FR2485013A1 - PROCESS FOR PRODUCING 3- (N-ARYL-N-ACYLAMINO) -GAMMA-BUTYROTHIOLATES AND PRODUCTS OBTAINED - Google Patents

Abstract

THE INVENTION RELATES TO METHODS FOR PREPARING 3- (N-ARYL-N-ACYLAMINO) -GAMMA-BUTYROTHIOLACTONES. THE PROCESS CONSISTS OF CLAVING THE CORRESPONDING ARYLAMINO-GAMMA-LACTONE WITH A THIOLATE-TYPE SALT TO OBTAIN THE CORRESPONDING ARYLAMINOTHIOLALCANE CARBOXYLATE, IN HYDROLYZING THE SALT THEN IN ACYLINATING THE ACID TO OBTAIN ACYLAMINOTHIOLALCANE . THIS PRODUCT IS THEN CYCLED TO FORM THE DESIRED COMPOUND. AS A VARIANT, THE ORDER OF ACYLATION AND CYCLING CAN BE REVERSE. THE 3- (N-ARYL-N-ACYLAMINO) -GAMMA-BUTYROTHIOLACTONS OBTAINED BY THE PROCESS OF THE INVENTION HAVE FUNGICIDAL PROPERTIES.

Description

The present invention relates to methods and intermediates

for the preparation of

  3- (N-aryl-N-acylamino) -gamma butyrothiolactones.

  3- (N-aryl-N-acylamino) -gamma butyrothio-

  lactones are known compounds endowed with

  gicidal and are described in Belgian Patent No. 871 668.

  In this Belgian patent, the compounds are prepared by

  the amination (anilination) of a 3-halogeno-gamma-butyrene

  thiolactone, followed by acylation with the halide

acyl suitably chosen.

  U.S. Patent Application 1,120,244 filed February 11, 1980 discloses a process for preparing such compounds by

  cleavage of N-aryl-N-acylamino lactonic

  corresponding with a thiolate salt and then treatment of (N-aryl-Nacylamino) -carboxy-thioalkane obtained as product with phosphorus trichloride to close

the core.

  Comments on the preparation of

  of some unsubstituted thiolactones in an article by Truce et al., published in the Journal of Organic Chemistry, Vol. 28, page 964 (April 1963).

  The present invention proposes a method permitting

  prepared in high yields of 3- (N-aryl-Nacylamino) -gamma thiobutyrolactones and

  intermediate compounds thus produced.

  The method of the invention comprises the steps of

  (a) to introduce a 3- (aryl- or substo-

  arylamino) -gamma butyrolactone or a 5-substituted derivative thereof in contact with a thiolate salt under reactive conditions to form the

  carboxylic salt of 1- (aryl- or subst-aryl) amino-1-thio-

  corresponding alkane and acidifying the salt to obtain the corresponding carboxy acid; and (b) bringing the product of step (a) into contact with an acyl halide under reactive conditions to form the corresponding acylamino derivative; and (c) introducing the product of step (b). )

  in contact with a cyclising agent that performs esterification

  application of a saturated fatty carboxylic acid with a low molecular weight primary alcohol, to form 3- (N-aryl- or subst-aryl-Nacylamino) -gamma-butyro-

  thiolactone or its substituted derivative in the 5-position

  laying. Alternatively, the order of steps (b) and (c) can be reversed, thereby cyclizing the intermediate compound of step (a) first and then

performing the acylation.

  In one embodiment, the process of the present invention may be advantageously schematized by the following overall reaction equations:

1 3 4

Ar - N 4 +

1 (A)

  ## STR1 ## ## STR2 ##

(B), - C = O

I (I)

0M

J ej .. goNS, 'o

Y '. 0 CR R2

  (I) + R1CX -> Ar - N - CH - CH - CH - SR (Salt or acid) (C) (2) 1 2 C = O B page 3 OR3 (II) aglycating agent i

(II.)?

(3) IC

C - R1

R O N esR2

(III).

  Ar is an aryl or substituted aryl radical (the latter sometimes referred to by the abbreviation subst.-aryl for clarity herein) having 1 to 4 substituents independently selected from the group consisting of fluoro, chloro bromo, iodo, lower alkyl or lower alkoxy;

  R is a lower alkyl radical (preferably

  tert-butyl); lower alkenyl (preferably allyl) or arylalkyl (preferably benzyl); R1 is a lower alkyl radical; lower alkoxy, cycloalkyl having 3 to 6 carbon atoms (preferably cyclopropyl); lower epoxyalkyl having 2 to 6 carbon atoms and comprising one or two groups

  epoxy; lower alkenyl; lower alkenyloxy; hydroxy

  Lower alklyl (preferably hydroxymethyl); halo-

  genalkyl having 1 to 3 halogen substituents and 1 to 6 carbon atoms; lower alkyl, alkylthioalkyl; -their; p. lzoEakyl lower (preferably

  ihnylthiomethyl (e) phenoxy-lower alkyl (preferably

  phenyl (phenylthio) phenylthio (lower alkyl) substituted (phenylthiomethyl substituted phenyl) or substituted phenylthio (lower) substituted (preferably phenylthiomethyl) substituted you) before one or two substituents

  on the core, chosen indipendammen-- in the group

  1: -, - radi.cau, - fluoro, chloro, bromo, iodo, alkyl: n ..... u.- or alko-v inerior; and R2 is hydrogen or a chloro, bromo, lower alk, phenyl or substituted phenyl radical having 1

  or 2 substituents independently selected from

  chloro, chloro, bromo or lower alkyl R3 is hydrogen or the group o -CR wherein R- is selected from the same group of substituents Ro M is an inorganic cation, preferably an alkali metal cation and m is his valence,

and. is the chloro or bromo radical.

  Step 1 of the process can be advantageous

  carried out by contacting the suitable compound of formula A bearing the desired Ar and R substituent with the thiolate of formula B, with reference to a solvent

  organic suitable under the reactive conditions.

  Normally, this process is carried out at temperatures in the range of about

  at 200 ° C., preferably from about 50 ° C. to 80 ° C. for about

  1 to 8 hours and preferably for about 1 to 4 hours. About 1 to 1.5 moles, preferably about 1 to 1.25 moles of the compound of formula B (based on the thiolate content) per mole of compound of formula A are normally used.

  When an organic solvent is used, this sol-

  Generally, only the reactant A is dissolved. Suitable inert organic solvents which can be used include, for example, dimethoxyethane, toluene, tetrahydrofuran, dimethylformamide, and the like.

  etc. and their compatible mixtures. We prefer

  Dimethoxyethane as a solvent. Normally, the liquid medium is used in a ratio of about 1

  to 3 moles of reactant A per liter of solvent.

  The best results are generally obtained.

  by using the process at temperatures in the range of about 50 to 80 ° C, using about 1 to 1.10 moles of B per mole of A in dimethoxyethane. Suitable thiolates of formula B which may be used include, for example, alkali metal thiolates such as sodium 2-methyl-2-propanethiolate, potassium 2-methyl-2-propanethiolabe;

  alkaline earth metal thiolates, a bis (alkyl)

  thiolate) calcium, ammonium thiolates; of the

  quaternary ammonium thiolates, for example benzyl

  tetramethylammonium thiolate, etc. As regards yields, when alkylmercaptides are used,

  tertiary alkylmercaptides are preferable to alkyl-

  secondary and primary mercaptides, and alkyl-

  secondary mercaptides are preferable to primary alkylmercaptides

  mayors. We usually get the best results

  using sodium 2-methyl-2-propanethiolate.

  In a preferred embodiment, the thiolate is

  prepared in situ by reaction of the corresponding RSH mercaptan

  ing. with an alkali metal alcoholate (for example

sodium methoxide).

  The compounds of formula A are known compounds and can be prepared by known methods

  for example by reaction of arylamine or

  corresponding arylamine with 3-chloro or 3-bromo

  corresponding butyrolactone, as described, for example, in Belgian Pat. No. 871,668 and in US Pat.

  United States of America Nos. 3,933,860 and 4,165,322.

  The product of step (1) is the corresponding salt M

  Formulation of the acid of Formula I. Before conducting the second stage of the process of the invention, it is very preferable to remove any unreacted compound (A) from the reaction product. This can conveniently be achieved by extraction, since the compound (A) is generally

  insoluble in water while the compound (I) is soluble

ble in water.

  The salt (I) can then be reacted with the acyl chloride or bromide (C) in accordance with step

  2 of the present invention or preferably, one.

  hydrolysis firstly to the acid (formula I) by treating

  with a weak acid such as acetic acid. Where appropriate, the hydrolysis can generally be conducted in situ. Acid treatment offers an advantage

  in some cases, it also gives a

  more pure acylation reaction

  it is obtained by direct acylation of the salt (I). Advance

  is offered because acid (eg

  acetic acid) is significantly less expensive than the acyl halide (C). Thus, when salt (I) is acylated directly, two moles of acyl halide are stoichiometrically required for each mole of salt (I). By hydrolysis of the salt (I) in the first place, one of these moles of acyl halide is replaced

  by a less expensive mole of acid.

  In the second step of the process, the salt of formula I or its acid is brought into contact with the

  acyl chloride of the formula -C under conditions of

  Reactive reactions, preferably in an inert organic solvent and optionally in the presence of a basic organic acceptor, under reactive conditions. It was found that this process step gave very high yields of formula II product. The acylated product of formula II also behaves better in the cyclization reaction (step 3) than the secondary amine does

  corresponding; this is likely due to the

  detection of the free NH group by an acyl group. The pro-

  duit is generally a mixture of the 1-carboxy acid and its anhydride (i.e.

O

R3 is the group CR1)

  according to the relative molar ratio of the reactants.

  This process is normally carried out at temperatures in the range of about 0 to 120 ° C for about 1 to 8 hours when

  basic acceptor. Temperatures are preferably used

  lower levels, normally from about 0 to 250C. Lors-

  that no basic acceptor is used, higher temperatures, normally about 80 to 1200 ° C, are then selected to expel the by-product hydrogen chloride gas. Generally, about 2 to 2.5 moles, preferably about 2 to 2.2 moles of acyl chloride (C) per mole of reactant (I) (salt) are used and about half of this amount is used.

  acyl halide when using the acid of

  mule I (i.e., about 1.0 to 1.5, preferably

  1.0 to 1.10 moles of acyl chloride per mole

of acid I).

  Suitable inert organic solvents that

  can be used include for example hydro-

  chlorinated carbides, such as methylene chloride,

  ethyl ketate, dimethoxymethane, benzenedioxane,

  tetrahydrofuran, etc., and their compatible mixtures.

  When conducting the reaction in the presence of an acceptor

  organic compound, which must react with the hydrochloric acid

  As suitable by-products, suitable basic acceptors which may be used include, for example, triethylamine, pyridine, 2,6-lutidine, sodium carbonate, and the like. Acyl chlorides and bromides (C) are known compounds which can be prepared by known methods or by obvious modifications of these processes (eg substitution of suitable substrates, solvents, etc.). It is generally preferred to use

acyl chlorides.

  The last step of the process is preferably carried out by contacting the compound of formula II with a suitable cyclising agent, preferably in a suitable inert organic solvent, under reactive conditions. Normally, this process is carried out at temperatures from about 100 ° C to reflux temperature, preferably above about 50 ° C for about 0.25 to 2 hours, preferably about 0.25 to 1 hour. . In general, about 1 to 5 moles, preferably about 2 to 2.5 moles of reactant II are used per mole of cyclizing agent. Optimum values of temperatures and proportions of cycling agents vary

  with the particular cyclising agent, for example when

  sulfuric acid is used as the cyclising agent,

  it is preferable to use only a relative amount

  weak. When, for example, phosphorus trichloride is used as the cyclising agent, it is preferable to use about 2 to 2.5 moles of reactant II.

  per mole of phosphorus trichloride.

  Similarly, since water is formed as a by-product, it is preferable to conduct the reaction

  under conditions that remove water from the reaction system

  nel, for example by distillation or by the use of

  cyclizing reagents, etc., which combine with water.

  Suitable inert organic solvents

  that can be used include, for example, hydro-

  chlorinated carbides such as methylene chloride, ethyl acetate, benzene, dialkyl glycols, for example 1,2-dimethoxyethane, etc., and their compatible mixtures. Normally about 0.5 to 3 moles are used

  of reactant II per liter of solvent.

