FR2533924B1 - - Google Patents

Info

Publication number
FR2533924B1
FR2533924B1 FR8216669A FR8216669A FR2533924B1 FR 2533924 B1 FR2533924 B1 FR 2533924B1 FR 8216669 A FR8216669 A FR 8216669A FR 8216669 A FR8216669 A FR 8216669A FR 2533924 B1 FR2533924 B1 FR 2533924B1
Authority
FR
France
Prior art keywords
group
alkyl
hydrogen
carbon atoms
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8216669A
Other languages
English (en)
French (fr)
Other versions
FR2533924A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR8216669A priority Critical patent/FR2533924A1/fr
Priority to US06/536,889 priority patent/US4530932A/en
Priority to AT83401915T priority patent/ATE25381T1/de
Priority to DE8383401915T priority patent/DE3369681D1/de
Priority to EP83401915A priority patent/EP0112191B1/fr
Priority to CA000438261A priority patent/CA1213280A/fr
Priority to JP58184593A priority patent/JPS5988481A/ja
Publication of FR2533924A1 publication Critical patent/FR2533924A1/fr
Application granted granted Critical
Publication of FR2533924B1 publication Critical patent/FR2533924B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
FR8216669A 1982-10-05 1982-10-05 Nouveaux derives du 4-(1h-indol-3-yl)a-methyl piperidine-1-ethanol, leurs sels, le procede de preparation, l'application a titre de medicaments et les compositions les renfermant Granted FR2533924A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR8216669A FR2533924A1 (fr) 1982-10-05 1982-10-05 Nouveaux derives du 4-(1h-indol-3-yl)a-methyl piperidine-1-ethanol, leurs sels, le procede de preparation, l'application a titre de medicaments et les compositions les renfermant
US06/536,889 US4530932A (en) 1982-10-05 1983-09-28 4-(1H-indol-3-yl)-α-methyl-piperidine-1-ethanol derivatives
AT83401915T ATE25381T1 (de) 1982-10-05 1983-09-29 4-(1h-indolyl-3-)alpha-methylpiperidin-1-ethano - derivate, ihre salze, verfahren zur herstellung, zusammenstellungen die sie enthalten und deren anwendung als heilmittel.
DE8383401915T DE3369681D1 (en) 1982-10-05 1983-09-29 4-(1h-indolyl-3-)-alpha-methyl piperidine-1-ethanol derivatives, their salts, process for their preparation, compositions containing them and their use as medicines
EP83401915A EP0112191B1 (fr) 1982-10-05 1983-09-29 Nouveaux dérivés du 4-(1H-indol-3-yl) alpha-méthylpipéridine 1-éthanol, leurs sels, le procédé de préparation, l'application à titre de médicaments et les compositions les renfermant
CA000438261A CA1213280A (fr) 1982-10-05 1983-10-04 PROCEDE DE PREPARATION DE NOUVEAUX DERIVES DE 4-(1H- INDOL-3-YL) .alpha.-METHYL PIPERIDINE-1-ETHANOL ET DE LEURS SELS
JP58184593A JPS5988481A (ja) 1982-10-05 1983-10-04 新規な４−（１Ｈ−インド−ル−３−イル）−α−メチルピペリジン−１−エタノ−ル誘導体、その塩、製造方法、薬剤としての用途および該新規な化合物を含有する組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8216669A FR2533924A1 (fr) 1982-10-05 1982-10-05 Nouveaux derives du 4-(1h-indol-3-yl)a-methyl piperidine-1-ethanol, leurs sels, le procede de preparation, l'application a titre de medicaments et les compositions les renfermant

Publications (2)

Publication Number Publication Date
FR2533924A1 FR2533924A1 (fr) 1984-04-06
FR2533924B1 true FR2533924B1 (enExample) 1985-05-03

Family

ID=9277978

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8216669A Granted FR2533924A1 (fr) 1982-10-05 1982-10-05 Nouveaux derives du 4-(1h-indol-3-yl)a-methyl piperidine-1-ethanol, leurs sels, le procede de preparation, l'application a titre de medicaments et les compositions les renfermant

Country Status (7)

