FR2602511A1 - Peptides et derives peptidiques, leur preparation et leur utilisation comme medicaments - Google Patents
Peptides et derives peptidiques, leur preparation et leur utilisation comme medicaments Download PDFInfo
- Publication number
- FR2602511A1 FR2602511A1 FR8710662A FR8710662A FR2602511A1 FR 2602511 A1 FR2602511 A1 FR 2602511A1 FR 8710662 A FR8710662 A FR 8710662A FR 8710662 A FR8710662 A FR 8710662A FR 2602511 A1 FR2602511 A1 FR 2602511A1
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- Prior art keywords
- phe
- boc
- group
- isobutyl
- tetrafluoro
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868619182A GB8619182D0 (en) | 1986-08-06 | 1986-08-06 | Peptides & derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2602511A1 true FR2602511A1 (fr) | 1988-02-12 |
Family
ID=10602311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8710662A Withdrawn FR2602511A1 (fr) | 1986-08-06 | 1987-07-27 | Peptides et derives peptidiques, leur preparation et leur utilisation comme medicaments |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS6348295A (enrdf_load_stackoverflow) |
| BE (1) | BE1001618A4 (enrdf_load_stackoverflow) |
| CH (1) | CH673655A5 (enrdf_load_stackoverflow) |
| DE (1) | DE3725137A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2602511A1 (enrdf_load_stackoverflow) |
| GB (2) | GB8619182D0 (enrdf_load_stackoverflow) |
| IT (1) | IT1211681B (enrdf_load_stackoverflow) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5071837A (en) * | 1990-11-28 | 1991-12-10 | Warner-Lambert Company | Novel renin inhibiting peptides |
| HU210647B (en) * | 1991-01-02 | 1995-06-28 | Merrell Dow Pharma | Process for producing antiviral difluoro-statone derivatives and pharmaceutical compositions containing them |
| US5717093A (en) * | 1993-07-08 | 1998-02-10 | Merrell Pharmaceuticals Inc. | Difluoro statone analogs |
| CN1130898A (zh) * | 1993-09-09 | 1996-09-11 | 默里尔药物公司 | 二氟斯特酮抗病毒类似物 |
| US6114380A (en) * | 1995-12-18 | 2000-09-05 | Merrell Pharmaceuticals Inc. | Difluoro statone analogs |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0173481A2 (en) * | 1984-08-06 | 1986-03-05 | The Upjohn Company | Peptides |
| GB2171103A (en) * | 1985-02-19 | 1986-08-20 | Sandoz Ltd | Fluorinated/chlorinated peptides |
| WO1986006379A1 (en) * | 1985-04-19 | 1986-11-06 | The Upjohn Company | Dihalo-statine substituted renin inhibitors |
| WO1987002675A1 (en) * | 1985-11-01 | 1987-05-07 | Pfizer Inc. | Difluorocyclostatine containing polypeptides |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA86746B (en) * | 1985-02-04 | 1986-09-24 | Merrell Dow Pharma | Novel peptidase inhibitors |
| EP0297815B1 (en) * | 1987-07-01 | 1994-07-27 | Pfizer Inc. | Fluorine containing renin inhibitors |
| JPH10183253A (ja) * | 1996-12-24 | 1998-07-14 | Nisshin Steel Co Ltd | 表面性状及び加工性に優れた冷延鋼板又は溶融めっき鋼板の製造方法 |
-
1986
- 1986-08-06 GB GB868619182A patent/GB8619182D0/en active Pending
-
1987
- 1987-07-27 BE BE8700830A patent/BE1001618A4/fr not_active IP Right Cessation
- 1987-07-27 FR FR8710662A patent/FR2602511A1/fr not_active Withdrawn
- 1987-07-28 IT IT8748235A patent/IT1211681B/it active
- 1987-07-29 DE DE19873725137 patent/DE3725137A1/de not_active Withdrawn
- 1987-07-31 CH CH2936/87A patent/CH673655A5/de not_active IP Right Cessation
- 1987-08-03 GB GB8718325A patent/GB2196958B/en not_active Expired - Lifetime
- 1987-08-05 JP JP62196151A patent/JPS6348295A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0173481A2 (en) * | 1984-08-06 | 1986-03-05 | The Upjohn Company | Peptides |
| GB2171103A (en) * | 1985-02-19 | 1986-08-20 | Sandoz Ltd | Fluorinated/chlorinated peptides |
| WO1986006379A1 (en) * | 1985-04-19 | 1986-11-06 | The Upjohn Company | Dihalo-statine substituted renin inhibitors |
| WO1987002675A1 (en) * | 1985-11-01 | 1987-05-07 | Pfizer Inc. | Difluorocyclostatine containing polypeptides |
Non-Patent Citations (3)
| Title |
|---|
| BIOCHEMISTRY, vol. 24, no. 8, 9 avril 1985, pages 1813-1817, American Chemical Society; M.H. GELB et al.: "Fluoro ketone inhibitors of hydrolytic enzymes" * |
| J. MED. CHEM., vol. 29, no. 10, 1986, pages 2080-2087, American Chemical Society; S. THAISRIVONGS et al.: "Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogues" * |
| JOURNAL OF MEDICINAL CHEMISTRY, vol. 28, no. 11, novembre 1985, pages 1553-1555, American Chemical Society; S. THAISRIVONGS et al.: "Difluorostatine- and difluorostatone-containing peptides as potent and specific renin inhibitors" * |
Also Published As
| Publication number | Publication date |
|---|---|
| GB8619182D0 (en) | 1986-09-17 |
| DE3725137A1 (de) | 1988-02-11 |
| BE1001618A4 (fr) | 1989-12-19 |
| CH673655A5 (enrdf_load_stackoverflow) | 1990-03-30 |
| JPS6348295A (ja) | 1988-02-29 |
| GB8718325D0 (en) | 1987-09-09 |
| GB2196958A (en) | 1988-05-11 |
| GB2196958B (en) | 1990-07-04 |
| IT8748235A0 (it) | 1987-07-28 |
| IT1211681B (it) | 1989-11-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |