FR2659327A1 - Derives du benzisothiazolinone-1-dioxyde, utilisables comme inhibiteurs des elastases. - Google Patents

Derives du benzisothiazolinone-1-dioxyde, utilisables comme inhibiteurs des elastases. Download PDF

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Publication number
FR2659327A1
FR2659327A1 FR9002951A FR9002951A FR2659327A1 FR 2659327 A1 FR2659327 A1 FR 2659327A1 FR 9002951 A FR9002951 A FR 9002951A FR 9002951 A FR9002951 A FR 9002951A FR 2659327 A1 FR2659327 A1 FR 2659327A1
Authority
FR
France
Prior art keywords
radical
formula
alkene
alkane
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR9002951A
Other languages
English (en)
French (fr)
Inventor
Robert Ladislas
Moczar Elemer
Hornebeck William
Georges
Kerneur Christian Marie-Pierre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique
Original Assignee
Centre National de la Recherche Scientifique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique filed Critical Centre National de la Recherche Scientifique
Priority to FR9002951A priority Critical patent/FR2659327A1/fr
Priority to AU72635/91A priority patent/AU636013B2/en
Priority to CA002037665A priority patent/CA2037665A1/en
Priority to US07/666,093 priority patent/US5338747A/en
Priority to ES91301895T priority patent/ES2102994T3/es
Priority to DE69126460T priority patent/DE69126460T2/de
Priority to EP91301895A priority patent/EP0446047B1/en
Priority to MYPI91000361A priority patent/MY106067A/en
Priority to AT91301895T priority patent/ATE154347T1/de
Priority to KR91003708A priority patent/KR960014782B1/ko
Priority to JP3125607A priority patent/JPH04234863A/ja
Priority to ZA911728A priority patent/ZA911728B/xx
Priority to BR919100938A priority patent/BR9100938A/pt
Priority to IN69/BOM/91A priority patent/IN172035B/en
Priority to TW080102851A priority patent/TW200472B/zh
Publication of FR2659327A1 publication Critical patent/FR2659327A1/fr
Priority to IDP185092A priority patent/ID820B/id
Priority to US08/230,048 priority patent/US5411978A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR9002951A 1990-03-08 1990-03-08 Derives du benzisothiazolinone-1-dioxyde, utilisables comme inhibiteurs des elastases. Pending FR2659327A1 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
FR9002951A FR2659327A1 (fr) 1990-03-08 1990-03-08 Derives du benzisothiazolinone-1-dioxyde, utilisables comme inhibiteurs des elastases.
AU72635/91A AU636013B2 (en) 1990-03-08 1991-03-06 Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors
CA002037665A CA2037665A1 (en) 1990-03-08 1991-03-06 Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors
US07/666,093 US5338747A (en) 1990-03-08 1991-03-07 Benzoisothiazolinone-1-dioxide derivatives as elastase inhibitors
ES91301895T ES2102994T3 (es) 1990-03-08 1991-03-07 Derivados de benzisotiazolinona-1-dioxido como inhibidores de elastasa.
DE69126460T DE69126460T2 (de) 1990-03-08 1991-03-07 Benzisothiazolinon-1-dioxyde als Elastase-Inhibitoren
EP91301895A EP0446047B1 (en) 1990-03-08 1991-03-07 Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors
MYPI91000361A MY106067A (en) 1990-03-08 1991-03-07 Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors.
AT91301895T ATE154347T1 (de) 1990-03-08 1991-03-07 Benzisothiazolinon-1-dioxyde als elastase- inhibitoren
KR91003708A KR960014782B1 (en) 1990-03-08 1991-03-08 Benzisothiazolinone 1-dioxide derivatives and elastase inhibitors composition comprising them
JP3125607A JPH04234863A (ja) 1990-03-08 1991-03-08 エラスターゼ阻害剤としてのベンゾイソチアゾリノン−１−ジオキシド誘導体
ZA911728A ZA911728B (en) 1990-03-08 1991-03-08 Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors
BR919100938A BR9100938A (pt) 1990-03-08 1991-03-08 Composicao que compreende um inibidor de elastase,derivados de 1-dioxido de benzisotiazolinona e processo para tratamento com cosmetico
IN69/BOM/91A IN172035B (enExample) 1990-03-08 1991-03-08
TW080102851A TW200472B (enExample) 1990-03-08 1991-04-13
IDP185092A ID820B (id) 1990-03-08 1992-01-29 Turunan benzisotiazolinon-1-dioksid sebagai penghambat elastase
US08/230,048 US5411978A (en) 1990-03-08 1994-04-19 Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9002951A FR2659327A1 (fr) 1990-03-08 1990-03-08 Derives du benzisothiazolinone-1-dioxyde, utilisables comme inhibiteurs des elastases.

Publications (1)

Publication Number Publication Date
FR2659327A1 true FR2659327A1 (fr) 1991-09-13

Family

ID=9394523

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9002951A Pending FR2659327A1 (fr) 1990-03-08 1990-03-08 Derives du benzisothiazolinone-1-dioxyde, utilisables comme inhibiteurs des elastases.

Country Status (16)

Country Link
US (2) US5338747A (enExample)
EP (1) EP0446047B1 (enExample)
JP (1) JPH04234863A (enExample)
KR (1) KR960014782B1 (enExample)
AT (1) ATE154347T1 (enExample)
AU (1) AU636013B2 (enExample)
BR (1) BR9100938A (enExample)
CA (1) CA2037665A1 (enExample)
DE (1) DE69126460T2 (enExample)
ES (1) ES2102994T3 (enExample)
FR (1) FR2659327A1 (enExample)
ID (1) ID820B (enExample)
IN (1) IN172035B (enExample)
MY (1) MY106067A (enExample)
TW (1) TW200472B (enExample)
ZA (1) ZA911728B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5306818A (en) * 1990-11-01 1994-04-26 Sterling Winthrop Inc. Tetrahydro 2-saccharinylmerthyl aryl carboxylates
US5250696A (en) * 1990-11-01 1993-10-05 Sterling Winthrop Inc. 2-saccharinylmethyl aryl carboxylate
US5512589A (en) * 1990-11-01 1996-04-30 Sterling Winthrop Inc. 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
AU653279B2 (en) * 1991-12-30 1994-09-22 Sanofi Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
TW226016B (enExample) * 1991-12-30 1994-07-01 Sterling Winthrop Inc
US6375948B1 (en) 1999-07-12 2002-04-23 Kao Corporation Treating method for suppressing hair growth
GB0129987D0 (en) * 2001-12-14 2002-02-06 Zylepsis Ltd Skin compositions
US7423155B2 (en) 2003-11-14 2008-09-09 3M Innovative Properties Company N-sulfonyldicarboximide containing tethering compounds
US7169933B2 (en) 2003-11-14 2007-01-30 3M Innovative Properties Company N-sulfonylaminocarbonyl containing compounds
US7943388B2 (en) 2003-11-14 2011-05-17 3M Innovative Properties Company Acoustic sensors and methods
US7179923B2 (en) 2003-11-14 2007-02-20 3M Innovative Properties Company N-sulfonylaminocarbonyl containing compounds
US7361767B2 (en) 2003-11-14 2008-04-22 3M Innovative Properties Company N-sulfonyldicarboximide containing tethering compounds
US7402678B2 (en) 2004-12-17 2008-07-22 3M Innovative Properties Company Multifunctional amine capture agents
US7342082B2 (en) 2004-12-17 2008-03-11 3M Innovative Properties Company Soluble polymers as amine capture agents and methods
EP1699768B1 (en) * 2003-12-30 2014-09-24 3M Innovative Properties Company Multifunctional amine capture agents
US7544754B2 (en) * 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
US7544755B2 (en) 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
US7544756B2 (en) 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
US8034448B2 (en) * 2008-08-19 2011-10-11 Los Alamos National Security, Llc Fibrous composites comprising carbon nanotubes and silica
AR079232A1 (es) 2009-12-01 2012-01-04 Lubrizol Advanced Mat Inc Polimeros multiproposito estables hidroliticamente
KR102537985B1 (ko) 2016-09-12 2023-05-30 인테그랄 헬스 인코퍼레이티드 Gpr120 조정제로서 유용한 단환형 화합물
WO2018049328A1 (en) 2016-09-12 2018-03-15 Numerate, Inc. Bicyclic compounds useful as gpr120 modulators

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4195023A (en) * 1975-08-20 1980-03-25 Merck & Co., Inc. 2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin
US4276298A (en) * 1978-03-24 1981-06-30 Merck & Co., Inc. 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2546164B1 (fr) * 1983-05-16 1987-07-17 Centre Nat Rech Scient Nouveaux derives de peptides, leur preparation et leur application comme inhibiteurs de l'elastase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4195023A (en) * 1975-08-20 1980-03-25 Merck & Co., Inc. 2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin
US4276298A (en) * 1978-03-24 1981-06-30 Merck & Co., Inc. 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF THE CHEMICAL SOCIETY, 1957, pages 492-493, Londres, GB; E. STEPHEN et al.: "The preparation of 2-acyl-3-oxo-4 : 5-benzo-1 : 2-thiazole 1 : 1 - dioxides (N-acylsaccharins) for the identification of monocarboxylic acids" *

Also Published As

Publication number Publication date
CA2037665A1 (en) 1991-09-09
ATE154347T1 (de) 1997-06-15
DE69126460T2 (de) 1997-12-04
KR960014782B1 (en) 1996-10-19
IN172035B (enExample) 1993-03-20
EP0446047B1 (en) 1997-06-11
JPH04234863A (ja) 1992-08-24
EP0446047A1 (en) 1991-09-11
ZA911728B (en) 1992-11-25
TW200472B (enExample) 1993-02-21
MY106067A (en) 1995-03-31
US5338747A (en) 1994-08-16
ID820B (id) 1996-07-22
BR9100938A (pt) 1991-11-05
ES2102994T3 (es) 1997-08-16
AU636013B2 (en) 1993-04-08
AU7263591A (en) 1991-09-12
US5411978A (en) 1995-05-02
DE69126460D1 (de) 1997-07-17
KR910016330A (ko) 1991-11-05

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