  A very wide range of cyclizing agents can be used. These reagents can be defined as reagents that perform the esterification of a saturated fatty carboxylic acid by contacting the acid with a low molecular weight primary alcohol. Suitable cycling agents that can be used

  include, for example, carboxylic acid anhydrides.

  such as acetic anhydride, phthalic anhydride, acyl chlorides, eg

  acetyl, benzoyl chloride; trichloroacid

  acetic; p-toluenesulfonic acid; dihydrogen

  monoalkyl phosphites, for example dihydrogen

  decyl phosphite; the ether complex of boron trifluoride; ion exchange resins of the sulfonic acid type; phosphorus trichloride, tribromide

  phosphoric acid, phosphoric acid, thio-

  nyl, phosphorus pentachloride, sulfuric acid,

  phosgene, oxalyl chloride, carboxylic acid

  etc. and their compatible mixtures.

  Very good results are obtained by carrying out the process using approximately 2 to 2.5 moles

  of reactant II per mole of phosphorus trichloride

  It is obtained in methylene chloride at temperatures in the range of about 5 to 15 ° C. Also good results are obtained using acetic acid with a small amount of sulfuric acid as

cyclising agent, at reflux.

  Alternatively, we can reverse the order

  of the acylation step and the cyclization step.

  This can be schematically represented by the following global reaction equations:

9H

  Cycling agent Ar - N (1) (2a) (salt or acid) O Y (IIa) * l oC - Ri (IIa) + R CCl 3) r R2

'R

(III)

  o Ar and R1 have the definitions given above.

  Steps (2a) and (3a) can be conducted as described above with respect to steps (3) and (2) respectively. Likewise, as in the case of step (2), it is preferable to use the acid form of formula I as starting material for the stage.

(2a) rather than the salt form.

  In each of the steps of the above process,

  unless otherwise specified, it is better to separate

  the respective products of formulas I and II before carrying out the next step of the process. Likewise, with the exception of the hydrolysis of salt I in its acid, it is

  generally preferable to drive the reaction of the in-

  in substantially anhydrous conditions. The

  respective products of formulas I, II, IIa and III may

  may be separated from the respective product mixtures

  reaction by any suitable purifica-

  such as, for example, evaporation, extraction, crystallizations, chromatography, distillation, etc. Particular illustrations of suitable methods of separation and purification are given in the examples which follow; however, it should be noted that one could also use other

suitable processes.

  It should also be noted that when conditions

  specific reaction conditions (eg temperatures, molar ratios, reaction times, etc.)

  have been indicated, conditions being

  above these ranges can also be used.

  even though they are generally less practical or less economically advantageous. Of

  same, the optimal reaction conditions (e.g.

  temperatures, solvents, reaction times) may vary with particular reactants,

  concentrations, etc. used but can be

undermined by routine.

  The following terms used in this

  memory have the definitions given below, except where

contrary.

  The term "halo" refers to fluoro groups,

chloro, bromo and iodo.

  The term "alkyl" refers to straight-chain and branched-chain alkyl groups. The term "lower alkyl" refers to straight and branched chain alkyl groups having 1 to 6 carbon atoms and includes primary> secondary and tertiary alkyl groups. Examples of lower alkyl groups include methyl, ethyl, n-propyl, isopropyl, n-butyl, t-butyl, n-hexyl, and the like.

  The term "alkoxy" refers to the radical of

  mule R'O- in which R 'is an alkyl group.

  The term "lower alkoxy" refers to alkoxy groups having 1 to 6 carbon atoms and includes, for example, methoxy, ethoxy, tert-butoxy, hexoxy, and the like. The term "lower epoxyalkyl" refers to epoxyalkyl groups having 2 to 6 carbon atoms and having one or two epoxy groups. These groups include, for example, 1,2 epoxypropyl groups (i.e., CH3-CH1 CH-); 2,4-epoxypentyl (i.e., 4'-methyloxetanylmethyl; CH3-CH-C CH-CH2-); 1,2,4,5-diepoxyhexyl (i.e., CH3-H-H-CH-CH2-); 1,2,4,5-diepoxyhexyl (i.e.

0 \, 0._

  CH 2 CH 2 CH 2 CH 2 CH 2 CH 3), etc. The term "lower hydroxyalkyl" refers to

  a group of formula HOR 'in which R' is a radical

  lower alkyl and includes, for example, hydroxymethyl, 3-hydroxypentyl, 2-hydroxyethyl and the like. The term "lower alkoxyalkyl" refers to the radical R'OR "- in which R'O is an alkoxy group

  lower and R "is a lower alkyl group.

  The term "lower alkylthioalkyl" refers to

  the radical R'SR "- in which R 'and R" represent

  depending on the lower alkyl groups. Examples of lower alkylthioalkyl groups include

  methylthionethyl and 4-tert-butylthiohexyl groups.

  The term "alkenyl" refers to unsaturated alkyl groups having a double bond and includes at least one

  both straight-chain and branched-chain alkenyl groups.

  The term "lower alkenyl" refers to alkenyl groups having 2 to 6 carbon atoms. Representative examples of lower alkenyl groups

  include allyl, but-3-enyl, 2-methyl-

  pent-4-enyl, etc. The term "lower alkenyloxy" refers to

  groups of the formula R 50 - in which R 5 is a radical

lower alkenyl cal.

  The term "lower alkenyloxyalkyl" is

  sign groups of the formula R 50 R '- in which R 5 is a lower alkenyl radical and R' is a lower alkyl radical. Representative examples of lower alkenyloxyalkyl groups include allyloxymethyl, 2- (but-3-enyloxy) hexyl, and the like. The term "aryl" refers to aryl groups having 6 to 12 carbon atoms and includes, for example,

phenyl and naphthyl groups.

  The term "lower phenoxyalkyl" denotes groups of the formula PhO-R'- in which Ph is the phenyl radical and R 'is a lower alkyl radical and includes, for example, phenoxymethyl, phenoxyhexyl, 5-phenoxy-3-methylpentyl, etc. The term "lower phenylthioalkyl" refers to groups of the formula Ph-S-R'- in which Ph

  is the phenyl radical and R 'is an alkyl radical

  and includes, for example, phenylthiomethyl, phenylthioethyl, 4-phenylthio-1-methylbutyl and the like. The term "substituted lower phenoxyalkyl" refers to groups of the formula Ph'-OR'- wherein R 'is a lower alkyl radical andph' is a group

  phenyl having one or two substituents selected, independently

  in the group of fluoro, chloro, bromo, iodo, lower alkyl, and lower alkoxy radicals. of the

  representative examples of lower phenoxyalkyl groups

  substituted compounds include 4-fluorophenoxy-

  methyl; 2-iodo-5-bromophénoxyméthyle; 2- (2,5-dimethyl-

  phenoxy) ethyl; 4- (2-methoxy-4-chlorophenoxy) -1-methyl-

butyl), etc.

