FR2558848B1 - Activeur de plasminogene kym, procede de preparation par culture d'un mutant de rhabdomyosarcome humain et composition pharmaceutique le renfermant dotee d'une activite thrombolytique - Google Patents

Activeur de plasminogene kym, procede de preparation par culture d'un mutant de rhabdomyosarcome humain et composition pharmaceutique le renfermant dotee d'une activite thrombolytique

Info

Publication number
FR2558848B1
FR2558848B1 FR8501183A FR8501183A FR2558848B1 FR 2558848 B1 FR2558848 B1 FR 2558848B1 FR 8501183 A FR8501183 A FR 8501183A FR 8501183 A FR8501183 A FR 8501183A FR 2558848 B1 FR2558848 B1 FR 2558848B1
Authority
FR
France
Prior art keywords
kym
plasminogen
mutant
activator
culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8501183A
Other languages
English (en)
French (fr)
Other versions
FR2558848A1 (fr
Inventor
Masaru Imada
Yoshihiro Yoshiyama
Munehiro Oda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Dairies Corp
Original Assignee
Meiji Milk Products Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Milk Products Co Ltd filed Critical Meiji Milk Products Co Ltd
Publication of FR2558848A1 publication Critical patent/FR2558848A1/fr
Application granted granted Critical
Publication of FR2558848B1 publication Critical patent/FR2558848B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FR8501183A 1984-01-30 1985-01-29 Activeur de plasminogene kym, procede de preparation par culture d'un mutant de rhabdomyosarcome humain et composition pharmaceutique le renfermant dotee d'une activite thrombolytique Expired FR2558848B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59013397A JPS60158115A (ja) 1984-01-30 1984-01-30 プラズミノーゲンアクチベーターの製造法

Publications (2)

Publication Number Publication Date
FR2558848A1 FR2558848A1 (fr) 1985-08-02
FR2558848B1 true FR2558848B1 (fr) 1989-06-09

Family

ID=11831979

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8501183A Expired FR2558848B1 (fr) 1984-01-30 1985-01-29 Activeur de plasminogene kym, procede de preparation par culture d'un mutant de rhabdomyosarcome humain et composition pharmaceutique le renfermant dotee d'une activite thrombolytique

Country Status (7)

Country Link
JP (1) JPS60158115A (enExample)
BE (1) BE901598A (enExample)
CA (1) CA1275062A (enExample)
DE (1) DE3502760A1 (enExample)
FR (1) FR2558848B1 (enExample)
GB (1) GB2153366B (enExample)
NL (1) NL8500132A (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6427472A (en) * 1987-07-21 1989-01-30 Meiji Milk Prod Co Ltd Production of human tissue plasminogen activator and cell strain using therein

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
DE3068549D1 (en) * 1979-11-13 1984-08-16 Syed Shaukat Husain Plasminogen activators useful as therapeutic and diagnostic agents and their isolation
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
JPS5852634B2 (ja) * 1980-12-05 1983-11-24 株式会社林原生物化学研究所 ウロキナ−ゼの製造法
IL63317A (en) * 1981-07-15 1985-05-31 Yeda Res & Dev Production of plasminogen activator
ZA831399B (en) * 1982-03-05 1984-02-29 Health Lab Service Board New fibrinolytic enzymes and methods for their production and pharmaceutical compositions containing them
JPS5913732A (ja) * 1982-07-16 1984-01-24 Mitsui Toatsu Chem Inc 血栓溶解剤
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤

Also Published As

Publication number Publication date
GB2153366A (en) 1985-08-21
GB2153366B (en) 1988-05-18
BE901598A (fr) 1985-07-29
NL8500132A (nl) 1985-08-16
JPS60158115A (ja) 1985-08-19
DE3502760A1 (de) 1985-08-08
FR2558848A1 (fr) 1985-08-02
CA1275062A (en) 1990-10-09
JPH0569506B2 (enExample) 1993-10-01
GB8501532D0 (en) 1985-02-20

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