FR2668928A1 - Use of homotaurine in cosmetics for care of the scalp and the stimulation of hair growth - Google Patents

Use of homotaurine in cosmetics for care of the scalp and the stimulation of hair growth Download PDF

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Publication number
FR2668928A1
FR2668928A1 FR9014191A FR9014191A FR2668928A1 FR 2668928 A1 FR2668928 A1 FR 2668928A1 FR 9014191 A FR9014191 A FR 9014191A FR 9014191 A FR9014191 A FR 9014191A FR 2668928 A1 FR2668928 A1 FR 2668928A1
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sep
cosmetic compositions
compositions according
homotaurine
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FR2668928B1 (en
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Lintner Karl
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Sederma SA
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Sederma SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The patent describes cosmetic preparations containing homotaurine, a sulphur amino acid, as a stimulator of the hair follicle and as an agent that decreases hair loss.

Description

La perte des cheveux et la calvitie sont de vieux problèmes de l'humanité, touchant plus les personnes du sexe masculin que celles du sexe féminin. Peu de personnes acceptent vraiment l'apparition de la calvitie du fait que les cheveux tombent et qu'aucun remède durable et efficace permet une repousse des cheveux perdus.Hair loss and baldness are old problems of humanity, affecting more males than females. Few people really accept the appearance of baldness because the hair falls and no lasting and effective remedy allows regrowth of lost hair.

Les produits proposés et commercialisés pour combattre ce phénomène sont de nature diverse, basés sur la connaissance encore incomplète des mécanismes de la pousse des cheveux. L'apport de soufre sous différentes formes, un apport en vitamines et en composés énergisants sont les plus souvent proposés.The products proposed and marketed to combat this phenomenon are of a different nature, based on the still incomplete knowledge of the mechanisms of hair growth. Sulfur intake in various forms, a contribution of vitamins and energizing compounds are most often proposed.

Le présent brevet a pour objet des préparations cosmétiques nouvelles qui, sans proposer une solution définitive, permettent une amélioration notable de la repousse des cheveux.The present patent relates to novel cosmetic preparations which, without providing a definitive solution, allow a significant improvement in hair regrowth.

L'utilisation des acides aminés naturels des protéines, comme apport nutritif pour les cellules de la peau et comme stimulateur de leur métabolisme, a fait l'objet de nombreuses publications et de certains brevets.The use of natural amino acids in proteins, as a nutrient supply for skin cells and as a stimulator of their metabolism, has been the subject of numerous publications and certain patents.

L'acide aminé, taurine, ne fait pas partie des vingt acides aminés trouvés dans les protéines. I1 est, néanmoins, présent dans l'organisme et reconnu comme acide aminé important du point de vue nutritionnel et énergétique. Sa particularité chimique résulte de la présence d'un groupe acide sulfonique remplaçant le groupe carboxylique. L'homotaurine est un analogue de la taurine, contenant un groupe CH2 en plus, entre le groupe amine et le groupe acide sulfonique. De ce fait, l'Homotaurine ressemble à un autre acide aminé de grande importance qui, lui non plus ne se trouve pas au sein des protéines, mais qui joue un rôle clef dans certains processus de neurotransmission : le GABA, (-amino-butyric acid.The amino acid, taurine, is not one of the twenty amino acids found in proteins. It is, nevertheless, present in the body and recognized as an amino acid important from the nutritional and energetic point of view. Its chemical peculiarity results from the presence of a sulfonic acid group replacing the carboxylic group. Homotaurine is a taurine analogue, containing an additional CH2 group, between the amine group and the sulfonic acid group. As a result, Homotaurine is similar to another important amino acid, which is also not found in proteins, but plays a key role in certain neurotransmission processes: GABA, (-amino-butyric) acid.

