FR2520739B1 - NEW INDOLEACETIC ESTER DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION - Google Patents

NEW INDOLEACETIC ESTER DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION

Info

Publication number
FR2520739B1
FR2520739B1 FR8220317A FR8220317A FR2520739B1 FR 2520739 B1 FR2520739 B1 FR 2520739B1 FR 8220317 A FR8220317 A FR 8220317A FR 8220317 A FR8220317 A FR 8220317A FR 2520739 B1 FR2520739 B1 FR 2520739B1
Authority
FR
France
Prior art keywords
new
preparation process
ester derivatives
therapeutic application
indoleacetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8220317A
Other languages
French (fr)
Other versions
FR2520739A1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SSP Co Ltd
Original Assignee
SSP Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1509982A external-priority patent/JPS58134077A/en
Priority claimed from JP5922982A external-priority patent/JPS58177966A/en
Application filed by SSP Co Ltd filed Critical SSP Co Ltd
Publication of FR2520739A1 publication Critical patent/FR2520739A1/en
Application granted granted Critical
Publication of FR2520739B1 publication Critical patent/FR2520739B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
FR8220317A 1982-02-02 1982-12-03 NEW INDOLEACETIC ESTER DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION Expired FR2520739B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1509982A JPS58134077A (en) 1982-02-02 1982-02-02 Novel indoleacetic ester derivative and preparation thereof
JP5922982A JPS58177966A (en) 1982-04-09 1982-04-09 Novel indoleacetic ester derivative and its preparation

Publications (2)

Publication Number Publication Date
FR2520739A1 FR2520739A1 (en) 1983-08-05
FR2520739B1 true FR2520739B1 (en) 1985-07-12

Family

ID=26351190

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8220317A Expired FR2520739B1 (en) 1982-02-02 1982-12-03 NEW INDOLEACETIC ESTER DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION

Country Status (6)

Country Link
CA (1) CA1187488A (en)
CH (1) CH649532A5 (en)
DE (1) DE3235850A1 (en)
FR (1) FR2520739B1 (en)
GB (1) GB2125786B (en)
IT (1) IT1149095B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6028957A (en) * 1983-07-27 1985-02-14 Kaken Pharmaceut Co Ltd Ester derivatives of indolylacetic acid and phenylacetic acid and their production
US4619937A (en) * 1984-02-02 1986-10-28 Warner-Lambert Company Saturated bicyclic lactam acids and derivatives as cognition activators
US6762182B1 (en) 1999-01-07 2004-07-13 Vanderbilt University Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors
US6207700B1 (en) 1999-01-07 2001-03-27 Vanderbilt University Amide derivatives for antiangiogenic and/or antitumorigenic use
US6306890B1 (en) 1999-08-30 2001-10-23 Vanderbilt University Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
CA2562783A1 (en) 2004-04-26 2005-12-01 Vanderbilt University Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity
CN101528222A (en) 2006-06-19 2009-09-09 范德比尔特大学 Methods and compositions for diagnostic and therapeutic targeting of COX-2
US9346803B2 (en) 2011-10-17 2016-05-24 Vanderbilt University Indomethacin analogs for the treatment of castrate-resistant prostate cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH601228A5 (en) * 1977-06-17 1978-06-30 Hisamitsu Pharmaceutical Co Antiinflammatory indomethacin esters active topically and orally
BE871709A (en) * 1978-10-31 1979-02-15 Abbott Lab PROCESS FOR PREPARATION OF COMPOUNDS WITH ANTI-INFLAMMATORY ACTIVITY

Also Published As

Publication number Publication date
GB2125786A (en) 1984-03-14
GB2125786B (en) 1985-10-02
FR2520739A1 (en) 1983-08-05
CH649532A5 (en) 1985-05-31
DE3235850A1 (en) 1983-08-11
IT1149095B (en) 1986-12-03
CA1187488A (en) 1985-05-21
IT8249205A0 (en) 1982-10-05

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Legal Events

Date Code Title Description
ST Notification of lapse