FR2559390A1 - Skin regeneration agents - Google Patents

Abstract

Agents for regenerating the skin contains, together with solid or liquid carriers and optional further additives, a mixture of (A) extract of plants of the genus Rumex and/or (B) extract of Urtica dioica and/or (C) extract of Juniperus communis in an amount of 1-8 wt.% of the agent. Pref. agents contain extracts A and B in a ratio of 1:0.7 to 1:1.5, and the concn. of extract C is pref. 0.1-1 wt.% (especially 0.1-0.5 wt.%).

Description

The present invention relates to a composite
regenerating skin containing a plant extract as an active ingredient, which can be effectively used to
treat lesions of the human skin caused by increased activity of epidermal cells, to treat, by
for example, certain kinds of eczema and psoriasis.

Human skin is subject to many kinds
environmental damage, which can cause damage
the condition of the skin often causing long lesions
duration. In addition to external circumstances, illnesses
interns of unknown origin, can also create lesions
skin, for example, psoriasis and eczema. In the current state of medical science, we do not know the reasons for these diseases, so we have not yet developed their treatment. We can however treat according to the symptoms of skin surface diseases, using different kinds of compositions, we can relieve the condition and achieve a significant improvement in mental state
of the patient also.

The object of the present invention is to provide a
cosmetic composition containing a plant extract, suscep
tible to increase the effectiveness of medical treatment in the
acute stage of skin diseases like eczema and psoriasis,
and reduce the duration of treatment. Conforming composition
to the present invention cleanses the surface of the skin, kills
diseased tissue, increases the rate of regeneration of
undercoats and thus treats the disease according to the symptoms.

 It has been found that extracts of different kinds of the Rumex species, of Urtica dioica and of Juniperus communis as well as their mixtures, have a strong activity of regeneration of the skin.

The present invention therefore relates to a skin regenerating composition, containing, as active ingredient, the extract of a plant of the species Rumex (extract A), an extract of Urtica dioca (extract B) and the volatile part of
Juniperus communis (extract C).

 These individual extracts are present in ratios which can vary widely in the composition according to the present invention. The Rumex and Urtica extracts (extracts A and B) also themselves have skin regeneration activity, but this effect never achieves the result obtained by using these extracts together.

The preferred mixing ratio of these extracts is 1: 0.7 to 1: 1.5.

 The content of extract (C) in the composition cannot exceed 1%, whatever the amounts of extracts A or B. It is preferably possible to use a ratio of 0 to 0.05%.

 The extracts in accordance with the present invention can be obtained from the Rumex species, preferably Rumex alpinus, Urtica dioica and Juniperus communis.

Roots, strain and leaves of the species
Rumex, the fruits of Juniperus communis and the buds of Urtica dioica, can be used to obtain these extracts and a drug obtained by drying is preferred.

Biologically active agents of the extracts used in accordance with the present invention are, for example
In the case of extract (A)
Anthraquinone derivatives, tannins and flavonoids.

The anthraquinone derivatives are present in plants in free or glycosidic form, the roots and the strain containing most of these, namely an amount of 1.5 to 4%. Mention may be made of chrysophenol, emodin and fiscion among the anthraquinone derivatives. Flavonoids are, for example, rutin and hyperoside, quercetin, quercytrin and vytexis. We are also looking for a tanning agent content of 2 to 5
In the case of extract (B)
Chlorophyll, provitamin A, vitamins B, C, K, vegetable acids, mineral salts.

In the case of extract (C)
Mono- and Sesquiterpenes.

 Camphene, a-pinene, S-limonene and cariophylene may be mentioned among the components of the volatile oil obtained from the fruits of the plant. The volatile oil content of the fruits is generally between 0.5 and 2%.

Preparation of plant extracts
Preparation of extracts (A) and (B).

Extract A is prepared from the roots, strain and leaves of the Rumex species, while extract
B is obtained from the buds of Urtica dicica (large nettle). The plant parts are extracted after having undergone or not various pretreatments (for example, drying, grinding).

