FR2487835A1 - Marquage de composes biologiquement interessants par la dichlorotriazinyl-aminofluoresceine - Google Patents

Marquage de composes biologiquement interessants par la dichlorotriazinyl-aminofluoresceine Download PDF

Info

Publication number
FR2487835A1
FR2487835A1 FR8114768A FR8114768A FR2487835A1 FR 2487835 A1 FR2487835 A1 FR 2487835A1 FR 8114768 A FR8114768 A FR 8114768A FR 8114768 A FR8114768 A FR 8114768A FR 2487835 A1 FR2487835 A1 FR 2487835A1
Authority
FR
France
Prior art keywords
dtaf
amino
added
conjugate
methanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8114768A
Other languages
English (en)
French (fr)
Other versions
FR2487835B1 (OSRAM
Inventor
Chao-Huei Jeffrey Wang
Stephen Denham Stroupe
Michael Ernest Jolley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of FR2487835A1 publication Critical patent/FR2487835A1/fr
Application granted granted Critical
Publication of FR2487835B1 publication Critical patent/FR2487835B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8114768A 1980-07-30 1981-07-29 Marquage de composes biologiquement interessants par la dichlorotriazinyl-aminofluoresceine Granted FR2487835A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17355380A 1980-07-30 1980-07-30

Publications (2)

Publication Number Publication Date
FR2487835A1 true FR2487835A1 (fr) 1982-02-05
FR2487835B1 FR2487835B1 (OSRAM) 1984-03-16

Family

ID=22632537

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8114768A Granted FR2487835A1 (fr) 1980-07-30 1981-07-29 Marquage de composes biologiquement interessants par la dichlorotriazinyl-aminofluoresceine

Country Status (9)

Country Link
JP (1) JPS5758695A (OSRAM)
AU (1) AU554360B2 (OSRAM)
BE (1) BE889788A (OSRAM)
CA (1) CA1160626A (OSRAM)
DE (1) DE3129705A1 (OSRAM)
FR (1) FR2487835A1 (OSRAM)
GB (1) GB2081257B (OSRAM)
IT (1) IT1137630B (OSRAM)
SE (1) SE8104227L (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4476228A (en) * 1982-11-08 1984-10-09 Abbott Laboratories Determination of unsaturated thyroxine binding protein sites using fluorescence polarization techniques
US4476229A (en) * 1982-11-08 1984-10-09 Abbott Laboratories Substituted carboxyfluoresceins

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4681859A (en) * 1984-09-21 1987-07-21 Ortho Diagnostic Systems Inc. Fluorescence polarization immunoassay for heavy antigens
EP0199042A1 (en) * 1985-03-26 1986-10-29 Abbott Laboratories Procainamide assay, tracers, immunogens and antibodies
DE3682105D1 (de) * 1985-04-01 1991-11-28 Abbott Lab Probe, tracers, immunogene und antikoerper von ethosuximid.
EP0218010A3 (en) * 1985-07-10 1988-01-07 Abbott Laboratories Ligand detection method and substituted carboxyfluorescein tracers therefor
EP0210410B1 (en) * 1985-07-22 1992-05-20 Abbott Laboratories Fluorescence polarization immunoassay and reagents for measurement of c-reactive protein
US4902630A (en) * 1985-07-22 1990-02-20 Abbott Laboratories Fluorescence polarization immunoassy and reagents for measurement of c-reactive protein
US4939264A (en) * 1986-07-14 1990-07-03 Abbott Laboratories Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies
EP0457213B1 (en) * 1990-05-16 1997-07-23 Abbott Laboratories Barbiturate assay, tracers, immunogens, antibodies and kit
FR2683911B1 (fr) * 1991-11-15 1995-02-03 Clonatec Reactif de diagnostic, ses applications dans un procede pour la determination qualitative et quantitative rapide d'un analyte dans un fluide a tester et dispositif pour la mise en óoeuvre dudit procede.
IT1298693B1 (it) * 1996-04-24 2000-01-12 Hoffmann La Roche Derivati della fluoresceina 4'-metil sostituiti
US20050118624A1 (en) * 2003-10-03 2005-06-02 Cumbre Inc. Fluorescent probes for ribosomes and method of use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1538018A (en) * 1976-12-06 1979-01-10 Blakeslee D Dichlorotriazinylaminofluorescein/protein conjugate immunofluorescence reagent and process for preparing same
US4213904A (en) * 1979-02-28 1980-07-22 Haugland Richard P Fluorescent labeling reagents containing the fluorescein and eosin chromophores

