate - 2,99% de vitamine PP - 2.99% vitamin PP - 1,2% de vitamine E naturelle - 1.2% natural vitamin E - 0,30% de bétacarotène naturel - 0.30% natural betacarotene - 1,2% de vitamine B5 - 1.2% vitamin B5 - 0,36% de vitamine B6 - 0.36% vitamin B6 -0,3% de vitamine B2 -0.3% vitamin B2 - 0,24% de vitamine B1 - 0.24% vitamin B1 - 0,04% de vitamine B9 - 0.04% vitamin B9 - 0,003% de vitamine B8 - 0.003% vitamin B8 - 0,00018% de vitamine B12.  - 0.00018% of vitamin B12. 6/ Comprimé de complément nutritionnel selon la revendication 5, caractérisé en ce qu'il comprend: 6 / nutritional supplement tablet according to claim 5, characterized in that it comprises: - 110 mg de carbonate de calcium - 110 mg of calcium carbonate - 30 mg de vitamine C - 30 mg of vitamin C - 16 mg de citrate de zinc - 16 mg zinc citrate - 5 mg de vitamine PP - 5 mg of vitamin PP - 2 mg de vitamine E naturelle - 2 mg of natural vitamin E - 0,5 mg de bétacarotène naturel - 0.5 mg of natural betacarotene - 2 mg de vitamine B5  - 2 mg of vitamin B5 - 0,6 mg de vitamine B6 - 0.6 mg of vitamin B6 - 0,5 mg de vitamine B2 - 0.5 mg of vitamin B2 - 0,4 mg de vitamine B1  - 0.4 mg of vitamin B1 - 67 g de vitamine B9 - 67 g of vitamin B9 - 50 g de vitamine B8  - 50 g of vitamin B8 - 0,3 g de vitamine B12 - 0.3 g of vitamin B12 -et le complément en masse à 300 mg d'un excipient formé par un mélange de dextrose, cellulose microcristalline, silice colloïdale et de stéarate de magnésium.  -and the mass supplement to 300 mg of an excipient formed by a mixture of dextrose, microcrystalline cellulose, colloidal silica and magnesium stearate.
FR9410269A 1994-08-19 1994-08-19 ABSORBABLE NUTRITIONAL SUPPLEMENT FOR THE DAILY BALANCE OF CHILDREN AND ADOLESCENTS. Expired - Fee Related FR2723682B1 (en)

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FR9410269A FR2723682B1 (en) 1994-08-19 1994-08-19 ABSORBABLE NUTRITIONAL SUPPLEMENT FOR THE DAILY BALANCE OF CHILDREN AND ADOLESCENTS.

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FR9410269A FR2723682B1 (en) 1994-08-19 1994-08-19 ABSORBABLE NUTRITIONAL SUPPLEMENT FOR THE DAILY BALANCE OF CHILDREN AND ADOLESCENTS.

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1175203A1 (en) * 1999-04-30 2002-01-30 Drugtech Corporation Folic acid supplement
FR2851920A1 (en) * 2003-03-06 2004-09-10 Larena Sa Compositions containing a glucose homeostasis modulator, a cardiovascular agent, and an antioxidant for the prevention and treatment of metabolic syndrome

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684529A (en) * 1984-03-09 1987-08-04 Kabushiki Kaisha Fuji Kikaku Process for the preparation of iodizable calcium composition
WO1991011117A2 (en) * 1990-02-05 1991-08-08 Board Of Regents, The University Of Texas System Dietary supplements comprising vitamins and minerals
WO1992021355A1 (en) * 1991-05-28 1992-12-10 The Procter & Gamble Company Calcium, trace mineral, vitamin d and drug therapy combinations
FR2693876A1 (en) * 1992-07-24 1994-01-28 Vani Micro-nutrient compsn. to combat the effects of stress - contains B vitamin(s), octacosanol, calcium, magnesium, chromium and zinc and opt. other micro-nutrients
EP0596717A1 (en) * 1992-11-05 1994-05-11 Chandra Consultants Nutritional supplement for the elderly
FR2704393A1 (en) * 1993-04-30 1994-11-04 Boiron Nutritional supplement which can be taken orally to optimise growth and maintain robustness of bones

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684529A (en) * 1984-03-09 1987-08-04 Kabushiki Kaisha Fuji Kikaku Process for the preparation of iodizable calcium composition
WO1991011117A2 (en) * 1990-02-05 1991-08-08 Board Of Regents, The University Of Texas System Dietary supplements comprising vitamins and minerals
WO1992021355A1 (en) * 1991-05-28 1992-12-10 The Procter & Gamble Company Calcium, trace mineral, vitamin d and drug therapy combinations
FR2693876A1 (en) * 1992-07-24 1994-01-28 Vani Micro-nutrient compsn. to combat the effects of stress - contains B vitamin(s), octacosanol, calcium, magnesium, chromium and zinc and opt. other micro-nutrients
EP0596717A1 (en) * 1992-11-05 1994-05-11 Chandra Consultants Nutritional supplement for the elderly
FR2704393A1 (en) * 1993-04-30 1994-11-04 Boiron Nutritional supplement which can be taken orally to optimise growth and maintain robustness of bones

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1175203A1 (en) * 1999-04-30 2002-01-30 Drugtech Corporation Folic acid supplement
JP2002543107A (en) * 1999-04-30 2002-12-17 ドラッグテック コーポレイション Folic acid supplements
EP1175203A4 (en) * 1999-04-30 2004-02-25 Drugtech Corp Folic acid supplement
EP1857102A1 (en) * 1999-04-30 2007-11-21 Drugtech Corporation Folic acid supplement
FR2851920A1 (en) * 2003-03-06 2004-09-10 Larena Sa Compositions containing a glucose homeostasis modulator, a cardiovascular agent, and an antioxidant for the prevention and treatment of metabolic syndrome

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Publication number Publication date
FR2723682B1 (en) 1996-09-27

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