The solubility and the ability of the different active ingredients to transition to be taken into account during extraction. Extraction can be performed between
O and 800C, to conserve biologically active plant materials. For manufacturing reasons, the extraction is preferably carried out at atmospheric pressure or at reduced pressure, at a temperature between 15 and 450C.

 Since the effective compounds of the composition have a variable chemical structure, a large number of solvents and mixtures of solvents can be used (for example, petroleum ether, benzene, chloroform, ethyl acetate , methanol, ethanol, isopropanol, water, etc.) to carry out the extraction, with a wide range of polarity. It has been found that the extracts prepared by ethanolic and isopropanolic extraction are the most advantageous for technological reasons, and because this avoids unwanted side effects. The extraction can be carried out in one or more stages. As the extraction time depends on the common effect of several factors (for example, the solvent, the temperature, the degree of disintegration, the extractor, etc.) , the end of the extraction in the case of the one-step process, will be indicated by the constancy of the content extracted from the extraction porduit. In the case of a technological process with several stages, the extraction is finished when the content of extract of the solvent is close to zero.

All extraction processes used in the laboratory and in the chemical industry are suitable for carrying out the extraction (for example, rinsing, maceration, digestion, percolation, extraction in one or more phases). From the economic point of view, among the physico-chemical parameters influencing the extraction, one can use a method of extraction by vibration with repeated filling, which requires a very simple apparatus and whose efficiency can be increased by a turbo-extraction .

 The preparation process can be shortened and simplified by extraction carried out under vacuum in a Soxhlet apparatus, since in this case the concentration of extract does not require a separate technological step. The next step is the concentration of the raw extract and the complete elimination of the solvent used - depending on its effect on health -. The concentrate obtained will be treated in anticipation of the method of use and formulated.

Preparation of the extract (C)
The fruit of Juniperus communis (juniper) is used after having undergone or not various pretreatment methods (for example, disintegration, drying) to prepare this extract. Solvent extraction is as described in connection with the preparation of extracts (A) and (B).

For technological and economic reasons, the volatile oil is preferably obtained by steam distillation. All distillation devices used in the laboratory and in industry are suitable for this process. The distillation can be carried out at atmospheric pressure, at a higher or lower pressure. The general technological requirements valid for volatile oil are also valid in this process.

 In addition to the foregoing provisions, the invention also comprises other provisions, which will emerge from the description which follows.

 The invention will be better understood with the aid of the additional description which follows, which refers to: examples of implementation of the method which is the subject of the present invention.

 It should be understood, however, that these examples of implementation are given solely by way of illustration of the subject of the invention, of which they do not in any way constitute a limitation.

Example 1
Preparation of the extract (A).

 1 kg of Rumex alpinus strain, air dried and passing through a metal IV sieve (Ph. Hg. Vi.) Is extracted with 5 times 5 dm3 of 70% ethanol at room temperature, for 6 times 6 hours with agitation. The combined and filtered extracts are concentrated until they have the density of an oil, at 400 ° C. under reduced pressure.

Yield 15-25%.

Example 2
Preparation of the extract (B).

 1 kg of air-dried leaves of Urtica disica and passing through a metal IV sieve (Ph. Hg. Vi.) Are extracted with 5 times 5 dm3 of 70% ethanol, at room temperature, for 4 times 4 hours with agitation. The combined and filtered extracts are concentrated until the density of an oil is obtained, at 400 ° C., under reduced pressure.

Yield: 15 to 25%.

Example 3
Preparation of the extract (C).

 The volatile oil of Juniperus communis fruit is obtained by steam distillation. The drying and grinding of the berry are carried out according to the technology generally used for a volatile oil. Steam distillation is carried out at an effective pressure of 5 atm at 1300C for 3.5 hours. The volatile oil is separated from the water by difference in densities.

 The extracts of active ingredients prepared in accordance with the present invention can be in the form of compositions commonly used in the cosmetic industry, that is to say solutions, emulsions, ointments, aerosols, foams, jellies and compositions for the bath (for example: effervescent tablets for the bath, shampoos, etc.). These compositions can contain supports, diluents and auxiliary agents, known and used in general in the cosmetic industry and prepared according to known techniques. These compositions can be obtained by known methods, for example, the active ingredients are mixed with emulsions, liquid solvents and ointment bases.

