CH682215A5 - - Google Patents

Description

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CH 682 215 A5

Description

The present invention relates to lenitives, primers and filling amalgams used in odontotherapy and, more particularly, lenitives against hypersensitivity, coating primers and canal filling materials. radiculodentaries.

Among dental stimuli, hypersensitivity and pulp pain are from a clinical point of view considered as sources of serious problems.

Hypersensitivity appears when living teeth are placed in a senso-sthenic state by exposure of their dentin and when they come into physical or chemical contact with cold or sweet and sour foods and drinks, with a cold spot, with current galvanic, with toothbrushes, toothpicks, etc., hypersensitivity resulting in induced pain and acute pain, although transient or fleeting.

According to Brännström's hydrodynamic theory relating to the mechanism of hypersensitivity, an external stimulus applying to the surface of the dentin causes a tissue (or pulp) fluid to move through the dentinal tubules inward or inward. outside and thereby stimulate the nerves of the pulp, which produces pain.

Although various other theories have also been suggested to explain the mechanism of hypersensitivity, it has so far been treated by therapies as diverse as those set out below.

Therapy (1): this therapy consists in providing exposed dental tubules with mechanical protection against Stimuli of external origin. To this end, these surfaces are coated with a product called "Hyperband" containing paraformaldehyde.

Therapy (2): this therapy consists in offering dental tubules protection against Stimuli of external origin, by promoting their intra-calcification in order to obstruct them. For this purpose - therapy (2-1) - the dental tubules are coated with a product called "Saforide", containing a solution of silver fluoride diamine, or with a product called "F vanish" containing a sodium fluoride . In a variant - therapy (2-2) - the principle of iontophoresis is applied, which consists in introducing deeply into the affected region, by means of a current, an ionized medicament into a solution.

Therapy (3): this therapy consists in coating the odontoblasts with a silver nitrate solution, intended to modify and coagulate them, in order to prevent them from reacting with stimuli of external origin.

Therapy (4): this therapy consists in irradiating laser beams.

Therapies (1) to (4) have been shown to be ineffective for subjects suffering from hypersensitivity, since they have the following defects.

As regards the coating based on the product "Hyperband" containing paraformaldehyde, intended to offer to the surfaces of exposed dentinal tubules mechanical protection against stimuli of external origin - therapy (1) - its use requires considerable work, since the powder and liquid components have to be mixed and kneaded together, and it is therefore limited because of the time required for the application of the coating, since it takes at least 5 to 6 hours to obtain a complete setting of the powder / liquid mixture. The effectiveness of the therapy (1) generally does not exceed 50%.

Therapy (2-1), which consists in applying the “Saforide” containing a silver fluoride diamine or the “F vanish” containing a sodium fluoride to the dentinal tubules, to promote their intra-calcification so as to obstruct them. and thus protect them from stimuli of external origin, has the disadvantage of blackening the affected affected area and is therefore undesirable from an aesthetic point of view and not suitable for adults. The effectiveness of the therapy (2-1) does not generally exceed 47%. The therapy (2-2) or iontophoresis therapy, in which the principle of electrophoresis is applied to introduce deeply into the affected region by means of a current an ionized drug in a solution, has the disadvantages of requiring a expensive ion feeder, demanding considerable work, triggering an apprehensive reaction in the patient, and the like. In addition, the use of therapy (2-2) is not good, since its effectiveness generally does not exceed 40%.

The therapy (3), in which the odontoblasts are modified and coagulated by the application of a coating based on a silver nitrate solution intended to prevent their reaction with stimuli of external origin, has the disadvantage of turn the coated region to black brown and is therefore not aesthetically desirable and unsuitable for adults. In addition, its effectiveness is generally 50% at best.

Therapy (4) using laser beam irradiation, in which laser beams are applied to the dentin surface of the affected area for about 1 minute, is effective but requires an expensive laser irradiator. In addition, therapy (4) is 80% effective in some cases but inappropriate in others.

The therapies used so far to treat hypersensitivity require not only long, arduous and delicate work but also, in some cases, special equipment and, even in cases where it is not necessary, they are expensive. Furthermore, they pose a problem for the patient due to the fact that the coated region turns black, which is aesthetically undesirable. Another pro2

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CH 682 215 A5

pallor is due to the lack of lasting effect, which means that the affected area must be periodically coated. So, clinicians still have to find a really effective therapy for hypersensitivity, despite the large number of people who suffer from it.

Pain in the pulp, on the other hand, is induced by physical or chemical factors, such as the preparation of cavities, the preparation of teeth for the fixation of dental prostheses, obturation with resins, traumatic occlusions, variations in atmospheric pressure, fatigue and food scraps, and causes all kinds of pain ranging from acute, pulsating and throbbing pain to mild pain. We consider that pulp pain in the broad sense is produced by causes similar to those of hypersensitivity mentioned above, but its pathogenesis, unlike that of hypersensitivity, is far from being elucidated.

Thus, pulp pain has been treated so far by means of coatings, such as preparations of calcium hydroxide, cements based on eugenol-zinc oxide, cements based on glassy ionomer and carboxylate and other cements. These cements are designed to serve as plasters mechanically deposited on the surfaces of the dentinal tubules, in order to protect them against stimuli of external origin.

Calcium hydroxide preparations have the disadvantages of never hardening, being unable to form roentgenograms, offering little resistance, and the like. Cements based on eugenol-zinc oxide consist of powders and liquid components which must be mixed and kneaded together before use. Since the powder / liquid ratio must be about 0.5 and a large amount of the powder component must be incorporated into the liquid component, mixing and kneading especially require considerable work. This cement can not therefore be used in cases where a filling with a composite resin must be put in place, because the liquid component or the eugenol interfere with the polymerization of the resin. Cements based on eugenol-zinc oxide also pose resistance problems, etc.

Cements based on glassy ionomer and carboxylate each consist of powders and liquid components which must be mixed and kneaded together before use. The mixing operation is also difficult and delicate there. Due to the pH of the liquid between 1.2 and 1.7, the mixture produces persistent pain in the patient after application. Since the cement tends to increase in thickness, a corresponding reduction in the thickness of the composite resin occurs, which poses an aesthetic problem, etc.

