FR2554820B1 - Appareil pour la synthese des polynucleotides - Google Patents

Appareil pour la synthese des polynucleotides

Info

Publication number
FR2554820B1
FR2554820B1 FR8417385A FR8417385A FR2554820B1 FR 2554820 B1 FR2554820 B1 FR 2554820B1 FR 8417385 A FR8417385 A FR 8417385A FR 8417385 A FR8417385 A FR 8417385A FR 2554820 B1 FR2554820 B1 FR 2554820B1
Authority
FR
France
Prior art keywords
polynucleotides
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8417385A
Other languages
English (en)
Other versions
FR2554820A1 (fr
Inventor
Akihiko Niina
Tatsuo Ohira
Shigemi Miyamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeon Corp
Original Assignee
Nippon Zeon Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Zeon Co Ltd filed Critical Nippon Zeon Co Ltd
Publication of FR2554820A1 publication Critical patent/FR2554820A1/fr
Application granted granted Critical
Publication of FR2554820B1 publication Critical patent/FR2554820B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00389—Feeding through valves
    • B01J2219/00391—Rotary valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00418—Means for dispensing and evacuation of reagents using pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
FR8417385A 1983-11-14 1984-11-14 Appareil pour la synthese des polynucleotides Expired FR2554820B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58213616A JPS60105691A (ja) 1983-11-14 1983-11-14 ポリヌクレオチド合成装置

Publications (2)

Publication Number Publication Date
FR2554820A1 FR2554820A1 (fr) 1985-05-17
FR2554820B1 true FR2554820B1 (fr) 1988-06-24

Family

ID=16642121

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8417385A Expired FR2554820B1 (fr) 1983-11-14 1984-11-14 Appareil pour la synthese des polynucleotides

Country Status (5)

