FR2662698A1 - Nouveaux facteurs de croissance neurotropes comprenant un peptide homeoboite. - Google Patents

Nouveaux facteurs de croissance neurotropes comprenant un peptide homeoboite. Download PDF

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Publication number
FR2662698A1
FR2662698A1 FR9006912A FR9006912A FR2662698A1 FR 2662698 A1 FR2662698 A1 FR 2662698A1 FR 9006912 A FR9006912 A FR 9006912A FR 9006912 A FR9006912 A FR 9006912A FR 2662698 A1 FR2662698 A1 FR 2662698A1
Authority
FR
France
Prior art keywords
peptide
arg
neurons
sequence
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR9006912A
Other languages
English (en)
French (fr)
Other versions
FR2662698B1 (enExample
Inventor
Alain Joliot
Alain Prochiantz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique
Original Assignee
Centre National de la Recherche Scientifique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9006912A priority Critical patent/FR2662698A1/fr
Application filed by Centre National de la Recherche Scientifique filed Critical Centre National de la Recherche Scientifique
Priority to DE69122472T priority patent/DE69122472T2/de
Priority to EP91910774A priority patent/EP0485578B1/fr
Priority to PCT/FR1991/000444 priority patent/WO1991018981A2/fr
Priority to PT97877A priority patent/PT97877A/pt
Priority to IE191491A priority patent/IE911914A1/en
Priority to BR919105783A priority patent/BR9105783A/pt
Priority to AT91910774T priority patent/ATE143691T1/de
Priority to JP51035391A priority patent/JP3282130B2/ja
Publication of FR2662698A1 publication Critical patent/FR2662698A1/fr
Priority to US08/238,518 priority patent/US5888762A/en
Application granted granted Critical
Publication of FR2662698B1 publication Critical patent/FR2662698B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
    • C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Insects & Arthropods (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FR9006912A 1990-06-05 1990-06-05 Nouveaux facteurs de croissance neurotropes comprenant un peptide homeoboite. Granted FR2662698A1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR9006912A FR2662698A1 (fr) 1990-06-05 1990-06-05 Nouveaux facteurs de croissance neurotropes comprenant un peptide homeoboite.
EP91910774A EP0485578B1 (fr) 1990-06-05 1991-06-05 Facteurs de croissance neurotropes comprenant un peptide homeoboite
PCT/FR1991/000444 WO1991018981A2 (fr) 1990-06-05 1991-06-05 Facteurs de croissance neurotropes comprenant un peptide homeoboite
PT97877A PT97877A (pt) 1990-06-05 1991-06-05 Processo para a preparacao de composicoes farmaceuticas contendo peptidos homeocaixas (semelhante a caixa)
DE69122472T DE69122472T2 (de) 1990-06-05 1991-06-05 Neurotropische wachstumsfaktoren, die ein homeobox-peptid enthalten
IE191491A IE911914A1 (en) 1990-06-05 1991-06-05 Novel neurotropic growth factors comprising a homeobox¹peptide
BR919105783A BR9105783A (pt) 1990-06-05 1991-06-05 Polipeptidio,processo para o tratamento em vidro de neuronios e composicoes celular e farmaceutica
AT91910774T ATE143691T1 (de) 1990-06-05 1991-06-05 Neurotropische wachstumsfaktoren, die ein homeobox-peptid enthalten
JP51035391A JP3282130B2 (ja) 1990-06-05 1991-06-05 ホメオボックス・ペプチドを含む新規な神経親和性成長因子
US08/238,518 US5888762A (en) 1990-06-05 1994-05-05 Neurotropic growth factors comprising a homeobox peptide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9006912A FR2662698A1 (fr) 1990-06-05 1990-06-05 Nouveaux facteurs de croissance neurotropes comprenant un peptide homeoboite.

Publications (2)

Publication Number Publication Date
FR2662698A1 true FR2662698A1 (fr) 1991-12-06
FR2662698B1 FR2662698B1 (enExample) 1995-03-24

Family

ID=9397246

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9006912A Granted FR2662698A1 (fr) 1990-06-05 1990-06-05 Nouveaux facteurs de croissance neurotropes comprenant un peptide homeoboite.

Country Status (9)

Country Link
EP (1) EP0485578B1 (enExample)
JP (1) JP3282130B2 (enExample)
AT (1) ATE143691T1 (enExample)
BR (1) BR9105783A (enExample)
DE (1) DE69122472T2 (enExample)
FR (1) FR2662698A1 (enExample)
IE (1) IE911914A1 (enExample)
PT (1) PT97877A (enExample)
WO (1) WO1991018981A2 (enExample)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0574527A4 (enExample) * 1991-03-05 1994-01-19 Colorado State University Research Foundation
WO1997011174A1 (en) * 1995-09-21 1997-03-27 Cyclacel Limited Cyclin depenpent kinase binding compounds
WO1997014794A1 (en) * 1995-10-20 1997-04-24 University Of Dundee ACTIVATION OF p53 PROTEIN
WO1997042222A1 (en) * 1996-05-08 1997-11-13 Cyclacel Limited Methods and means for inhibition of cdk4 activity
US6242201B1 (en) 1994-11-03 2001-06-05 Cyclacel Limited Identification of the P21WaF1-PCNA interaction site and therapeutic applications thereof
FR2897780A1 (fr) * 2006-02-28 2007-08-31 Centre Nat Rech Scient Utilisation de la proteine a homeodomaine engrailed comme anxiolytique
US8809350B2 (en) 2004-08-27 2014-08-19 Cyclacel Limited Purine and pyrimidine CDK inhibitors and their use for the treatment of autoimmune diseases
WO2017071889A1 (en) * 2015-09-23 2017-05-04 Centre National De La Recherche Scientifique Homeoproteins for use in the treatment of neurodegenerative disorders