The problems accompanying the application of the therapies hitherto used to treat pulp pain are due to the difficult and delicate execution of the mixing and kneading operations, to the tendency of the cement film to increase in thickness, and similar. From the patient's point of view, these therapies have the disadvantages of producing persistent pain when placing the filling, of being unable to achieve an aesthetic marriage of colors, and the like.

This is why, it remains for clinicians to find a really effective therapy or lenitives (or primers) effective against pulp pain, despite the large number of people who suffer from it.

Various materials for sealing the radiculodentary canals have been used to close a passage from the oral cavity to the tissues surrounding the apex of the root, by obstructing the radiculodentary canal formed and cleaned and the apical foramen, or by promoting growth and calcification of the connective tissues surrounding the apex of the root. For example, gutta-percha points, silver points, calcium hydroxide preparations, iodoform preparations, formaldehyde preparations and eugenol-type fillings have been used. zinc oxide.

(1) The gutta-percha point technique:

Gutta-percha is a material of suitable plasticity, which ensures a good seal and which is stable, but which has difficulty finding its way through the thin sinuous canals of the dental roots.

(2) The silver point technique:

Silver has such finesse and elasticity that it allows blockage of the sinuous canals of the dental roots, but it is so difficult to remove and so prone to corrosion that it can cause tissue damage.

(3) Preparations based on calcium hydroxide:

These preparations, which are pasty and mainly designed to promote healing of bone scars and the formation of hard tissue, have the disadvantages of never taking, lacking air tightness, not being able to be x-rayed, be devoid of antiseptic action, and the like.

(4) Iodoform preparations:

These preparations damage the tissues less, can be X-rayed and are antiseptic, but they have the defect of never taking once put in place.

(5) Formaldehyde preparations:

They are antiseptic and disinfectant, but they tend to severely damage the periodontium of the root apex when removed from the root.

(6) Fillings based on zinc eugenol oxide:

This material has a lenitive and antiseptic action to which is added increased tightness, but it has the disadvantage of irritating the periodontium of the root ends and of having a tendency to contract.

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The qualities that lenitives must have against hypersensitivity are the following:

(1) they must avoid stimulating the dental pulp and the gums and be able to reduce or eliminate the pain caused;

(2) they must not cause any alteration of the teeth;

(3) they must not tarnish the teeth;

(4) they must produce their effect without requiring complex work;

(5) they must take immediate action;

(6) they must have a prolonged effect;

(7) they must not cause any pain to the patient during or after treatment; and

(8) they must be able to be applied without special materials or equipment.

The qualities that remedies for pulp pain (coating primers) must have are the following:

(1) they must avoid stimulating the dental pulp and the gums and be able to reduce or eliminate the pain caused;

(2) they must not cause any alteration of the dentin;

(3) they must not produce any tarnishing of the dentin;

(4) they must produce their effect without requiring complex work;

(5) they must take immediate action;

(6) they must have a prolonged effect;

(7) they must not cause any pain to the patient during or after treatment;

(8) they must be able to be applied without special materials or equipment; and

(9) they must not prevent the polymerization of the resins.

The table below illustrates the effectiveness of traditional therapies used against hypersensitivity and pulp pain.

Table 1

Tradename

(1)

(2)

(3)

(4)

(5)

(6)

(7)

(8)

(9)

Efficiency

Hyperband

O

O

AT

AT

X

O

O

O

50%

Saforide

AT

AT

X

AT

AT

AT

AT

O

47%

Silver nitrate solution

AT

AT

X

AT

AT

AT

AT

O

50%

Laser beams

O

O

O

O

O

O

O

X

80%

Calcium hydroxide preparation

O

O

AT

O

AT

AT

O

o

O

50%

Zinc oxide eugenol cement

O

O

AT

X

AT

AT

O

0

X

50%

Carboxylate cement

0

O

AT

AT

O

O

X

0

o

50%

O: Satisfactory (1) to (9): See below A: Less satisfactory X: Unsatisfactory

As can be seen from Table 1, the traditional therapies used for hypersensitivity not only pose problems, not least because they irritate the dental pulp and tarnish the gums and dentin, but they also have the disadvantages. in particular to make mixing and kneading operations difficult and delicate and not to produce a reliable result or a lasting effect. Likewise, the traditional therapies used for pulp pain not only pose problems, in particular because they irritate the dental pulp and tarnish the gums and dentin, but they also have the disadvantage in particular of making it impossible fillings with resins.

The present invention therefore aims to provide an odontotherapy material which advantageously combines both the qualities necessary for treating hypersensitivity and those necessary for treating pulpal pain.

The qualities that the filling material of the radiculodentary canals must have are the following:

(1) it must be characterized by good biocompatibility with living bodies;

(2) he must avoid stimulating and altering the part of the periodontium surrounding the apical foramen;

(3) it must be non-porous;

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(4) it should not tarnish the dentin;

(5) it must not undergo any change in quality;

(6) it must be removable, if necessary;

(7) it must be radiopaque; and

(8) it must be easy to handle.

Among the materials available for filling the radiculodentary canals currently available, there is a sealing agent capable of sealing the apical foramen of the radiculodentary canal, which is mainly required to have good biocompatibility. To this end, the gutta-percha point technique is generally used today. Even using the length gauges available on the market, it is almost impossible to accurately measure the size of the root apex in the radiculodental canal. The gutta-percha point technique poses a problem that, once such a filling has been placed under pressure in the radiculodentary canal, either it exerts a push in the root apex or it is not well sealed.

According to Brännström's theory of fluid dynamics of the causes of hypersensitivity, external irritation on the surface of the dentin causes tissue (or pulp) fluid to flow through the dentin tubules and cause , in doing so, a variation in their internal pressure, which irritates the fibers of the dentinal nerves to produce pain. Therefore, a technique which would eliminate the problems associated with traditional therapies against hypersensitivity and pulp pain and which would meet the conditions required to treat both would be to control the movement of fluids in the dentinal tubules. On the basis of the results of various studies on this subject, it has been discovered that it is desirable to seal the dentinal tubules with a material which hardly dissolves in water and produces no stimulation. It was also noted that such material should be able to seal the elongated dentinal tubules.

