FR2527210B1 - - Google Patents

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Publication number
FR2527210B1
FR2527210B1 FR8208632A FR8208632A FR2527210B1 FR 2527210 B1 FR2527210 B1 FR 2527210B1 FR 8208632 A FR8208632 A FR 8208632A FR 8208632 A FR8208632 A FR 8208632A FR 2527210 B1 FR2527210 B1 FR 2527210B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8208632A
Other languages
French (fr)
Other versions
FR2527210A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR8208632A priority Critical patent/FR2527210A1/fr
Priority to SE8302747A priority patent/SE8302747L/xx
Priority to NO831737A priority patent/NO831737L/no
Priority to DK219183A priority patent/DK219183A/da
Priority to ZA833539A priority patent/ZA833539B/xx
Priority to BE0/210788A priority patent/BE896764A/fr
Priority to IL68721A priority patent/IL68721A0/xx
Priority to AU14616/83A priority patent/AU1461683A/en
Priority to LU84808A priority patent/LU84808A1/fr
Priority to GR71371A priority patent/GR78568B/el
Priority to HU831720A priority patent/HU189660B/hu
Priority to NL8301739A priority patent/NL8301739A/nl
Priority to PT76716A priority patent/PT76716B/pt
Priority to DE19833317961 priority patent/DE3317961A1/de
Priority to GB08313625A priority patent/GB2120250A/en
Priority to JP58086526A priority patent/JPS58210083A/ja
Priority to IT21143/83A priority patent/IT1194244B/it
Priority to ES522478A priority patent/ES522478A0/es
Priority to CH267983A priority patent/CH654579B/fr
Publication of FR2527210A1 publication Critical patent/FR2527210A1/fr
Application granted granted Critical
Publication of FR2527210B1 publication Critical patent/FR2527210B1/fr
Granted legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C10M129/00—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing oxygen
    • C10M129/02—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing oxygen having a carbon chain of less than 30 atoms
    • C10M129/04—Hydroxy compounds
    • C10M129/10—Hydroxy compounds having hydroxy groups bound to a carbon atom of a six-membered aromatic ring
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    • C10M129/00—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing oxygen
    • C10M129/86—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing oxygen having a carbon chain of 30 or more atoms
    • C10M129/95—Esters
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    • C10M133/00—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing nitrogen
    • C10M133/52—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing nitrogen having a carbon chain of 30 or more atoms
    • C10M133/56—Amides; Imides
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    • C10M135/00—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing sulfur, selenium or tellurium
    • C10M135/08—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing sulfur, selenium or tellurium containing a sulfur-to-oxygen bond
    • C10M135/10—Sulfonic acids or derivatives thereof
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    • C10M137/00—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing phosphorus
    • C10M137/02—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing phosphorus having no phosphorus-to-carbon bond
    • C10M137/04—Phosphate esters
    • C10M137/10—Thio derivatives
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    • C10M141/00—Lubricating compositions characterised by the additive being a mixture of two or more compounds covered by more than one of the main groups C10M125/00 - C10M139/00, each of these compounds being essential
    • C10M141/12—Lubricating compositions characterised by the additive being a mixture of two or more compounds covered by more than one of the main groups C10M125/00 - C10M139/00, each of these compounds being essential at least one of them being an organic compound containing atoms of elements not provided for in groups C10M141/02 - C10M141/10
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    • C10M159/00—Lubricating compositions characterised by the additive being of unknown or incompletely defined constitution
    • C10M159/12—Reaction products
    • C10M159/20—Reaction mixtures having an excess of neutralising base, e.g. so-called overbasic or highly basic products
    • C10M159/22—Reaction mixtures having an excess of neutralising base, e.g. so-called overbasic or highly basic products containing phenol radicals
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    • C10M159/12—Reaction products
    • C10M159/20—Reaction mixtures having an excess of neutralising base, e.g. so-called overbasic or highly basic products
    • C10M159/24—Reaction mixtures having an excess of neutralising base, e.g. so-called overbasic or highly basic products containing sulfonic radicals
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    • C10M163/00—Lubricating compositions characterised by the additive being a mixture of a compound of unknown or incompletely defined constitution and a non-macromolecular compound, each of these compounds being essential
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    • C10M2207/00—Organic non-macromolecular hydrocarbon compounds containing hydrogen, carbon and oxygen as ingredients in lubricant compositions
    • C10M2207/02—Hydroxy compounds
    • C10M2207/023—Hydroxy compounds having hydroxy groups bound to carbon atoms of six-membered aromatic rings
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    • C10M2207/023—Hydroxy compounds having hydroxy groups bound to carbon atoms of six-membered aromatic rings
    • C10M2207/026—Hydroxy compounds having hydroxy groups bound to carbon atoms of six-membered aromatic rings with tertiary alkyl groups
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    • C10M2207/027—Neutral salts thereof
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    • C10M2207/26—Overbased carboxylic acid salts
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    • C10M2209/084—Acrylate; Methacrylate
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    • C10M2215/00—Organic non-macromolecular compounds containing nitrogen as ingredients in lubricant Compositions
    • C10M2215/02—Amines, e.g. polyalkylene polyamines; Quaternary amines
    • C10M2215/04—Amines, e.g. polyalkylene polyamines; Quaternary amines having amino groups bound to acyclic or cycloaliphatic carbon atoms
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    • C10M2215/24—Organic non-macromolecular compounds containing nitrogen as ingredients in lubricant Compositions having hydrocarbon substituents containing thirty or more carbon atoms, e.g. nitrogen derivatives of substituted succinic acid
    • C10M2215/26—Amines
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    • C10M2215/28—Amides; Imides
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    • C10M2217/04—Macromolecular compounds from nitrogen-containing monomers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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    • C10M2219/087—Thiols; Sulfides; Polysulfides; Mercaptals containing sulfur atoms bound to acyclic or cycloaliphatic carbon atoms containing hydroxy groups; Derivatives thereof, e.g. sulfurised phenols
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    • C10M2227/00—Organic non-macromolecular compounds containing atoms of elements not provided for in groups C10M2203/00, C10M2207/00, C10M2211/00, C10M2215/00, C10M2219/00 or C10M2223/00 as ingredients in lubricant compositions
    • C10M2227/06—Organic compounds derived from inorganic acids or metal salts
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FR8208632A 1982-05-18 1982-05-18 Enantiomeres d'hexahydro-2,3,3a,4,5,6 1h-indolo(3,2,1-de) (naphtyridine-1,5), leur procede de separation et leur application en therapeutique Granted FR2527210A1 (fr)

Priority Applications (19)

Application Number Priority Date Filing Date Title
FR8208632A FR2527210A1 (fr) 1982-05-18 1982-05-18 Enantiomeres d'hexahydro-2,3,3a,4,5,6 1h-indolo(3,2,1-de) (naphtyridine-1,5), leur procede de separation et leur application en therapeutique
NO831737A NO831737L (no) 1982-05-18 1983-05-16 Fremgangsmaate for fremstilling av indolo-naftyridinderivater
SE8302747A SE8302747L (sv) 1982-05-18 1983-05-16 Indol-naftyridiner
PT76716A PT76716B (fr) 1982-05-18 1983-05-17 Procede de preparation des enantiomeres de l'hexahydro-2,3,3a,4,5,6 1h-indolo <3,2,1-de><naphtyridine-1,5>
BE0/210788A BE896764A (fr) 1982-05-18 1983-05-17 Enantiomeres d'hexahydro-2,3,3a,4,5,6 1h-indola [3,2,1-de] [naphtyridine 1,5] leur procede de separation et leur application en therapeutique.
IL68721A IL68721A0 (en) 1982-05-18 1983-05-17 Enantiomers of 2,3,3a,4,5,6-hexahydro-1h-indolo(3,2,1-de)-(1,5-naphthyridine),their preparation and pharmaceutical compositions containing them
AU14616/83A AU1461683A (en) 1982-05-18 1983-05-17 Enantiomers of hexahydra-1h-indolo (3,2,1-de)-(1,5- naphthyridine)
LU84808A LU84808A1 (fr) 1982-05-18 1983-05-17 Enantiomeres d'hexahydro-2,3,3a,4,5,6 1h-indolo(3,2-1-de)(naphtyridine-1,5),leur procede de separation et leur application en therapeutique
GR71371A GR78568B (OSRAM) 1982-05-18 1983-05-17
HU831720A HU189660B (en) 1982-05-18 1983-05-17 Process for the separation of enantiomers of 2,3,3a,4,5,6-hexahydro-1h-indolo/3,2,1-de/ 1,5-naphthyridine and for preparing pharmaceutical compositions containing such compounds
DK219183A DK219183A (da) 1982-05-18 1983-05-17 Enantiomere af 2,3,3a,4,5,6-hexahydro-1h-indolo(3,2,1-de)(1,5-naphthyridin), fremgangsmaade til deres adskillelse samt deres anvendelse
ZA833539A ZA833539B (en) 1982-05-18 1983-05-17 Enantiomers of 2,3,3a,4,5,6-hexahydro-1h-indolo(3,2,1-de)(1,5-naphthyridine)
DE19833317961 DE3317961A1 (de) 1982-05-18 1983-05-17 Enantiomere von 2,3,3a,4,5,6-hexahydro-1h-indolo(3,2,1-de)(1,5-naphthyridin), verfahren zu ihrer trennung und sie enthaltende arzneimittel
GB08313625A GB2120250A (en) 1982-05-18 1983-05-17 Enantiomers of 2,3,3a,4,5,6- hexahydro-1H-indolo(3,2,1- de)-[1,5-naphthyridine]
JP58086526A JPS58210083A (ja) 1982-05-18 1983-05-17 ナフチリジン誘導体のエナンチオマ−
IT21143/83A IT1194244B (it) 1982-05-18 1983-05-17 Enantiomeri di esaidro-2,3,3a,4,5,6 1h-indol (3,2,1-de) (naftiridina-1,5),processo di loro separazione e loro impiego in terapeutica
ES522478A ES522478A0 (es) 1982-05-18 1983-05-17 Procedimiento de separacion de los enantiomeros del hexahidro-2,3,3a,4,5,6-1h-indol(3,2,1-de) (naftiridina-1,5)
CH267983A CH654579B (OSRAM) 1982-05-18 1983-05-17
NL8301739A NL8301739A (nl) 1982-05-18 1983-05-17 Werkwijze voor het scheiden van enantiomeren van 2,3,3a,4,5,6-hexahydro 1h-indool 3,2,1-denaftyridine-1,5, de hexahydroenantiomeren en de therapeutische toepassing hiervan.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8208632A FR2527210A1 (fr) 1982-05-18 1982-05-18 Enantiomeres d'hexahydro-2,3,3a,4,5,6 1h-indolo(3,2,1-de) (naphtyridine-1,5), leur procede de separation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2527210A1 FR2527210A1 (fr) 1983-11-25
FR2527210B1 true FR2527210B1 (OSRAM) 1985-04-12

