FR2554820B1 - Appareil pour la synthese des polynucleotides - Google Patents
Appareil pour la synthese des polynucleotidesInfo
- Publication number
- FR2554820B1 FR2554820B1 FR8417385A FR8417385A FR2554820B1 FR 2554820 B1 FR2554820 B1 FR 2554820B1 FR 8417385 A FR8417385 A FR 8417385A FR 8417385 A FR8417385 A FR 8417385A FR 2554820 B1 FR2554820 B1 FR 2554820B1
- Authority
- FR
- France
- Prior art keywords
- polynucleotides
- synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00286—Reactor vessels with top and bottom openings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00389—Feeding through valves
- B01J2219/00391—Rotary valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00418—Means for dispensing and evacuation of reagents using pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/005—Beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/0059—Sequential processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58213616A JPS60105691A (ja) | 1983-11-14 | 1983-11-14 | ポリヌクレオチド合成装置 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2554820A1 FR2554820A1 (fr) | 1985-05-17 |
FR2554820B1 true FR2554820B1 (fr) | 1988-06-24 |
Family
ID=16642121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8417385A Expired FR2554820B1 (fr) | 1983-11-14 | 1984-11-14 | Appareil pour la synthese des polynucleotides |
Country Status (5)
Country | Link |
---|---|
US (1) | US4671941A (fr) |
JP (1) | JPS60105691A (fr) |
DE (1) | DE3441659A1 (fr) |
FR (1) | FR2554820B1 (fr) |
GB (1) | GB2150574B (fr) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2582655B1 (fr) * | 1985-06-03 | 1988-12-23 | Centre Nat Rech Scient | Multi-synthetiseur de peptides semi-automatique en phase solide |
US5147608A (en) * | 1988-04-29 | 1992-09-15 | Millipore Corporation | Apparatus and process for performing repetitive chemical processing |
DE3816934A1 (de) * | 1988-05-18 | 1989-11-23 | Ramalho Ortigao Jose Flavio | Neue sequenzierungsmethode fuer einzel- oder doppelstraengige nucleinsaeuren an fester phase |
US5262530A (en) * | 1988-12-21 | 1993-11-16 | Applied Biosystems, Inc. | Automated system for polynucleotide synthesis and purification |
US5053454A (en) * | 1989-02-15 | 1991-10-01 | Sri International | Multiple polymer synthesizer |
US5545522A (en) | 1989-09-22 | 1996-08-13 | Van Gelder; Russell N. | Process for amplifying a target polynucleotide sequence using a single primer-promoter complex |
US7049102B1 (en) | 1989-09-22 | 2006-05-23 | Board Of Trustees Of Leland Stanford University | Multi-gene expression profile |
US5252296A (en) * | 1990-05-15 | 1993-10-12 | Chiron Corporation | Method and apparatus for biopolymer synthesis |
AU2170092A (en) * | 1991-05-24 | 1992-12-30 | President And Fellows Of Harvard College, The | Parallel sequential reactor |
WO1993000625A1 (fr) * | 1991-06-21 | 1993-01-07 | Sloan-Kettering Institute For Cancer Research | Synthetiseur multi-usage commande par ordinateur, du type a module |
US5639603A (en) * | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
DE69217497T2 (de) * | 1991-09-18 | 1997-06-12 | Affymax Tech Nv | Verfahren zur synthese der verschiedenen sammlungen von oligomeren |
US5651943A (en) * | 1991-11-19 | 1997-07-29 | Arizona Board Of Regents, On Behalf Of The University Of Arizona | Apparatus and method for random polymer synthesis |
US5368823A (en) * | 1993-02-11 | 1994-11-29 | University Of Georgia Research Foundation, Inc. | Automated synthesis of oligonucleotides |
NZ276860A (en) * | 1993-11-02 | 1997-09-22 | Affymax Tech Nv | Apparatus and its use for synthesising diverse molecular products on substrates |
US6165778A (en) * | 1993-11-02 | 2000-12-26 | Affymax Technologies N.V. | Reaction vessel agitation apparatus |
US5503805A (en) * | 1993-11-02 | 1996-04-02 | Affymax Technologies N.V. | Apparatus and method for parallel coupling reactions |
US6558633B1 (en) | 1994-09-21 | 2003-05-06 | Isis Pharmaceuticals, Inc. | Chemical reaction apparatus and methods |
US5681534A (en) * | 1995-07-20 | 1997-10-28 | Neves; Richard S. | High throughput oligonucleotide synthesizer |
US5641459A (en) * | 1995-08-17 | 1997-06-24 | Pharmacia Biotech Ab | Machine for synthesizing oligonucleotides |
US5792431A (en) * | 1996-05-30 | 1998-08-11 | Smithkline Beecham Corporation | Multi-reactor synthesizer and method for combinatorial chemistry |
US5762881A (en) * | 1996-10-29 | 1998-06-09 | Bohdan Automation, Inc. | Apparatus for multiple, simultaneous synthesis of organic compounds |
US6033631A (en) * | 1997-04-28 | 2000-03-07 | Chiron Corporation | Synthesizer with reagent recycling |
US6224832B1 (en) | 1997-05-30 | 2001-05-01 | Smithkline Beecham Corporation | Multi-reactor synthesizer and method for combinatorial chemistry |