On the basis of these findings, the inventors have carried out intensive and extensive studies with a view to finding a material capable of sealing the elongated dentinal tubules and of presenting increased safety in use, and the result of which is the odontotherapy material proposed. here.

Thus, the present invention is characterized for this purpose by a material as defined in claim 1. This substance can then be used to seal elongated dentinal tubules or the apex of the root in the radiculodentary canal.

More specifically, the liquid A is essentially composed of an aqueous solution containing 1 to 70% of one or more compounds chosen from the sodium, potassium and lithium salts of an inorganic or organic acid, while the liquid B mainly consists of an aqueous solution containing 1 to 70% of one or more compounds chosen from chlorides, nitrates, sulfates and acetates of calcium, zinc, strontium, magnesium, barium, iron, copper, silver, lead and tin. In use, liquids A and B are mixed together.

The substances used in liquid A, which is in the form of an aqueous solution containing 1 to 70% of such a substance, can consist of one or more compounds chosen from sodium, potassium and lithium salts phosphoric acid, pyrophosophoric acid, tripolyphosphoric acid, phosphonic acid, phosphinic acid, sulfuric acid, sulfurous acid, carbonic acid, hydrogen fluoride, sulfide hydrogen and silicic acid or elements such as the acid groups of carboxyl, phosphoric, thiophosphoric, pyrophos-phoric, phosphonic, phosphinic and sulfonic groups, all being water-soluble. Some of the water can be substituted with alcohol, acetone, dimethyl sulfoxide and the like. Mention will in particular be made of trisodium phosphate, disodium phosphate, monosodium phosphate, sodium pyrophospate, dihydrogen sodium pyrophosphate, sodium tripolyphosphate, sodium metaphosphate, sodium phosphate, sodium phosphite, sodium sulfate sodium, sodium sulfite, sodium carbonate, sodium fluoride, sodium sulfide, sodium silicate, sodium benzoate, sodium salicylate, sodium oxalate, sodium malate, malonate sodium, sodium citrate, sodium succinate, sodium gluconate, sodium pacrylate, sodium methacrylate, sodium vinyl benzoate, sodium styrene sulfonate, sodium phthalate and sodium trimellite sodium, as well as polymers or copolymers of sodium acrylate, sodium methacrylate and sodium maleate. One can also use the substances represented by the chemical formulas I to III below or their equivalents. Naturally potassium and lithium salts of the above mentioned substances can also be used.

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I. C H

C H3

I

CC

II

o

-0- (CH,) n-R

not.

C H

H

I

VS

c - o

II

o

(C H 2) n - R

III. C H, = C H

(R represents the following formulas 1 to 9)

R = - O O C

O> - C O O N a C O O N a

II

_ O— P - ONa

I

We have

- O -

0

II

P - O

1

We have

I?

P- O -

We have

S

il o - P - O N a I

We have

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S S

He he

- O — P - O - P —- O -

i i

ONa ONa

5

0

he

- O - P - O

1

We have

6

- CH (COONa) 2

7

- OOCCH = CHCOONa

8

~ OOCCH2CH2COONa

9

The substances used in liquid B, which is in the form of an aqueous solution containing 1 to 70% of such a substance, can consist of one or more compounds chosen from chlorides, nitrates, sulfates and calcium, zinc, strontium, magnesium, barium, iron, copper, silver, lead and tin acetates, all of which are water soluble. Part of the water can be substituted with alcohol, acetone, dimethyl sulfoxide or the like. Mention will in particular be made of calcium chloride, zinc chloride, strontium chloride, magnesium chloride, aluminum chloride, iron chloride, copper chloride, barium chloride, tin chloride. , zinc sulfate, strontium sulfate, magnesium sulfate, aluminum sulfate, copper sulfate, calcium nitrate, zinc nitrate, strontium nitrate, magnesium nitrate, nitrate d , iron nitrate, copper nitrate, silver nitrate, barium nitrate, lead nitrate, barium acetate, calcium acetate, strontium acetate, acetate magnesium, zinc acetate and lead acetate and others.

Although their concentration is generally not determinable, these substances can enter for 1 to 70% in liquid A or B. However, these substances should preferably enter for 3 to 30% in liquid A or B for the treatment of hypersensitivity and pulp pain. At a concentration of less than 1%, on the one hand, the reaction product pecipite less and its application must, therefore, be repeated three or four times in order to seal the radiculodentary canal. At a concentration above 70%, on the other hand, it takes a long time to dissolve the component in water, which makes work difficult. Consequently, it is considered that the concentrations which produce an effect in a single operation, which allow this effect to be prolonged and which facilitate the work of dissolution are between 3 and 30%.

These substances should preferably constitute 10 to 60% of the treatment material used to seal the apex of the root in the radiculodental canal. At a concentration below 10%, the reaction product precipitates so little that the apex of the root cannot be completely sealed, while at a concentration above 60%, it takes a long time to dissolve the component in the water, making the tra

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difficult. Consequently, it is considered that the concentrations which make it possible to seal the apex of the root in the radiculodentary canal in a single operation and which facilitate the work of dissolution are between 10 and 60%.

Liquids A and / or B may contain, in addition to water and the essential component, a monomer component having one or more hydrophilic groups, such as hydroxyl, carboxyl and sulfonene groups, and, at the same time, a polymerizable double bond. By way of example, mention may in particular be made of 2-hydroxyethyl (meth) acrylate, 2-hydroxypropyl (meth) acrylate, 3-hydroxypropyl (meth) acrylate, 2,3-dihydroxypropyl (meth) acrylate, l methacrylic acid, acrylic acid, 2-acrylami-de-2-methylpropanesulfone acid, N-vinylpyrrolidone, polyethylene glycol di (meth) acrylate and mixtures thereof. The concentrations of these monomers in water are preferably between 5 and 80%.

The method of using the dental therapy material described in the present invention is as follows.