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2682875A1 (fr) * 1991-10-24 1993-04-30 Fidia France Sarl Utilisation de l'acide polysialique alpha2-8 pour la regulation de l'action des peptides homeoboites.
US5846743A (en) * 1995-02-22 1998-12-08 Brigham And Women's Hospital, Inc. Polyphoshoinositide binding peptides for intracellular drug delivery
GB9814527D0 (en) * 1998-07-03 1998-09-02 Cyclacel Ltd Delivery system
US6800286B1 (en) 1998-08-19 2004-10-05 The Regents Of The University Of Colorado Chimeric fibroblast growth factor proteins, nucleic acid molecules, and uses thereof
ES2318906T3 (es) 1998-11-13 2009-05-01 Cyclacel Limited Vectores de transposicion derivados de helice 3 de homeodominio de antennapedia.
FR2810046B1 (fr) * 2000-06-07 2004-09-10 Neurotech Procede d'immortalisation conditionnelle de cellules et les constructions proteiques pour sa mise en oeuvre
DE10027777A1 (de) * 2000-06-07 2001-12-13 Otogene Ag Transfektionsverfahren
GB0803352D0 (en) 2008-02-22 2008-04-02 Ntnu Technology Transfer As Oligopeptidic compounds and uses thereof
AU2010238346A1 (en) 2009-04-14 2011-11-03 Trojan Technologies Ltd. Therapeutic Antennapedia-antibody molecules and methods of use thereof
GB201507722D0 (en) 2015-05-06 2015-06-17 Norwegian Univ Sci & Tech Ntnu Anti-bacterial agents and their use in therapy
JP2026503094A (ja) 2023-01-13 2026-01-27 ブレインエバー 安定化エングレイルドタンパク質水性組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5082670A (en) * 1988-12-15 1992-01-21 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BIO ESSAYS, vol. 10, nos. 2,3, février-mars 1989, pages 82-85; D.G. WILKINSON: "Homeobox genes and development of the vertebrate CNS" *
MOL. CELL. BIOL., vol. 6, no. 12, décembre 1986, pages 4676-4689; A. LAUGHON et al.: "Structure of transcripts from the homeotic antennapedia gene of Drosophila melanogaster: Two promoters control the major protein-coding region" *
NUCLEIC ACIDS RESEARCH, vol. 17, 1989, pages 10385-10402; D. ACAMPORA et al.: "The human HOX gene family" *
PROC. NATL. ACAD. SCI., vol. 86, juin 1989, pages 4756-4760; P. ERNFORS et al.: "A cell line producing recombinant nerve growth factor evokes growth responses in instrinsic and grafted central cholinergic neurons" *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0574527A4 (enExample) * 1991-03-05 1994-01-19 Colorado State University Research Foundation
US6242201B1 (en) 1994-11-03 2001-06-05 Cyclacel Limited Identification of the P21WaF1-PCNA interaction site and therapeutic applications thereof
US6569833B1 (en) 1995-09-21 2003-05-27 Cyclacel Limited Cyclin dependent kinase binding peptides
WO1997011174A1 (en) * 1995-09-21 1997-03-27 Cyclacel Limited Cyclin depenpent kinase binding compounds
WO1997014794A1 (en) * 1995-10-20 1997-04-24 University Of Dundee ACTIVATION OF p53 PROTEIN
US6962792B1 (en) 1996-05-08 2005-11-08 Cyclacel Limited Methods and means for inhibition of Cdk4 activity
WO1997042222A1 (en) * 1996-05-08 1997-11-13 Cyclacel Limited Methods and means for inhibition of cdk4 activity
US8809350B2 (en) 2004-08-27 2014-08-19 Cyclacel Limited Purine and pyrimidine CDK inhibitors and their use for the treatment of autoimmune diseases
FR2897780A1 (fr) * 2006-02-28 2007-08-31 Centre Nat Rech Scient Utilisation de la proteine a homeodomaine engrailed comme anxiolytique
WO2007099227A3 (fr) * 2006-02-28 2007-10-18 Centre Nat Rech Scient Utilisation de la proteine a homeodomaine engrailed comme anxiolytique
US8575105B2 (en) 2006-02-28 2013-11-05 Centre National De La Recherche Scientifique Use of the engrailed homeodomain protein as anxiolytic
WO2017071889A1 (en) * 2015-09-23 2017-05-04 Centre National De La Recherche Scientifique Homeoproteins for use in the treatment of neurodegenerative disorders
EP3960195A1 (en) * 2015-09-23 2022-03-02 Centre national de la recherche scientifique Engrailed for treatment of amyotrophic lateral sclerosis

Also Published As

Publication number Publication date
JP3282130B2 (ja) 2002-05-13
FR2662698B1 (enExample) 1995-03-24
EP0485578B1 (fr) 1996-10-02
DE69122472D1 (de) 1996-11-07
WO1991018981A2 (fr) 1991-12-12
WO1991018981A3 (fr) 1992-03-19
DE69122472T2 (de) 1997-04-17
ATE143691T1 (de) 1996-10-15
EP0485578A1 (fr) 1992-05-20
IE911914A1 (en) 1991-12-18
BR9105783A (pt) 1992-07-21
JPH05502885A (ja) 1993-05-20
PT97877A (pt) 1992-04-30

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