US6086831A (en) * | 1998-06-10 | 2000-07-11 | Mettler-Toledo Bohdan, Inc. | Modular reaction block assembly with thermoelectric cooling and heating |
US6759014B2 (en) * | 2001-01-26 | 2004-07-06 | Symyx Technologies, Inc. | Apparatus and methods for parallel processing of multiple reaction mixtures |
US6787112B1 (en) | 1998-08-13 | 2004-09-07 | Symyx Technologies, Inc. | Parallel reactor with internal sensing and method of using same |
US6455316B1 (en) | 1998-08-13 | 2002-09-24 | Symyx Technologies, Inc. | Parallel reactor with internal sensing and method of using same |
US6913934B2 (en) * | 1998-08-13 | 2005-07-05 | Symyx Technologies, Inc. | Apparatus and methods for parallel processing of multiple reaction mixtures |
US6306658B1 (en) | 1998-08-13 | 2001-10-23 | Symyx Technologies | Parallel reactor with internal sensing |
US6548026B1 (en) | 1998-08-13 | 2003-04-15 | Symyx Technologies, Inc. | Parallel reactor with internal sensing and method of using same |
US6528026B2 (en) | 1998-08-13 | 2003-03-04 | Symyx Technologies, Inc. | Multi-temperature modular reactor and method of using same |
US6264891B1 (en) * | 1998-12-22 | 2001-07-24 | Eos Biotechnology, Inc. | Apparatus and method for concurrent chemical synthesis |
JP2002536158A (ja) * | 1999-02-05 | 2002-10-29 | インヴィトロゲン・コーポレーション | 流体またはガスの自動送達のためのシステム、方法およびコンピュータプログラム製品 |
US6143252A (en) * | 1999-04-12 | 2000-11-07 | The Perkin-Elmer Corporation | Pipetting device with pipette tip for solid phase reactions |
US6132686A (en) * | 1999-05-28 | 2000-10-17 | Mettler-Toledo Bohdan, Inc. | Pressurized reaction block |
US6994827B2 (en) * | 2000-06-03 | 2006-02-07 | Symyx Technologies, Inc. | Parallel semicontinuous or continuous reactors |
FR2823590B1 (fr) * | 2001-04-17 | 2003-07-25 | Eads Airbus Sa | Panneau d'attenuation acoustique comportant une couche resistive a composante structurale renforcee |
US6867050B2 (en) * | 2001-05-16 | 2005-03-15 | Academia Sinica | Apparatus and methods for chemical synthesis |
JP2006151948A (ja) * | 2004-11-04 | 2006-06-15 | Institute Of Physical & Chemical Research | 糖鎖合成方法および糖鎖自動合成装置 |
US7576037B2 (en) * | 2005-11-18 | 2009-08-18 | Mei Technologies, Inc. | Process and apparatus for combinatorial synthesis |
CN111019806B (zh) * | 2019-12-25 | 2023-08-11 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | 基因序列分选合成装置及分选合成方法 |
US11571677B2 (en) | 2020-10-28 | 2023-02-07 | CSBio Instrumentation Co. | Peptide synthesis instrumentation |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3531258A (en) * | 1967-11-16 | 1970-09-29 | Us Health Education & Welfare | Apparatus for the automated synthesis of peptides |
JPS4820995B1 (fr) * | 1968-07-08 | 1973-06-25 | ||
US3881872A (en) * | 1972-08-15 | 1975-05-06 | Jeol Ltd | Automatic analyzing device |
US4083690A (en) * | 1975-10-02 | 1978-04-11 | Kirin Beer Kabushiki Kaisha | Automatic preparation of sample for analysis |
US4153416A (en) * | 1977-06-06 | 1979-05-08 | Bonner Alex G | Process and apparatus for pulse labelling protein material in the Edman degradation process |
GB2084899B (en) * | 1980-09-23 | 1985-05-30 | California Inst Of Techn | Apparatus and method for the sequential performance of chemical processes |
US4362699A (en) * | 1981-03-10 | 1982-12-07 | Bio Research, Inc. | Apparatus for high pressure peptide synthesis |
EP0102995A1 (fr) * | 1982-03-08 | 1984-03-21 | Celltech Limited | Synthese de polynucleotides |
FR2544720B1 (fr) * | 1983-04-19 | 1987-11-27 | California Inst Of Techn | Installation perfectionnee et procede pour la synthese de composes chimiques, en particulier d'oligonucleotides |
US4483964A (en) * | 1983-06-20 | 1984-11-20 | Chiron Corporation | Reactor system and method for polynucleotide synthesis |
US4517338A (en) * | 1983-06-20 | 1985-05-14 | Chiron Corporation | Multiple reactor system and method for polynucleotide synthesis |
GB2143240B (en) * | 1983-07-13 | 1988-01-13 | Nippon Zeon Co | Apparatus for synthesizing polynucleotide |
JPS6054398A (ja) * | 1983-09-02 | 1985-03-28 | Nippon Zeon Co Ltd | ポリヌクレオチド合成装置 |
EP0156875A4 (fr) * | 1983-09-22 | 1986-02-13 | Hossain H Saneii | Synthetiseur de peptide en phase solide. |
-
1983
- 1983-11-14 JP JP58213616A patent/JPS60105691A/ja active Pending
-
1984
- 1984-11-13 GB GB08428620A patent/GB2150574B/en not_active Expired
- 1984-11-13 US US06/670,939 patent/US4671941A/en not_active Expired - Fee Related
- 1984-11-14 DE DE19843441659 patent/DE3441659A1/de not_active Withdrawn
- 1984-11-14 FR FR8417385A patent/FR2554820B1/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB8428620D0 (en) | 1984-12-19 |
DE3441659A1 (de) | 1985-06-13 |
FR2554820A1 (fr) | 1985-05-17 |
GB2150574B (en) | 1987-09-03 |
JPS60105691A (ja) | 1985-06-11 |
GB2150574A (en) | 1985-07-03 |
US4671941A (en) | 1987-06-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |