FR2656522A1 - ODONTOTHERAPEUTIC MATERIALS. - Google Patents

Abstract

We describe an odontotherapeutic material based on two liquids A and B containing materials capable of immediately forming, by mixing, precipitates difficult to dissolve. Liquids A and B are applied successively to the affected region.

Description

ODONTOTHERAPEUTIC MATERIALS

  The present invention relates to lenitives, primers and filling materials used for odontotherapy, and more particularly to lenitives for hypersensitivity, coating primers and

  filling material for root canals.

  Among the stimuli to the teeth are hyper-

  tenderness and pulpalgia, which are considered

  clinically as posing serious problems.

  Hypersensitivity is induced when vital teeth are placed in senso-sthenic conditions, by exposure of their dentins, and come into physical or chemical contact with cold or bittersweet foods and cold or bittersweet drinks, cold, a galvanic current, toothbrushes, toothpicks, etc., and cause induced pain and acute pain,

  although they are transient and short-lived.

  Brânnstrâm's hydrodynamic theory on the mechanism of hypersensitivity teaches that an external stimulus, applied to the surface of the dentin, brings a fluid

  tissue (or pulp) to move through the canali-

  dentin cules inward or outward and thereby stimulates the dentin nerves in the pulp to

cause pain.

  However, as various other theories have

  also suggested on the mechanism of hypersensitivity

  t, this one was treated until now by various therapies,

as set out below.

  (1) Mechanical protection of the surfaces of the exposed dentinal canaliculi vis-à-vis external stimuli For this purpose, a "Hyperband" containing

  paraformaldehyde is applied to these surfaces.

  (2) Protection of the dentinal canaliculi from

  stimulus of external origin by favoring their intra-

  calcification with a view to their closure For this purpose, a

  "Saforide" containing a solution of silver fluoride-

  diammine or a "F vanish" containing fluoride

  sodium is applied to the dentinal canaliculi -

  therapy (2-1) As a variant, the principle of iontophoresis is applied to introduce an ionized medicament into a solution, deep in the affected region, using the therapy current (2-2). (3) A solution of silver nitrate is applied to the odontoblasts to modify and coagulate them, thus preventing them from reacting with stimuli of external origin.

  (4) Irradiation by laser beams.

  These therapies (1) - (4) have been found to be ineffective for those suffering from hypersensitivity, to

  know that they have the following faults.

  For example, applying "Hyperband" containing paraformaldehyde to protect the surfaces of the exposed dentinal canaliculi

  mechanical, vis-à-vis external stimuli -

  therapy (1) is very labor intensive, since the powder and liquid components have to be mixed and kneaded together for use, and so there is a time limitation, because such a long period only 5-6 hours is required to fully cure the powder / liquid mixture In addition, the effectiveness of therapy (1) is generally as low

than 50%.

  Therapy (2-1), in which the "Saforide" containing a silver-diammine fluoride or F vanish

  containing sodium fluoride is applied to the canali-

  dentin cules to promote their intracalcification, in order to close them and thus protect them from external stimuli, causes the coated affected area to darken, and is therefore undesirable from the point of view aesthetic and unsuitable for adults In addition, the effectiveness of therapy (2-1) is generally as low as 47% Problems with therapy (2-2) or iontophoresis therapy, in which the principle electrophoresis is applied to introduce an ionized drug into a solution, deep, in the affected part, using a current, are that an expensive ionization device is required; that it involves a lot of work; that it scares the patient; and the like In addition, therapy (2-2) is not profitable in its operation, as can be understood by a

  efficiency which is generally as low as 40%.

  The therapy (3), in which the odontoblasts are modified and coagulated by the application of a silver nitrate solution to prevent them from reacting with stimuli of external origin, makes the coated region blackish-brown in color, and is thus aesthetically undesirable and

  unsuitable for adults In addition, it generally

  efficiency of at most 50%.

  The laser beam irradiation therapy (4), in which laser beams are applied to the dentin surface of the affected part for about 1 minute, is effective, but requires an expensive device for emitting laser beams. therapy (4) is 80% effective in some cases, but it

is not good in others.

  The therapies hitherto used to treat hypersensitivity not only involve time-consuming and inconvenient work, but may also require special equipment. Even without that, they incur very high costs. Furthermore, from the patient's point of view , one problem is that the coated area

  becomes black and, therefore, aesthetically undesirable.

  Another problem is that, for lack of lasting effect, the affected region must be coated periodically. Thus, clinicians have yet to find a therapy having a decisive efficacy despite the fact that many people

suffer from hypersensitivity.

  In addition, pulpalgia is induced by physical or chemical factors, such as the preparation of

  cavities, preparing teeth for orthopedic prostheses

  of which are fixed, obturation with resins, traumatic occlusion, changes in atmospheric pressure, fatigue and food debris, and it causes

  pain ranging from acute, pulsating and throbbing pain

  mild pain Pulpalgia is generally considered to be caused for reasons

  analogous to those mentioned about hypersensitivity

  but still far from being pathogenically

  elucidated, as is the case of hypersensitivity.

  As a result, the pulpalgia was so far

  treated with interior coatings, such as preparations

  tions of calcium hydroxide, zinc oxide cements-

  eugenol, glass ionomer cements and carboxylate cements and others These cements are intended to be applied mechanically as a coating on the surfaces of the dentinal canaliculi to protect them against stimuli

of external origin.

  The problems with calcium hydroxide preparations are that they are never hardened; that they are unable to form x-rays;

  that they have poor resistance, and the like.

  Zinc oxide-eugenol cements consist of powdery and liquid components which must be mixed and kneaded together for use Since the liquid / powder ratio must be approximately 0.5 and a large amount of the pulverulent component must be incorporated into the liquid component, mixing and kneading involve above all a lot of work.Moreover, this cement cannot be used in cases in which a composite resin must be put in place for filling, because the liquid component or eugenol interferes with the polymerization of this resin Zinc oxide-eugenol cements also pose resistance problems, etc. The glass ionomer and carboxylate cements each consist of powdery and liquid components which

  must be mixed and kneaded together for use

  sation The mixture is again awkward Due to the fact that the liquid has a p H of 1.2 to 1.7, the mixture causes

  prolonged pain in the patient during filling.

  Since the cement film is likely to increase

  thick, there is a corresponding decrease in thickness

  of a composite resin, posing an aesthetic problem, etc. The handling problems with the therapies used so far to treat pulpalgia are that mixing and kneading are awkward; that the film of

  cement is likely to increase in thickness, and the like

  res From the patient's point of view, the problems are that they cause prolonged pain in the patient during filling; that we cannot get harmonization

  color aesthetics, and the like.

  Thus, clinicians have yet to find a therapy with decisive efficacy or effective lenitives (or primary) for pulpalgia, despite the fact

  that many people suffer from pulpalgia.

  Various materials for filling the root canals

  were used to block the passage

  from the oral cavity to around the root tip

  milk by closing the formed and cleaned root canal and the apical orifice, or promoting the growth and calcification of the connective tissue around the root tip For example, gutta-percha cones, silver cones, preparations calcium hydroxide, iodoform preparations, formaldehyde preparations, and zinc oxide-eugenol sealants have

been used.

  (1) Gutta-Percha cone This material has an appropriate plasticity, it provides a high sealability and is stable, but it has difficulty finding its way to

  through the thin and sinuous root canals.

  P (2) Silver Cone This material is so fine and so rich in elasticity that it is suitable for closing the sinuous root canal, but it is so difficult to extract and so prone to corrosion that it can cause disorders. tissues. (3) Preparation of Calcium Hydroxide The problems which arise with this preparation, which is a pasty material, intended mainly to promote the healing of bone scars and the formation of hard tissue, is that it never undergoes setting; that it does not have air tightness; that she is unable to be x-rayed; that she is free from all action

antiseptic, and the like.

  (4) Preparation of Iodoform This material is less harmful to the tissue, it is suitable for radiography and it is antiseptic, but it has the defect of never being taken when it

  is in place for the obturation.

  (5) Preparation of Formaldehyde This material has antiseptic and disinfectant actions, but it is very likely to place the periodontium of the root tip in the diseased state when

  the material is pushed out of it.

  (6) Obturation material based on Zinc-Eugénol oxide This material has lenitive and antiseptic actions with increased sealing ability, but it is irritating towards the periodontium of the tip

  root and is subject to removal.

  In what follows, we indicate the requirements that a lenitive for hypersensitivity must satisfy: (1) it must be non-stimulating vis-à-vis the dental pulp and gums, and reduce or eliminate any pain induced; (2) it must not cause damage to the teeth; (3) it must not cause abnormal staining of the teeth; (4) it must produce its effect through simple work; (5) it must have an immediate effect; (6) it must retain its effect; (7) it must not cause pain to the patient during or after treatment; and (8) it must allow the dispensing of equipment or

special equipment.

  In what follows, we indicate the requirements that a remedy for pulpalgia (primary coating) must meet: (1) it must be non-stimulating vis-à-vis the dental pulp and gums, and reduce or remove any induced pain; (2) it must not cause damage to the dentin; (3) it should not cause abnormal dentin coloration; (4) it must produce its effect through simple work; (5) it must have an immediate effect; (6) it must retain its effect; (7) it must not cause pain to the patient during or after treatment; and (8) it must make it possible to dispense with special material or apparatus; and

  (9) it must not inhibit the polymerization of the resin.

  Table 1, given below, shows the effectiveness with which conventional therapies combat

  hypersensitivity and pulpalgia.

Table 1

Mark

  from (1) (2) (3) (4) (5) (6) (7) (8) (9) Effi-

  manufactures capacity Hyperband OOAAXOOO 50% Saforide AAXO 47% Nitrate solution AAXAAO 50% Silver Laser beams OOOOOOOX 80% Preparation of hydroxide OAOAAOOO 50% Calcium Oxide oxide of OOAXAOOX 50% Zinc-Eugenol Cement Type OOAOOXOO 50% Carboxylate O: Satisfactory (1) - (9): See above A: Less satisfactory X: Unsatisfactory As Table 1 allows us to understand, conventional therapies for the treatment of hypersensitivity, not only pose the problems, to as an example only,

  to be irritating to the dental pulp and provocative

  have abnormal coloration of the gums and dentin, but they are also disadvantageous in that, by way of example only, they make the work of mixing and kneading inconvenient and that their effect is neither reliable nor lasting Also, the classic therapies of

  treatment of pulpalgia, not only poses the problems-

  mes, by way of example only, to be irritating towards the dental pulp and to give rise to an abnormal coloration of the gums and of the dentin, but also they are disadvantageous in the fact that, as a 'example only, they can prohibit a filling by the resin. The object of the present invention is therefore to provide an odontotherapeutic material which can successfully satisfy both what is required for the treatment of hypersensitivity and what is required for the treatment of

pulpalgia.

  In the following, we indicate the requirements that the

  root canal obturation material must satisfy

  re (1) it must have good biocompatibility with a living body; (2) it must be non-stimulating and harmless towards the part of the periodontium which surrounds the apical orifice; (3) it must be non-porous; (4) it should not cause abnormal dentin coloration; (5) it must not undergo any change in quality; (6) it should be eliminated, if necessary; (7) it must have radioopacity; and

  (8) it must be easy to handle.

  Among the materials commonly available for obturating the root canals, there is a sealing agent capable of occluding the apical orifice of the root canal, which must essentially have good biocompatibility. For this purpose, currently mainly a gutta-percha cone However, even with a commercially available root canal length gauge, it is almost impossible to

  accurately measure the dimension of the root tip

  root canal problem One problem with the guttapercha cone is that when it is actually

  place for obturation under pressure, in the root canal

  laire, it sinks through the root tip, or it

is not well sealed.

  In accordance with what Branstrom's hydrodynamic theory teaches about the reasons for the appearance of hypersensitivity, external irritation, applied to the

  surface of the dentin, brings a tissue fluid (or pulpai-

  re) to flow through dentinal canaliculi and, in this way, to give rise to a variation in their internal pressure, irritating the fibers of the dentinal nerves, to cause pain Thus, a key to solving the

  problems associated with conventional hypersensitivity therapy

  lity and pulpalgia and to satisfy what is required to treat them, is to control the movement of fluid in the dentinal canaliculi From the results of various studies carried out to obtain this, it has now

  been discovered that it is desirable to seal the canalicu-

  dentin with a material that is difficult to dissolve

  dre in water and which is non-stimulating He also noticed that such a material is necessary to seal

elongated dentinal canaliculi.