  The term "substituted phenylthio-lower alkyl

  killed "refers to groups of formula Ph'-S-R'- in the

  R 'is a lower alkyl radical and Ph' is a phenyl group bearing one or two substituents independently selected from the group of fluoro, chloro, bromo, iodo, lower alkyl and lower alkoxy radicals. Representative examples of phenylthioalkyl groups

  substituted subgroups include 4-fluorinated

  phenylthiomethyl; 2-iodo-5-bromophénylthiométhyle;

  2- (2,5-dimethylphenylthio) ethyl; 4- (2-hexoxy-4-chloro-

  phenylthio) -l-methylbutyl, etc. The term "unsubstituted fatty acid" refers to carboxylic acids of formula R'COOH in which

  R 'is an alkyl group having 1 to 20 carbon atoms.

  The term "low molecular weight primary alcohol" refers to a primary alcohol having a molecular weight of less than about 70 such as, for example, methanol, ethanol, etc. As mentioned above, the products of formula III are useful in the fight against fungi, especially against fungal infections of plants (see Belgian Patent No. 871 668). The compounds were

  applied for example as fungicides against mala-

  fungal diseases of plants such as downy mildew, eg Plasmopara viticola (vines) and Peronospora parasitica <cabbage and spinach), late blight of solanaceae, eg Phytophthora infestans (tomatoes and potatoes) and crown rot and root rot ,

for example Phytophthora.

  These compounds are particular fungicides

  useful because they stop certain types of

  fungal infections, established. This allows the use

  the fungicides of the invention because they do not need to be applied to plants

  as long as a fungal infection does not really exist.

  Therefore, a preventive program of fungicide application against a potential fungal infection

is not necessary.

  When used as fungicides, the compounds are applied in fungicidally effective amounts to fungi and / or their medium, such as vegetative hosts and non-vegetative hosts, for example animal products. The amount used naturally depends on several factors such as

  that the host, the type of fungus and the compound

applied. As with most pesticidal compounds, the compounds of the invention are usually not applied at full strength but are

  generally incorporated in diluents or

  biologically inert compounds normally used to facilitate the dispersion of active fungicidal compounds,

  given that the wording and the method of application

  may affect the activity of the fungicide. So,

  the compounds can be formulated and applied in

  powdered powders, wettable powders, emulsifiable concentrates, solutions, or any of a variety of other known types of formulations,

  depending on the desired mode of application.

  Wettable powders are in the form

  finely divided particles that disperse easily

  in water or other dispersant. These compounds

  normally contain about 5 to 80% fungicide, the remainder being an inert material

  which contains dispersing agents, emulsifying agents

  and wetting agents. The powder can be applied

  on the ground in the form of a dry powder or

  in the form of a suspension in water. Examples of carriers include fuller's earth, kaolin-type clays, silicas, and other highly absorbable wettable mineral diluents. Examples of wetting, dispersing or emulsifying agents include aryl and alkyl aryl sulfonates and their sodium salts,

  alkylamide sulfonates, including methyl tau

  fat wrinkles; alkylaryl polyether alcohols, sulfuric esters of higher alcohols and polyvinyl alcohols; polyethylene oxides, sulfonated animal and vegetable oils; petroleum oils

  sulphonated fatty acid esters of polyhydric alcohols

  hydroxyl and the adducts of ethylene oxide

  lene of these esters; and the products of sea

  long chain captains and ethylene oxide. Name-

  many other types of useful surfactants are

  commercially available. The surfactant, when

  that it is used, normally represents 1 to 15% in

weight of the fungicidal composition.

  Powders are mixtures, flowing

  active fungicide with finely divided solids such as talc, natural clays, kieselghur, pyrophyllite, chalk, diatomaceous earth, calcium phosphates, calcium and magnesium carbonates, sulfur, lime,

  flourous powders and other solid substances

  and inorganic agents which act as dispersants or carriers for the active substance. These materials

  finely divided solids have an average diameter of

  ticules of lines of about 50 micrometers. A representative powder coating formulation contains 75%

  silica and 25% of the active substance.

  Useful liquid concentrates include emulsifiable concentrates which are compositions

  homogeneous liquids or pastes which are readily dispersed in water or other dispersant, and may be fully

  formed of the fungicide - with a liquid or solid emulsifier, or may also contain a liquid vehicle such as xylene, heavy aromatic naphthas,

  isophorone and other non-volatile organic solvents.

  For the application, these concentrates are dispersed in

  water or in another liquid vehicle and are normally

  spray applied to the area to be treated.

  Other formulations useful for

  fungicidal agents include simple solutions of the active fungicide in a dispersant in which it is

  fully soluble at the desired concentration, for example

  acetone, alkylated naphthalenes, xylene or other organic solvents. Granular formulations in which the fungicide is attached to relatively coarse particles are of particular interest for aerial distribution or penetration of cover vegetation. Pressurized sprayable compositions can also be used, usually aerosols in which the active ingredient is dispersed

  in a finely divided form as a result of

  a vehicle formed of a low-boiling solvent-dispersant, for example a "Freon". All

  these techniques of formulation and application of fungi-

  Cides are well known in the art.

  The optimum percentages by weight of fungicide

  (active compound) may vary according to the way in which the composition is to be applied and

  particular type of formulation, but they are

  typically 0.5 to 95% by weight of the fungicidal composition.

  The fungicidal compositions can be

  and other active ingredients, including other fungicides, insecticides,

248 5013

  nematicides, bactericides, growth substances

  plants, fertilizers, etc. The non-limiting examples given below

  provide a better understanding of the present invention.

  All temperature ranges mentioned above and below, unless otherwise specified, correspond to the Celsius system and the term "room temperature"

  denotes a temperature of about 20-250C. The term

  cent (or "%") means a percentage by weight and the term

  "mole" or "moles" refers to gram-molecules.

