FR2655048A1 - Procede d'obtention de copolymeres bioactifs par greffage de motifs vinyliques et copolymeres greffes resultants. - Google Patents
Procede d'obtention de copolymeres bioactifs par greffage de motifs vinyliques et copolymeres greffes resultants. Download PDFInfo
- Publication number
- FR2655048A1 FR2655048A1 FR8915575A FR8915575A FR2655048A1 FR 2655048 A1 FR2655048 A1 FR 2655048A1 FR 8915575 A FR8915575 A FR 8915575A FR 8915575 A FR8915575 A FR 8915575A FR 2655048 A1 FR2655048 A1 FR 2655048A1
- Authority
- FR
- France
- Prior art keywords
- protein
- copolymers
- vinyl
- collagen
- bioactive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001577 copolymer Polymers 0.000 title claims abstract description 27
- 229920002554 vinyl polymer Polymers 0.000 title claims abstract description 21
- 230000000975 bioactive effect Effects 0.000 title claims abstract description 11
- 238000000034 method Methods 0.000 title claims description 21
- 230000008569 process Effects 0.000 title claims description 8
- 229920000578 graft copolymer Polymers 0.000 title description 3
- ORGHESHFQPYLAO-UHFFFAOYSA-N vinyl radical Chemical class C=[CH] ORGHESHFQPYLAO-UHFFFAOYSA-N 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 40
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 40
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims abstract description 22
- 239000000178 monomer Substances 0.000 claims abstract description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 9
- 239000003112 inhibitor Substances 0.000 claims abstract description 8
- 229940126062 Compound A Drugs 0.000 claims abstract description 5
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000005445 natural material Substances 0.000 claims abstract description 3
- 239000000463 material Substances 0.000 claims description 29
- 102000008186 Collagen Human genes 0.000 claims description 16
- 108010035532 Collagen Proteins 0.000 claims description 16
- 229920001436 collagen Polymers 0.000 claims description 15
- 239000003431 cross linking reagent Substances 0.000 claims description 11
- 229920000728 polyester Polymers 0.000 claims description 11
- 230000002792 vascular Effects 0.000 claims description 8
- 238000001042 affinity chromatography Methods 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 5
- 230000009471 action Effects 0.000 claims description 4
- 239000012072 active phase Substances 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 108090000935 Antithrombin III Proteins 0.000 claims description 3
- 230000020764 fibrinolysis Effects 0.000 claims description 3
- 230000001737 promoting effect Effects 0.000 claims description 3
- 239000012429 reaction media Substances 0.000 claims description 3
- 229920000936 Agarose Polymers 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims description 2
- 102000016359 Fibronectins Human genes 0.000 claims description 2
- 108010067306 Fibronectins Proteins 0.000 claims description 2
- 108091005804 Peptidases Proteins 0.000 claims description 2
- 102000035195 Peptidases Human genes 0.000 claims description 2
- 239000004365 Protease Substances 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 229960005348 antithrombin iii Drugs 0.000 claims description 2
- 230000010261 cell growth Effects 0.000 claims description 2
- 230000001413 cellular effect Effects 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 238000005345 coagulation Methods 0.000 claims description 2
- 230000015271 coagulation Effects 0.000 claims description 2
- 239000003446 ligand Substances 0.000 claims description 2
- 239000007791 liquid phase Substances 0.000 claims description 2
- 229920002635 polyurethane Polymers 0.000 claims description 2
- 239000004814 polyurethane Substances 0.000 claims description 2
- 230000002760 pro-activator Effects 0.000 claims description 2
- 230000002285 radioactive effect Effects 0.000 claims description 2
- 229940043517 specific immunoglobulins Drugs 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 229920002994 synthetic fiber Polymers 0.000 claims description 2
- 229920006027 ternary co-polymer Polymers 0.000 claims description 2
