FR2498929A1 - NOVEL HUMIDIZING COMPOSITION BASED ON SODIUM LACTATE, GLYCERIN, UREA AND NATIVE COLLAGEN - Google Patents
NOVEL HUMIDIZING COMPOSITION BASED ON SODIUM LACTATE, GLYCERIN, UREA AND NATIVE COLLAGEN Download PDFInfo
- Publication number
- FR2498929A1 FR2498929A1 FR8101971A FR8101971A FR2498929A1 FR 2498929 A1 FR2498929 A1 FR 2498929A1 FR 8101971 A FR8101971 A FR 8101971A FR 8101971 A FR8101971 A FR 8101971A FR 2498929 A1 FR2498929 A1 FR 2498929A1
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- Prior art keywords
- urea
- proportion
- sodium lactate
- glycerin
- collagen
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 102000008186 Collagen Human genes 0.000 title claims abstract description 23
- 108010035532 Collagen Proteins 0.000 title claims abstract description 23
- 229920001436 collagen Polymers 0.000 title claims abstract description 23
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 title claims abstract description 17
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title claims abstract description 13
- 239000004202 carbamide Substances 0.000 title claims abstract description 11
- 235000011187 glycerol Nutrition 0.000 title claims abstract description 11
- 239000001540 sodium lactate Substances 0.000 title claims abstract description 11
- 229940005581 sodium lactate Drugs 0.000 title claims abstract description 11
- 235000011088 sodium lactate Nutrition 0.000 title claims abstract description 11
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 title claims description 5
- 235000013877 carbamide Nutrition 0.000 title 1
- 239000003906 humectant Substances 0.000 claims abstract description 26
- 239000002537 cosmetic Substances 0.000 claims abstract description 6
- 239000007864 aqueous solution Substances 0.000 claims abstract description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 239000004615 ingredient Substances 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 8
- 229920001184 polypeptide Polymers 0.000 description 8
- 102000004196 processed proteins & peptides Human genes 0.000 description 8
- 108090000765 processed proteins & peptides Proteins 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 239000006071 cream Substances 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- -1 halide ion Chemical class 0.000 description 6
- BXWNKGSJHAJOGX-UHFFFAOYSA-N n-hexadecyl alcohol Natural products CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 6
- 239000002304 perfume Substances 0.000 description 6
- 239000005662 Paraffin oil Substances 0.000 description 5
- 229960000541 cetyl alcohol Drugs 0.000 description 5
- 235000013336 milk Nutrition 0.000 description 5
- 210000004080 milk Anatomy 0.000 description 5
- 239000004166 Lanolin Substances 0.000 description 4
- 229940039717 lanolin Drugs 0.000 description 4
- 235000019388 lanolin Nutrition 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 230000002335 preservative effect Effects 0.000 description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 3
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 3
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 3
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 3
- 229940031574 hydroxymethyl cellulose Drugs 0.000 description 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 3
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 3
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 229930182558 Sterol Natural products 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 239000007764 o/w emulsion Substances 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 229920005862 polyol Polymers 0.000 description 2
- 150000003077 polyols Chemical class 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 150000004671 saturated fatty acids Chemical class 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 150000003432 sterols Chemical class 0.000 description 2
- 235000003702 sterols Nutrition 0.000 description 2
- 229940099259 vaseline Drugs 0.000 description 2
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- FGEUKKGODAGXOD-FMIVXFBMSA-N cyclohexyl (e)-3-(4-methoxyphenyl)prop-2-enoate Chemical compound C1=CC(OC)=CC=C1\C=C\C(=O)OC1CCCCC1 FGEUKKGODAGXOD-FMIVXFBMSA-N 0.000 description 1
- SDIXRDNYIMOKSG-UHFFFAOYSA-L disodium methyl arsenate Chemical compound [Na+].[Na+].C[As]([O-])([O-])=O SDIXRDNYIMOKSG-UHFFFAOYSA-L 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000008309 hydrophilic cream Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 229910052622 kaolinite Inorganic materials 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N n-octadecyl alcohol Natural products CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 230000003169 placental effect Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/14—Preparations for removing make-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
COMPOSITION HUMECTANTE. CETTE COMPOSITION CONTIENT EN SOLUTION AQUEUSE: -DU LACTATE DE SODIUM EN UNE PROPORTION DE 3 A 8; -DE LA GLYCERINE EN UNE PROPORTION DE 12 A 24; -DE L'UREE EN UNE PROPORTION DE 30 A 42; ET -DU COLLAGENE NATIF, EN UNE PROPORTION INFERIEURE A 0,5, LESDITS POURCENTAGES ETANT EXPRIMES PAR RAPPORT AU POIDS TOTAL DE LA COMPOSITION HUMECTANTE. CETTE COMPOSITION TROUVE UNE APPLICATION DANS DES COMPOSITIONS COSMETIQUES OU PHARMACEUTIQUES.HUMECTANT COMPOSITION. THIS COMPOSITION CONTAINS IN AQUEOUS SOLUTION: - SODIUM LACTATE IN A PROPORTION OF 3 TO 8; - GLYCERINE IN A PROPORTION OF 12 TO 24; -OF THE UREA IN A PROPORTION OF 30 TO 42; AND -OF NATIVE COLLAGEN, IN A PROPORTION LESS THAN 0.5, THE SAID PERCENTAGES BEING EXPRESSED IN RELATION TO THE TOTAL WEIGHT OF THE WETTING COMPOSITION. THIS COMPOSITION FINDS AN APPLICATION IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS.
Description
-1--1-
La présente invention a pour objet une nouvelle com- The present invention relates to a novel
position humectante utilisable dans des compositions cosmétiques humectant position for use in cosmetic compositions
ou pharmaceutiques.or pharmaceutical.
Il est de pratique courante d'utiliser en cosmétique des humectants c'està-dire des substances hygroscopiques per- mettant d'absorber l'humidité de l'air ambiant et de maintenir la teneur en eau des compositions de sorte que celles-ci n'ont pas tendance à sécher. Par ailleurs les propriétés hygroscopiques du film d'humectant lorsqu'il est appliqué sur la peau constitue un facteur important permettant d'influencer favorablement la It is common practice to use in cosmetics humectants that is to say hygroscopic substances permitting to absorb moisture from the ambient air and to maintain the water content of the compositions so that they do not tend to dry. Moreover, the hygroscopic properties of the humectant film when it is applied to the skin constitute an important factor making it possible to influence favorably the
souplesse et le toucher de la peau.flexibility and touch of the skin.
Parmi les nombreuses substances humectantes les plus couramment utilisées on peut citer les sels de sodium tels que le lactate de sodium ou le pyrrolidone carboxylate de sodium, les polyols tels que-la glycérine, le sorbitol et le propylène glycol Among the many humectants most commonly used include sodium salts such as sodium lactate or sodium pyrrolidone carboxylate, polyols such as glycerine, sorbitol and propylene glycol
ainsi que d'autres substances telles que l'urée. as well as other substances such as urea.
Il a également été proposé d'utiliser des mélanges de ces substances bien que l'on n'ait pu constater dans ce cas un It has also been proposed to use mixtures of these substances although it has not been possible
effet particulièrement sensible de synergie. particularly sensitive effect of synergy.
Parmi ces mélanges il a été tout particulièrement décrit dans le brevet britannique n01.471.679 l'association Among these mixtures it has been particularly described in British Patent No. 4171,679 the association
d'acide pyrrolidone carboxylique ou d'un de ses sels hygroscopi- pyrrolidone carboxylic acid or a hygroscopic salt thereof
ques, d'un sel d'acide a-hydroxy carboxylique en C2-C5 et no- of a C2-C5 α-hydroxy carboxylic acid salt and
tamment le sel de sodium de l'acide glycolique ou lactique et especially the sodium salt of glycolic or lactic acid and
d'une substance polypeptidique de collagène modifie. of a modified collagen polypeptide substance.
Selon ce brevet on doit entendre par l'expression "substance polypeptidique de collagène modifié" une substance polypeptidique ayant des groupes amino quaternisés avec un ion halogénure et ayant des groupes carboxy terminaux estérifiés par un amino-alcool en C3-C12 ou une substance polypeptidique ayant des groupes amino terminaux ayant réagi avec un acide gras saturé ou insaturé et ayant des groupes carboxy terminaux ayant réagi avec un polyol, la substance polypeptidique dans chaque cas étant dérivée de collagène et possédant un poids moléculaire moyen According to this patent, the term "modified collagen polypeptide substance" is intended to mean a polypeptide substance having amino groups quaternized with a halide ion and having carboxy terminal groups esterified with a C3-C12 aminoalcohol or a polypeptide substance having end-amino groups reacted with a saturated or unsaturated fatty acid and having carboxyl groups reacted with a polyol, the polypeptide substance in each case being derived from collagen and having an average molecular weight
correspondant à un di, tri ou tétrapeptides. corresponding to a di, tri or tetrapeptide.
D'après ce brevet les proportions des différents ingrédients peuvent varier dans un rapport en poids de 0,75-1,25 pour l'acide pyrrolidone carboxylique ou son sel hygroscopique, According to this patent, the proportions of the various ingredients can vary in a weight ratio of 0.75 to 1.25 for pyrrolidone carboxylic acid or its hygroscopic salt,
de 0,75 à 1,25 pour le sel d'acide a-hydroxy carboxylique en C2- from 0.75 to 1.25 for the C2-α-hydroxy carboxylic acid salt.
