FR2581314A1 - Dispositif medical pour l'administration transdermique de medicaments fortement ionises insolubles dans les corps gras - Google Patents
Dispositif medical pour l'administration transdermique de medicaments fortement ionises insolubles dans les corps gras Download PDFInfo
- Publication number
- FR2581314A1 FR2581314A1 FR8606278A FR8606278A FR2581314A1 FR 2581314 A1 FR2581314 A1 FR 2581314A1 FR 8606278 A FR8606278 A FR 8606278A FR 8606278 A FR8606278 A FR 8606278A FR 2581314 A1 FR2581314 A1 FR 2581314A1
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- Prior art keywords
- medical device
- penetration enhancer
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- skin
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- 229950009195 phenylpropanol Drugs 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000005077 polysulfide Substances 0.000 description 1
- 229920001021 polysulfide Polymers 0.000 description 1
- 150000008117 polysulfides Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 229920000131 polyvinylidene Polymers 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 229960004604 propranolol hydrochloride Drugs 0.000 description 1
- 239000002964 rayon Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000013464 silicone adhesive Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000009121 systemic therapy Methods 0.000 description 1
- KFVSLSTULZVNPG-UHFFFAOYSA-N terbutaline sulfate Chemical compound [O-]S([O-])(=O)=O.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1 KFVSLSTULZVNPG-UHFFFAOYSA-N 0.000 description 1
- 229960002494 tetracaine hydrochloride Drugs 0.000 description 1
- 229960004989 tetracycline hydrochloride Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 239000002759 woven fabric Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/730,713 US4645502A (en) | 1985-05-03 | 1985-05-03 | Transdermal delivery of highly ionized fat insoluble drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2581314A1 true FR2581314A1 (fr) | 1986-11-07 |
Family
ID=24936525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8606278A Pending FR2581314A1 (fr) | 1985-05-03 | 1986-04-30 | Dispositif medical pour l'administration transdermique de medicaments fortement ionises insolubles dans les corps gras |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4645502A (enExample) |
| JP (1) | JPH01170476A (enExample) |
| CA (1) | CA1252361A (enExample) |
| DE (1) | DE3614843A1 (enExample) |
| ES (1) | ES8801987A1 (enExample) |
| FR (1) | FR2581314A1 (enExample) |
| GB (1) | GB2174605B (enExample) |
| IT (1) | IT1203553B (enExample) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4772474A (en) * | 1985-08-09 | 1988-09-20 | Alza Corporation | Dispenser with internal arrangement of lamina means for dispensing beneficial agent |
| US5000957A (en) * | 1984-03-19 | 1991-03-19 | Alza Corporation | Dispenser comprising hydrophilic osmopolymer |
| US4844984A (en) * | 1984-03-19 | 1989-07-04 | Alza Corporation | Dispensing system with means for increasing delivery of beneficial agent from the system |
| US4756710A (en) * | 1985-04-05 | 1988-07-12 | Merck & Co., Inc. | pH-Mediated drug delivery system |
| US4904475A (en) * | 1985-05-03 | 1990-02-27 | Alza Corporation | Transdermal delivery of drugs from an aqueous reservoir |
| US4917676A (en) * | 1986-11-20 | 1990-04-17 | Ciba-Geigy Corporation | User-activated transdermal therapeutic system |
| US4906463A (en) * | 1986-12-22 | 1990-03-06 | Cygnus Research Corporation | Transdermal drug-delivery composition |
| AU607172B2 (en) * | 1986-12-22 | 1991-02-28 | Cygnus, Inc. | Diffusion matrix for transdermal drug administration |
| US5006342A (en) * | 1986-12-22 | 1991-04-09 | Cygnus Corporation | Resilient transdermal drug delivery device |
| US4911707A (en) * | 1987-02-13 | 1990-03-27 | Ciba-Geigy Corporation | Monolithic user-activated transdermal therapeutic system |
| US4788062A (en) * | 1987-02-26 | 1988-11-29 | Alza Corporation | Transdermal administration of progesterone, estradiol esters, and mixtures thereof |
| US5080646A (en) * | 1988-10-03 | 1992-01-14 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
| GB8804164D0 (en) * | 1988-02-23 | 1988-03-23 | Tucker J M | Bandage for administering physiologically active compound |
| GB2232892B (en) * | 1988-02-23 | 1991-07-24 | John Mark Tucker | Occlusive body for administering a physiologically active substance |
| US5169382A (en) * | 1988-10-03 | 1992-12-08 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
| DE3844247A1 (de) * | 1988-12-29 | 1990-07-12 | Minnesota Mining & Mfg | Vorrichtung, insbesondere pflaster zum transdermalen verabreichen eines medikaments |
| CA2026885C (en) * | 1989-02-06 | 1998-12-01 | Keiichirou Okabe | Interface for iontophorese |
| DE3905051A1 (de) * | 1989-02-18 | 1990-08-30 | Lohmann Therapie Syst Lts | Therapeutisches system zur verzoegerten und gesteuerten transdermalen oder transmucosalen verabreichung von wirkstoffen (i) |
| US5096715A (en) * | 1989-11-20 | 1992-03-17 | Alko Ltd. | Method and means for treating alcoholism by extinguishing the alcohol-drinking response using a transdermally administered opiate antagonist |
| US5462744A (en) * | 1989-12-01 | 1995-10-31 | Boehringer Ingelheim Kg | Transdermal system for the administration of pharmacological compounds under pH-controlled conditions |
| DE3939703C2 (de) * | 1989-12-01 | 1998-07-02 | Boehringer Ingelheim Kg | Verbesserte transdermale Applikation von pharmakologisch aktiven Verbindungen |
| DE69115471T2 (de) * | 1990-03-30 | 1996-05-02 | Alza Corp., Palo Alto, Calif. | Gerät zur iontophoretischen verabreichung von medikamenten |
| US5149719A (en) * | 1990-04-27 | 1992-09-22 | Minnesota Mining And Manufacturing Company | Composition for transdermal penetration of medicaments |
| US5512292A (en) * | 1990-10-29 | 1996-04-30 | Alza Corporation | Transdermal contraceptive formulations methods and devices |
| US5164190A (en) * | 1990-12-11 | 1992-11-17 | Theratech, Inc. | Subsaturated transdermal drug delivery device exhibiting enhanced drug flux |
| CA2116036A1 (en) * | 1991-10-18 | 1993-04-29 | F. Eugene Yates | Device for the transdermal administration of melatonin |
| JP3786684B2 (ja) * | 1992-05-13 | 2006-06-14 | アルザ・コーポレーション | オキシブチニンの経皮投与 |
| US5900250A (en) * | 1992-05-13 | 1999-05-04 | Alza Corporation | Monoglyceride/lactate ester permeation enhancer for oxybutnin |
| US5607691A (en) * | 1992-06-12 | 1997-03-04 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
| DE4308649C2 (de) * | 1993-03-18 | 1995-11-16 | Lohmann Gmbh & Co Kg | Medizinisches Pflastermaterial sowie Verfahren zu seiner Herstellung und dessen Verwendung |