 Liquid solvents which can be used can be ethanol, isopropanol, water and other solvents which are not harmful to health and do not have any unfavorable interaction with plant extracts. When preparing emulsions, it is possible to use washable bases of the h / e type authorized in the cosmetic industry. It is preferable to use an emulsion prepared with Tegonuls 90, lanolin, and stearin. Ointments can also be prepared from the extract of the active ingredient. The base of the composition is represented by various simple and combined ointment bases of the w / o type (oily) and of the w / o type (washable) respectively forming an emulsion system, which also contain stabilizers and preservatives. prefers the base of ointment type w / o (oily), from the point of view of the quality of preservation. In order to prepare aerosols, inert materials such as halogenated hydrocarbons, butane, nitrogen and carbon dioxide can be used which are gaseous at room temperature under atmospheric pressure.

 The mixtures of active ingredients can be used alone or mixed with other active ingredients in these compositions. They can be mixed, for example, with vitamins A, B5 and F of the skin, as well as with other active ingredients that soothe and treat the skin.

 The compositions can also contain additives used in the cosmetic industry, for example, perfumes and dyes.

 Thanks to the active ingredient in plant extracts, the composition according to the present invention can favorably influence the metabolism and regeneration of epidermal cells and also exert an antiseptic activity. The composition improves the blood supply to the epidermis and, with the anti-phlogistic activity of the tannin, it effectively stops skin inflammation.

 When using the composition, there appears a slight skin inflammation reaction, histamine is released and hyperemia develops. This process can contribute to tissue healing and locally strengthen the body's defense response.

 The antiseptic and anti-phlogistic activities of the composition are very important for the damaged skin surface, because skin affected by psoriasis or eczema is more sensitive to different infections and inflammations.

Examples of preparation of the composition
Example 4
Solution, form to spray.

 10 g of extract A prepared according to the procedure of Example 1 and 10 g of extract B prepared according to Example 2 are dissolved in 400 ml of 70% ethanol. 2 g of extract C of Example 3 are mixed in this solution. The solution thus obtained can be applied to the surface of the skin by coating or preferably, under the action of a gas.

Example 5
Emulsion.

1.5 g of extract A of Example 1 are dissolved in 5 ml of isopropanol, 1.2 g of extract B in 2.5 ml of isopropanol, then the resulting solutions are mixed and 0.1 g extract
C with 30 g of water. The mixture is then dissolved in an emulsion having the following composition: 1 g of Tegonuls 90, 3 g of isopropyl alcohol, 5 g of lanolin, 4 g of stearin, 1 g of triethanolamine and 80 g of water.

Example 6
Ointment.

 1.8 g of extract A prepared according to the procedure of Example 1 are dissolved in 6 ml of 70% ethanol and 1.5 g of extract B prepared according to the procedure of Example 2 in 3 ml of 70% ethanol. The solutions obtained and the extract (C) prepared as described in Example 3 are mixed in an ointment base, the composition of which is as follows: 10 g of oleum lini (linseed oil), 40 g unguentum oleosum (ointment), 30 g unguentum emollinus, 11 g unguentum verselini albi (petrolatum album).

 As is apparent from the above, the invention is in no way limited to those of its modes of implementation, embodiment and application which have just been described more explicitly; on the contrary, it embraces all the variants which may come to the mind of the technician in the matter, without departing from the scope or the scope of the present invention.

Claims (3)

 1. A skin regenerating composition containing plant extracts, as active ingredients, characterized in that it comprises, as active ingredients, 1 to 8% by weight of a mixture,  (A) an extract from a plant of the Rumex species, and / or,  (B) an extract of Urtica dioica, and / or  (C) an extract of Juniperus communis, in addition to solid carriers and / or liquid diluents, and possibly other additives.  2. Composition according to claim 1, characterized in that it contains, as active ingredient, a mixture 1: 0.7 to 1: 1.5 of the extracts (A) and (B).  3. Composition according to claim 1, characterized in that it contains the extract (C) in an amount of 0.1 to 1, preferably 8.1 to 0.5% by weight.