- 102000004411 Antithrombin III Human genes 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 6
- 230000004071 biological effect Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 5
- 229920000298 Cellophane Polymers 0.000 description 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 4
- 238000004132 cross linking Methods 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 229960002897 heparin Drugs 0.000 description 4
- 229920000669 heparin Polymers 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- -1 tpA Proteins 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 229920000139 polyethylene terephthalate Polymers 0.000 description 3
- 239000005020 polyethylene terephthalate Substances 0.000 description 3
- 102100022977 Antithrombin-III Human genes 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 229960000583 acetic acid Drugs 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 230000002427 irreversible effect Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 238000004078 waterproofing Methods 0.000 description 2
- 229920002126 Acrylic acid copolymer Polymers 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000012422 Collagen Type I Human genes 0.000 description 1
- 108010022452 Collagen Type I Proteins 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 108010023197 Streptokinase Proteins 0.000 description 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 229910000365 copper sulfate Inorganic materials 0.000 description 1
- 229910000366 copper(II) sulfate Inorganic materials 0.000 description 1
- 239000007822 coupling agent Substances 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Chemical compound CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000002634 heparin fragment Substances 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 125000005395 methacrylic acid group Chemical group 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 230000000019 pro-fibrinolytic effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000003660 reticulum Anatomy 0.000 description 1
- 238000004626 scanning electron microscopy Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229960005202 streptokinase Drugs 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F289/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds not provided for in groups C08F251/00 - C08F287/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/06—Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Biophysics (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Graft Or Block Polymers (AREA)
- Materials For Medical Uses (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8915575A FR2655048A1 (fr) | 1989-11-27 | 1989-11-27 | Procede d'obtention de copolymeres bioactifs par greffage de motifs vinyliques et copolymeres greffes resultants. |
| PCT/FR1990/000858 WO1991008242A1 (fr) | 1989-11-27 | 1990-11-27 | Procede d'obtention de copolymeres par greffage de motifs vinyliques et copolymeres greffes resultants |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8915575A FR2655048A1 (fr) | 1989-11-27 | 1989-11-27 | Procede d'obtention de copolymeres bioactifs par greffage de motifs vinyliques et copolymeres greffes resultants. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2655048A1 true FR2655048A1 (fr) | 1991-05-31 |
| FR2655048B1 FR2655048B1 (enrdf_load_stackoverflow) | 1995-02-24 |
Family
ID=9387817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8915575A Granted FR2655048A1 (fr) | 1989-11-27 | 1989-11-27 | Procede d'obtention de copolymeres bioactifs par greffage de motifs vinyliques et copolymeres greffes resultants. |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR2655048A1 (enrdf_load_stackoverflow) |
| WO (1) | WO1991008242A1 (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999008717A3 (en) * | 1997-08-15 | 1999-05-06 | Surmodics Inc | Latent reactive polymers with biologically active moieties |
| WO2005039641A3 (en) * | 2003-10-15 | 2006-05-26 | Univ California | Biomacromolecule polymer conjugates |