- To treat hypersensitivity:

(1) clean and dry the affected area;

(2) apply liquid A to the affected part from a dental tray using a sponge;

(3) applying liquid B to the coating layer formed by liquid A, from another dental tray, using a sponge; and

(4) remove with a cotton pad the excess liquid which has settled on the affected part and on the other parts.

- To treat pulp pain (with a coating primer):

(1) apply a cavity cleaning agent, marketed by G-C Dental Industriai Corp. under the trade name "GC Dentine Conditioner", on the affected region, in order to remove the layers of smears which have been deposited during the mechanical cutting of dentin;

(2) clean and dry the affected area;

(3) apply liquid A to the affected area using a sponge;

(4) apply by means of a sponge the liquid B to the coating coating formed by the liquid A;

(5) remove with a cotton pad the excess liquid which has deposited on the affected part and on the other parts; and

(6) coat the formed coatings with dental bonding material to allow setting.

The order of application of liquids A and B can be reversed.

- To seal the apex of the root of the radiculodental canal:

(1) enlarge the root canal with a dental reamer, dental file or the like and thoroughly clean the inside of the canal;

(2) thoroughly clean the interior of the radiculodental canal again with liquid A, using a dental syringe; and

(3) introduce under pressure the liquid B through the apex of the root inside the radiculodentary canal, again using a syringe.

The order of application of liquids A and B can be reversed.

Examples:

The odontotherapy materials of the present invention are now presented in a more precise but not exclusive manner with reference to several examples of use. The application of the components forming the dental therapy materials of the present invention is set out in Examples 1 to 34 below.

Example 1:

A 5% aqueous solution of disodium phosphate is prepared as liquid A1, and its pH is adjusted to 7.4 with a 5% aqueous solution of sodium phosphate.

A 10% aqueous solution of calcium chloride is then prepared as liquid B1 and its pH is adjusted to 7.4 with a 5% solution of hydrochloric acid.

The affected area of the hypersensitive patient is cleaned and dried, and A1 fluid is applied to it with a sponge. Then, the liquid B1 is applied by means of a sponge to the coating layer formed by the liquid A1. The patient is immediately relieved of his pain.

Examples 2 to 22:

The same procedure is followed as in Example 1, with the exception of the use of liquids A2-22 and B2-22. The results are identical to those described in Example 1.

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Example 2:

Liquid A2

Liquid mixture composed of a 5% aqueous solution of disodium phosphate and a 2% aqueous solution of sodium fluoride, and whose pH is adjusted to 7.2 with a 5% aqueous solution of sodium phosphate.

Liquid B2

10% aqueous solution of calcium chloride, the pH of which is adjusted to 7.2 with a 5% aqueous solution of hydrochloric acid.

Example 3:

Liquid A3

10% aqueous solution of trisodium phosphate, the pH of which is adjusted to 7.0 with a 10% aqueous solution of monosodium phosphate.

Liquid B3

20% aqueous solution of zinc chloride, the pH of which is adjusted to 7.0 with a 5% aqueous solution of sodium hydroxide.

Example 4:

Liquid A4

10% aqueous solution of trisodium phosphate, the pH of which is adjusted to 7.0 with a 10% aqueous solution of monosodium phosphate.

Liquid B4

A 20% aqueous solution of strontium chloride, the pH of which is adjusted to 7.0 with a 1% aqueous solution of sodium hydroxide.

Example 5:

Liquid A5

A 5% aqueous solution of disodium phosphate, the pH of which is adjusted to 7.0 with a 5% aqueous solution of monosodium phosphate.

Liquid B5

20% aqueous solution of zinc chloride, the pH of which is adjusted to 7.0 with a 5% aqueous solution of sodium hydroxide.

Example 6:

Liquid A6

A 5% aqueous solution of disodium phosophate, the pH of which is adjusted to 7.0 with a 5% aqueous solution of monosodium phosphate.

Liquid B6

A 20% aqueous solution of strontium chloride, the pH of which is adjusted to 7.0 with a 5% aqueous solution of sodium hydroxide.

Example 7:

Liquid A7

A 5% aqueous solution of sodium pyrophosphate, the pH of which is adjusted to 7.4 with a 5% aqueous solution of monosodium phosphate.

Liquid B7

15% aqueous solution of calcium chloride, the pH of which is adjusted to 7.4 with a 5% aqueous solution of hydrochloric acid.

Example 8:

Liquid A8

A 5% aqueous solution of sodium pyrophosphate, the pH of which is adjusted to 7.4 with a 5% aqueous solution of monosodium phosphate.

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Liquid B8

10% aqueous solution of zinc chloride, the pH of which is adjusted to 7.4 with a 5% aqueous solution of sodium hydroxide.

Example 9:

Liquid A9

A 5% aqueous solution of sodium pyrophosphate, the pH of which is adjusted to 7.4 with a 5% aqueous solution of monosodium phosphate.

Liquid B9

20% aqueous solution of strontium chloride, the pH of which is adjusted to 7.4 with a 5% aqueous solution of sodium hydroxide.

Example 10:

Liquid A10

A 10% aqueous solution of sodium malonate, the pH of which is adjusted to 7.4 with a 5% aqueous solution of sodium phosphate.

Liquid B10

10% aqueous solution of zinc chloride, the pH of which is adjusted to 7.4 with a 5% aqueous solution of sodium hydroxide.

Example 11:

Liquid A11

5% aqueous solution of sodium salicylate, the pH of which is adjusted to 7.4 with a 5% aqueous solution of sodium phosphate.

Liquid B11

20% aqueous solution of zinc chloride, the pH of which is adjusted to 7.4 with a 5% aqueous solution of sodium hydroxide.

Example 12:

Liquid A12

Liquid mixture composed of a 5% aqueous solution of disodium phosphate and a 5% aqueous solution of sodium pyrophosphate, and whose pH is adjusted to 7.0 with a 5% aqueous solution of sodium phosphate.

Liquid B12

20% aqueous solution of zinc chloride, the pH of which is adjusted to 7.0 with a 5% aqueous solution of sodium hydroxide.