| US5451407A (en) * | 1993-06-21 | 1995-09-19 | Alza Corporation | Reduction or prevention of skin irritation or sensitization during transdermal administration of a irritating or sensitizing drug |
| WO1995001167A2 (en) * | 1993-06-25 | 1995-01-12 | Alza Corporation | Incorporating poly-n-vinyl amide in a transdermal system |
| NZ274711A (en) * | 1993-09-29 | 1996-11-26 | Alza Corp | Composition for administration of active agent by application to a body surface or membrane comprising permeability enhancing amount of monoglyceride(s) and lactate ester(s) |
| US5466465A (en) * | 1993-12-30 | 1995-11-14 | Harrogate Holdings, Limited | Transdermal drug delivery system |
| US5762955A (en) | 1994-02-04 | 1998-06-09 | Smith; Stephen Jay | Method for application and maintenance of medication on body tissue |
| US5503843A (en) * | 1994-04-22 | 1996-04-02 | Flora Inc. | Transdermal delivery of alpha adrenoceptor blocking agents |
| US5498417A (en) * | 1994-05-12 | 1996-03-12 | Coating Sciences, Inc. | Transdermal delivery of appetite suppressant drug |
| DE4423850A1 (de) * | 1994-07-07 | 1996-01-11 | Labtec Gmbh | Transdermales therapeutisches System zur Applikation von Naloxon |
| US5861439A (en) * | 1994-11-14 | 1999-01-19 | Alza Corporation | Method for enhanced electrotransport agent delivery |
| US5562917A (en) * | 1994-12-23 | 1996-10-08 | Pentech Pharmaceuticals, Inc. | Transdermal administration of apomorphine |
| FR2732896B1 (fr) * | 1995-04-11 | 1997-06-13 | Prographarm Lab | Forme pharmaceutique transdermique pour l'administration percutanee de l'apomorphine |
| US6572879B1 (en) * | 1995-06-07 | 2003-06-03 | Alza Corporation | Formulations for transdermal delivery of pergolide |
| US5785991A (en) * | 1995-06-07 | 1998-07-28 | Alza Corporation | Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate |
| US5840327A (en) * | 1995-08-21 | 1998-11-24 | Alza Corporation | Transdermal drug delivery device having enhanced adhesion |
| US5730721A (en) * | 1996-01-25 | 1998-03-24 | Vesture Corporation | Medical applicator and method |
| SE9601528D0 (sv) * | 1996-04-23 | 1996-04-23 | Pharmacia Ab | Transdermally administered dextromethorphan as antitissue agent |
| US6512010B1 (en) * | 1996-07-15 | 2003-01-28 | Alza Corporation | Formulations for the administration of fluoxetine |
| US5985317A (en) * | 1996-09-06 | 1999-11-16 | Theratech, Inc. | Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents |
| AU4990797A (en) * | 1996-10-24 | 1998-05-15 | Alza Corporation | Permeation enhancers for transdermal drug delivery compositions, devices, and methods |
| US6203817B1 (en) | 1997-02-19 | 2001-03-20 | Alza Corporation | Reduction of skin reactions caused by transdermal drug delivery |
| US7150881B2 (en) | 1997-06-26 | 2006-12-19 | Mylan Technologies, Inc. | Adhesive mixture for transdermal delivery of highly plasticizing drugs |
| US6660295B2 (en) | 1997-09-30 | 2003-12-09 | Alza Corporation | Transdermal drug delivery device package with improved drug stability |
| US6267984B1 (en) | 1997-12-22 | 2001-07-31 | Alza Corporation | Skin permeation enhancer compositions comprising a monoglyceride and ethyl palmitate |
| US6096943A (en) * | 1998-01-09 | 2000-08-01 | Maiwald; Diane C | Skin wound protector |
| US6699497B1 (en) | 1998-07-24 | 2004-03-02 | Alza Corporation | Formulations for the transdermal administration of fenoldopam |
| US6348210B1 (en) | 1998-11-13 | 2002-02-19 | Alza Corporation | Methods for transdermal drug administration |
| CN101693023A (zh) | 1998-12-18 | 2010-04-14 | 阿尔扎有限公司 | 透明的透皮烟碱输送装置 |
| ES2395057T3 (es) * | 1999-03-25 | 2013-02-07 | Metabolix, Inc. | Dispositivos y aplicaciones médicas de polímeros polihidroxialcanoato |
| JP2002541094A (ja) * | 1999-04-01 | 2002-12-03 | アルザ・コーポレーション | ポリウレタン薬物貯蔵部を含んでなる経皮薬物送達装置 |
| US6696078B1 (en) * | 1999-07-21 | 2004-02-24 | Edwin J. Masters | System and methods for local intradermal treatment |
| CA2382599C (en) | 1999-08-30 | 2005-11-08 | Tepha, Inc. | Flushable disposable polymeric products |
| US6495229B1 (en) * | 1999-09-17 | 2002-12-17 | Avery Dennison Corporation | Pattern coated adhesive article |
| JP4358978B2 (ja) * | 2000-09-05 | 2009-11-04 | 日東電工株式会社 | 経皮吸収製剤 |
| US20020119187A1 (en) * | 2000-09-29 | 2002-08-29 | Cantor Adam S. | Composition for the transdermal delivery of fentanyl |
| WO2002092069A1 (en) * | 2001-05-11 | 2002-11-21 | Elan Corporation, Plc | Permeation enhancers |
| DE10141651B4 (de) * | 2001-08-24 | 2007-02-15 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System (TTS) mit dem Wirkstoff Fentanyl und Verfahren zu seiner Herstellung |
| DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| US20040033253A1 (en) * | 2002-02-19 | 2004-02-19 | Ihor Shevchuk | Acyl opioid antagonists |
| JP4199485B2 (ja) * | 2002-06-07 | 2008-12-17 | 久光製薬株式会社 | 貼付剤 |
| US20040258742A1 (en) * | 2003-04-11 | 2004-12-23 | Van Osdol William Woodson | Transdermal administration of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methyl guanidines |
| ATE461681T1 (de) * | 2003-04-29 | 2010-04-15 | Gen Hospital Corp | Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln |
| EP1638615B1 (en) | 2003-05-08 | 2014-10-29 | Tepha, Inc. | Polyhydroxyalkanoate medical textiles and fibers |
| EP1651273B1 (en) * | 2003-07-08 | 2012-08-29 | Tepha, Inc. | Poly-4-hydroxybutyrate matrices for sustained drug delivery |
| JP2007503221A (ja) * | 2003-08-22 | 2007-02-22 | テファ， インコーポレイテッド | ポリヒドロキシアルカノエート神経再生デバイス |
| US7105263B2 (en) * | 2003-12-30 | 2006-09-12 | Samsung Electronics Company | Dry toner comprising encapsulated pigment, methods and uses |
| US20070196452A1 (en) * | 2004-06-07 | 2007-08-23 | Jie Zhang | Flux-enabling compositions and methods for dermal delivery of drugs |
| US8741332B2 (en) | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for dermally treating neuropathic pain |
| US8907153B2 (en) | 2004-06-07 | 2014-12-09 | Nuvo Research Inc. | Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same |
| US8741333B2 (en) | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for treating dermatitis or psoriasis |
| US20060008432A1 (en) * | 2004-07-07 | 2006-01-12 | Sebastiano Scarampi | Gilsonite derived pharmaceutical delivery compositions and methods: nail applications |
| ATE473021T1 (de) * | 2004-08-03 | 2010-07-15 | Tepha Inc | Nichtkräuselnde polyhydroxyalkanoatnähte |
| US8252319B2 (en) | 2004-10-21 | 2012-08-28 | Durect Corporation | Transdermal delivery system for sufentanil |
| DE602005021909D1 (de) | 2004-10-21 | 2010-07-29 | Durect Corp | Transdermale verabreichungssysteme |
| EP1845951B1 (en) * | 2005-01-28 | 2010-09-15 | Tepha, Inc. | Embolization using poly-4-hydroxybutyrate particles |
| US20060223786A1 (en) * | 2005-04-01 | 2006-10-05 | Smith David J | Transdermal pain control method and device |
| JP2007175117A (ja) * | 2005-12-27 | 2007-07-12 | Hisamitsu Pharmaceut Co Inc | イオントフォレーシス装置及びその製造方法 |
| JP2007175116A (ja) * | 2005-12-27 | 2007-07-12 | Hisamitsu Pharmaceut Co Inc | イオントフォレーシス装置及びその製造方法 |
| US8518926B2 (en) * | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
| US20070259930A1 (en) * | 2006-04-10 | 2007-11-08 | Knopp Neurosciences, Inc. | Compositions and methods of using r(+) pramipexole |
| US20070248657A1 (en) * | 2006-04-25 | 2007-10-25 | Smith David J | Multi-compartment transdermal pain control device |
| US20070280972A1 (en) * | 2006-04-25 | 2007-12-06 | Zars, Inc. | Adhesive solid gel-forming formulations for dermal drug delivery |
| US9271932B2 (en) | 2006-04-28 | 2016-03-01 | Children's Hospital Medical Center | Fusogenic properties of saposin C and related proteins and peptides for application to transmembrane drug delivery systems |
| ES2379117T3 (es) | 2006-05-16 | 2012-04-20 | Knopp Neurosciences, Inc. | Composiciones de R(+) y S(-) pramipexol y métodos de utilización de las mismas |
| US7943683B2 (en) * | 2006-12-01 | 2011-05-17 | Tepha, Inc. | Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers |
| US8524695B2 (en) * | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| JP2010521496A (ja) | 2007-03-14 | 2010-06-24 | ノップ ニューロサイエンシーズ、インク． | キラル精製置換ベンゾチアゾールジアミンの合成 |
| US20090088707A1 (en) * | 2007-10-01 | 2009-04-02 | Michael Adams | Dressing, method and kit for skin crack repair |
| US9700552B2 (en) * | 2008-02-28 | 2017-07-11 | Syntropharma Limited | Pharmaceutical compositions for treatment of addiction |
| CA2734491A1 (en) | 2008-08-19 | 2010-02-25 | Knopp Neurosciences, Inc. | Compositions and methods of using (r)-pramipexole |
| US20100221313A1 (en) * | 2008-12-01 | 2010-09-02 | Innovative Pharmaceuticals, Llc | Transdermal reservoir patch |
| AU2010262970A1 (en) * | 2009-06-19 | 2012-01-12 | Knopp Neurosciences, Inc. | Compositions and methods for treating amyotrophic lateral sclerosis |
| KR20130073893A (ko) | 2010-04-13 | 2013-07-03 | 나지브 바불 | 1-메틸-2''-6''-피페콜옥실리디드의 피부 약제학적 조성물 및 사용 방법 |
| US20120157536A1 (en) * | 2010-12-20 | 2012-06-21 | Polytherapeutics, Inc. | Composition for transdermal administration of non-steroidal anti-flammatory drug |
| WO2012096866A2 (en) | 2011-01-10 | 2012-07-19 | Inverseon, Inc. | Use of beta-adrenergic inverse agonists for smoking cessation |
| WO2013096816A1 (en) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| EP2999444A4 (en) | 2013-05-20 | 2016-10-12 | Mylan Inc | ADVANCED TRANSDERMAL DOSAGE OF PRAMIPEXOL FOR THE TREATMENT OF NEUROLOGICAL DISEASES |
| CN105764507B (zh) | 2013-07-12 | 2019-07-19 | 诺普生物科学有限责任公司 | 治疗升高的嗜酸性粒细胞和/或嗜碱性粒细胞的水平 |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| EP3033081B1 (en) | 2013-08-13 | 2021-05-12 | Knopp Biosciences LLC | Compositions and methods for treating chronic urticaria |
| WO2015023786A1 (en) | 2013-08-13 | 2015-02-19 | Knopp Biosciences Llc | Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders |
| US10500303B2 (en) | 2014-08-15 | 2019-12-10 | Tepha, Inc. | Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof |
| EP3230500B1 (en) | 2014-12-11 | 2025-06-18 | Tepha, Inc. | Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof |
| US10626521B2 (en) | 2014-12-11 | 2020-04-21 | Tepha, Inc. | Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2143564A1 (en) * | 1969-04-01 | 1973-02-09 | Alza Corp | Impregnated bandage - for long term administration of pharmacologically active materials at controlled rates |
| US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| US3996934A (en) * | 1971-08-09 | 1976-12-14 | Alza Corporation | Medical bandage |
| GB2093694A (en) * | 1981-02-17 | 1982-09-08 | Alza Corp | Dosage form for coadministering drug and percutaneous absorption enhancer |
| GB2100605A (en) * | 1981-06-29 | 1983-01-06 | Alza Corp | Bandage for administering drugs. |
| FR2567761A1 (fr) * | 1984-07-23 | 1986-01-24 | Alza Corp | Dispositif d'apport transdermique pour l'administration de fentanyl |
| EP0178140A2 (en) * | 1984-10-09 | 1986-04-16 | Alza Corporation | Transdermal therapeutic systems for the administration of nalozone, naltrexone and nalbuphine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1510569A (en) * | 1976-07-02 | 1978-05-10 | American Home Prod | Dosage form for the administration of a medicament to a moist body surface |
| US4460372A (en) * | 1981-02-17 | 1984-07-17 | Alza Corporation | Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer |
| FR2534140B1 (fr) * | 1982-10-12 | 1986-01-31 | Fournier Laboratoires | Nouveau dispositif pour l'administration percutanee de medicaments |
| JPS59155267A (ja) * | 1983-02-23 | 1984-09-04 | 帝国製薬株式会社 | 経皮吸収用カプセルパツド貼付剤 |
-
1985
- 1985-05-03 US US06/730,713 patent/US4645502A/en not_active Expired - Lifetime
-
1986
- 1986-04-16 GB GB08609219A patent/GB2174605B/en not_active Expired
- 1986-04-18 ES ES554169A patent/ES8801987A1/es not_active Expired
- 1986-04-30 IT IT67361/86A patent/IT1203553B/it active
- 1986-04-30 FR FR8606278A patent/FR2581314A1/fr active Pending
- 1986-05-01 JP JP61101899A patent/JPH01170476A/ja active Pending
- 1986-05-02 DE DE19863614843 patent/DE3614843A1/de active Granted
- 1986-05-02 CA CA000508216A patent/CA1252361A/en not_active Expired
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2143564A1 (en) * | 1969-04-01 | 1973-02-09 | Alza Corp | Impregnated bandage - for long term administration of pharmacologically active materials at controlled rates |
| US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| US3996934A (en) * | 1971-08-09 | 1976-12-14 | Alza Corporation | Medical bandage |
| GB2093694A (en) * | 1981-02-17 | 1982-09-08 | Alza Corp | Dosage form for coadministering drug and percutaneous absorption enhancer |
| GB2100605A (en) * | 1981-06-29 | 1983-01-06 | Alza Corp | Bandage for administering drugs. |
| FR2567761A1 (fr) * | 1984-07-23 | 1986-01-24 | Alza Corp | Dispositif d'apport transdermique pour l'administration de fentanyl |
| EP0178140A2 (en) * | 1984-10-09 | 1986-04-16 | Alza Corporation | Transdermal therapeutic systems for the administration of nalozone, naltrexone and nalbuphine |
Also Published As
| Publication number | Publication date |
|---|---|
| GB8609219D0 (en) | 1986-05-21 |
| IT1203553B (it) | 1989-02-15 |
| DE3614843A1 (de) | 1986-11-06 |
| JPH01170476A (ja) | 1989-07-05 |
| ES554169A0 (es) | 1988-03-16 |
| CA1252361A (en) | 1989-04-11 |
| IT8667361A0 (it) | 1986-04-30 |
| DE3614843C2 (enExample) | 1989-04-27 |
| ES8801987A1 (es) | 1988-03-16 |
| GB2174605B (en) | 1988-09-01 |
| GB2174605A (en) | 1986-11-12 |
| US4645502A (en) | 1987-02-24 |
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