  In view of what has just been explained, the inventors have carried out intensive and in-depth studies

  to find a material that can seal canalicu-

  the elongated dentin and be safer during use, and they managed to discover the material

  odontotherapeutic according to this invention.

  Thus, the present invention provides a two-component system, consisting of liquids A and B, intended to be applied successively to the affected part on which they are allowed to react with each other to form a substance which is difficult to dissolve in l This substance can then be used to seal elongated dentinal canaliculi or the root tip of the

root canal.

  More specifically, liquid A is mainly

  also an aqueous solution containing 1-70% of at least one of the sodium, potassium or lithium salts of acids

  mineral or organic, while liquid B is mainly

  an aqueous solution containing 1-70% of at least one of the chlorides, nitrates, sulfates and acetates of calcium, zinc, strontium, magnesium, aluminum, barium, iron, copper, silver, lead and tin. use the

  liquids A and B are mixed together.

  The substances used for liquid A in the form of a 1-70% aqueous solution, may be at least one of the sodium, potassium and lithium acid salts

  phosphoric, pyrophosphoric acid, tripolyphosic acid

  phoric, metaphosphoric acid, polyphosphoric acid,

  phosphonic acid, phosphinic acid, sulfuric acid,

  that sulfurous acid, carbonic acid, hydrogen fluoride, hydrogen sulfide and silicic acid, or substances containing, as acid groups, carboxyl, phosphoric, thiophosphoric, pyrophosphoric, phosphonic groups, phosphinic and sulfonic, all being soluble in water Part of the water can be replaced by an alcohol, acetone, dimethyl sulfoxide or the like. Specific mention is made of trisodium phosphate,

  disodium phosphate, monosodium phosphate, pyrophos-

  sodium phate, sodium dihydrogen pyrophosphate, sodium tripolyphosphate, sodium metaphosphate, sodium phosphate, sodium phosphite, sodium sulfate, sodium sulfite, sodium carbonate, sodium fluoride, sodium sulfide, sodium silicate, sodium benzoate, sodium salicylate, sodium oxalate, sodium malate, sodium malonate, sodium citrate, sodium succinate, sodium gluconate sodium, sodium acrylate, sodium methacrylate, sodium vinyl benzoate, sodium styrene sulfonate, sodium phthalate and sodium trimellitate, as well as acrylate polymers or copolymers

  sodium, sodium methacrylate or sodium maleate.

  It is also possible to use substances represented by

  the following chemical formulas I-III, or their equivalents

  slow It goes without saying that the potassium and lithium salts of the substances mentioned above can also be used. CH 1 IIC, HF = CC O (CH) n R Il H Tl CH 2 = C -C -O - (CCH) nR 1 IC H, = CCO (C Hz) n RO Im CH = C H- <k C Il O -O- (C Hz) n R (R represents 1 "9 represented below)

R = -OOC

OCOO N a COO Na I -O P -ON a O Na

0 O

He he

-O-P o P -_- O-

i I O Na O Na S O P O Na I O Na

e N O O D ZH D EH D DO O-

N H L = H O O -

(e N O O D) H D-

e NO

L 'N O

-I

<-0 O -

he

L 'N O

e NO -O d Il s e N O P-NO I

-O d -O-

It s AND

ZZ 9999 Z

  The substances used for liquid B, in the form of a 1-70% aqueous solution, may be at least one of the chlorides, nitrates, sulfates and acetates of calcium, zinc, strontium, magnesium, aluminum, barium , iron, copper, silver, lead or tin, all of which are soluble in water Part of the water can be replaced by an alcohol, acetone, dimethylsulfoxide, or the like. Specific mention is made of calcium chloride, zinc chloride, strontium chloride, magnesium chloride, aluminum chloride, iron chloride, copper chloride, barium chloride, tin chloride, zinc sulfate, strontium sulfate , magnesium sulfate, aluminum sulfate, copper sulfate, calcium nitrate, zinc nitrate, nitrate

  strontium, magnesium nitrate, aluminum nitrate,

  nium, iron nitrate, copper nitrate, silver nitrate, barium nitrate, lead nitrate, barium acetate, calcium acetate, strontium acetate, magnesium acetate, zinc acetate and

lead acetate, and the like.

  Although not generally determinable, the substances can represent 1-70% of the liquid A or B However, the substances must preferably represent 3-30% of the liquid A or B, for the treatment hypersensitivity and pulpalgia At a concentration of less than 1%, the reaction product is less precipitated, and its application must then be repeated three or four times to seal the root canal Furthermore, at a concentration greater than 70%, it is necessary time to dissolve the component in water, making the work inconvenient The concentration range, which provides an effect in one operation allows this effect to be maintained and makes the dissolution work easy, is therefore considered to be

being 3-30%.

  The substances should preferably represent -60% of a treatment material for filling the root tip of the root canal. At a concentration of less than 10%, the reaction product is so little precipitated that the root tip cannot not

  be completely sealed, while at a higher concentration

  less than 60%, it takes time to dissolve the component in water, making the work inconvenient The concentration range, which allows the root tip of the root canal to be closed in one operation and which makes the work of dissolution easy, is therefore considered to be

lying at 10-60%.

  Liquids A and / or B may contain, in addition to water and the essential component, a monomer component having one or more hydrophilic groups, such as hydroxyl, carboxyl and sulfone groups, and, at the same time, a double bond polymerizable By way of illustration, mention may be made, for example, of (meth) acrylate of hydroxy-2

  ethyl, 2-hydroxypropyl (meth) acrylate, (meth) acryl-

  3-hydroxypropyl late, 2,3-hydroxypropyl (meth) acrylate, methacrylic acid, acrylic acid, 2-acrylamide-2-methylpropane sulfonic acid, N- vinylpyrrolidone, polyethylene glycol di (meth) acrylate, and mixtures thereof The concentrations of these monomers in water are preferably within the range

5-80%.

  The way in which we use dental therapy

  The tick according to this invention will now be explained.

  For hypersensitivity: (1) the affected area is cleaned and dried; (2) liquid A is applied to the affected area from a dental tray using a sponge; (3) liquid B is applied to the coating of liquid A from another dental tray, with a sponge; and (4) the excess liquid deposited on the affected part and the

  other parts is removed by a cotton ball.

  The order of application of liquids A and B can be reversed. For the treatment of pulpalgia (with a coating primer): (1) a cavity cleaning agent, marketed by GC Dental Industrial Corp, under the trademark of "GC Dentine Conditioner", is applied to the affected region to remove layers of soiling which have been formed by the mechanical cutting of dentin; (2) the affected area is cleaned and dried; (3) liquid A is applied to the affected area with a sponge; (4) liquid B is applied to the coating of liquid A with a sponge; (5) the excess liquid deposited on the affected part and the other parts is removed by a cotton ball; and (6) a dental bonding material is applied to the

  resulting coatings for setting.

  The order of application of liquids A and B can be

reversed.

  For sealing the root tip of the root canal

  laire: (1) the root canal is widened by a reamer, file, or the like, and the root canal is thoroughly cleaned inside; (2) the root canal is again cleaned inside with liquid A, using a dental syringe; and (3) fluid B is forced through the root tip into the root canal, again using a

syringe.

  The order of application of liquids A and B can be reversed.

Examples

  The odontotherapeutic materials according to this invention will now be explained by way of further illustration, but in a nonlimiting manner, with references to

  their examples The components forming odonto-

  therapeutic are set forth in accordance with Examples 1-34.

Example 1

  A 5% aqueous solution of disodium phosphate was prepared as Al liquid, which was then adjusted to p H 7.4 by a 5% aqueous solution of sodium phosphate. Next, a 10% aqueous solution of calcium chloride was prepared as liquid BI, which

  then adjusted to p H 7.4 with a solution of chlorhy-

dric at 5%.

  The affected area of a patient with hyper-

  sensitivity was cleaned and dried, and the liquid Al was applied to it using a sponge Then the liquid Bl was applied to the coating of liquid Al using a sponge The patient no longer immediately

felt pain.

Examples 2-22 The procedures of Example 1 were followed, except that the

  liquids A 2-22 and B 2-22 were used The results were the same as those described

in Example 1.

Example 2

Liquid A 2 -

Liquid B 2 -

  A mixed liquid of a 5% aqueous solution of disodium phosphate with a 2% aqueous solution of sodium fluoride, which has been adjusted to p H 7.2 by a 5% aqueous solution

monosodium phosphate.

  A 10% aqueous solution of calcium chloride, which was adjusted to p H 7.2 by a

  5% aqueous hydrochloric acid solution.

Example 3

Liquid A 3 -

Liquid B 3 -

  A 10% aqueous solution of trisodium phosphate, which was adjusted to p H 7.0 with a 10% aqueous solution of monosodium phosphate. A 20% aqueous solution of zinc chloride, which was adjusted to p H 7.0 by a

  5% aqueous solution of sodium hydroxide.

Example 4

Liquid A 4 -

Liquid B 4 -

  A 10% aqueous solution of trisodium phosphate, which was adjusted to p H 7.0 with a 10% aqueous solution of monosodium phosphate. A 20% aqueous solution of strontium chloride, which was adjusted to p H 7.0 by a

  1% aqueous solution of sodium hydroxide.

Example 5

Liquid A 5 -

  A 5% aqueous solution of disodium phosphate

  dique, which was adjusted to p H 7.0 by a

  5% aqueous solution of monosodium phosphate

than.

Liquid B 5 -

  A 20% aqueous solution of zinc chloride, which was adjusted to p H 7.0 by a

  5% aqueous solution of sodium hydroxide.

Example 6

Liquid A 6 -

Liquid B 6 -

  A 5% aqueous solution of disodium phosphate

  dique, which was adjusted to p H 7.0 by a

  5% aqueous solution of monosodium phosphate

  than. A 20% aqueous solution of strontium chloride, which was adjusted to p H 7.0 by a

  5% aqueous solution of sodium hydroxide.

Example 7

Liquid A 7 -

Liquid B 7 -

  A 5% aqueous solution of sodium pyrophosphate, which was adjusted to p H 7.4 by a

  5% aqueous solution of monosodium phosphate

  than. A 15% aqueous solution of calcium chloride, which was adjusted to p H 7.4 by a

  5% aqueous hydrochloric acid solution.

Example 8

Liquid A 8 -

* Liquid B 8 -

  A 5% aqueous solution of sodium pyrophosphate, which was adjusted to p H 7.4 by a

  5% aqueous solution of monosodium phosphate

  than. A 10% aqueous solution of zinc chloride, which was adjusted to p H 7.4 by a

  5% aqueous solution of sodium hydroxide.

Example 9

Liquid A 9 -

Liquid B 9 -

  A 5% aqueous solution of sodium pyrophosphate, which was adjusted to p H 7.4 by a

  5% aqueous solution of monosodium phosphate

  than. A 20% aqueous solution of strontium chloride, which was adjusted to p H 7.4 by a

  5% aqueous solution of sodium hydroxide.

Example 10

  Liquid A 10 A 10% aqueous solution of sodium malonate, which has been adjusted to p H 7.4 by a

  5% aqueous solution of monosodium phosphate

  than. Liquid B 10 A 10% aqueous solution of zinc chloride, which has been adjusted to p H 7.4 by a

  5% aqueous solution of sodium hydroxide.

Example 11

Liquid All -

Liquid Bll -

  A 5% aqueous solution of sodium salicylate, which was adjusted to p H 7.4 by a

  5% aqueous solution of monosodium phosphate

  than. A 20% aqueous solution of zinc chloride, which was adjusted to p H 7.4 by a

  5% aqueous solution of sodium hydroxide.

Example 12

Liquid A 12 -

  A mixed liquid of a 5% aqueous solution of disodium phosphate with a 5% aqueous solution of sodium pyrophosphate, which

  was adjusted to p H 7.0 with an aqueous solution

  use 5% monosodium phosphate.

  Liquid B 12 A 20% aqueous solution of zinc chloride, which has been adjusted to p H 7.0 by a

  5% aqueous solution of sodium hydroxide.

Example 13

Liquid A 13 -

Liquid B 13 -

  A mixed liquid of a 5% aqueous solution of disodium phosphate with a 5% aqueous solution of sodium polyacrylate, which has been adjusted to p H 7.0 by an aqueous solution

5% monosodium phosphate.

  A 20% aqueous solution of calcium chloride, which was adjusted to p H 7.0 by a

  5% hydrochloric acid solution.

Example 14

Liquid A 14 -

Liquid B 14 -

  A mixed liquid of a 5% aqueous solution of disodium phosphate with a 5% aqueous solution of sodium polyacrylate, which has been adjusted to p H 7.0 by an aqueous solution

5% monosodium phosphate.

  A 20% aqueous solution of zinc chloride, which was adjusted to p H 7.0 by a

  5% solution of sodium hydroxide.

Example 15

Liquid A 15 -

Liquid B 15 -

  A mixed liquid of a 5% aqueous solution of disodium phosphate with a 1% aqueous solution of disodium phosphate, which has been adjusted to p H 7.0 by an aqueous solution

5% monosodium phosphate.

  A 10% aqueous solution of calcium chloride, which was adjusted to p H 7.0 by a

  5% hydrochloric acid solution.

Example 16

Liquid A 16 -

Liquid B 16 -

  A 2.5% aqueous solution of disodium phosphate, which was adjusted to p H 7.4 with a 2.5% aqueous solution of monosodium phosphate. A 5% aqueous solution of calcium chloride, which has been adjusted to p H 7, 4 by a

  5% aqueous hydrochloric acid solution.

Example 17

Liquid A 17 -

Liquid B 17 -

  A 10% aqueous solution of disodium phosphate, which was adjusted to p H 7.4 by a

  10% aqueous solution of monosodium phosphate

  than. A 15% aqueous solution of calcium chloride, which was adjusted to p H 7.4 by a

  5% aqueous hydrochloric acid solution.

Example 18

Liquid A 18 -

Liquid B 18 -

  A 2.5% aqueous solution of disodium phosphate, which was adjusted to p H 7.4 by a

  5% aqueous solution of phosphate monopotas-

  if that. A 10% aqueous solution of calcium chloride, which was adjusted to p H 7.4 by a

  5% aqueous hydrochloric acid solution.

Example 19

Liquid A 19 -

  A 2.5% aqueous solution of dipotassium phosphate, which was adjusted to p H 7.4 by a 2.5% aqueous solution of sodium phosphate. Liquid B 19 A 5% aqueous solution of calcium chloride, which has been adjusted to p H 7.4 by a

  5% aqueous hydrochloric acid solution.

Example 20

Liquid A 20 -

Liquid B 20 -

  A 5% aqueous solution of phosphate dipo-

  tassic, which was adjusted to p H 7.4 by a

  5% aqueous solution of monosodium phosphate

  than. A 5% aqueous solution of calcium chloride, which was adjusted to p H 7.4 by a

  5% aqueous hydrochloric acid solution.

Example 21

Liquid A 21 -

Liquid B 21 -

  A 10% aqueous solution of dipotassium phosphate, which was adjusted to p H 7.4 by a 10% aqueous solution of sodium phosphate. A 5% aqueous solution of calcium chloride, which has been adjusted to p H 7, 4 by a

  5% aqueous hydrochloric acid solution.

Example 22

Liquid A 22 -

Liquid B 22 -

  A 20% aqueous solution of dipotassium phosphate, which was adjusted to p H 7.4 by a 20% aqueous solution of monosodium phosphate. A 10% aqueous solution of calcium chloride, which was adjusted to p H 7.4, by a

  5% aqueous hydrochloric acid solution.

Example 23

  A 5% aqueous solution of disodium phosphate was prepared as liquid A 23, which was then adjusted to p H 7.4 by a 5% aqueous solution of sodium phosphate. Then a 10% aqueous solution of chloride

  calcium was prepared as liquid B 23.

  The affected area of a patient with hyper-

  sensitivity was cleaned and dried, and the liquid A 23 was applied to it using a sponge Then the liquid B 23 was applied to the coating of liquid A 23, using a sponge The patient immediately has no more

felt pain.

Example 24

  A 5% aqueous solution of disodium phosphate has

  been prepared as liquid A 24.

  Then a 10% aqueous solution of chloride

  calcium was prepared as liquid B 24.

  The affected area of a patient with hyper-

  sensitivity was cleaned and dried, and the liquid A 24 was applied to it using a sponge Then, the liquid B 24 was applied to the coating of liquid A 24,

  from another dental tray, using a sponge.

  The patient immediately felt no more pain.

Example 25

  A 5% aqueous solution of disodium phosphate was prepared as liquid A 25, which was then adjusted to p H 7.4 by a 5% aqueous solution of sodium phosphate. Next, 5% calcium chloride was dissolved in an aqueous solution containing 25% 2-hydroxyethyl methacrylate to form a liquid B 25, which in turn was adjusted to p H 7.4 by an aqueous solution at 5 %

hydrochloric acid.

  For filling with dental resin, a Class I cavity was formed in the lower first molar of a patient. To remove the layers of dirt, a cavity cleaning agent marketed by GC Dental Industrial Corp, under the brand of "Dentine Conditioner" was applied to the cavity, followed by water cleaning and drying. After that, the liquid A 25 was applied to the cavity using a sponge, and the liquid B 25 was then applied to the coating of liquid A 25, using a sponge.

  rest the resulting coatings for approximately 30 seconds

  Air was then blown into the cavity using a dental syringe to dry the coatings,

  followed by the application of a cured composition

  light, consisting of 30% methacrylate hy-

  2-droxy ethyl, 68% triethylene glycol dimethacrylate,

  1% dimethylaminoethyl methacrylate and 1% camphor-

  quinone The resulting coatings were exposed to visible light with a visible light-emitting dental device for one minute for setting After

  this, a light-curable type resin

  Specialized by GC Dental Industrial Corp, under the trademark "Graft LC" was introduced into the cavity and hardened by irradiation of 30 seconds of visible light, using a dental device for emitting visible light. patient was significantly relieved of pain and maintained in good condition even after

a month has passed.