Example 13:

Liquid A13

Liquid mixture composed of a 5% aqueous solution of disodium phosphate and a 5% aqueous solution of sodium polyacrylate, and whose pH is adjusted to 7.0 with a 5% aqueous solution of sodium phosphate.

Liquid B13

20% aqueous solution of calcium chloride, the pH of which is adjusted to 7.0 with a 5% solution of hydrochloric acid.

Example 14:

Liquid A14

Liquid mixture composed of a 5% aqueous solution of disodium phosphate and a 5% aqueous solution of sodium polyacrylate, and whose pH is adjusted to 7.0 with a 5% aqueous solution of sodium phosphate.

Liquid B14

20% aqueous solution of zinc chloride, the pH of which is adjusted to 7.0 with a 5% solution of sodium hydroxide.

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Example 15:

Liquid A15

Liquid mixture composed of a 5% aqueous solution of disodium phosphate and a 1% aqueous solution of sodium phosphate, and whose pH is adjusted to 7.0 with an aqueous solution of 5% sodium phosphate.

Liquid B15

10% aqueous solution of calcium chloride, the pH of which is adjusted to 7.0 with a 5% solution of hydrochloric acid.

Example 16:

Liquid A16

2.5% aqueous solution of disodium phosophate, the pH of which is adjusted to 7.4 with a 2.5% aqueous solution of monosodium phosphate.

Liquid B16

5% aqueous solution of calcium chloride, the pH of which is adjusted to 7.4 with a 5% aqueous solution of hydrochloric acid.

Example 17:

Liquid A17

A 10% aqueous solution of disodium phosophate, the pH of which is adjusted to 7.4 with a 10% aqueous solution of monosodium phosphate.

Liquid B17

15% aqueous solution of calcium chloride, the pH of which is adjusted to 7.4 with a 5% aqueous solution of hydrochloric acid.

Example 18:

Liquid A18

2.5% aqueous solution of disodium phosophate, the pH of which is adjusted to 7.4 with a 5% aqueous solution of monopotassium phosphate.

Liquid B18

10% aqueous solution of calcium chloride, the pH of which is adjusted to 7.4 with a 5% aqueous solution of hydrochloric acid.

Example 19:

Liquid A19

2.5% aqueous solution of dipotassium phosophate, the pH of which is adjusted to 7.4 with a 2.5% aqueous solution of monosodium phosphate.

Liquid B19

5% aqueous solution of calcium chloride, the pH of which is adjusted to 7.4 with a 5% aqueous solution of hydrochloric acid.

Example 20:

Liquid A20

A 5% aqueous solution of dipotassium phosophate, the pH of which is adjusted to 7.4 with a 5% aqueous solution of monosodium phosphate.

B20 liquid

5% aqueous solution of calcium chloride, the pH of which is adjusted to 7.4 with a 5% aqueous solution of hydrochloric acid.

Example 21:

Liquid A21

10% aqueous solution of dipotassium phosophate, the pH of which is adjusted to 7.4 with a 10% aqueous solution of monosodium phosphate.

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CH 682 215 A5

Liquid B21

5% aqueous solution of calcium chloride, the pH of which is adjusted to 7.4 with a 5% aqueous solution of hydrochloric acid.

Example 22:

Liquid A22

A 20% aqueous solution of dipotassium phosophate, the pH of which is adjusted to 7.4 with a 20% aqueous solution of monosodium phosphate.

Liquid B22

10% aqueous solution of calcium chloride, the pH of which is adjusted to 7.4 with a 5% aqueous solution of hydrochloric acid.

Example 23:

An aqueous solution containing 5% disodium phosphate is prepared as liquid A23, and its pH is adjusted to 7.4 with an aqueous solution containing 5% monosodium phosphate.

A 10% aqueous solution of calcium chloride is then prepared as liquid B23.

The affected area of the hypersensitivity patient is cleaned and dried and the A23 liquid is applied to it with a sponge. Then, the liquid B23 is applied by means of a sponge to the coating layer formed by the liquid A23. The patient is immediately relieved of his pain.

Example 24:

A 5% aqueous solution of disodium phosphate is prepared as liquid A24.

A 10% aqueous solution of calcium chloride is then prepared as liquid B24.

The affected area of the hypersensitivity patient is cleaned and dried and the A24 liquid is applied to it with a sponge. Then, the liquid B24 is applied by means of a sponge, from another dental tray, to the coating layer formed by the liquid A24. The patient is immediately relieved of his pain.

Example 25:

A 5% aqueous solution of disodium phosphate is prepared as liquid A25, and its pH is adjusted to 7.4 with a 5% aqueous solution of sodium phosphate.

5% of calcium chloride is then dissolved in an aqueous solution containing 25% 2-hydroxyethyl methacrylate, in order to form the liquid B25, the pH of which in turn is adjusted to 7.4 with an aqueous solution of 5% hydrochloric acid.

For filling with dental resin, a Class I cavity is formed in the patient's first lower molar. To remove smear layers, a cavity cleaning agent - sold by G-C Dental Industriai Corp. - is applied to the cavity. under the trade name "Dentine Conditioner" - then clean with water and dry. Liquid A25 is then applied to the cavity by means of a sponge, then liquid B25 is applied by means of a sponge to the coating layer formed by liquid A25. The coatings thus formed are left to stand for approximately 30 seconds. Air is then blown into the cavity by means of a dental syringe, in order to dry the coatings, then the application of a photovolcanized composition consisting of 30% 2-hydroxyethyl methacrylate, 68% of triethylene glycol dimethacrylate, with 1% of dimethylaminoethyl methacrylate and with 1% of camphor quinone. The plasters formed are exposed to visible light by means of a dental visible light irradiator for one minute, to allow setting. Then, the cavity is closed with a type of photovolcanized resin - marketed by G-C Dental Industriai Corp. under the trade name "Graft LC" - and the resin is allowed to set by irradiating visible light for 30 seconds using a dental visible light irradiator. The patient is relieved of his pain and his condition remains good even after a period of one month.

