FR2547587B1 - Steroides radioactifs, leur procede de preparation, leur application a la mise en evidence des recepteurs de glucocorticoides et au dosage du nombre de sites de fixation - Google Patents

Steroides radioactifs, leur procede de preparation, leur application a la mise en evidence des recepteurs de glucocorticoides et au dosage du nombre de sites de fixation

Info

Publication number
FR2547587B1
FR2547587B1 FR8309811A FR8309811A FR2547587B1 FR 2547587 B1 FR2547587 B1 FR 2547587B1 FR 8309811 A FR8309811 A FR 8309811A FR 8309811 A FR8309811 A FR 8309811A FR 2547587 B1 FR2547587 B1 FR 2547587B1
Authority
FR
France
Prior art keywords
evidence
determination
application
preparation process
glucocorticoid receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8309811A
Other languages
English (en)
French (fr)
Other versions
FR2547587A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR8309811A priority Critical patent/FR2547587B1/fr
Priority to NO841797A priority patent/NO162193C/no
Priority to AT84401202T priority patent/ATE43132T1/de
Priority to CA000456494A priority patent/CA1222743A/fr
Priority to DE8484401202T priority patent/DE3478225D1/de
Priority to FI842397A priority patent/FI83784C/fi
Priority to EP84401202A priority patent/EP0128839B1/fr
Priority to JP59120899A priority patent/JPS6034987A/ja
Priority to US06/620,457 priority patent/US4664850A/en
Publication of FR2547587A1 publication Critical patent/FR2547587A1/fr
Application granted granted Critical
Publication of FR2547587B1 publication Critical patent/FR2547587B1/fr
Priority to US06/797,140 priority patent/US4865767A/en
Priority to CA000529937A priority patent/CA1242696A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0048—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
FR8309811A 1983-06-14 1983-06-14 Steroides radioactifs, leur procede de preparation, leur application a la mise en evidence des recepteurs de glucocorticoides et au dosage du nombre de sites de fixation Expired FR2547587B1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR8309811A FR2547587B1 (fr) 1983-06-14 1983-06-14 Steroides radioactifs, leur procede de preparation, leur application a la mise en evidence des recepteurs de glucocorticoides et au dosage du nombre de sites de fixation
NO841797A NO162193C (no) 1983-06-14 1984-05-04 Radioaktiv steroid, fremgangsmaate ved dets fremst., middel for paavisning in vitro av mottagere for glucocorticoiderog for bestemmelse av antall bindingspunkter for glucocorticoidene og anvendelse av steroidet for dette formaal
CA000456494A CA1222743A (fr) 1983-06-14 1984-06-13 Steroides radioactifs, leur procede de preparation, leur application a la mise en evidence des recepteurs de glucocorticoides et au dosage du nombre de sites de fixation
DE8484401202T DE3478225D1 (en) 1983-06-14 1984-06-13 Labelled steroids, process for their preparation and intermediates, their use in the localization of the glucocorticoid receptors and in the dosage of the number of binding sites
FI842397A FI83784C (fi) 1983-06-14 1984-06-13 Radioaktiva steroider och deras mellanprodukter, foerfarande foer framstaellning av dessa och deras laemplighet foer paovisande av glukokortikoidreceptorer och bestaemmande av antalet bindningsstaellen.
EP84401202A EP0128839B1 (fr) 1983-06-14 1984-06-13 Stéroides radioactifs, leur procédé et leurs intermédiaires de préparation, leur application à la mise en évidence des récepteurs de glucocorticoides et au dosage du nombre de sites de fixation
AT84401202T ATE43132T1 (de) 1983-06-14 1984-06-13 Radioaktive steroide, ihre herstellung, zwischenprodukte, ihre anwendung zur hervorhebung der glucocorticoidrezeptoren und zur bestimmung der zahl der bindungsstellen.
JP59120899A JPS6034987A (ja) 1983-06-14 1984-06-14 放射性ステロイド、その製造法並びに糖性コルチコイド受容体の検出及び固定箇所数の定量に使用するための薬剤
US06/620,457 US4664850A (en) 1983-06-14 1984-06-14 Novel radioactive steroids
US06/797,140 US4865767A (en) 1983-06-14 1985-12-19 Novel radioactive steroids
CA000529937A CA1242696A (fr) 1983-06-14 1987-02-17 Intermediaires pour la preparation de steroides radioactifs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8309811A FR2547587B1 (fr) 1983-06-14 1983-06-14 Steroides radioactifs, leur procede de preparation, leur application a la mise en evidence des recepteurs de glucocorticoides et au dosage du nombre de sites de fixation