  The term "equivalent" refers to a quantity of reagent

  equal to the moles of the previous or next reaction

  mentioned in the preparation or in the example,

  expressing itself in moles or in a weight or a finite volume.

  Likewise, unless otherwise specified, mixtures of

  Cemic and / or diastereomeric mixtures are used as starting materials and, accordingly, racemic mixtures and / or diastereomeric mixtures are obtained as products. Where necessary, examples are repeated to produce sufficient quantities of starting materials for subsequent preparations and examples. The abbreviation A.E. designates the elemental analysis, expressed in "% by weight" for

  both calculated and found values.

  When reference is made to the spectrum of

  proton magnetic resonance (r.mx.p.), this spectrum is determined at 60 mHz and the singlet (s), large singlet (1s), doublet (d), double doublet (dd) values are assigned to the signals, triplets (t), double triplets (dt),

quadruplets (q) and multiplets (m).

EXAMPLE 1

  This example illustrates process step (1)

  of the present invention and the optional hydrolysis

salt (I) in its acid.

  In this example, 15 ml of dimethoxy-

  anhydrous ethane with 1.98 g (0.022 mole) of 2-methyl-2-

  propanediol and 1.08 g (0.02 mole) of sodium methoxide.

  The mixture is refluxed for one hour and then cooled to room temperature and 4.10 g is added.

  (0.02 moles) 3- (2,6-dimethylphenylamino) -gamma-butyro-

  lactone. The resultant mixture is refluxed for 1.25 hours and then about 0.2 g of sodium methylate is added and the mixture is refluxed for a further hour.

  another hour. At the end of this period,

  said mixture and added 20 ml of ice water. The mixture is then extracted with toluene and the remaining aqueous phase is acidified with glacial acetic acid.

  at pH 6 and extracted with methylene chloride. The ex-

  chloromethylenic line is then washed three times with water, dried over magnesium sulphate and evaporated

  which gives 2.80 g of 1-carboxy-1- (2,6-dimethylphenyl)

  amino) -3-tert-butylthiopropane in the form of a

viscous oil.

  Similarly, following the same mode of operation but using the corresponding starting lactones

  instead of 3- (2,6-dimethylphenylamino) -gamma-butyro-

  lactone, the following compounds are prepared respectively:

  1-carboxy-l- (2,3,6-triméthylphénylamino) -3-

tert-butylthiopropane;

  1-carboxy-l- (2-methoxy-6-methylphenylamino) -3

tert-butylthiopropane; and

  1-carboxy-l-naphthylamino-3-t-butylthio-

  propane. By following the same procedure but reacting the thiolates respectively as

  potassium allylthiolate, ammonium benzylthiolate

  nium and sodium naphthylthiolate directly with each of the starting butyrolactones used above instead of preparing the thiolate in situ, the corresponding thioethylene, thiobenzene and thionaphthylene analogs of each of the products are likewise obtained.

above.

EXAMPLE 2

  This example illustrates the second step of the

method of the invention.

  In this example, 1.1 g (0.0037 mole) of 1-carboxy-1- (2,6-dimethylphenylamino) -3-tertiary

  butylthiopropane in 10 ml of methylene chloride

  holding 0.56 g (0.0554 moles) of triethylamine. We cool

  The mixture is added at 0 ° C. and 0.44 g (0.0041 mol) of methoxyacetyl chloride are added dropwise thereto and the resultant mixture is stirred at 0 ° C. for 10 minutes. The mixture is then allowed to warm to room temperature

  for 30 minutes then poured into ice water.

  The chloromethylenic phase is extracted, washed once

  with aqueous hydrochloric acid, twice with water and then

  hydrate magnesium sulphate and evaporate, this

  which gives 1.3 g of 1-carboxy-1-LN- (2,6-dimethylphenyl) -

  methoxyacetamido-3-tert-butylthiopropane containing a small amount of 1-methoxyacetyloxycarbonyl derivative in the form of an oil. The transformation obtained for this step, on the basis of the carboxylated material

starting point, is around 95%.

  Similarly, following this procedure but

  using respectively the products of the example

  1 as the starting material, the corresponding methoxyacetamido derivatives of formula (I) are respectively prepared. By following the same procedure but replacing the methoxyacetyl chloride respectively

  chloroacetyl chloride, cyclohexyl chloride,

  propylcarbonyl, benzoyl chloride and chloure

  of 2,3-epoxybutyryl, the

  chloracetamido, cyclopropylamido, benzoylamido

  and 2,3-epoxybutyramido of each of the above compounds.

EXAMPLE 3

  This example illustrates the third step of

method of the invention.

  In this example, 1.7 g (0.0046

  mole) 1-carboxy-1- [N- (2,6-dimethylphenyl) -N-methoxy]

  acetamido-3-tert-butylthiopropane prepared as

  in accordance with Example 2 above in 10 ml of anhydrous methylene chloride. The mixture is then cooled to 0 ° C. and 0.317 g (0.0023 mol) of phosphorus trichloride are added thereto. The mixture is stirred at 0 ° C. for 20 minutes and is then allowed to warm to room temperature and is stirred for one hour at

  the ambient temperature and then it is deactivated by

  ice. The solution is then decanted

  to remove a small amount of solid precipitate that has formed. The chloromethylenic phase is then

  separated and washed successively with water, a solution

  5% by weight of sodium carbonate, twice with water, 1N aqueous hydrochloric acid and twice more with water. The washed mixture is then dehydrated over sodium sulfate

  magnesium and evaporated to give 1.0 g of 3- (N-methoxy)

  acetyl-N-2,6-dimethylphenylamino) -gamma-butyrothiolactone

  in the form of an oil. The oil is then crystallized

  in isopropyl alcohol. The spectrum below

  red and the magnetic resonance spectrum protons of the crystalline product are identical to the spectra

  a control sample of 3- (N-methoxyacetyl-N-2,6-

  dimethylphenylamino) -gamma-butyrothiolactone. Similarly, following the same procedure

  but using the corresponding products of the

  2 as starting materials, respective preparations are

  the corresponding butyrothiolactone derivatives.

EXAMPLE 3A

  This example illustrates the third step of the process of the invention in which an agent is used.

  cyclizing different from that used in the example

ple 3.