C5 et de 3,75 y 6,25 pour le dérivé polypeptidique de collagène -2modifié. La présente invention se rapporte également a une association particulière d'agents humectants permettant de conférer une excellente conservation des compositions et de conférer par ailleurs des propriétés adoucissantes et assou- C5 and 3.75 and 6.25 for the polypeptide derivative of collagen -2 modified. The present invention also relates to a particular combination of humectants for imparting excellent preservation of the compositions and to further confer softening and softening properties.
plissantes de la peau.wrinkling of the skin.
La présente invention a pour objet une composition humectante contenant en solution aqueuse: - du lactate de sodium en une proportion de 3 à 8%, - de la glycérine en une proportion de 12 à 24%, - de l'urée en une proportion de 30 à 42%, et - du collagène natif en une proportion inférieure The present invention relates to a humectant composition containing in aqueous solution: sodium lactate in a proportion of 3 to 8%, glycerin in a proportion of 12 to 24%, urea in a proportion of 30 to 42%, and - native collagen in a lower proportion
à 0,5% en poids.at 0.5% by weight.
Les différents essais effectués ont permis de montrer The various tests carried out have made it possible to show
que seule cette assocation dans les proportions mentionnées ci- that this association in the proportions mentioned
dessus était susceptible de conférer les propriétés recherchées. above was likely to confer the desired properties.
En particulier il s'est avéré que la présence du collagène natif était indispensable en vue de l'obtention d'un In particular, it was found that the presence of native collagen was essential in order to obtain a
bon pouvoir humectant.good humectant power.
De préférence la composition humectante selon l'in- Preferably the humectant composition according to the invention
vention contient en solution aqueuse: - de 4 à 7% en poids de lactate de sodium, - de 15,5 à 21% en poids de glycérine, - de 33,5 à 39% en poids d'urée, et - du collagène natif en une proportion inférieure The invention contains in aqueous solution: 4 to 7% by weight of sodium lactate, 15 to 21% by weight of glycerine, 33 to 39% by weight of urea, and collagen. native in a lower proportion
à 0,2% en poids.at 0.2% by weight.
Par collagène natif, on entend un collagène présentant les caractéristiques suivantes: Il est constitué d'une triple hélice comprenant trois chaînes hélicoîdales a, e et y dont les masses moléculaires By native collagen is meant a collagen having the following characteristics: It consists of a triple helix comprising three helical chains a, e and y whose molecular masses
respectives sont 100.000, 200.000 et 300,000. respective amounts are 100,000, 200,000 and 300,000.
La chaine a est constituée de 2 sous-unités al et a2, chacune de masse moléculaire 100.000, et se différenciant légèrement entre elles par la nature des acides aminés qui les The chain a consists of 2 subunits α1 and α2, each having a molecular weight of 100,000, and differing slightly from each other by the nature of the amino acids which form them.
constituent.up.
La chaine e est constituée de deux sous-unités i1, laquelle est constituée de 2 sous-unités Ei et 12, laquelle est constituée d'une sous- unités a1 et d'une sous-unité a2' The chain e consists of two subunits i1, which consists of 2 subunits Ei and 12, which consists of a subunits a1 and a subunit a2 '
Chacune des sous-unités 11 et P12 a une masse molé- Each of the subunits 11 and P12 has a molecular weight
culaire de 200.000.200,000.
-3 - D'autre part, à l'extrémité de chaque hélice, selon le mode d'extraction du collagène, se trouve ou non une chaine On the other hand, at the end of each helix, depending on the mode of extraction of the collagen, there is or is not a chain
linéaire polypeptidique, dite télopeptide, de longueur 50 A environ. polypeptide linear, called telopeptide, of length approximately 50 A.
Le collagène utilisé dans les compositions selon l'invention peut présenter des télopeptides ou non. Ce collagène natif se différencie totalement de la substance po1ypeptidique de collagène modifié utilisé dans le brevet britannique n'l.471.679 par le fait que selon l'invention il s'agit de collagène natif extrait à froid de la peau de jeunes The collagen used in the compositions according to the invention may have telopeptides or not. This native collagen is totally different from the modified collagen polypeptide substance used in British Patent No. 4171,679 in that according to the invention it is a native collagen extracted cold from the skin of young
animaux et plus particulièrement de la peau de jeunes veaux. animals and more particularly the skin of young calves.
Du fait des conditions particulières de son extraction ce collagène natif est donc de structure non modifiée et est non dégradée. La composition humectante selon l'invention peut être employée dans toutes les compositions nécessitant généralement la présence d'un agent humectant soit pour une bonne conservation des compositions soit pour améliorer l'apparence ou l'aspect de Due to the particular conditions of its extraction, this native collagen is therefore of unmodified structure and is not degraded. The humectant composition according to the invention can be used in all the compositions generally requiring the presence of a humectant for either a good preservation of the compositions or to improve the appearance or the appearance of
la peau.the skin.