Country Link
US (1) US4671941A (fr)
JP (1) JPS60105691A (fr)
DE (1) DE3441659A1 (fr)
FR (1) FR2554820B1 (fr)
GB (1) GB2150574B (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2582655B1 (fr) * 1985-06-03 1988-12-23 Centre Nat Rech Scient Multi-synthetiseur de peptides semi-automatique en phase solide
US5147608A (en) * 1988-04-29 1992-09-15 Millipore Corporation Apparatus and process for performing repetitive chemical processing
DE3816934A1 (de) * 1988-05-18 1989-11-23 Ramalho Ortigao Jose Flavio Neue sequenzierungsmethode fuer einzel- oder doppelstraengige nucleinsaeuren an fester phase
US5262530A (en) 1988-12-21 1993-11-16 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
US5053454A (en) * 1989-02-15 1991-10-01 Sri International Multiple polymer synthesizer
US7049102B1 (en) 1989-09-22 2006-05-23 Board Of Trustees Of Leland Stanford University Multi-gene expression profile
US5545522A (en) 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US5252296A (en) * 1990-05-15 1993-10-12 Chiron Corporation Method and apparatus for biopolymer synthesis
DE69212156T2 (de) * 1991-05-24 1996-12-05 Harvard College Paralleler und sequentieller reaktor
AU2262592A (en) * 1991-06-21 1993-01-25 Sloan-Kettering Institute For Cancer Research Computer-controlled, module type, multipurpose synthesizer
US5770358A (en) * 1991-09-18 1998-06-23 Affymax Technologies N.V. Tagged synthetic oligomer libraries
US5639603A (en) * 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5651943A (en) * 1991-11-19 1997-07-29 Arizona Board Of Regents, On Behalf Of The University Of Arizona Apparatus and method for random polymer synthesis
US5368823A (en) * 1993-02-11 1994-11-29 University Of Georgia Research Foundation, Inc. Automated synthesis of oligonucleotides
US5503805A (en) * 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
NZ276860A (en) * 1993-11-02 1997-09-22 Affymax Tech Nv Apparatus and its use for synthesising diverse molecular products on substrates
US6165778A (en) * 1993-11-02 2000-12-26 Affymax Technologies N.V. Reaction vessel agitation apparatus
US6558633B1 (en) * 1994-09-21 2003-05-06 Isis Pharmaceuticals, Inc. Chemical reaction apparatus and methods
US5681534A (en) * 1995-07-20 1997-10-28 Neves; Richard S. High throughput oligonucleotide synthesizer
US5641459A (en) * 1995-08-17 1997-06-24 Pharmacia Biotech Ab Machine for synthesizing oligonucleotides
US5792431A (en) * 1996-05-30 1998-08-11 Smithkline Beecham Corporation Multi-reactor synthesizer and method for combinatorial chemistry
US5762881A (en) * 1996-10-29 1998-06-09 Bohdan Automation, Inc. Apparatus for multiple, simultaneous synthesis of organic compounds
EP0979236B1 (fr) * 1997-04-28 2009-07-29 Novartis Vaccines and Diagnostics, Inc. Appareil permettant de synthetiser des oligomeres, en particulier des peptoides, qui comporte un recyclage de reactifs
US6224832B1 (en) 1997-05-30 2001-05-01 Smithkline Beecham Corporation Multi-reactor synthesizer and method for combinatorial chemistry
US6086831A (en) * 1998-06-10 2000-07-11 Mettler-Toledo Bohdan, Inc. Modular reaction block assembly with thermoelectric cooling and heating
US6455316B1 (en) 1998-08-13 2002-09-24 Symyx Technologies, Inc. Parallel reactor with internal sensing and method of using same
US6306658B1 (en) 1998-08-13 2001-10-23 Symyx Technologies Parallel reactor with internal sensing
US6787112B1 (en) 1998-08-13 2004-09-07 Symyx Technologies, Inc. Parallel reactor with internal sensing and method of using same
US6528026B2 (en) * 1998-08-13 2003-03-04 Symyx Technologies, Inc. Multi-temperature modular reactor and method of using same
US6759014B2 (en) * 2001-01-26 2004-07-06 Symyx Technologies, Inc. Apparatus and methods for parallel processing of multiple reaction mixtures
US6913934B2 (en) * 1998-08-13 2005-07-05 Symyx Technologies, Inc. Apparatus and methods for parallel processing of multiple reaction mixtures
US6548026B1 (en) 1998-08-13 2003-04-15 Symyx Technologies, Inc. Parallel reactor with internal sensing and method of using same
US6264891B1 (en) * 1998-12-22 2001-07-24 Eos Biotechnology, Inc. Apparatus and method for concurrent chemical synthesis
JP2002536158A (ja) * 1999-02-05 2002-10-29 インヴィトロゲン・コーポレーション 流体またはガスの自動送達のためのシステム、方法およびコンピュータプログラム製品
US6143252A (en) * 1999-04-12 2000-11-07 The Perkin-Elmer Corporation Pipetting device with pipette tip for solid phase reactions
US6132686A (en) * 1999-05-28 2000-10-17 Mettler-Toledo Bohdan, Inc. Pressurized reaction block
US6994827B2 (en) * 2000-06-03 2006-02-07 Symyx Technologies, Inc. Parallel semicontinuous or continuous reactors
FR2823590B1 (fr) * 2001-04-17 2003-07-25 Eads Airbus Sa Panneau d'attenuation acoustique comportant une couche resistive a composante structurale renforcee
US6867050B2 (en) * 2001-05-16 2005-03-15 Academia Sinica Apparatus and methods for chemical synthesis
JP2006151948A (ja) * 2004-11-04 2006-06-15 Institute Of Physical & Chemical Research 糖鎖合成方法および糖鎖自動合成装置
US7576037B2 (en) * 2005-11-18 2009-08-18 Mei Technologies, Inc. Process and apparatus for combinatorial synthesis
CN111019806B (zh) * 2019-12-25 2023-08-11 广东顺德工业设计研究院(广东顺德创新设计研究院) 基因序列分选合成装置及分选合成方法
US11571677B2 (en) * 2020-10-28 2023-02-07 CSBio Instrumentation Co. Peptide synthesis instrumentation
CN115999470A (zh) * 2022-12-19 2023-04-25 北京铭毅智造科技有限公司 一种基于芯片方式的寡核苷酸链合成装置及合成方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3531258A (en) * 1967-11-16 1970-09-29 Us Health Education & Welfare Apparatus for the automated synthesis of peptides
JPS4820995B1 (fr) * 1968-07-08 1973-06-25
US3881872A (en) * 1972-08-15 1975-05-06 Jeol Ltd Automatic analyzing device
US4083690A (en) * 1975-10-02 1978-04-11 Kirin Beer Kabushiki Kaisha Automatic preparation of sample for analysis
US4153416A (en) * 1977-06-06 1979-05-08 Bonner Alex G Process and apparatus for pulse labelling protein material in the Edman degradation process
GB2084899B (en) * 1980-09-23 1985-05-30 California Inst Of Techn Apparatus and method for the sequential performance of chemical processes
US4362699A (en) * 1981-03-10 1982-12-07 Bio Research, Inc. Apparatus for high pressure peptide synthesis
JPS59500318A (ja) * 1982-03-08 1984-03-01 セルテツク　リミテツド ポリヌクレオチド合成
FR2544720B1 (fr) * 1983-04-19 1987-11-27 California Inst Of Techn Installation perfectionnee et procede pour la synthese de composes chimiques, en particulier d'oligonucleotides
US4517338A (en) * 1983-06-20 1985-05-14 Chiron Corporation Multiple reactor system and method for polynucleotide synthesis
US4483964A (en) * 1983-06-20 1984-11-20 Chiron Corporation Reactor system and method for polynucleotide synthesis
DE3425763A1 (de) * 1983-07-13 1985-01-24 Nippon Zeon Co., Ltd., Tokio/Tokyo Verfahren zur synthese von polynukleotiden
JPS6054398A (ja) * 1983-09-02 1985-03-28 Nippon Zeon Co Ltd ポリヌクレオチド合成装置
EP0156875A4 (fr) * 1983-09-22 1986-02-13 Hossain H Saneii Synthetiseur de peptide en phase solide.

Also Published As

Publication number Publication date
GB2150574B (en) 1987-09-03
FR2554820A1 (fr) 1985-05-17
US4671941A (en) 1987-06-09
GB2150574A (en) 1985-07-03
JPS60105691A (ja) 1985-06-11
DE3441659A1 (de) 1985-06-13
GB8428620D0 (en) 1984-12-19

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Legal Events

Date Code Title Description
ST Notification of lapse