  In this example, a solution containing 0.24 g of sulfuric acid, 4 ml of toluene and

  6 ml of acetic acid at 2.35 mmol of 1-carboxy-1-N-

  (2,6-dimethylphenyl) -N-methoxyacetamido / -3-tert-butyl-

  thiopropane. The mixture is then refluxed (about 110 ° C.) for two hours, then cooled and washed twice with 10 ml of water. (We add

  a small amount of methylene chloride to prevent

  expensive solids to precipitate during washing). The washed mixture is then evaporated to dryness at 50 ° C., which

  gives 3.65 g of 3- (N-methoxy-acetyl-N-2,6-dimethylphenyl)

  amino) -gamma-butyrothiolactone in the form of a material

  solid. Aqueous liquors are collected and extracted

  methylene chloride. Chloromethylenic extract

  evaporated to dryness, giving another 0.27 g of 3- (N-

  methoxyacetyl) -N-2,6-dimethylphenylamino) -gamma-butyro-

  thiolactone in the form of a solid substance.

  Similarly, following the same procedure

  but using the corresponding products of the

  2 as starting materials, respectively

  the corresponding butyrothiolactone derivatives.

EXAMPLE 4

  Examples 4 to 6 illustrate the process of the invention in the case where the salt (I) is directly

  acylated without prior conversion to the acid.

  In this example, 9.5 g (0.1 mole) is added

  2-methyl-2-propanethiol to a suspension under stirring.

  containing 6 g of sodium methylate (0.1 mole)

  in 70 ml of anhydrous 1,2-dimethoxyethane at room temperature

  ambient temperature. The resulting mixture is stirred at room temperature.

  ambient temperature for about 30 minutes (which

  lagging production of 2-methyl-2-propanethiolate

  sodium) and then 20.5 g (0.1 mole) of

  dimethylphenylamino) -gamma-butyrolactone. We heat up

  The mixture is refluxed until the suspension becomes a clear solution (approximately one hour). The solution is evaporated to remove the solvent and the methanol formed as a by-product and thus the residue is obtained.

  1- (2,6-dimethylphenylamino) -1- (2-tert-butylthioethyl) -

sodium acetate (I).

  Similarly, following the same procedure

  but using as starting materials the 3-aryl-

  or 3-Subst.-arylamino-gamma-butyrolactonf, the following compounds are prepared respectively: 1- (phenylamino) -1- (2-tert-butylthioethyl) sodium acetate:

  1- (4-flurophénylamino) -l- (2-tert-butyl-

sodium thioethyl) acetate;

  1- (2-iodophenylamino) -l- (2-tertiobutylthio-

ethyl) sodium acetate;

  1- (2,6-Dichloro-phenylamino) -l- (2-tert

sodium thioethyl) acetate;

  1- (2-methoxyphenylamino) -1- (2-tertiobutylthio-

ethyl) sodium acetate;

  1- (2-methyl-4-pentylphénylamino) -1- (2-tert

  butylthioethyl :) sodium acetate;

  1- (2,6-dibromophénylamino) -l- (2-tert

thioethyl.) sodium acetate;

  1- (2-methyl-3-chloro-phenylamino) -l- (2-tert

  butylthioethyl.) sodium acetate.

  Similarly, following the same procedure

  but replacing 2-methyl-2-propane-

  sodium thiolate prepared in situ by hex-4-enylthio-

  In the case of potassium starch, calcium di (methylthiolate) and ammonium benzylthiolate, the corresponding analogous salts of each of the above products are prepared respectively.

EXAMPLE 5

  In this example, the 1- (2,6-

  sodium dimethylphenylamino) -1- (2-tert-butylthioethyl) acetate (I) obtained as the residue in Example 4 in 250 ml of dimethoxyethane and the solution is heated to

  reflux. 7.5 g (0.1 mole) of N, N-dimethyl-

  formamide then 9.5 g (0.1 mole) of acryloyl chloride are added and, at this point, the solution takes on a hue

  light brown. The mixture is allowed to cool to room temperature

  7.5 g (0.1 mole) of N, N-dimethylformamide are added and 9.5 g (0.1 mole) of acryloyl chloride are added. The mixture is then refluxed for one hour and then evaporated under vacuum to remove the solvent. The residue is stirred into diethyl ether, filtered through diatomaceous earth and dried. evaporates, which gives the anhydride

  acrylic acid-1- (2,6-dimethylphenyl) -N-acryloyl-

  amino / 1- (2-tert-butylthioethyl) acetic acid as residue. Similarly, following the same procedure and using the corresponding products of Example 4 as starting materials, the following compounds are prepared respectively:

  acrylic acid anhydride-1- (N-phenyl) -N-

  acryloylamino) -1- (2-tert-butylthioéthyl) acetic acid;

  acrylic acid anhydride-1- (4-fluoro)

  phenyl) -N-acryloylàmnino: 7-2-tert-butylthioéthyl-acetic

tick;

  acrylic acid anhydride-1-LN- (2,6-dichloroacetic acid)

  rophényl) -N-acryloylamino / -2-tert-butylthioéthyl-acetic

tick;

  1- (N- (2-methoxy) acrylic acid anhydride

  phenyl) -N-acryloylamino7 / -2-tertia-butylthioéthyl-acetic

than;

  acrylic acid anhydride-1-ZN- (2-methylethyl)

  4-pentylphenyl) -N-acryloylamino7-2-tert-butylthioéthyl-

acetic;

  acrylic acid anhydride-1- / N- (2,6-dibromo

  phenyl) -N-tert-acryloylamino7-2 butylthioéthyl-acetic

than; and

  acrylic acid anhydride-1-- N- (2-methyl)

  3-chlorophenyl) -N-acryloylamino7-2-tert-butylthioéthyl

acetic.

  Similarly, following the same procedure

  but replacing the acryloyl chloride, respectively

  by acetyl chloride; dichloroacetyl chloride; hydroxyacetyl chloride; methoxyacetyl chloride; methylthioacetyl chloride;

  phenylthioacetyl chloride; phenoxy chloride

  acetyl; 2,6-dimethylphenylacetyl chloride; 4-methoxyphenylacetyl chloride and 2,3-epoxybutyryl chloride, the corresponding diacyl derivatives of each of the above compounds are respectively prepared,

for example:

  1-N- (2,6-dimethyl) acetic acid anhydride

  phenyl) acetamido / -2-tert-butylthioéthyl-acetic acid;

  dichloroacetic acid anhydride-1- (N-phenyl)

  dichloracétamido) -2-tert-butylthioéthyl-acetic acid;

  hydroxyacetic acid anhydride-1- / N- (4-

  fluorophenyl) -hydroxyacétamido / -2-tert-butylthioéthyl-

acetic;

  methoxyacetic acid anhydride-1- / N- (2,6-

  dimethylphenyl) -méthoxyacétamido7-2-t-butylthio-

* ethyl acetic;

  methylthioacetic acid anhydride-1- / N-

  (2,6-dichlorophenyl) -méthylthioacétamidc7-2-tert-butyl

thioethyl-acetic acid;

  phenylthioacetic acid anhydride-l- / aN- (2-

  methoxyphenyl) -phénylthioacétamido / -2-t-butylthio-

ethyl-acetic acid;

  phenoxyacetic acid anhydride-1- / N- (2-

  methyl-4-pentylphenyl) -phénoxyacétamido7-2-tert-butyl

thioethyl-acetic acid;

  (2,6-dimethylphenyl) acetic acid anhydride

  1- / N- (2,6-dibromophenyl) - (2,6-dimethylphenyl-acetamido / -

2-tert-butylthioéthyl-acetic acid;

  (4-ethoxyphenyl) acetic acid anhydride

  / N- (2-methyl-3-chlorophenyl) - (4-ethoxyphenyl) acétamido7-

2-tert-butylthioéthyl-acetic acid;

  2,3-epoxybutyric acid anhydride-1- / N- (2,6-

  dimethylphenyl) -2,3-époxybutyramido7-2-tert-butylthio-

ethyl-acetic, etc.

EXAMPLE 6

  In this example, the acid anhydride is mixed

  1-acrylic-l- / N - (2,6-dimethylphenyl) -N-acryloylamino / 7-

  2-tert-butylthioethyl-acetic acid obtained as residue in Example 5 with 200 ml of dimethoxyethane and then

  42 g (0.3 mole) of phosphorus chloride are slowly added.

  The resulting mixture is cooled to approximately 8 ° C. and then

  stir at room temperature overnight

  about 12 hours). Thin layer chromatographic analysis of a small sample of this material reveals the presence of a few unreacted starting materials (i.e. butylthiopropane derivative) and two other products. . The reaction mixture is then refluxed for 24 hours and then evaporated to remove the solvent. The residue is dissolved in methylene chloride and washed with saturated sodium bicarbonate to neutralize the acid components and then washed with water and dried over magnesium sulfate. The methylene chloride is then evaporated to give an oily residue. The oily residue is

  then chromatographed on 250 g of silica gel, the elu-

  tion being carried out successively with the ether of

  oil; 95% petroleum ether in ethyl ether

  lic; 90% petroleum ether in ethyl ether

  lic; 75% petroleum ether in ethyl ether

  lic. The silica gel column is then eluted again with 50% ether in ether.

  ethyl, which gives about 3 g of 3- (N-acryloyl)

  N-2,6-phenylamino) -gamma-butyrothiolactone. Similarly, following the same procedure, the products of Example 5 are respectively converted into the corresponding derivatives of gamna-butyrothiolactone,

for example

  3- (N-acryloyl-N-2,6-dichlorophenylamino) -gamma

butyrothiolactone;

  3- / N-acryloyl-N- (2-methyl-3-chlorophenyl) -

amino / -gamma-butyrothiolactone;

  3- (N-dichloroacetyl-N-phenylamino) -gamma

butyrothiolactone;

  3- (N-methoxyacetyl-N-2 ', 6'-dimethylphenylamino) -

  gamma-butyrothiolactone; 3- (N-phénylthioacétyl-N-2'-methoxyphenylamino) -gamma-butyrothiolactone;

  3 - / - N- (2,6-dimethylphenyl) acétyl7-N- (2,6-di-

  bromophenyl) -aminro / -gamma-butyrothiolactone;

  3- / N- (2,3-époxybutyryl) -N- (2,6-dimethylphenyl) -

  amino / -gamma-butyrothiolactone; etc.

EXAMPLE 7

  In this example, we repeat the operating modes

  Examples 2 and 5 but using bromides

  of corresponding acyl in place of acyl chloride.

  Samples of the resulting products of formula II are then respectively converted to the corresponding compounds of formula III by application of the procedure of example 3 and the procedures of

Example 3A.

EXAMPLE 8

  This example illustrates the process variant

of the invention.

  A. A solution of 11.89 g of 3- (N-

  2,6-dimethylphenylamino) -gamma-butyrolactone in

  dimethoxyethane with 6.5 g of tert-butyl sodium

  mercaptan. The solution is refluxed for 4 hours and the solvent is removed. The residue is dissolved in water, the solution is acidified with hydrochloric acid and extracted with methylene chloride. The organic phase is collected, dried over MgSO 4 and the solvent is removed to obtain 15.2 g of a viscous oil (the infrared spectrum reveals the presence of the group

-CO2H).

  B. A 5 g portion of the oil is stirred in ml (15.7 g) of phosphorus trichloride at room temperature for two days. Excess phosphorus trichloride is removed at 60 ° C. and the residue is dissolved in methylene chloride, the solution is washed with water and dehydrated. The residue is purified on a column

  of silica gel to give 1.31 g of 3- (N-2,6-dimethyl)

  phenylaminorgamma-butyrolathiolactone (yield 34.8%). C. The product of step B is then acylated by the procedure described in Example 2 above,

  which gives 3- (N-methoxyacetyl-N-2,6-dimethylphenyl)

  amino) -gamma-butyrothiolactone. It goes without saying that the present invention has been described only for explanatory purposes but in no way limiting and that many modifications can be made to it.

without leaving his frame.