Publications (2)

Publication Number Publication Date
FR2547587A1 FR2547587A1 (fr) 1984-12-21
FR2547587B1 true FR2547587B1 (fr) 1985-10-25

Family

ID=9289758

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8309811A Expired FR2547587B1 (fr) 1983-06-14 1983-06-14 Steroides radioactifs, leur procede de preparation, leur application a la mise en evidence des recepteurs de glucocorticoides et au dosage du nombre de sites de fixation

Country Status (9)

Country Link
US (2) US4664850A (enExample)
EP (1) EP0128839B1 (enExample)
JP (1) JPS6034987A (enExample)
AT (1) ATE43132T1 (enExample)
CA (2) CA1222743A (enExample)
DE (1) DE3478225D1 (enExample)
FI (1) FI83784C (enExample)
FR (1) FR2547587B1 (enExample)
NO (1) NO162193C (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2592047B1 (fr) * 1985-12-19 1988-03-04 Roussel Uclaf Complexes organometalliques de produits steroides ayant une affinite pour les recepteurs progestogene et gluco-corticoide et leur application au dosage des recepteurs hormonaux
CA2330611A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
US20110305751A1 (en) 2009-02-20 2011-12-15 To-Bbb Holding B.V. Glutathione-based drug delivery system
AU2010245823B2 (en) 2009-05-06 2016-11-24 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1465484A (fr) * 1965-10-27 1967-01-13 Composés stéroïdes du type cétonique
FR2398077A1 (fr) * 1977-07-19 1979-02-16 Roussel Uclaf Steroides marques au tritium, leur procede de preparation et leur application pour le dosage et la localisation des recepteurs tissulaires hormonaux des steroides
FR2398076A1 (fr) * 1977-07-19 1979-02-16 Roussel Uclaf Steroides marques au tritium, leur procede de preparation et leur application pour le dosage et la localisation des recepteurs tissulaires hormonaux des steroides
FR2430952A1 (fr) * 1978-07-13 1980-02-08 Roussel Uclaf Nouveaux derives acetyleniques de l'androst 4-ene, leur procede de preparation et leur application comme medicament

Also Published As

Publication number Publication date
NO162193B (no) 1989-08-14
FI83784C (fi) 1991-08-26
US4664850A (en) 1987-05-12
FI842397L (fi) 1984-12-15
FR2547587A1 (fr) 1984-12-21
DE3478225D1 (en) 1989-06-22
FI842397A0 (fi) 1984-06-13
NO162193C (no) 1989-11-22
ATE43132T1 (de) 1989-06-15
EP0128839A3 (en) 1985-09-18
NO841797L (no) 1984-12-17
JPS6034987A (ja) 1985-02-22
EP0128839A2 (fr) 1984-12-19
FI83784B (fi) 1991-05-15
CA1222743A (fr) 1987-06-09
EP0128839B1 (fr) 1989-05-17
JPH0460479B2 (enExample) 1992-09-28
CA1242696A (fr) 1988-10-04
US4865767A (en) 1989-09-12

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FR2547587B1 (fr) Steroides radioactifs, leur procede de preparation, leur application a la mise en evidence des recepteurs de glucocorticoides et au dosage du nombre de sites de fixation
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Legal Events

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CA Change of address
CD Change of name or company name
TP Transmission of property
ST Notification of lapse