  Examples 26 and 27 The procedures of Example 25 were followed except that the liquids A 26-27 and B 26-27, mentioned just below, were used. The results

  were the same as those described in Example 25.

Liquid A 26 -

Liquid B 26 -

Liquid A 27 -

Liquid B 27 -

  A 5% aqueous solution of disodium phosphate

  dique, which was adjusted to p H 7.4 by a

  5% aqueous solution of monosodium phosphate

  than. % zinc oxide were dissolved in an aqueous solution containing 30% 2-hydroxyethyl methacrylate oxide, which was adjusted to p H 7.4 by an aqueous solution

5% sodium hydroxide.

  A mixed liquid of a 5% aqueous solution of disodium phosphate with a 1% aqueous solution of sodium vinyl benzoate, which has been adjusted to p H 7.4 by a solution

  aqueous 5% monosodium phosphate.

  % calcium chloride were dissolved in an aqueous solution containing 20% 2-hydroxyethyl methacrylate, which was adjusted to p H 7.4 by an aqueous solution containing% hydrochloric acid.

Example 28

  A 5% aqueous solution of disodium phosphate was prepared as liquid A 28, which was then adjusted to p H 7.4 by a 5% aqueous solution of sodium phosphate. Next, a 10% aqueous solution of calcium chloride was prepared as liquid B 28, which in turn was adjusted to p H 7.4 by a 5% aqueous solution

hydrochloric acid.

  For filling with dental resin, a Class I cavity was formed in the first upper molar of a patient. To remove layers of dirt, a cavity cleaning agent marketed by GC Dental Industrial Corp, under the brand of "Dentine Conditioner" was applied to the cavity, followed by washing with water and drying. After that, the liquid A 28 was applied to the cavity using a sponge, and the liquid B 28 was then applied to the liquid coating A 28, using a sponge. The resulting coatings were allowed to stand for about one minute. Air was then blown into the cavity.

  using a dental syringe to dry the coatings

  followed by the application of a light curable composition marketed by Kuraray Co. Ltd under the trademark "Photobond" The resulting layers were exposed to visible light using a Dental device for emission of visible light for one minute for setting After that, a light-curable type resin marketed by Kuraray Co Ltd, under the trademark "Photo Clearfil"

  was introduced into the cavity and hardened by irradiation-

  60 seconds of visible light, using a visible light dental device The patient was significantly relieved of his pain and kept in good health

  condition even after two months have passed.

Example 29

  A 5% aqueous solution of disodium phosphate was mixed with 1% sodium vinyl benzoate to prepare a liquid A 29, which was then adjusted to p H 7.4

  with a 5% aqueous solution of monosodium phosphate.

  Next, a 10% aqueous solution of calcium chloride was prepared as liquid B 29, which in turn was adjusted to p H 7, 4 with a 5% aqueous solution

hydrochloric acid.

  For filling with dental resin, a Class I cavity was formed in a patient's first upper molar. To remove layers of dirt, a cavity cleaning agent marketed by GC Dental Industrial Corp, under the brand of "Dentine Conditioner" was applied to the cavity, followed by water cleaning and drying. After that, the liquid A 29 was applied to the cavity using a sponge, and the liquid B 29 was then applied to the coating of liquid A 29, using a sponge The resulting coatings were left to stand for approximately 30 seconds Then air was blown into the cavity

  using a dental syringe to dry the coatings

  followed by the application of a light curable composition marketed by Kuraray Co. Ltd under the trademark "Photobond" The resulting layers were exposed to visible light using a device dental light emission visible for 30 seconds, for setting After that, a light-curable type resin marketed by

  Kuraray Co Ltd under the trademark "Photo Clearfil" -

  was introduced into the cavity and hardened by irradiation-

  60 seconds of visible light, using a visible light dental device The patient was significantly relieved of his pain and kept in good health

  condition even after three months have passed.

Example 30

  The procedures of Example 29 were followed, except that a 5% aqueous solution of disodium phosphate, adjusted to p H 7.4 with a 5% aqueous solution of monosodium phosphate, was used in as a liquid A 30; a 30% aqueous solution of 2-hydroxyethyl methacrylate, in which 5% calcium chloride has been dissolved and which has been adjusted to p H 7.4 by a 5% aqueous solution of hydrochloric acid, a was used as liquid B 30; and that the coatings were exposed to visible light for one minute Les

  results were the same as those mentioned in Example-

ple 29.

Example 31

  A 5% aqueous solution of disodium phosphate was prepared as liquid A 31, which was then adjusted to p H 7.4 by a 5% aqueous solution of sodium phosphate. Next, a 10% aqueous solution of calcium chloride was prepared as liquid B 31, which in turn was adjusted to p H 7.4 by a 5% aqueous solution

hydrochloric acid.

  For filling with dental resin, a Class I cavity was formed in the second lower premolar of a patient. To remove the layers of dirt, a cavity cleaning agent marketed by GC Dental Industrial Corp, under the brand of "Dentine Conditioner" was applied to the cavity, followed by water cleaning and drying. After that, the liquid A 31 was applied to the cavity using a sponge, and the liquid B 31 was then applied to the coating of liquid A 31, using a sponge The resulting coatings were left to stand for approximately seconds Then air was blown into the cavity

  using a dental syringe to dry the coatings

  followed by the introduction and setting of a light-curable type resin marketed by ICI Co Ltd, under the trademark "Occlusin" The patient was significantly relieved of his pain and maintained

  in good condition even after one month has passed.

Example 32

  The procedures of Example 31 were followed, except that a mixture of a 3% aqueous solution of disodium phosphate with a 6% aqueous solution of sodium vinyl benzoate, which was adjusted to p H 7.4 by a 5% aqueous solution of sodium phosphate, was used as liquid A 32; and that a 10% aqueous solution of calcium chloride, adjusted to p H 7.4 with a 5% aqueous solution of hydrochloric acid, was used as liquid B 32 The results, even after it 2 months have passed, were the same as those mentioned in

Example 31.