Parmi les compositions dans lesquelles la composition humectante selon l'invention peut être employée on peut en particulier citer sans que cette énumération soit limitative les lotions, les crèmes de soins pour le visage, les laits corporels, Among the compositions in which the humectant composition according to the invention may be used, mention may in particular be made without this list being limited to lotions, face care creams, body milks,
les laits ou crèmes démaquillantes, les laits ou crèmes anti- milks or make-up removing creams, milks or anti-creams
solaires, les fonds de teint, les crèmes teintées, les crèmes solar, foundations, tinted creams, creams
anti-rides ou pour le contour des yeux. anti-wrinkle or for the eye area.
De façon générale on utilise en vue d'obtenir de bons résultat'-.s une proportion de 5 à 60%r en poids de la composition In general, in order to obtain good results, a proportion of 5 to 60% by weight of the composition is used.
humectante selon l'invention.humectant according to the invention.
De même la composition humectante selon l'invention peut être utilisée dans des compositions pharmaceutiques ou plus Similarly, the humectant composition according to the invention can be used in pharmaceutical compositions or more
particulièrement dermopharmaceutiques dans les mêmes proportions. especially dermopharmaceuticals in the same proportions.
On va maintenant donner à titre d'illustration plu- We will now give as an illustration several
sieurs exemples de compositions humectantes selon l'invention ainsi que plusieurs exemples de compositions cosmétiques ou several examples of humectant compositions according to the invention as well as several examples of cosmetic compositions or
pharmaceutiques les contenant.pharmaceutical products containing them.
EXEMPLE AEXAMPLE A
- lactate de sodium (solution à 60% dans l'eau)............... 9g glycérine................ 18,5g - urée.................. 36g -4- collagène (solution à 0,3% dans l'eau)................................ - sodium lactate (60% solution in water) ............... 9g glycerine ................ 18,5g - urea .................. 36g -4- collagen (0.3% solution in water) ............. ...................
EXEMPLE BEXAMPLE B
- lactate de sodium (solution à 60% dans l'eau)........................... - sodium lactate (60% solution in water) ...........................
....DTD: - glycérine............................. .... DTD: - glycerin .............................
- uréeee........................- urea ........................
- collagène (solution à 0,3% dans l'eau)................................ - collagen (0.3% solution in water) ................................
EXEMPLE CEXAMPLE C
- lactate de sodium (solution à 60% dans l'eau)........................... - sodium lactate (60% solution in water) ...........................
....DTD: - glycérine............................. .... DTD: - glycerin .............................
- urée.................................. - urea ..................................
- collagène (solution à 0,3% dans l'eau)............................... - collagen (0.3% solution in water) ...............................
EXEMPLE DEXAMPLE D
- lactate de sodium (solution à 60% dans - sodium lactate (60% solution in
l *eau)................................ the water)................................
- glycérine............................. - glycerin .............................
- urée............................- urea ............................
- collagène (solution à 0,3% dans l'eau)................................ - collagen (0.3% solution in water) ................................
EXEMPLES DE COMPOSITIONSEXAMPLES OF COMPOSITIONS
EXEMPLE 1EXAMPLE 1
On prépare selon l'invention une sous forme d'une émulsion eau-dansl'huile mélange des ingrédients suivants: In the form of a water-in-oil emulsion, the following ingredients are prepared according to the invention:
- acide lanolique.............- lanolic acid .............
- arginine....................- arginine ....................
- lanoline hydrogénée.........- hydrogenated lanolin .........
- huile de paraffine..........- paraffin oil..........
- composition humectante selon- humectant composition according to
l'exemple A.................example A .................
- conservateur................- conservative ................
- parfum......................- perfume ......................
- eau q.s.p...................- water q.s.p ...................
EXEMPLE 2EXAMPLE 2
On prépare selon l'invention une sous forme d'une émulsion huile-dansl'eau crème pour le visage en procédant au 13,5g 1,5g ,Og ,0g 22g 0,15g 0, !0g Qg crème pour le visage en procédant au 36,5g log 17g g 38g 8g g 39g 33g 8g 16g 36g g -5- mélange des ingrédients suivants: - triglycérides d'acides gras saturés vendus sous la dénomination de "MIGLYOL 812" In the form of an oil-in-water cream emulsion for the face is prepared according to the invention in the form of 13.5 g of 1.5 g, 0.8 g of 0.25 g of 0.15 g of 0.1 g of facial cream, and at 36.5g log 17g g 38g 8g g 39g 33g 8g 16g 36g g -5- mixture of the following ingredients: - triglycerides of saturated fatty acids sold under the name "MIGLYOL 812"
par la Société Dynamit Nobel.by Dynamit Nobel.
- alcool cétylique............- cetyl alcohol ............
- décylester d'acide oléique..- oleic acid decylester ..
- huile de vaseline...........- Vaseline oil ...........
- éther polyglycolique d'alcool cétylique oxyéthyléné à l'aide - Polyglycolic ether of cetyl alcohol oxyethylenated using
de 10 moles d'oxyde d'éthylène.10 moles of ethylene oxide.
