FR2614891B1 - Nouveaux derives de la forskoline, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant ainsi que des intermediaires de leur procede de preparation - Google Patents

Nouveaux derives de la forskoline, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant ainsi que des intermediaires de leur procede de preparation

Info

Publication number
FR2614891B1
FR2614891B1 FR8706242A FR8706242A FR2614891B1 FR 2614891 B1 FR2614891 B1 FR 2614891B1 FR 8706242 A FR8706242 A FR 8706242A FR 8706242 A FR8706242 A FR 8706242A FR 2614891 B1 FR2614891 B1 FR 2614891B1
Authority
FR
France
Prior art keywords
preparation process
forskoline
medicaments
intermediates
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR8706242A
Other languages
English (en)
French (fr)
Other versions
FR2614891A1 (fr
Inventor
Bernard Delpech
Robert Lett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR8706242A priority Critical patent/FR2614891B1/fr
Priority to IT47912/88A priority patent/IT1219567B/it
Priority to CH1649/88A priority patent/CH676598A5/fr
Priority to NL8801174A priority patent/NL8801174A/nl
Priority to GB08810463A priority patent/GB2205564A/en
Priority to DE3815213A priority patent/DE3815213A1/de
Priority to JP63109294A priority patent/JPS63284169A/ja
Publication of FR2614891A1 publication Critical patent/FR2614891A1/fr
Application granted granted Critical
Publication of FR2614891B1 publication Critical patent/FR2614891B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
FR8706242A 1987-05-04 1987-05-04 Nouveaux derives de la forskoline, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant ainsi que des intermediaires de leur procede de preparation Expired - Fee Related FR2614891B1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR8706242A FR2614891B1 (fr) 1987-05-04 1987-05-04 Nouveaux derives de la forskoline, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant ainsi que des intermediaires de leur procede de preparation
CH1649/88A CH676598A5 (enrdf_load_stackoverflow) 1987-05-04 1988-05-03
IT47912/88A IT1219567B (it) 1987-05-04 1988-05-03 Derivati di forskolina,loro procedimento ed intermedi di preparazione,loro applicazione in qualita' di medicamenti e composizioni farmaceutiche che li contengono
GB08810463A GB2205564A (en) 1987-05-04 1988-05-04 Forskoline derivatives
NL8801174A NL8801174A (nl) 1987-05-04 1988-05-04 Nieuwe verbindingen van forskoline, werkwijze en tussenprodukten voor hun bereiding, hun toepassing als geneesmiddelen en farmaceutische preparaten, die hen bevatten.
DE3815213A DE3815213A1 (de) 1987-05-04 1988-05-04 Neue derivate des forskolins sowie ihre herstellung und pharmazeutische verwendung
JP63109294A JPS63284169A (ja) 1987-05-04 1988-05-06 フォルスコリンの新規な誘導体、その製造方法及び中間体、医薬としてのその使用、並びにそれを含有する医薬組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8706242A FR2614891B1 (fr) 1987-05-04 1987-05-04 Nouveaux derives de la forskoline, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant ainsi que des intermediaires de leur procede de preparation

Publications (2)

Publication Number Publication Date
FR2614891A1 FR2614891A1 (fr) 1988-11-10
FR2614891B1 true FR2614891B1 (fr) 1991-05-24

Family

ID=9350729

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8706242A Expired - Fee Related FR2614891B1 (fr) 1987-05-04 1987-05-04 Nouveaux derives de la forskoline, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant ainsi que des intermediaires de leur procede de preparation

Country Status (7)

Country Link
JP (1) JPS63284169A (enrdf_load_stackoverflow)
CH (1) CH676598A5 (enrdf_load_stackoverflow)
DE (1) DE3815213A1 (enrdf_load_stackoverflow)
FR (1) FR2614891B1 (enrdf_load_stackoverflow)
GB (1) GB2205564A (enrdf_load_stackoverflow)
IT (1) IT1219567B (enrdf_load_stackoverflow)
NL (1) NL8801174A (enrdf_load_stackoverflow)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268471A (en) * 1990-07-24 1993-12-07 Hoechst Aktiengesellschaft Process for the preparation of 6-acyl, 7-acyl, and 6,7-diacyl analogues of forskolin and intermediates thereof
RU2045523C1 (ru) * 1990-07-24 1995-10-10 Хехст АГ СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 6β -(3-АМИНОЗАМЕЩЕННЫХ ПРОПИОНИЛОКСИ)-ФОРСКОЛИНА ИЛИ ИХ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫХ СОЛЕЙ
YU128191A (sh) * 1990-07-24 1994-09-09 Hoechst Aktiengesellschaft Postupak za dobijanje 6-acilnih, 7-acilnih i 6,7-diacilnih analoga forskolina i njegovih intermedijata
CN1089092C (zh) * 1997-10-30 2002-08-14 中国科学院动物研究所 一种促分化抑增殖抗癌药二萜类化合物及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE43545B1 (en) * 1975-09-06 1981-03-25 Hoechst Ag Pharmacologically active substance obtainable from plants
AU2717777A (en) * 1976-07-21 1979-01-25 Hoechst Ag Pharmacologically effective substance from plants belonging to the family of labiatae
US4517200A (en) * 1982-12-27 1985-05-14 Schering-Plough Corporation Method for treating allergic reactions with forskolin

Also Published As

Publication number Publication date
GB8810463D0 (en) 1988-06-08
GB2205564A (en) 1988-12-14
NL8801174A (nl) 1988-12-01
IT8847912A0 (it) 1988-05-03
FR2614891A1 (fr) 1988-11-10
IT1219567B (it) 1990-05-18
CH676598A5 (enrdf_load_stackoverflow) 1991-02-15
DE3815213A1 (de) 1988-11-17
JPS63284169A (ja) 1988-11-21

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