Country Link
US (1) US4530932A (enExample)
EP (1) EP0112191B1 (enExample)
JP (1) JPS5988481A (enExample)
AT (1) ATE25381T1 (enExample)
CA (1) CA1213280A (enExample)
DE (1) DE3369681D1 (enExample)
FR (1) FR2533924A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2567884B1 (fr) * 1984-07-19 1987-03-06 Roussel Uclaf Nouveaux derives de l'indole, leur preparation, leur application comme medicaments et les compositions les renfermant
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
US4742057A (en) * 1985-12-05 1988-05-03 Fujisawa Pharmaceutical Co., Ltd. Antiallergic thiazole compounds
PH24976A (en) * 1987-08-13 1990-12-26 Glaxo Group Ltd Indole derivatives
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
DK733788A (da) * 1988-01-14 1989-07-15 Fujisawa Pharmaceutical Co Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
US5322851A (en) * 1990-07-02 1994-06-21 H. Lundbeck A/S Indole derivatives
DK158590D0 (da) * 1990-07-02 1990-07-02 Lundbeck & Co As H Indolderivater
US5643784A (en) * 1990-12-04 1997-07-01 H, Lundbeck A/S Indan derivatives
NZ243065A (en) 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
DK78692D0 (da) * 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
AU675964B2 (en) * 1992-08-05 1997-02-27 John Wyeth & Brother Limited Amide derivatives
DK148292D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Forbindelser
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
DE19500689A1 (de) * 1995-01-12 1996-07-18 Merck Patent Gmbh Indolpiperidin-Derivate
KR19980703048A (ko) * 1995-03-20 1998-09-05 피터쥐.스트링거 5-치환-3-(1,2,3,6-테트라히드로피리딘-4-일)- 및 3-(피페리딘-4-일)-1ｈ-인돌: 신규한 5-ｈｔ1ｆ 아고니스트
EP1242072A4 (en) * 1999-12-17 2004-02-04 Bristol Myers Squibb Co ANTIPSYCHOTIC HETEROCYCLIC COMPOUNDS
MXPA06004626A (es) * 2003-11-17 2006-06-27 Boehringer Ingelheim Int Indoles sustituidos con piperidina o sus heteroderivados y su uso como moduladores del receptor de quemocina (ccr3).
WO2006117314A2 (en) * 2005-04-30 2006-11-09 Boehringer Ingelheim International Gmbh Novel piperidin- substituted indoles and their use as ccr-3 modulators

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2322470A1 (de) * 1973-05-04 1974-11-21 Boehringer Sohn Ingelheim Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung
FR2349331A1 (fr) * 1976-04-30 1977-11-25 Roussel Uclaf Nouveaux derives de 2,3 dihydro a/4-(3-indolyl) 1-piperidinyl/methyl 1,4-benzodioxin-2-methanol, un procede pour leur preparation et leur application comme medicaments
US4264599A (en) * 1977-07-08 1981-04-28 Ciba-Geigy Corporation Piperidino-propanols
FR2420536A1 (fr) * 1978-03-22 1979-10-19 Roussel Uclaf Nouveaux derives de 1,3-dihydro 3-/1-/2-(2,3-dihydro 1,4-benzodioxin-2-yl)2-hydroxyethyl/piperidin-4-yl/2h-indol-2-one, procede pour leur preparation et application comme medicaments
FR2460947A1 (fr) * 1979-07-13 1981-01-30 Roussel Uclaf Nouveau derives n-substitues du tetrahydropyridinyl-indole, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
JPS5924990B2 (ja) * 1979-11-21 1984-06-13 協和醗酵工業株式会社 新規なピペリジン誘導体
US4344945A (en) * 1980-03-10 1982-08-17 Kyowa Hakko Kogyo Co., Ltd. Piperidine derivatives

Also Published As

Publication number Publication date
FR2533924A1 (fr) 1984-04-06
JPH0460996B2 (enExample) 1992-09-29
US4530932A (en) 1985-07-23
ATE25381T1 (de) 1987-02-15
DE3369681D1 (en) 1987-03-12
CA1213280A (fr) 1986-10-28
JPS5988481A (ja) 1984-05-22
EP0112191B1 (fr) 1987-02-04
EP0112191A1 (fr) 1984-06-27

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Legal Events

Date Code Title Description
ST Notification of lapse