- poudre de polyéthylène......- polyethylene powder ......
- composition humectante selon- humectant composition according to
l'exemple A.................example A .................
- eau + conservateur q.s.p....- water + preservative q.s.p ....
EXEMPLE 3EXAMPLE 3
procédant On prépare selon l'invention un lait démaquillant en au mélange des ingrédients suivants: - huile de paraffine.......... 10,0g Procedure A cleansing milk is prepared according to the invention by mixing the following ingredients: - paraffin oil .......... 10.0g
- éther stéarylique polyoxyé-polyoxyethylene stearyl ether
thyléné à l'aide de 10 moles d'oxyde d'éthylène.......... 2,0g - éther cétylique polyoxyéthyléné l'aide de 10 moles d'oxyde d'éthylène........... thylene treated with 10 moles of ethylene oxide .......... 2,0g - polyoxyethylene cetyl ether using 10 moles of ethylene oxide ....... ....
..... 2,0g - monostéarate de glycérine... 4,Og - alcool cétylique.........DTD: ... 1,0g - alcool stéarylique........... 1,0g hydroxy-propyl méthyl cellulose 0,3g - 2"Cocoyl"-1 (sodium carboxy méthyl)-i -/ 2-(sodium carboxy..DTD: méthoxy) éthyl_/-2 - imidazoli- ..... 2,0g - glycerin monostearate ... 4, Og - cetyl alcohol ......... DTD: ... 1.0g - stearyl alcohol ......... 1.0g hydroxypropyl methylcellulose 0.3g - 2 "Cocoyl" -1 (sodium carboxymethyl) -1- / 2- (sodium carboxy..DTD: methoxy) ethyl- / - 2-imidazole
nium hydroxyde, produit vendu sous la dénomination de Miranol C2M......... nium hydroxide, product sold under the name Miranol C2M .........
.............. 2,0g -p-hydroxybenzoate de méthyle. 0,2g - argile de type kaolinite.... 5,0g - composition humectante selon l'exemple B..........DTD: ....... 17g 4,0g 0,5g ,0g 13,0g 4,0g 4, 0g 27,5g g -6-..DTD: - parfum...................... .............. 2.0g-methyl p-hydroxybenzoate. 0.2g - kaolinite clay ... 5.0g - humectant composition according to example B .......... DTD: ....... 17g 4.0g 0.5g, 0g 13,0g 4,0g 4, 0g 27,5g g -6 - .. DTD: - perfume ......................
- eau q.s.p...................- water q.s.p ...................
On prépare un lait corporel en proci ts suivants: Body milk is prepared as follows:
- palmitate d'isopropyle......- Isopropyl palmitate ......
- huile de paraffine..........- paraffin oil..........
- mélange d'alcools et de stérols de lanoline produit vendu sous la dénomination d'Amerchol L 101 - mixture of alcohols and lanolin sterols product sold under the name of Amerchol L 101
par la Société Américan Choles-by the American Choles-
térol products..............térol products ..............
- acide stéarique.............- stearic acid .............
- monostéarate de glycérol autoémulsionnable........... - self-emulsifiable glycerol monostearate ...........
- alcool cétylique...........- cetyl alcohol ...........
- triéthanolamine.............- triethanolamine .............
- hydroxy méthyl cellulose....- hydroxy methyl cellulose ....
-propylêneglycol............. - p-hydroxybenzoate de méthyle - composition humectante selon propylene glycol ............. - methyl p-hydroxybenzoate - humectant composition according to
l'exemple B.................example B .................
- parfum......................- perfume ......................
- eau q.s.p...................- water q.s.p ...................
0,05g g rdant au mélange des ,0g ,Og 0,3g 1,4g 2,0g 0,2g 0,75g 0,5g 2,0g 0,35g g 0,lg g 0.05g g at the mixture of, 0g, Og 0.3g 1.4g 2.0g 0.2g 0.75g 0.5g 2.0g 0.35g g 0, lg g
EXEMPLE 5EXAMPLE 5
procédant On prépare selon l'invention une crème solaire en au mélange des ingrédients suivants: - lanolate de magnésium....... 2,85g - alcool de lanoline.......... 6,65g - palmitate d'isopropyle...... 22,20g - huile de paraffine.......... 26,o00g - ozokérite................... 2,00g composition humectante selon l'exemple D................. 22g - filtre solaire vendu sous la dénomination de "Parsol Ultra'" par la Société Givaudan..... 5,00g - eau + conservateur q.s.p.... 100g According to the invention, the following ingredients are prepared according to the invention: - magnesium lanolate ....... 2,85g - lanolin alcohol .......... 6,65g - palmitate isopropyl ...... 22.20g - paraffin oil .......... 26, o00g - ozokerite ................... 2.00 g humectant composition according to example D ................. 22g - solar filter sold under the name "Parsol Ultra '" by the company Givaudan ..... 5,00g - water + preservative qsp ... 100g
EXEMPLE 6EXAMPLE 6
On prépare selon l'invention une crème solaire eau- According to the invention, a water-based sunscreen is prepared according to the invention.