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998943A (en) * 1973-10-02 1976-12-21 Syva Company Double receptor fluorescent immunoassay

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1538018A (en) * 1976-12-06 1979-01-10 Blakeslee D Dichlorotriazinylaminofluorescein/protein conjugate immunofluorescence reagent and process for preparing same
US4213904A (en) * 1979-02-28 1980-07-22 Haugland Richard P Fluorescent labeling reagents containing the fluorescein and eosin chromophores

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EXBK/73 *
EXBK/76 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4476228A (en) * 1982-11-08 1984-10-09 Abbott Laboratories Determination of unsaturated thyroxine binding protein sites using fluorescence polarization techniques
US4476229A (en) * 1982-11-08 1984-10-09 Abbott Laboratories Substituted carboxyfluoresceins

Also Published As

Publication number Publication date
FR2487835B1 (OSRAM) 1984-03-16
CA1160626A (en) 1984-01-17
AU7203681A (en) 1982-02-04
IT8123207A1 (it) 1983-01-28
AU554360B2 (en) 1986-08-21
BE889788A (fr) 1982-01-29
JPS5758695A (en) 1982-04-08
SE8104227L (sv) 1982-01-31
DE3129705A1 (de) 1982-05-27
GB2081257A (en) 1982-02-17
DE3129705C2 (OSRAM) 1988-03-10
IT1137630B (it) 1986-09-10
IT8123207A0 (it) 1981-07-28
GB2081257B (en) 1984-11-07

Similar Documents

Publication Publication Date Title
US5198537A (en) Digoxigenin derivatives and use thereof
US9212385B2 (en) Fluorinated resorufin compounds and their application
CA1334026C (fr) Cryptates de terres rares, procedes d'obtention, intermediaires de synthese et application a titre de marqueurs fluorescents
FR2500165A1 (fr) Procede et reactifs d'immunodetermination par polarisation de fluorescence utilisant des carboxyfluoresceines
FR2487835A1 (fr) Marquage de composes biologiquement interessants par la dichlorotriazinyl-aminofluoresceine
US4363759A (en) Chemiluminescent-labeled haptens and antigens
FI90542B (fi) Kemiluminoivia akridiinijohdannaisia, niiden valmistus ja niiden käyttö luminesenssi-immunoanalyyseissä
US5952185A (en) Photo-activatable biotin derivatives and their use to reduce interference in immunoassays
JPS62174067A (ja) レゾルフイン誘導体並びにその製法
FR2748027A1 (fr) Derives de la fluoresceine 4'-methyl-substituee
Simons Jr et al. Fluorescent chemoaffinity labeling. Potential application of a new affinity labeling technique to glucocorticoid receptors
NO314308B1 (no) Biotin-innholdende chemiluminiserende markör, anvendelse av markören for fremstilling av en diagnostisk analyse, diagnostisk analyse og settfor diagnostisk analysering
US4226993A (en) Amino-functionalized phthalhydrazides
US4297273A (en) Chemiluminescent phthalhydrazide-labeled protein and polypeptide conjugates
US3891669A (en) Thiol-group detecting fluorescence reagents
JPH02216055A (ja) 炭水化物含有化合物の検出方法
US4355165A (en) Amino-functionalized phthalhydrazide intermediates
BE1011206A4 (fr) Derives chimioluminescents heterocycliques.
JP2526359B2 (ja) ノルトリプチリン測定方法および測定用試薬抗体
US4551275A (en) Desmethylimipramine derivatives and poly(amino acid) conjugates
EP0641439B1 (en) Reagents and methods for the quantification of imipramine or desipramine in biological fluids
US4226992A (en) Amino-functionalized naphthalene-1,2-dicarboxylic acid hydrozides
FR2625565A1 (fr) Esters, thioesters et amides chimioluminescents perfectionnes, et analyses les utilisant
CA2062239A1 (en) Hydantoin derivatives for competitive enzyme immunoassays

Legal Events

Date Code Title Description
ST Notification of lapse