L'objet de l'invention, décrite ici, est la découverte que les acides aminés, non naturels de formule générale NH2-X-SO3H où X représente une chaîne alkyle de C1 à C10, linéaire ou ramifiée, en particulier 1 'Homotaurine (acide 3-amino-propane sulfonique)
ossèdent une activité stimulante, énergisante et préventive au niveau du cuir chevelu. Cette activité peut être renforcée de façon synergique en associant ces acides aminés à des polysaccharides sulfatés et des filtrats de culture bactérienne.The subject of the invention, described here, is the discovery that the unnatural amino acids of general formula NH 2 -X-SO 3 H where X represents a linear or branched C 1 to C 10 alkyl chain, in particular homotaurine ( 3-amino-propane sulfonic acid)
This is a stimulating, energizing and preventive activity on the scalp. This activity can be synergistically enhanced by combining these amino acids with sulfated polysaccharides and bacterial culture filtrates.

Un exemple va illustrer cet effet
Des lotions capillaires préparées avec de l'Homotaurine, des chondroitines sulfates de requin et un filtrat de jus de
fermentation bactérienne, ont été comparées dans le test suivant
Quarante-cinq personnes, de sexe masculin, ont été sélectionnées sur le critère de la fréquence de la chute des cheveux. Un examen dermatologique général a été opéré.An example will illustrate this effect
Hair lotions prepared with Homotaurine, chondroitin sulphate shark and a juice filtrate
bacterial fermentation, were compared in the following test
Forty-five people, male, were selected on the basis of the frequency of hair loss. A general dermatological examination was performed.

2
A un endroit, au centre du crâne, une surface de 2 cm a été rasée puis photographiée immédiatement après rasage, puis trois jours plus tard. Les photographies obtenues sont ensuite soumises à une analyse morphométrique par un système informatique d'analyse d'images.2
At one point, in the center of the skull, a surface of 2 cm was shaved and then photographed immediately after shaving, then three days later. The resulting photographs are then subjected to morphometric analysis by an image analysis computer system.

Le nombre de cheveux ainsi que leur longueur sont calculés pour chaque zone digitalisée. (Phototrichogramme).The number of hairs and their length are calculated for each digitized area. (Phototrichogram).

Après une application des lotions pendant trois mois, le même protocole est réalisé.After applying the lotions for three months, the same protocol is performed.

Ces phototrichogrammes permettent d'évaluer quantitativement, par analyse statistique des images digitalisées, l'amélioration de la vigueur, de la santé et de la vitesse de repousse des cheveux.These phototrichograms make it possible to quantitatively evaluate, by statistical analysis of the digitized images, the improvement of the vigor, the health and the speed of regrowth of the hair.

Les résultats obtenus montrent clairement un effet synergique, entre la présence d'Homotaurine et le filtrat bactérien, tout en indiquant un effet de l'Homotaurine seule, toutefois, de moindre degré.

Figure img00020001
The results obtained clearly show a synergistic effect, between the presence of Homotaurine and the bacterial filtrate, while indicating an effect of Homotaurine alone, however, to a lesser degree.
Figure img00020001

<tb><Tb>

<SEP> AVANT <SEP> TRAITEMENT
<tb> Moyenne <SEP> Pourcentage <SEP> de <SEP> cheveux <SEP> Pousse
<tb> Moyenne <SEP> <SEP> en <SEP> Télogènes <SEP> Catagènes <SEP> en <SEP> 3 <SEP> jours
<tb> 15 <SEP> jours <SEP> Anagènes <SEP> Télogènes <SEP> Catagènes <SEP> (mm) <SEP>
<tb> <SEP> FORMULE <SEP> 1 <SEP> 60 <SEP> 15 <SEP> 25 <SEP> 0,85 <SEP> + <SEP> 0,04
<tb> <SEP> FORMULE <SEP> 2 <SEP> 62 <SEP> 17 <SEP> 21 <SEP> 0,90 <SEP> + <SEP> 0,05
<tb> <SEP> FORMULE <SEP> 3 <SEP> 59 <SEP> 13 <SEP> 28 <SEP> 0,88 <SEP> + <SEP> 0,04
<tb>

Figure img00030001
<SEP> BEFORE <SEP> TREATMENT
<tb> Average <SEP> Percentage <SEP> of <SEP> Hair <SEP> Shoot
<tb> Average <SEP><SEP> in <SEP> Telogenes <SEP> Catagens <SEP> in <SEP> 3 <SEP> days
<tb> 15 <SEP> days <SEP> Anagens <SEP> Telogenes <SEP> Catagens <SEP> (mm) <SEP>
<tb><SEP> FORMULA <SEP> 1 <SEP> 60 <SEP> 15 <SEP> 25 <SEP> 0.85 <SEP> + <SEP> 0.04
<tb><SEP> FORMULA <SEP> 2 <SEP> 62 <SEP> 17 <SEP> 21 <SEP> 0.90 <SEP> + <SEP> 0.05
<tb><SEP> FORMULA <SEP> 3 <SEP> 59 <SEP> 13 <SEP> 28 <SEP> 0.88 <SEP> + <SEP> 0.04
<Tb>
Figure img00030001

<tb> <SEP> APRES <SEP> TRAITEMENT
<tb> Moyenne <SEP> Pourcentage <SEP> de <SEP> cheveux <SEP> Pousse
<tb> sur <SEP> en <SEP> 3 <SEP> jours
<tb> 15 <SEP> jours <SEP> Anagènes <SEP> Catagènes <SEP> (mm) <SEP>
<tb> <SEP> FORMULE <SEP> 1 <SEP> 75 <SEP> 8 <SEP> 17 <SEP> 1,11 <SEP> + <SEP> 0,05
<tb> <SEP> FORMULE <SEP> 2 <SEP> 70 <SEP> | <SEP> 9 <SEP> 21 <SEP> 1,02 <SEP> + <SEP> 0,06
<tb> <SEP> FORMULE <SEP> 3 <SEP> 66 <SEP> 11 <SEP> 23 <SEP> 1,01 <SEP> + <SEP> 0,04
<tb>
FORMULE 1 = Homotaurine 0,2 %
Chondroitine sulfate 0,1 %
Filtrat bactérien 1,0 %
Excipient q.s.p. 100
FORMULE 2 = Homotaurine 0,3 %
Chondroitine sulfate 0,1 %
Excipient q.s.p. 100
FORMULE 3 = Homotaurine 0,5 %
Excipient q.s.p. 100
L'objet de l'invention concerne les compositions cosmétiques dont la concentration de l'acide aminé est comprise entre 0,1 et 10 %, dont la quantité du filtrat bactérien est comprise entre 0,2 et 20 % et dont la concentration en polysaccharides est comprise entre 0,05 et 5 %
Ces compositions cosmétiques peuvent être des lotions, gels, émulsions ou shampooings et peuvent contenir des liposomes, des micro- ou nanocapsules ou -particules comme vecteurs des produits actifs. <tb><SEP> AFTER <SEP> TREATMENT
<tb> Average <SEP> Percentage <SEP> of <SEP> Hair <SEP> Shoot
<tb> on <SEP> in <SEP> 3 <SEP> days
<tb> 15 <SEP> days <SEP> Anagens <SEP> Catagens <SEP> (mm) <SEP>
<tb><SEP> FORMULA <SEP> 1 <SEP> 75 <SEP> 8 <SEP> 17 <SEP> 1,11 <SEP> + <SEP> 0,05
<tb><SEP> FORMULA <SEP> 2 <SEP> 70 <SEP> | <SEP> 9 <SEP> 21 <SEP> 1.02 <SEP> + <SEP> 0.06
<tb><SEP> FORMULA <SEP> 3 <SEP> 66 <SEP> 11 <SEP> 23 <SEP> 1.01 <SEP> + <SEP> 0.04
<Tb>
FORMULA 1 = Homotaurine 0.2%
Chondroitin sulfate 0.1%
Bacterial filtrate 1.0%
Excipient qs 100
FORM 2 = Homotaurine 0.3%
Chondroitin sulfate 0.1%
Excipient qs 100
FORM 3 = Homotaurine 0.5%
Excipient qs 100
The object of the invention relates to cosmetic compositions whose concentration of the amino acid is between 0.1 and 10%, the amount of the bacterial filtrate is between 0.2 and 20% and the concentration of polysaccharides is between 0.05 and 5%
These cosmetic compositions may be lotions, gels, emulsions or shampoos and may contain liposomes, micro- or nanocapsules or particles as vectors of the active products.