EXEMPLE 4EXAMPLE 4
ingrédient e -7- dans-l'huile en procédant au mélange des - monostéarate de glycérol autoémulsionnable........... Ingredient e -7- in-oil by blending - autoemulsifiable glycerol monostearate ...........
- myristate d'isopropyle......- isopropyl myristate ......
- perhydrosqualène............- perhydrosqualene ............
- p-hydroxybenzoate de méthylemethyl p-hydroxybenzoate
- hydroxy méthyl cellulose....- hydroxy methyl cellulose ....
- 2-éthoxyéthyl p-méthoxycin-2-ethoxyethyl p-methoxycin
namate...................... - composition humectante selon namate ...................... - humectant composition according to
l'exemple C.................example C .................
- parfum......................- perfume ......................
- eau q.s.p...................- water q.s.p ...................
ingrédients suivants: ,00g 16,00g ,00g 0,3g 0,5g ,0g 26g 0,1g 6 g following ingredients:, 00g 16.00g, 00g 0.3g 0.5g, 0g 26g 0.1g 6g
EXEMPLE 7EXAMPLE 7
On prépare selon l'invention un fond de teint sous forme d'une émulsion huile-dans-l'eau en procédant au mélange des ingrédients suivants: lanolate d'isopropyle....... 4,0g - acide stéarique............. 2,6g stéarate de glycérol autoémulsionnable........... 5,0g - huile de paraffine.......... 10,0g - vaseline.................... 10,0g triithanolamine............. 1,2g - lauryl sulfate de sodium.... 1,lg bentonite................... 2,5g - composition humectante selon l'exemple A................. 16g - oxyde de fer rouge.......... 0,7g - oxyde de fer jaune.......... 0,9g - oxyde de titane............. 2,0g parfum...................... 0,lg - eau + conservateur q.s.p.... 100g According to the invention, a foundation is prepared in the form of an oil-in-water emulsion by mixing the following ingredients: isopropyl lanolate 4.0 g - stearic acid ........... 2.6g autoemulsifiable glycerol stearate ........... 5.0g - paraffin oil .......... 10.0g - Vaseline .................... 10,0g triithanolamine ............. 1,2g - sodium lauryl sulfate .... 1, lg bentonite ................... 2.5g - humectant composition according to example A ................ 16g - red iron oxide .......... 0,7g - yellow iron oxide .......... 0,9g - titanium oxide ........ ..... 2.0g perfume ...................... 0, lg - water + preservative qsp ... 100g
EXEMPLE 8EXAMPLE 8
On prépare selon l'invention une crème pour le contour des yeux sous forme d'une émulsion huile-dans-l'eau en procédant au mélange des ingrédients suivants: - monostéarate de glycérol autoémulsionnable........ A cream for the eye contour is prepared according to the invention in the form of an oil-in-water emulsion by mixing the following ingredients: - self-emulsifiable glycerol monostearate ........
.. 3,0g -8- - mélange d'alcools et de stérols de lanoline vendu sous la dénomination d'Amerchol L 101 par la Société Américan Cholesterol Products.................... 3,0g - perhydrosqualêne............ 10,Og palmitate d'isopropyle..... 1,Og - alcool cétylique............ 2,0g lécithine de soja........... 0,5g - hydroxy méthyl cellulose.... 0,5g extraits placentaires..... 2,0g - extraits amnio-sérique...... 1,Og composition humectante selon l'exemple B 28g - parfum..................... . 0,5g - eau + conservateur q.s.p lOO....100g..DTD: .. 3.0g -8- - mixture of alcohols and lanolin sterols sold under the name Amerchol L 101 by the American Cholesterol Products Company ................. ... 3.0g - perhydrosqualene ............ 10, Og isopropyl palmitate ..... 1, Og - cetyl alcohol ............ 2.0g soy lecithin ........... 0.5g - hydroxy methyl cellulose .... 0.5g placental extracts ..... 2.0g - amnio-serum extracts .... .. 1, Og humectant composition according to Example B 28g - perfume ...................... 0.5g - water + preservative q.s.p lOO .... 100g..DTD:
Claims (3)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8101971A FR2498929A1 (en) | 1981-02-02 | 1981-02-02 | NOVEL HUMIDIZING COMPOSITION BASED ON SODIUM LACTATE, GLYCERIN, UREA AND NATIVE COLLAGEN |
