FR2509730A1 - Nouveaux phenols o-halogenes et o-substitues par un heterocycle, leur procede de preparation, medicaments les contenant, notamment anti-hypertenseurs, et nouveaux intermediaires de synthese - Google Patents

Nouveaux phenols o-halogenes et o-substitues par un heterocycle, leur procede de preparation, medicaments les contenant, notamment anti-hypertenseurs, et nouveaux intermediaires de synthese Download PDF

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Publication number
FR2509730A1
FR2509730A1 FR8114011A FR8114011A FR2509730A1 FR 2509730 A1 FR2509730 A1 FR 2509730A1 FR 8114011 A FR8114011 A FR 8114011A FR 8114011 A FR8114011 A FR 8114011A FR 2509730 A1 FR2509730 A1 FR 2509730A1
Authority
FR
France
Prior art keywords
formula
tetrahydro
tert
butyl
imidazolinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8114011A
Other languages
English (en)
French (fr)
Other versions
FR2509730B1 (enExample
Inventor
Jean-Marie Teulon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carpibem SA
Original Assignee
Carpibem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carpibem SA filed Critical Carpibem SA
Priority to FR8114011A priority Critical patent/FR2509730A1/fr
Priority to JP57502218A priority patent/JPS58501127A/ja
Priority to AU87316/82A priority patent/AU8731682A/en
Priority to MC82FR8200120D priority patent/MC1517A1/xx
Priority to EP82401339A priority patent/EP0070779A3/fr
Priority to PCT/FR1982/000120 priority patent/WO1983000333A1/fr
Publication of FR2509730A1 publication Critical patent/FR2509730A1/fr
Priority to DK119783A priority patent/DK119783A/da
Application granted granted Critical
Publication of FR2509730B1 publication Critical patent/FR2509730B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
    • C07C45/565—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom by reaction with hexamethylene-tetramine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/56—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
    • C07C47/565—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/56—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
    • C07C47/57—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR8114011A 1981-07-17 1981-07-17 Nouveaux phenols o-halogenes et o-substitues par un heterocycle, leur procede de preparation, medicaments les contenant, notamment anti-hypertenseurs, et nouveaux intermediaires de synthese Granted FR2509730A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR8114011A FR2509730A1 (fr) 1981-07-17 1981-07-17 Nouveaux phenols o-halogenes et o-substitues par un heterocycle, leur procede de preparation, medicaments les contenant, notamment anti-hypertenseurs, et nouveaux intermediaires de synthese
JP57502218A JPS58501127A (ja) 1981-07-17 1982-07-19 置換基の１つが複素環基である新規ジ−オルト置換フェノ−ル，それらの製造方法，それらの化合物を含む特に抗−高血圧性剤，薬物および新規合成中間体
AU87316/82A AU8731682A (en) 1981-07-17 1982-07-19 Anti-hypertensor, heterocyclically di-orthosubstituted phenols
MC82FR8200120D MC1517A1 (fr) 1981-07-17 1982-07-19 Nouveaux phenols di-orthosubstitues dont une des substitutions est un heterocycle,leur procede de preparation,medicaments les contenant notamment anti-hypertenseurs et nouveaux intermediaires de synthese
EP82401339A EP0070779A3 (fr) 1981-07-17 1982-07-19 Nouveaux phénols di-ortho substitués dont une des substitutions est un hétérocycle, leur procédé de préparation, médicaments les contenant, notamment anti-hypertenseurs et nouveaux intermédiaires de synthèse
PCT/FR1982/000120 WO1983000333A1 (fr) 1981-07-17 1982-07-19 Phenols di-orthosubstitues a substitution heterocyclique, anti-hypertenseurs.
DK119783A DK119783A (da) 1981-07-17 1983-03-15 Di-orthosubstituerede phenoler, hvori en af substituenterne er en heterocyclisk gruppe, fremgangsmaade til fremstilling deraf samt midler indeholdende forbindelserne

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8114011A FR2509730A1 (fr) 1981-07-17 1981-07-17 Nouveaux phenols o-halogenes et o-substitues par un heterocycle, leur procede de preparation, medicaments les contenant, notamment anti-hypertenseurs, et nouveaux intermediaires de synthese

Publications (2)

Publication Number Publication Date
FR2509730A1 true FR2509730A1 (fr) 1983-01-21
FR2509730B1 FR2509730B1 (enExample) 1984-01-06

Family

ID=9260633

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8114011A Granted FR2509730A1 (fr) 1981-07-17 1981-07-17 Nouveaux phenols o-halogenes et o-substitues par un heterocycle, leur procede de preparation, medicaments les contenant, notamment anti-hypertenseurs, et nouveaux intermediaires de synthese

Country Status (7)

Country Link
EP (1) EP0070779A3 (enExample)
JP (1) JPS58501127A (enExample)
AU (1) AU8731682A (enExample)
DK (1) DK119783A (enExample)
FR (1) FR2509730A1 (enExample)
MC (1) MC1517A1 (enExample)
WO (1) WO1983000333A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3332780A1 (de) * 1983-09-10 1985-03-28 Hoechst Ag, 6230 Frankfurt 6-sulfoxyphenolderivate, ihre herstellung und ihre verwendung als cytoprotekiva

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB591683A (en) * 1945-05-02 1947-08-26 Boots Pure Drug Co Ltd Improvements in and relating to the manufacture of heterocyclic compounds
GB614032A (en) * 1946-07-01 1948-12-08 Boots Pure Drug Co Ltd Improvements in the manufacture of heterocyclic compounds
FR2081505A1 (enExample) * 1970-02-12 1971-12-03 American Home Prod

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54145631A (en) * 1978-04-05 1979-11-14 Ube Ind Ltd Preparation of 2-cyanophenol derivative
JPS54145632A (en) * 1978-04-05 1979-11-14 Ube Ind Ltd Preparation of 2-cyanophenol derivative
JPS6039349B2 (ja) * 1979-06-20 1985-09-05 宇部興産株式会社 ２−シアノフエノ−ル誘導体の製法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB591683A (en) * 1945-05-02 1947-08-26 Boots Pure Drug Co Ltd Improvements in and relating to the manufacture of heterocyclic compounds
GB614032A (en) * 1946-07-01 1948-12-08 Boots Pure Drug Co Ltd Improvements in the manufacture of heterocyclic compounds
FR2081505A1 (enExample) * 1970-02-12 1971-12-03 American Home Prod

Also Published As

Publication number Publication date
DK119783D0 (da) 1983-03-15
JPS58501127A (ja) 1983-07-14
DK119783A (da) 1983-03-15
FR2509730B1 (enExample) 1984-01-06
EP0070779A3 (fr) 1983-06-22
WO1983000333A1 (fr) 1983-02-03
EP0070779A2 (fr) 1983-01-26
MC1517A1 (fr) 1984-02-10
AU8731682A (en) 1983-03-17

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