Claims (10)

REVENDICATIONS 1. Compositions cosmétiques caractérisées en ce qu'elles1. Cosmetic compositions characterized in that they contiennent au moins un acide aminé de la formule générale NH2-X-SO3H  contain at least one amino acid of the general formula NH2-X-SO3H X représente une chaîne alkyle de C1 à C10, linéaire ou X represents an alkyl chain of C1 to C10, linear or ramifiée. branched. 2. Compositions cosmétiques selon la revendication 1,2. Cosmetic compositions according to claim 1, caractérisées en ce qu'elles contiennent de l'Homotaurine characterized in that they contain Homotaurine (X = -CH2CH2CH2-) (X = -CH2CH2CH2-) 3. Compositions cosmétiques selon les revendications 1 et 2,3. Cosmetic compositions according to claims 1 and 2, caractérisées en ce qu'elles contiennent des polysaccharides characterized in that they contain polysaccharides sulfatés sulfated 4. Compositions cosmétiques selon les revendications de 1 à4. Cosmetic compositions according to claims from 1 to 3, caractérisées en ce qu'elles contiennent un filtrat de 3, characterized in that they contain a filtrate of fermentation bactérienne bacterial fermentation 5. Compositions cosmétiques selon les revendications de 1 àCosmetic compositions according to claims 1 to 5 4, caractérisées en ce que la concentration de l'acide aminé 4, characterized in that the concentration of the amino acid est compris entre 0,1 et 10 %. is between 0.1 and 10%. 6. Compositions cosmétiques selon les revendications de 1 à6. Cosmetic compositions according to claims from 1 to 5, caractérisées en ce que les polysaccharides sont des 5, characterized in that the polysaccharides are chondroitines sulfates. chondroitin sulphates. 7. Compositions cosmétiques selon les revendications de 1 àCosmetic compositions according to claims from 1 to 6, caractérisées en ce que la concentration en polysaccharides 6, characterized in that the concentration of polysaccharides est comprise entre 0,05 et 5% is between 0.05 and 5% 8. Composition cosmétiques selon les revendications de 1 à 7,Cosmetic composition according to claims 1 to 7, caractérisées en ce que la quantité de filtrat bactérien est characterized in that the amount of bacterial filtrate is comprise entre 0,2 et 20 %.  between 0.2 and 20%. 9. Compositions cosmétiques selon les revendications de 1 à9. Cosmetic compositions according to claims from 1 to 8, caractérisées en ce qu'elles sont sous forme de lotions, 8, characterized in that they are in the form of lotions, gels, émulsions ou shampooings. gels, emulsions or shampoos. 10. Compositions cosmétiques selon les revendications de 1 à10. Cosmetic compositions according to claims from 1 to 9, caractérisées en ce qu'elles contiennent des liposomes 9, characterized in that they contain liposomes des micro- ou nanocapsules ou -particules comme vecteur des micro- or nanocapsules or particles as a vector of produits actifs.  active products.
FR9014191A 1990-11-12 1990-11-12 Use of homotaurine in cosmetics for care of the scalp and the stimulation of hair growth Granted FR2668928A1 (en)

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FR2668928B1 FR2668928B1 (en) 1994-12-16