Examples 26 & 27:

The same procedure is followed as in Example 25, except for the use of the liquids A26-27 and B26-27, mentioned below. The results are identical to those described in Example 25. Liquid A26 - 5% aqueous solution of disodium phosophate, the pH of which is adjusted to 7.4 with a 5% aqueous solution of monosodium phosphate. Liquid B26 - 10% of zinc oxide is dissolved in an aqueous solution containing 30% 2-hydroxyethyl methacrylate oxide, the pH of which is adjusted to 7.4 with a 5% aqueous solution of sodium hydroxide.

Liquid A27

Liquid mixture composed of a 5% aqueous solution of disodium phosphate and an aqueous solution12

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se to 1% sodium vinyl benzoate, and whose pH is adjusted to 7.4 with a 5% aqueous solution of monosodium phosphate.

Liquid B27

10% of calcium chloride is dissolved in an aqueous solution containing 20% of 2-hydroxyethyl methacrylate, the pH of which is adjusted to 7.4 with a 5% aqueous solution of hydrochloric acid.

Example 28:

A 5% aqueous solution of disodium phosphate is prepared as liquid A28, and its pH is adjusted to 7.4 with a 5% aqueous solution of monosodium phosphate.

A 10% aqueous solution of calcium chloride is then prepared as liquid B28, the pH of which is in turn adjusted to 7.4 with a 5% aqueous solution of hydrochloric acid.

For filling with dental resin, a Class I cavity is formed in the patient's first upper molar. To remove smear layers, a cavity cleaning agent - sold by G-C Dental Industriai Corp. - is applied to the cavity. under the trade name "Dentine Conditioner" - then clean with water and dry. Liquid A28 is then applied to the cavity by means of a sponge, then liquid B28 is applied by means of a sponge to the coating layer formed by liquid A28. The coatings thus formed are left to stand for approximately one minute. Air is then blown over the cavity using a dental syringe to dry the coatings, followed by the application of a photovolcanized composition - marketed by Kuraray Co., Ltd. under the trade name "Photobond". The plasters formed are exposed to visible light by means of a dental visible light irradiator for one minute, to allow setting. Then, the cavity is closed with a type of photovolcanized resin sold by Kuraray Co., Ltd. under the trade name "PhotoClearfil" - and the resin is allowed to set by irradiating visible light for 60 seconds using a dental visible light irradiator. The patient is relieved of his pain and his condition remains good even after a period of two months.

Example 29:

A 5% aqueous solution of disodium phosphate is mixed with 1% sodium vinyl benzoate, to prepare the liquid A29, the pH of which is then adjusted to 7.4 with a 5% aqueous solution of monosodium phosphate.

Then, as liquid B29, a 10% aqueous solution of calcium chloride is prepared, the pH of which is in turn adjusted to 7.4 with a 5% aqueous solution of hydrochloric acid.

For filling with dental resin, a Class I cavity is formed in the patient's first upper molar. To remove smear layers, a cavity cleaning agent - sold by G-C Dental Industriai Corp. - is applied to the cavity. under the trade name "Dentine Conditioner" - then clean with water and dry. Liquid A29 is then applied to the cavity by means of a sponge, then liquid B29 is applied by means of a sponge to the coating layer formed by liquid A29. The coatings thus formed are left to stand for approximately 30 seconds. Air is then blown over the cavity using a dental syringe to dry the coatings, followed by the application of a photovolcanized composition - marketed by Kuraray Co., Ltd. under the trade name "Photobond". The coatings formed are exposed to visible light by means of a dental visible light irradiator for 30 seconds, to allow setting. Then, the cavity is closed with a type of photovolcanized resin - marketed by Kuraray Co., Ltd. under the trade name "PhotoClearfil" - and the resin is allowed to set by irradiating visible light for 60 seconds using a dental visible light irradiator. The patient is relieved of his pain and his condition remains good even after a period of three months.

Example 30:

The same procedure is followed as in Example 29, except that used: as liquid A30, a 5% aqueous solution of disodium phosphate, the pH of which is adjusted to 7.4 with a 5% aqueous solution of sodium phosphate; as liquid B30, a 30% aqueous solution of 2-hydroxyethyl methacrylate in which 5% of calcium chloride is dissolved and whose pH is adjusted to 7.4 with a 5% aqueous solution of hydrochloric acid; and except for the time of exposure of the coatings to visible light which is one minute. The results obtained are identical to those mentioned in Example 29.

Example 31:

An aqueous solution containing 5% disodium phosphate is prepared as liquid A31, and its pH is adjusted to 7.4 with an aqueous solution containing 5% monosodium phosphate.

A 10% aqueous solution of calcium chloride is then prepared as liquid B31, the pH of which is in turn controlled at 7.4 with a 5% aqueous solution of hydrochloric acid.

For filling with dental resin, a Class I cavity is formed in the second premolar

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lower of the patient. To remove smear layers, a cavity cleaning agent - sold by G-C Dental Industriai Corp. - is applied to the cavity. under the trade name "Dentine Conditioner" - then clean with water and dry. Liquid A31 is then applied to the cavity by means of a sponge, then liquid B31 is applied by means of a sponge to the coating layer formed by liquid A31. The coatings thus formed are left to stand for approximately 30 seconds. Air is then blown over the cavity using a dental syringe to dry the plaster, then applied and allowed to set is a type of photovolcanized filling resin - marketed by ICI Co., Ltd. under the trade name "Occlusin". The patient is relieved of his pain and his condition remains good even after a period of one month.

Example 32:

The same procedure is followed as in Example 31, except that used: as liquid A32, a mixture composed of an aqueous solution at 3% of disodium phosphate and an aqueous solution at 6% of vinyl benzoate sodium and the pH of which is adjusted to 7.4 with a 5% aqueous solution of sodium phosphate; and as liquid B32, a 10% aqueous solution of calcium chloride, the pH of which is adjusted to 7.4 with a 5% aqueous solution of hydrochloric acid. The results obtained, even after a period of 2 months, are identical to those mentioned in Example 31.

Example 33:

An aqueous solution containing 5% disodium phosphate is prepared as liquid A33, and its pH is adjusted to 7.4 with an aqueous solution containing 5% monosodium phosphate. A 10% aqueous solution of zinc chloride is then prepared as liquid B33, the pH of which is in turn controlled at 7.4 with a 5% aqueous solution of sodium hydroxide.

For filling with dental resin, a Class I cavity is formed in the patient's second lower premolar. To remove smear layers, a cavity cleaning agent - sold by G-C Dental Industriai Corp. - is applied to the cavity. under the trade name "GC Dentine Conditioner" - then clean with water and dry. Liquid A33 is then applied to the cavity by means of a sponge, then liquid B33 is applied by means of a sponge to the coating layer formed by liquid A33. The coatings thus formed are left to stand for approximately 30 seconds. Air is then blown onto the cavity by means of a dental syringe, in order to dry the coatings, then the application of a photovolcanized composition consisting of 30% 2-hydroxyethyl methacrylate, 68% of triethylene glycol dimethacrylate, with 1% dime-thylaminoethyl methacrylate and with 1% camphor quinone. The plasters formed are exposed to visible light by means of a dental visible light irradiator for one minute, to allow setting. Then, the cavity is closed with a type of photovolcanized resin - marketed by G-C Dental Industriai Corp. under the trade name “GC Graft LC” and the resin is allowed to set by irradiating visible light for 30 seconds using a dental visible light irradiator. The patient is relieved of his pain and his condition remains good even after a period of three months.

Example 34:

A 5% aqueous solution of disodium phosphate is prepared as liquid A34, and its pH is adjusted to 7.4 with a 5% aqueous solution of sodium phosphate. A 10% aqueous solution of calcium chloride is then prepared as liquid B34, the pH of which is in turn adjusted to 7.4 with a 5% aqueous solution of hydrochloric acid.

After preparation of the teeth for fixation of a dental prosthesis by means of a diamond point, the affected area of the pain patient is cleaned and dried. Liquid A34 is applied to the affected region by means of a sponge and liquid B34 is applied by means of a sponge to the coating layer formed by liquid A34. The patient is immediately relieved of his pain.

Example 35:

A 5% aqueous solution of disodium phosphate is mixed with a 2% aqueous solution of sodium fluoride, to prepare the liquid A35, the pH of which is then adjusted to 7.2 with a 5% aqueous solution of monosodium phosphate. Then, as liquid B35, a 10% aqueous solution of calcium chloride is prepared, the pH of which is in turn adjusted to 7.2 with a 5% aqueous solution of hydrochloric acid.

The affected area of the patient, who suffers from a damage to the root forks, is subjected to radicular flattening, the patient then complaining of pain. After cleaning and drying of the affected region, the liquid A35 is applied to said region by means of a sponge and the liquid B35 is applied by means of a sponge to the coating layer formed by the liquid A35. The patient is immediately relieved of his pain.

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Example 36:

A 10% aqueous solution of disodium phosphate is prepared as liquid A36, and its pH is adjusted to 7.4 with a 5% aqueous solution of sodium phosphate. A 10% aqueous solution of calcium chloride is then prepared as liquid B36, the pH of which is in turn adjusted to 7.4 with a 5% aqueous solution of hydrochloric acid.

After having reamed and filed the molar, the root of which requires treatment of the canal, in order to enlarge the canal, and after having carefully cleaned it inside, said canal is again cleaned with liquid A36, using a dental syringe. Liquid B36 is then introduced under pressure near the apical foramen into the root canal, again using a dental syringe, in order to obtain precipitates. Paper dots are then used to remove excess fluid, and then an inspection is carried out using radiography equipment. After verifying that the apical foramen is well sealed, the root canal is closed with gutta-percha points. After six months confirmation is obtained by genetic engineering that the periradicular and periodontal tissues are still in good condition.

Comparative example 1:

A diamine silver fluoride preparation containing a diamine silver fluoride solution marketed by Bibrand Medico Dental Co., Ltd. under the trade name "Saforide" - is applied to a patient complaining of hypersensitivity, without however relieving their pain. A darkening of the patient's teeth is then observed.

Comparative example 2:

The patient is exposed to light laser radiation using "Stmalaser" equipment manufactured by Sedatelec Co., Ltd. The pain disappears from the upper jaw, but the condition of the lower jaw remains pathological.

Comparative example 3:

For filling with dental resin, a Class II cavity is formed in the patient's first upper molar. A photovolcanized composition is applied to the cavity - marketed by Kuraray Co., Ltd. under the trade name "Photobond". The coating formed is then exposed to visible light by means of a dental visible light irradiator for one minute, to allow setting. Then the cavity is closed with a type of photovolcanized resin - marketed by Kuraray Co., Ltd. under the trade name "PhotoClearfil" - and the resin is exposed to visible light for 30 seconds using a dental visible light irradiator. Immediately after the obturation, the patient complains of pain. The pain persists for a week. On the tenth day, the pain becomes more serious and we decide to have a pulpectomy.

Comparative example 4:

After reaming and filing the molar, the root of which requires treatment of the canal, in order to enlarge the canal, the interior of the canal is carefully cleaned. Paper dots are then used to remove excess water and the root canal is closed with gutta-percha dots.

After obturation, it is observed by ro-genography that the point exerts a push on 1 mm through the apex of the root. The next day, the inflammation becomes more severe and the pain increases. A new treatment of the root canal must therefore be carried out.

According to the present invention, liquids A and B, which contain substances capable of forming, with rapid mixing, hardly dissolving precipitates, are applied successively to the affected region, on which they are allowed to react with each other to form the dissolving substance difficult to seal an elongated dentinal tubule.

Liquid A is essentially composed of an aqueous solution containing 1 to 70% of one or more compounds chosen from sodium, potassium and lithium salts of inorganic or organic acids, while liquid B consists mainly of an aqueous solution containing 1 to 70% of one or more compounds chosen from chlorides, nitrates, sulfates and acetates of calcium, zinc, strontium, magnesium, aluminum, barium, iron, copper, silver, lead and tin.

When the odontotherapy material of the present invention is used as a hypersensitivity lenitive, liquid A is applied to the affected area, already cleaned and dried, using a sponge, and liquid B is applied using 'a sponge on the coating layer formed by liquid A. The order of application of liquids A and B can be reversed.