| GB8202754A GB2092444B (en) | 1981-02-02 | 1982-02-01 | Humectant composition for the skin containing collagen and urea |
| IT19388/82A IT1150163B (en) | 1981-02-02 | 1982-02-01 | SUMMER LACTATE, GLYCERINE, UREA AND NATURAL COLLAGEN COMPOSITION |
| JP57013428A JPS57150608A (en) | 1981-02-02 | 1982-02-01 | Wetting agent composition |
| BE0/207192A BE891972A (en) | 1981-02-02 | 1982-02-01 | NEW HUMECTING COMPOSITION BASED ON SODIUM LACTATE, GLYCERINE, UREA AND NATIVE COLLAGEN |
| DE19823203260 DE3203260A1 (en) | 1981-02-02 | 1982-02-01 | MOISTURIZING AGENT BASED ON SODIUM LACTATE, GLYCERINE, UREA AND NATURAL COLLAGEN |
| CA000395338A CA1171265A (en) | 1981-02-02 | 1982-02-01 | Sodium lactate, glycerine, urea and native collagen based wetting composition |
| CH600/82A CH651471A5 (en) | 1981-02-02 | 1982-02-01 | HUMECTING COMPOSITION BASED ON SODIUM LACTATE, GLYCERINE, UREA AND NATIVE COLLAGEN. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8101971A FR2498929A1 (en) | 1981-02-02 | 1981-02-02 | NOVEL HUMIDIZING COMPOSITION BASED ON SODIUM LACTATE, GLYCERIN, UREA AND NATIVE COLLAGEN |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2498929A1 true FR2498929A1 (en) | 1982-08-06 |
| FR2498929B1 FR2498929B1 (en) | 1984-04-13 |
Family
ID=9254738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8101971A Granted FR2498929A1 (en) | 1981-02-02 | 1981-02-02 | NOVEL HUMIDIZING COMPOSITION BASED ON SODIUM LACTATE, GLYCERIN, UREA AND NATIVE COLLAGEN |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS57150608A (en) |
| BE (1) | BE891972A (en) |
| CA (1) | CA1171265A (en) |
| CH (1) | CH651471A5 (en) |
| DE (1) | DE3203260A1 (en) |
| FR (1) | FR2498929A1 (en) |
| GB (1) | GB2092444B (en) |
| IT (1) | IT1150163B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4322395C1 (en) * | 1993-07-01 | 1994-07-28 | Kuehnl Petzoldt Christa Dr Med | Shower lotion for the treatment and care of dry skin |
| DE4341001A1 (en) * | 1993-12-02 | 1995-06-08 | Beiersdorf Ag | Topical preparations containing L-arginine |
| FR2854070A1 (en) * | 2003-04-24 | 2004-10-29 | Oreal | Treatment of visible and/or tactile irregularities on human skin, for attenuating wrinkles, fine lines, pigmentation marks and/or acne scars, comprises applying topically to skin composition comprising, in medium, urea |
| WO2004093838A1 (en) * | 2003-04-24 | 2004-11-04 | L'oreal | Cosmetic peeling method using urea |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4454159A (en) * | 1981-12-28 | 1984-06-12 | Albert Musher | Dermatological treatment preparations |
| JPS6089410A (en) * | 1983-10-20 | 1985-05-20 | Shiseido Co Ltd | Cosmetic |
| JPS6133105A (en) * | 1984-07-24 | 1986-02-17 | Shiseido Co Ltd | Skin external preparation |
| JPS627A (en) * | 1985-03-04 | 1987-01-06 | Shiseido Co Ltd | Skin external agent containing incorporated urea |
| DE3538412A1 (en) * | 1985-10-29 | 1987-05-07 | Volker Dr Krainbring | Urea ointment |
| JPH0774144B2 (en) * | 1986-03-12 | 1995-08-09 | 久光製薬株式会社 | Skin composition containing urea |
| US5366081A (en) | 1987-08-26 | 1994-11-22 | United States Surgical Corporation | Packaged synthetic absorbable surgical elements |
| US5222978A (en) | 1987-08-26 | 1993-06-29 | United States Surgical Corporation | Packaged synthetic absorbable surgical elements |
| US5051272A (en) * | 1988-07-19 | 1991-09-24 | United States Surgical Corporation | Method for improving the storage stability of a polymeric article susceptible to hydrolytic degradation and resulting article |
| US5306289A (en) * | 1987-08-26 | 1994-04-26 | United States Surgical Corporation | Braided suture of improved characteristics |
| US5359831A (en) | 1989-08-01 | 1994-11-01 | United States Surgical Corporation | Molded suture retainer |
| JP2866114B2 (en) * | 1989-09-20 | 1999-03-08 | 株式会社資生堂 | Cosmetics |
| JPH07300419A (en) * | 1993-12-06 | 1995-11-14 | Lansinoh Lab Inc | Composition of lanolin/lanolin acid ester for treating skin |
| FR2718639B1 (en) * | 1994-04-18 | 1996-05-15 | Oreal | Cosmetic and / or dermatological composition containing a tri (alpha-hydroxyacylate) of glycerol as the only precursor of glycerol. |