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2696932A1 (en) * 1992-10-19 1994-04-22 Sederma Sa Cosmetic compsns. contg. plant extracts and microbial culture filtrate - exhibits synergistic effects w.r.t. stimulating growth of fibroblasts, reducing depth of wrinkles and improving skin tone
FR2841101A1 (en) * 2002-06-21 2003-12-26 Oreal Oral administration of taurine and hypotaurine for the prevention and treatment of hair loss
FR2841102A1 (en) * 2002-06-21 2003-12-26 Oreal Oral administration of taurine and hypotaurine for the prevention and treatment of hair loss
FR2841129A1 (en) * 2002-06-21 2003-12-26 Oreal Use of taurine, hypotaurine, homotaurine or their salts to prepare topical compositions for treating or preventing hair follicle aging or alopecia
EP2255782A1 (en) * 2009-05-25 2010-12-01 Keune Haircosmetics Manufacturing B.V. Composition for the prevention or treatment of hair loss, and method of preparation
EP2260845A3 (en) * 2002-06-21 2012-08-22 L'Oréal Use of polyphenols for the treatment of alopecia
IT201800003880A1 (en) * 2018-03-22 2019-09-22 Jean Paul Myne Srl Cosmetic treatment for improving the aesthetic appearance and physical-mechanical characteristics of keratins through the use of organic sulfo-amino binding substances.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU82689A1 (en) * 1980-04-28 1980-12-15 Herbaria Orszagos Gyogynoeveny HAIR GROWTH COMPOSITION AND PROCESS FOR PREPARING THE SAME
GB2167958A (en) * 1984-12-06 1986-06-11 Roussel Uclaf Compositions for treating the scalp
JPS61145109A (en) * 1984-12-19 1986-07-02 Nakanishi Eiko Cosmetic
WO1990009778A1 (en) * 1989-03-03 1990-09-07 Bioetica Cosmetic composition for hair growth containing a glycoprotein

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU82689A1 (en) * 1980-04-28 1980-12-15 Herbaria Orszagos Gyogynoeveny HAIR GROWTH COMPOSITION AND PROCESS FOR PREPARING THE SAME
GB2167958A (en) * 1984-12-06 1986-06-11 Roussel Uclaf Compositions for treating the scalp
JPS61145109A (en) * 1984-12-19 1986-07-02 Nakanishi Eiko Cosmetic
WO1990009778A1 (en) * 1989-03-03 1990-09-07 Bioetica Cosmetic composition for hair growth containing a glycoprotein

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol. 139, 1982, pages 143-160, New York, US; S.W. SCHAFFER et al.: "Taurine transport by recon3tituted membrane vesicles" *
PATENT ABSTRACTS OF JAPAN, vol. 10, no. 339 (C-385)[2395], 15 novembre 1986; & JP-A-61 145 109 (EIKO NAKANISHI) 02-07-1986 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2696932A1 (en) * 1992-10-19 1994-04-22 Sederma Sa Cosmetic compsns. contg. plant extracts and microbial culture filtrate - exhibits synergistic effects w.r.t. stimulating growth of fibroblasts, reducing depth of wrinkles and improving skin tone
FR2841101A1 (en) * 2002-06-21 2003-12-26 Oreal Oral administration of taurine and hypotaurine for the prevention and treatment of hair loss
FR2841102A1 (en) * 2002-06-21 2003-12-26 Oreal Oral administration of taurine and hypotaurine for the prevention and treatment of hair loss
FR2841129A1 (en) * 2002-06-21 2003-12-26 Oreal Use of taurine, hypotaurine, homotaurine or their salts to prepare topical compositions for treating or preventing hair follicle aging or alopecia
EP2260845A3 (en) * 2002-06-21 2012-08-22 L'Oréal Use of polyphenols for the treatment of alopecia
EP2255782A1 (en) * 2009-05-25 2010-12-01 Keune Haircosmetics Manufacturing B.V. Composition for the prevention or treatment of hair loss, and method of preparation
IT201800003880A1 (en) * 2018-03-22 2019-09-22 Jean Paul Myne Srl Cosmetic treatment for improving the aesthetic appearance and physical-mechanical characteristics of keratins through the use of organic sulfo-amino binding substances.

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