Example 33

  A 5% aqueous solution of disodium phosphate was prepared as liquid A 33, which was then adjusted to p H 7.4 with a 5% aqueous solution of sodium phosphate Next, a 10% aqueous solution of chloride of zinc was prepared as liquid B 33, which was in turn regulated at p H 7.4 by a 5% aqueous solution

sodium hydroxide.

  For filling with dental resin, a Class I cavity was formed in the second lower premolar of a patient. To remove the layers of dirt, a cavity cleaning agent marketed by GC Dental Industrial Corp, under the brand of "GC Dentine Conditioner" was applied to the cavity, followed by cleaning with water and drying. After that, the liquid A 33 was applied to the cavity using a sponge, and the liquid B 33 was then applied to the coating of liquid A 33, using a sponge. The resulting coatings were allowed to stand for about 30 seconds. Air was then blown into the cavity with a dental syringe to drying of the coatings, followed by the application of a light-curable composition, consisting of 30% 2-hydroxyethyl methacrylate, 68% triethylene glycol dimethacrylate, 1% d-methacrylate imethylaminoethyl and 1% camphor-quinone The resulting coatings were exposed

  to visible light with a dental emitting device

  sion with visible light for one minute, for setting After that, a light-curable type resin marketed by GC Dental Industrial Corp, under the trademark "GC Graft LC" was introduced into the cavity and cured by irradiation of 30 seconds of visible light, using a visible light emission dental device The patient was significantly relieved of his pain and kept in good condition even

  after three months have passed.

Example 34

  A 5% aqueous solution of disodium phosphate was prepared as liquid A 34, which was then subjected to p H 7.4 with a 5% aqueous solution of sodium phosphate Next, a 10% aqueous solution of chloride of calcium was prepared as liquid B 34, which was in turn adjusted to p H 7.4 with a 5% aqueous solution

hydrochloric acid.

  After preparation of the tooth for a fixed orthodontic prosthesis with a diamond tip, the affected area of a patient suffering from pain was cleaned and dried. Liquid A 34 was applied to the affected area using a sponge. , and liquid B 34 was applied to the coating of liquid A 34, using a sponge Le

  patient was immediately relieved of his pain.

Example 35

  A 5% aqueous solution of disodium phosphate was mixed with a 2% aqueous solution of sodium fluoride to prepare a liquid A 35, which in turn was adjusted to p H 7.2 by a 5% aqueous solution monosodium phosphate Then a 10% aqueous solution of calcium chloride was prepared as liquid B 35, which was in turn adjusted to p H 7.2 by a 5% aqueous solution

hydrochloric acid.

  Since the affected area of a patient with a bifurcation complication was subjected to root straightening, the patient complained of pain After cleaning and drying the affected area, liquid A 35 was applied on this region using a sponge, and liquid B 35 was applied to the coating of

  liquid A 35 using a sponge The patient was immediately

relieved of his pain.

Example 36

  A 10% aqueous solution of disodium phosphate was prepared as liquid A 36, which in turn

  was adjusted to p H 7.4 with a 5% aqueous solution of phos-

  monosodium phate Then a 15% aqueous solution of calcium chloride was prepared as liquid B 36, which was in turn adjusted to p H 7.4 by a solution

  aqueous with 5% hydrochloric acid.

  After the molar to receive root canal treatment has been reamed and filed to widen the

  root canal and the root canal has been completed

  internally cleaned, it was again cleaned inside with liquid A 36, using a dental syringe Then, liquid B 36 was forced near the apical opening in the canal root, again at

  using a dental syringe to obtain precipitates.

  A few paper cones were then used to remove the excess liquid, followed by an examination using an x-ray machine After it was confirmed that the apical opening was sealed, a few cones gutta-percha were introduced into the root canal After six months, radiography confirmed that the periradicular and periodontal tissues were

kept in good condition.

  Comparative Example 1 A preparation of silver fluoride-diammine,

  containing a silver fluoride-diammine solution -

  marketed by Bibrand Medico Dental Co, Ltd under the trademark "Saforide" was applied to a patient complaining of hypersensitivity, but the patient was not relieved of his pain The patient's teeth are

turned black.

  Comparative Example 2 The patient was exposed for 30 seconds to a soft laser with "Stmalaser" manufactured by Sedatelec Co, Ltd.

  However, the pain withdrew from the upper jaw.

  re, but the lower jaw was still ill.

  Comparative Example 3 For filling with dental resin, a Class II cavity was formed in the first upper molar of a patient. Applied to the cavity, a light-curable composition sold by Kuraray Co, Ltd, under the brand. "Photobond" was cured by exposure to visible light for one minute using a visible light-emitting dental apparatus. After that, a light-curable type resin marketed by Kuraray Co , Ltd, under the trademark "Photo Clearfil" was introduced into the cavity, followed by 30 seconds exposure to visible light, using braces

  emission of visible light Immediately after shutter-

  tion, the patient complained of pain The pain persisted for a week On the tenth day when the pain became more serious, a pulpectomy

Has been done.

  Comparative Example 4 The molar to receive a root canal treatment was reamed and filed to widen the root canal, and the root canal was cleaned well inside After that, some paper cones were used to remove the water in excess, and some gutta-percha cones were then introduced into the root canal. After the introduction, the X-ray indicated that the cone was pressed about 1 mm through the root tip The next day, the inflammation became

  more serious, and the pain increased So the treatment

  The root canal had to be performed again.

  In accordance with this invention, liquids A and B containing substances capable of rapidly forming, by mixing, precipitates which are difficult to dissolve, are applied successively to the affected region, on which they are allowed to react with each other to form the hard-to-dissolve substance, thereby sealing a canaliculus

elongated dentin.

  Liquid A is mainly an aqueous solution containing 1-70% of at least one of the sodium, potassium and lithium salts of mineral or organic acids, while liquid B is mainly an aqueous solution containing 1 -70% of at least one of the chlorides, nitrates, sulfates and acetates of calcium, zinc, strontium, magnesium, aluminum, barium, iron, copper, silver,

lead or tin. When the odontotherapeutic material according to this invention is used

  as a lenitive for hypersensitivity, liquid A is applied to the affected area, already cleaned and dried, using a sponge, and liquid B is then applied to the coating of liquid A, with a sponge L ' order of application of liquids A and B can be reversed. When the odontotherapeutic material according to this invention is used as a pulpalgia lenitive (or as a coating primer), a cavity cleaning agent marketed by GC Dental Industrial Corp. under the trademark "GC Dentine Conditioner" is applied to the dentin portion of the affected area to remove layers of soiling, followed by cleaning and drying of the affected area Liquid A is applied to the affected area with a sponge, and liquid B is

  applied to the coating of liquid A, with a sponge.