When the odontotherapy material of the present invention is used as a lenitive (or as a coating primer) against pulp pain, a cavity cleaning agent marketed by G-C Den-

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tal Industriai Corp. under the trade name "GC Dentine Contioner", is applied to the dentin part of the affected area to remove smear layers, then the affected area is cleaned and dried. Liquid A is applied to the affected region using a sponge and liquid B is applied using a sponge to the coating layer formed by liquid B. A dental bonding material is then applied to the plasters thus formed to allow the setting. The order of application of liquids A and B can be reversed.

When the odontotherapy material of the present invention is used to seal the apex of the root in the radiculodental canal, said canal is enlarged using a dental reamer, a dental file, etc. and the interior is thoroughly cleaned. The radiculodental canal is then carefully cleaned again with liquid A, using a dental syringe. Then the liquid B is introduced under pressure through the apex of the root inside the radiculodentary canal, again using a syringe. The order of application of liquids A and B can be reversed.

As presented in detail above, when the odontotherapy material of the present invention is used as a lenitive against hypersensitivity, the liquids A and B, with or without adjusting their pH, are applied successively to the affected area to react with each other, forming a difficult-to-dissolve substance capable of sealing elongated dentinal tubules. We can thus control the movement of fluids in the dentinal tubules, according to the theory of fluid dynamics of Brännström, which then suppresses any stimulus on the dental pulp.

The odontotherapy material of the present invention also meets the eight conditions, listed below, which are supposed to possess the traditional lenitive used against hypersensitivity:

(1) he must avoid stimulating the dental pulp and gums and be able to reduce or eliminate the pain caused;

(2) it must not cause any alteration of the teeth;

(3) there must be no tarnishing of the teeth;

(4) it must produce its effect without requiring complex work;

(5) it must have immediate action;

(6) it must have a prolonged effect;

(7) it must not cause any pain to the patient during or after treatment; and

(8) it must be able to be applied without special materials or equipment.

When the odontotherapy material of the present invention is used as a lenitive (or as a coating primer) against pulpal pain, liquids A and B, with or without adjusting their pH, are applied successively to the region affected by so as to react with each other, thus forming a substance, which is difficult to dissolve, in the dentinal tubules and on the surface of the dentin, which can then be taken to set with or without a photovolcanized composition. We can thus control the movement of fluids in the dentinal tubules, according to the theory of fluid dynamics of Brännström, which then suppresses any stimulus on the dental pulp. The odontotherapy material of the present invention also makes it possible to perform, with increased safety, the placement of fillings, with cements or coatings available on the market as bases, and the application of dental resins on these fillings. Overall, the odontotherapy material of the present invention meets the nine conditions, listed below, that are supposed to possess the traditional lenitive used against pulp pain:

(1) he must avoid stimulating the dental pulp and gums and be able to reduce or eliminate the pain caused;

(2) it must not cause any alteration of the dentin;

(3) it must not produce any tarnishing of the dentin;

(4) it must produce its effect without requiring complex work;

(5) it must have immediate action;

(6) it must have a prolonged effect;

(7) it must not cause any pain to the patient during or after treatment;

(8) it must be capable of being applied without special materials or equipment, and

(9) it must not participate in the ploymerization of the resin.

The dental therapy material of the present invention can also be used after scaling or root planing.

The odontotherapy material of the present invention can also be used to determine whether the pain is induced by hypersensitivity or by pulpitis.

In addition, when the dental therapy material of the present invention is used to seal the apex in the radiculodental canal, liquids A and B, with or without adjusting their pH, are successively introduced under pressure into the radiculodental canal, into which they react with each other to form a hard-dissolving substance, thereby sealing the apex of the root in a fixed position. Therefore, the pushing of the gutta-percha point through the root apex, which is one of the problems encountered with traditional materials, can be avoided.

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Claims (11)

Claims 1. Odontotherapy material based on two liquids A and B intended to be applied successively to the affected region containing substances capable of forming immediately by mixing precipitates which are difficult to dissolve. 2. odontotherapy material according to claim 1 comprising a photopolymerizable composition. 3. odontotherapy material according to claim 1 or 2, in which the liquid A is an aqueous solution containing 1 to 70% of one or more compounds chosen from the sodium, potassium and lithium salts of an acid. inorganic or organic. 4. odontotherapy material according to claim 1 or 2, in which the liquid B is an aqueous solution containing 1 to 70% of one or more compounds chosen from chlorides, nitrates, sulfates and calcium acetates, zinc, strontium, magnesium, aluminum, barium, iron, copper, silver, lead and tin, or calcium chloride, zinc chloride or strontium chloride. 5. odontotherapy material according to claim 3, in which inorganic acids are chosen from the group comprising phosphoric acid, pyrophosphoric acid, tripolyphosphoric acid, metaphosphoric acid, polyphosphoric acid, l phosphonic acid, phosphinic acid, sulfuric acid, sulfurous acid, carbonic acid, hydrogen fluoride, hydrogen sulfide and silicic acid. 6. odontotherapy material according to claim 3, wherein the sodium or potassium salts of an inorganic acid are sodium phosphate, potassium phosphate, sodium fluoride or sodium pyrophosphate. 7. odontotherapy material according to claim 3, in which the organic acids are chosen from the group composed of acids containing, as acid groups, carboxyl, phosphoric, thiophosphoric, pyrophosphoric, phosphonic, phosphinic and sulfone groups. 8. The odontotherapy material according to claim 3, wherein the organic acid is a polymer. 9. odontotherapy material according to claim 3 or 7, wherein the organic acid has a polymerizable double bond. 10. odontotherapy material according to one of claims 1, 2, 3 or 9, in which the liquids A and / or B contain, in addition to water and essential components, a monomer substance containing one or more groups hydrophilic, such as hydroxyl, carboxyl and sulfone groups, and, at the same time, a polymerizable double bond. 11. odontotherapy material according to one of claims 1, 2, 3 or 9, in which the liquids A and / or B contain, in addition to water and essential components, 1 to 70% of methacrylate 2- hydroxyethyl. 17