Family

ID=9274131

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8208632A Granted FR2527210A1 (fr) 1982-05-18 1982-05-18 Enantiomeres d'hexahydro-2,3,3a,4,5,6 1h-indolo(3,2,1-de) (naphtyridine-1,5), leur procede de separation et leur application en therapeutique

Country Status (19)

Country Link
JP (1) JPS58210083A (OSRAM)
AU (1) AU1461683A (OSRAM)
BE (1) BE896764A (OSRAM)
CH (1) CH654579B (OSRAM)
DE (1) DE3317961A1 (OSRAM)
DK (1) DK219183A (OSRAM)
ES (1) ES522478A0 (OSRAM)
FR (1) FR2527210A1 (OSRAM)
GB (1) GB2120250A (OSRAM)
GR (1) GR78568B (OSRAM)
HU (1) HU189660B (OSRAM)
IL (1) IL68721A0 (OSRAM)
IT (1) IT1194244B (OSRAM)
LU (1) LU84808A1 (OSRAM)
NL (1) NL8301739A (OSRAM)
NO (1) NO831737L (OSRAM)
PT (1) PT76716B (OSRAM)
SE (1) SE8302747L (OSRAM)
ZA (1) ZA833539B (OSRAM)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU84664A1 (fr) * 1983-02-25 1984-11-08 Onmichem S A Alkyl-4-indolonaphtyridines et leur application therapeutique
US5231181A (en) * 1991-03-21 1993-07-27 Syntex (U.S.A.) Inc. Process for the preparation of (8as,12as,13as)-decahydroisoquino ((2,1-g) (1,6)-naphthyridin-8-one derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES503557A0 (es) * 1980-07-03 1982-04-01 Omnichem Sa Procedimiento de preparacion de alquil-3 tetrahidro-1,2,3, 3a-4h-indolo(3,2,1-de)-1,5-naftiridinas.
FR2494693A1 (fr) * 1980-11-21 1982-05-28 Synthelabo Derives de l'hexahydro-2,3,3a,4,5,6 1h-indolo(3,2,1-de)(naphtyridine-1,5), leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
LU84808A1 (fr) 1985-03-21
ES8403126A1 (es) 1984-03-01
IT1194244B (it) 1988-09-14
FR2527210A1 (fr) 1983-11-25
GB8313625D0 (en) 1983-06-22
BE896764A (fr) 1983-11-17
PT76716A (fr) 1983-06-01
HU189660B (en) 1986-07-28
IL68721A0 (en) 1983-09-30
GB2120250A (en) 1983-11-30
NL8301739A (nl) 1983-12-16
CH654579B (OSRAM) 1986-02-28
AU1461683A (en) 1983-11-24
GR78568B (OSRAM) 1984-09-27
SE8302747D0 (sv) 1983-05-16
ZA833539B (en) 1984-02-29
ES522478A0 (es) 1984-03-01
PT76716B (fr) 1986-03-27
DK219183D0 (da) 1983-05-17
IT8321143A0 (it) 1983-05-17
DE3317961A1 (de) 1983-11-24
NO831737L (no) 1983-11-21
JPS58210083A (ja) 1983-12-07
DK219183A (da) 1983-11-19
SE8302747L (sv) 1983-11-19

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