| US7812224B2 (en) | 1997-04-04 | 2010-10-12 | Board Of Regents Of University Of Nebraska | Methods and materials for making and using transgenic dicamba-degrading organisms |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69118826T2 (de) * | 1990-11-27 | 1996-11-14 | Fuji Photo Film Co Ltd | Propenamidderivate, deren Polymere, Copolymere und deren Verwendung |
| GB2284606A (en) * | 1993-11-24 | 1995-06-14 | Aspid S A De C V | Polymerised collagen-based anti-fibroid composition |
| ES2079311B1 (es) * | 1993-11-30 | 1996-09-01 | Aspid S A De C V | Una composicion anti-fibrotica a base de colageno polimerizado. |
| US6506895B2 (en) | 1997-08-15 | 2003-01-14 | Surmodics, Inc. | Photoactivatable nucleic acids |
| DE19818077A1 (de) * | 1998-04-22 | 1999-10-28 | Biotechnolog Forschung Gmbh | Immobilisierte Substrate, damit gefertigte Trenngele und Verfahren zum Nachweis von Enzymaktivitäten nach elektrophoretischer Protein-Trennung |
| JP2004525268A (ja) * | 2000-04-20 | 2004-08-19 | エモリー ユニバーシテイ | 医療用途のためのネイティブタンパク質模倣繊維、繊維ネットワ−クおよび織地 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2211507A1 (enrdf_load_stackoverflow) * | 1972-12-22 | 1974-07-19 | Unisearch Ltd | |
| SU883052A1 (ru) * | 1979-11-14 | 1981-11-23 | Всесоюзный кардиологический научный центр АМН СССР | Иммуносорбент |
-
1989
- 1989-11-27 FR FR8915575A patent/FR2655048A1/fr active Granted
-
1990
- 1990-11-27 WO PCT/FR1990/000858 patent/WO1991008242A1/fr unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2211507A1 (enrdf_load_stackoverflow) * | 1972-12-22 | 1974-07-19 | Unisearch Ltd | |
| SU883052A1 (ru) * | 1979-11-14 | 1981-11-23 | Всесоюзный кардиологический научный центр АМН СССР | Иммуносорбент |
Non-Patent Citations (5)
| Title |
|---|
| CHEMICAL ABSTRACTS, vol. 109, no. 8, 22 août 1988, page 435, résumé no. 61406c, Columbius, Ohio, US; Y. IMANISHI et al.: "Design ans synthesis of biocompatible polymeric materials", J. MACROMOL. SCI. CHEM. 1988, A25(5-7), 555-70 * |
| CHEMICAL ABSTRACTS, vol. 75, no. 16, 18 octobre 1971, page 21, résumé no. 99120x, Columbus, Ohio, US; & CS-A-137 456 (O. WICHTERLE et al.) 15-07-1970 * |
| CHEMICAL ABSTRACTS, vol. 84, no. 4, 26 janvier 1976, page 22, résumé no. 18010x, Columbus, Ohio, US; G.N. GAYLORD et al.: "Donor-acceptor complexes in copolymerization. LII. Alternating copolymer graft copolymers. IX. Grafting og poly(styrene-alt-acrylonotrile) onto starch, casein, and collagen", & J. POLYM. SCI., POLYM. LETT. ED. 1975, 13(11), 693-6 * |
| CHEMICAL ABSTRACTS, vol. 96, no. 21, 24 mai 1982, pages 375-376, résumé no. 177447j, Columbus, Ohio, US; & SU-A-883 052 (ALL-UNION CARDIOLOGICAL RESEARCH CENTER) 23-11-1981 * |
| POLYMER SCIENCE, U.S.S.R., vol. 2, no. 3, 1961, pages 308-309; L. KISS et al.: "Graft copolymerization of methyl methacrylate and styrene on to gelatin induced by ionizing radiation" * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7812224B2 (en) | 1997-04-04 | 2010-10-12 | Board Of Regents Of University Of Nebraska | Methods and materials for making and using transgenic dicamba-degrading organisms |
| US8119380B2 (en) | 1997-04-04 | 2012-02-21 | Board Of Regents Of University Of Nebraska | Methods and materials for making and using transgenic dicamba-degrading organisms |
| US8629323B2 (en) | 1997-04-04 | 2014-01-14 | Board Of Regents Of The University Of Nebraska | Methods and materials for making and using transgenic dicamba-degrading organisms |
| WO1999008717A3 (en) * | 1997-08-15 | 1999-05-06 | Surmodics Inc | Latent reactive polymers with biologically active moieties |
| US6121027A (en) * | 1997-08-15 | 2000-09-19 | Surmodics, Inc. | Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups |
| US6514734B1 (en) | 1997-08-15 | 2003-02-04 | Surmodics, Inc. | Polybifunctional reagent having a polymeric backbone and latent reactive moieties and bioactive groups |
| WO2005039641A3 (en) * | 2003-10-15 | 2006-05-26 | Univ California | Biomacromolecule polymer conjugates |
| US7786213B2 (en) | 2003-10-15 | 2010-08-31 | The Regents Of The University Of California | Biomacromolecule polymer conjugates |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2655048B1 (enrdf_load_stackoverflow) | 1995-02-24 |
| WO1991008242A1 (fr) | 1991-06-13 |
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