  After that, a dental bonding material is applied to

  the resulting coatings for setting The order of application

  tion of liquids A and B can be reversed.

  When the odontotherapeutic material according to this invention is used to seal the root tip of the root canal, the root canal is enlarged by a reamer, file, etc., then it is then thoroughly cleaned inside. After that, the root canal is at cleaned again inside with liquid A, using a dental syringe Then, liquid B is forced through the root tip into the root canal, again using a syringe The order application of liquids A

and B can be reversed.

  As explained in detail above, when the odontotherapeutic material according to this invention is used as a hypersensitivity lenitive, liquids A and B, with or without adjusted p H, are applied successively to the affected region for their reaction l with each other, forming a difficult-to-dissolve substance capable of sealing elongated dentinal canaliculi This makes it possible to control the movement of fluids in the dentinal canaliculi, which is discussed in the hydrodynamic theory of Branstrom, by disconnecting the stimulus from

dental pulp.

  The odontotherapeutic material according to this invention

  tion can also satisfy all of the eight points of requirements listed below, which the conventional hypersensitivity lenitive is supposed to possess: (1) it must be non-stimulating with respect to the dental pulp and gums, and alleviate or eliminate any induced pain; (2) it must not cause damage to the teeth; (3) it must not cause abnormal staining of the teeth; (4) it must produce its effect through simple work; (5) it must have an immediate effect; (6) it must retain its effect; (7) it must not cause pain to the patient during or after treatment; and (8) it must allow the dispensing of equipment or

special equipment.

  When the odontotherapeutic material according to this invention is used as a pulpalgia lenitive (or coating primer), liquids A and B, with or without adjusted p H, are applied successively to the affected region, on which they react one with the other. other to form a

  difficult to dissolve in denti-

  and on the dentin surface, which can then be

  cured with or without a light-curable composition.

  This allows to control the movement of fluids in the

  canaliculus referred to in the hydrodynamic theory

  that of Brannstrom, by disconnecting the stimuli from the dental pulp. The odontotherapeutic material according to this invention also allows commercially available dental cements or internal coating agents, used as bases to be put in place for filling and to dental resins to be placed on these with

  greater security All in all, the odonto-

  therapeutic according to this invention can satisfy all of the nine points of requirements listed below, which the conventional lenitive of pulpalgia is supposed to have: (1) it must be non-stimulating with respect to the dental pulp and the gums , and alleviate or eliminate any induced pain; (2) it must not cause damage to the dentin; (3) it should not cause abnormal dentin coloration; (4) it must produce its effect through simple work; (5) it must have an immediate effect; (6) it must retain its effect; (7) it must not cause pain to the patient during or after treatment; (8) it must make it possible to dispense with special material or apparatus; and (9) it must not participate in the polymerization of the resin. Also, the odontotherapeutic material according to this invention can be used after descaling and

straightening of the roots.

  The odontotherapeutic material according to this invention

  tion can also be used to learn if the

  pain is induced by hypersensitivity or pulpitis.

  In addition, when the odontotherapeutic material according to this invention is used to seal the tip of the

  root canal, fluids A and B, with or without adjustment

  p H, are successively forced into the root canal

  laire, in which they react with each other to form a substance difficult to dissolve and to seal in this way the root point in a fixed manner Thus, the insertion of a cone of gutta-percha through the root point , which is one of the problems with the material

classic, can be avoided.

Claims (7)

  1 Odontotherapeutic material, based on two liquids A and B containing substances capable of immediately forming, by mixing, precipitates difficult to dissolve, said liquids A and B being applied successively on the affected region.   2 Odontotherapeutic material according to the claim   tion 1, characterized in that it is intended to be   cured by a light-curable composition.   3 Odontotherapeutic material according to the claim   tion 1 or 2, characterized in that the liquid A is an aqueous solution containing 1-70% of at least one of the sodium, potassium and lithium salts of acids mineral or organic.   4 Odontotherapeutic material according to one of   claims 1 or 2, characterized in that the   liquid B is an aqueous solution containing 1-70% of at least one of the chlorides, nitrates, sulfates and acetates of calcium, zinc, strontium, magnesium, aluminum, barium, iron, copper, silver, lead and tin, or calcium chloride,   zinc chloride or strontium chloride.   Odontotherapeutic material according to claim 3, characterized in that the mineral acids are chosen from the group consisting of phosphoric acid, pyrophosphoric acid, tripolyphosphoric acid, metaphosphoric acid, polyphosphoric acid, l phosphonic acid, phosphinic acid, sulfuric acid,   sulfurous acid, carbonic acid, hydrogen fluoride   ne, hydrogen sulfide and silicic acid, or sodium phosphate, potassium phosphate, fluoride   sodium or sodium pyrophosphate.   6 Odontotherapeutic material according to the claim   tion 3, characterized in that organic acids   are selected from the group consisting of acids   nant, as acid groups, the carboxyl groups,   phosphoric, thiophosphoric, pyrophosphoric, phosphoni- que, phosphinique et sulfone.   7 Odontotherapeutic material according to the claim   tion 3, characterized in that the organic acid is a polymer. 8 odontotherapeutic material according to claim 3 or 6, characterized in that the acid   organic has a polymerizable double bond.   9 Odontotherapeutic material according to one of   Claims 1, 2, 3 and 8, characterized in that the   liquids A and / or B contain, in addition to water and essential components, a monomeric material containing one or   several hydrophilic groups, such as hydroxy-   the, carboxyl and sulfone, and, at the same time, a double polymerizable bond.   Odontotherapeutic material according to one of the   Claims 1, 2, 3 and 8, characterized in that the   liquids A and / or B contain, in addition to water and essential components, 1-70% of 2-hydroxyethyl methacrylate.