| DE19529773A1 (en) * | 1995-08-12 | 1997-02-13 | Beiersdorf Ag | Weak, water-soluble mono:carboxylic acids used in skin care prepns. - as active agent for regeneration and promotion of the natural protective and barrier function of healthy or diseased skin |
| JP2002167328A (en) * | 2000-11-29 | 2002-06-11 | Toyo Aerosol Ind Co Ltd | Composition and aerosol composition for external skin preparation |
| DE10133201A1 (en) * | 2001-07-07 | 2003-01-23 | Beiersdorf Ag | Use of topical compositions containing electrolytes in combination with polyols and/or urea to, e.g. improve skin condition or to treat or prevent skin disorders |
| DE10133202A1 (en) * | 2001-07-07 | 2003-01-16 | Beiersdorf Ag | Topical compositions containing osmolytes, useful e.g. for treating or preventing dry skin or inflammatory conditions of the skin, e.g. eczema, polymorphic light dermatosis or psoriasis |
| US7344658B2 (en) | 2002-01-23 | 2008-03-18 | Allmighty Co., Ltd. | Radiation protector and utilization thereof |
| DE10241541A1 (en) * | 2002-09-05 | 2004-03-18 | Nguyen-Petersen, Chanh-Dinh, Dr.med. | Urea is used in cosmetics, including fat-free and greasy cosmetics, used for treating scalp disorders accompanied by dandruff and/or itching, especially in shampoo |
| JP7336357B2 (en) * | 2019-11-05 | 2023-08-31 | 日本精化株式会社 | Lactic acid ester and cosmetics containing the same |
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|---|---|---|---|---|
| FR2003312A1 (en) * | 1968-03-06 | 1969-11-07 | Medisan Ab | SKIN HYGIENE PRODUCT AND SUPPORT FOR SKIN HYGIENE PRODUCTS |
| FR2305971A1 (en) * | 1975-04-04 | 1976-10-29 | Freudenberg Carl | COSMETIC ACTIVE SUBSTANCE BASED ON COLLAGEN |
| GB1471679A (en) * | 1973-07-17 | 1977-04-27 | Avon Prod Inc | Moisturizing compositions |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2064604C3 (en) * | 1970-12-30 | 1982-10-21 | Chemisches Laboratorium Dr. Kurt Richter Gmbh, 1000 Berlin | Skin care products |
-
1981
- 1981-02-02 FR FR8101971A patent/FR2498929A1/en active Granted
-
1982
- 1982-02-01 BE BE0/207192A patent/BE891972A/en not_active IP Right Cessation
- 1982-02-01 CH CH600/82A patent/CH651471A5/en not_active IP Right Cessation
- 1982-02-01 DE DE19823203260 patent/DE3203260A1/en active Granted
- 1982-02-01 IT IT19388/82A patent/IT1150163B/en active
- 1982-02-01 CA CA000395338A patent/CA1171265A/en not_active Expired
- 1982-02-01 GB GB8202754A patent/GB2092444B/en not_active Expired
- 1982-02-01 JP JP57013428A patent/JPS57150608A/en active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2003312A1 (en) * | 1968-03-06 | 1969-11-07 | Medisan Ab | SKIN HYGIENE PRODUCT AND SUPPORT FOR SKIN HYGIENE PRODUCTS |
| GB1471679A (en) * | 1973-07-17 | 1977-04-27 | Avon Prod Inc | Moisturizing compositions |
| FR2305971A1 (en) * | 1975-04-04 | 1976-10-29 | Freudenberg Carl | COSMETIC ACTIVE SUBSTANCE BASED ON COLLAGEN |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4322395C1 (en) * | 1993-07-01 | 1994-07-28 | Kuehnl Petzoldt Christa Dr Med | Shower lotion for the treatment and care of dry skin |
| DE4341001A1 (en) * | 1993-12-02 | 1995-06-08 | Beiersdorf Ag | Topical preparations containing L-arginine |
| FR2854070A1 (en) * | 2003-04-24 | 2004-10-29 | Oreal | Treatment of visible and/or tactile irregularities on human skin, for attenuating wrinkles, fine lines, pigmentation marks and/or acne scars, comprises applying topically to skin composition comprising, in medium, urea |
| WO2004093838A1 (en) * | 2003-04-24 | 2004-11-04 | L'oreal | Cosmetic peeling method using urea |
Also Published As
| Publication number | Publication date |
|---|---|
| IT8219388A0 (en) | 1982-02-01 |
| CH651471A5 (en) | 1985-09-30 |
| DE3203260A1 (en) | 1982-09-23 |
| GB2092444A (en) | 1982-08-18 |
| DE3203260C2 (en) | 1992-08-27 |
| CA1171265A (en) | 1984-07-24 |
| IT1150163B (en) | 1986-12-10 |
| BE891972A (en) | 1982-08-02 |
| JPS57150608A (en) | 1982-09-17 |
| JPH0375523B2 (en) | 1991-12-02 |
| FR2498929B1 (en) | 1984-04-13 |
| GB2092444B (en) | 1985-11-13 |
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