Claims (21)

  1. Process for producing compounds of formula: C-R1 Ar N R2 02 / S (III)   wherein Ar is aryl or substituted aryl having one to four substituents independently selected from the group consisting of fluoro, chloro, bromo, iodo, lower alkyl and lower alkoxy; and R 1 is lower alkyl, lower alkoxy, cycloalkyl having 3 to 6 carbon atoms, epoxy lower alkyl, lower alkenyl, lower alkenyloxy, hydroxymethyl, haloalkyl having one to three   halogen substituents and 1 to 6 carbon atoms, alkoxy-   lower alkyl, lower alkylthioalkyl, phenylthio-   lower alkyl, phenoxy-lower alkyl, phenylthio-   lower alkyl or lower substituted phenoxy-lower alkyl   having one or two substituents on. the core, chosen   depending on the group comprising the fluoro, chloro, bromo, iodo, lower alkyl and lower alkoxy radicals; and R2 is hydrogen, chloro, bromo, lower alkyl, phenyl, substituted phenyl having one or two substituents on the ring independently selected from the group consisting of fluoro, chloro, bromo or lower alkyl; characterized in that it comprises the steps of:   (a) contacting the arylamino-gamma   corresponding butyrolactone of formula: H Ar - N Z7 $ O.R2   (A) wherein Ar and R2 are as defined above, with a thiolate salt under reactive conditions   to form the 1- (Ar-amino) -3-thiopropane salt Corresponding 1-carboxylic acid;   (b) contacting said 1- (Ar-amino) -3 salt   1-carboxylic thiopropane with an acyl halide of formula o0 R1CX   wherein R 1 is as defined above and X is the chloro or bromo (c) group contacted with the N-acylamine product of step (b) with a cyclizing agent, thereby esterifying a saturated carboxylic fatty acid   by contact with a low molecular weight primary alcohol   then, under reactive conditions, thereby forming the corresponding compound of formula III, or optionally, conducting step (c) prior to step (b) to form the corresponding intermediate thiolactone   and acylation of said intermediate thiolactone according to   in step (b) to form the compound of formula III.   2. Process for the preparation of compounds of formula: II C-R 1 Ar 2 T \   (III) wherein Ar is an aryl or substituted aryl group having one to four substituents independently selected from the group consisting of fluoro, chloro, bromo, iodo, lower alkyl and lower alkoxy; and R 1 is lower alkyl, lower alkoxy, cycloalkyl having 3 to 6 carbon atoms, epoxy lower alkyl, lower alkenyl, lower alkenyloxy, hydroxymethyl, haloalkyl having one to three   halogen substituents and 1 to 6 carbon atoms, alkoxy-   lower alkyl, lower alkylthioalkyl, phenylthio-   lower alkyl, phenoxy-lower alkyl, phenylthio-   lower alkyl or substituted phenoxy-lower alkyl   having one or two substituents on the ring, chosen in   depending on the group comprising the fluoro, chloro, bromo, iodo, lower alkyl and lower alkoxy radicals and R2 is hydrogen, chloro, bromo, lower alkyl, phenyl, substituted phenyl having one or two independently selected ring substituents in the group consisting of fluoro, chloro, bromo or lower alkyl; characterized in that it comprises the following steps:   (a) contacting the arylamino-gamma   corresponding butyrolactone of formula: H Ar - N "2 - ( (A) in which   Ar and R2 have the definitions given below.   above, with a thiolate salt under reactive conditions   to form the 1- (aryl-amino) -3-thiopropane salt   Corresponding 1-carboxylic acid; (b) contacting said carboxylic salt with an acid under substantially reactive conditions   to form the corresponding 1- (arylamino) -1-carboxy-3-thiopropane   laying; (c) contacting 1- (aryl-amino) -1-carboxy-3-thiopropane with an acyl halide of the formula: ## STR2 ## wherein R 1 is as defined above and X is chloro or bromo radical (d) contacting the N-acylamine product   of step (c) with a cyclising agent, capable of   to turn carboxylic acids or esters into halides   of acids under reactive conditions in such a way as to   sea the corresponding compound of formula III.   3. Process for preparing compound compounds mule: O C-R1 Ar N J77} R2   wherein Ar is aryl or substituted aryl having one to four substituents independently selected from the group consisting of fluoro, chloro, bromo, iodo, lower alkyl and lower alkoxy; and R 1 is lower alkyl, lower alkoxy, cycloalkyl having 3 to 6 carbon atoms, epoxy lower alkyl, lower alkenyl, lower alkenyloxy, hydroxymethyl, halogenyl having 1 to 3   halogen substituents chosen indCpeenianvent in the   taking the fluoro radicals, chnoro; braoe and iodo; al] oxo-   lower alkyl, lower alkylthioalkyl, phenylthio-   lower alkyl or phenoxy-lower alkylphenylthic-   a lower alkyl or substituted poly-lower alkyl having   one or two substituents on the kernel.   in the group consisting of fluoro, chloro, bromo, iodo, lower alkyl and lower alkoxy; and R is hydrogen, chloro, bromo, iodo, lower alkyl, phenyl, substituted phenyl having one or two substituents on the ring independently selected from the group consisting of fluoro, chloro, bromo, iodo or lower alkyl; characterized in that it comprises the following steps: (a) contacting an arylaminolactone of the formula: ## STR1 ## wherein Ar and R2 have the definitions given above with a thiolate salt of formula: MSR   wherein M is an alkali metal cation and R is a lower alkyl, lower alkenyl, aryl-lower alkyl radical in an organic liquid carrier inert under reactive conditions at temperatures in the range of about 20 to 200 ° C. to form the corresponding compound of formula: ## STR2 ## I (I) OM in which   Ar, R and R2 have the definitions given below.   above; (b) contacting the compound of formula (I) with an acyl halide of formula: R -C-X   wherein R is as defined above and X is chloro or bromo;   in an inert organic solvent under reactive conditions.   at temperatures between about 0.degree. to 120.degree. C. so as to form the corresponding acylated product chosen from the group of formulas: O O IIt It 1RR2 CR1 R2 CR1 R2   x Ar - 1CH-CH2-CH-SR; Ar-N-CH-CH2-CH-SR Ar-N-CIH-CH2-CHI-SR-HS I I   C = O OH (IIa) O-CR1 (IIb) in which R   Ar, R 1, R and R are as defined above and R is a lower alkyl radical or (c) bringing the acylated product of step (b) into contact with a condensation agent selected from the compounds carrying out the reaction. esterification of a saturated fatty acid with a low molecular weight primary alcohol in an inert organic solvent under conditions   reagents in order to ensure the corresponding compound of Formula III.   4. Process for the preparation of compounds of formula: O - R1 Ar-N / tR2 S   wherein Ar is aryl or substituted aryl having one to four substituents independently selected from the group consisting of fluoro, chloro, bromo, iodo, lower alkyl and lower alkoxy; and R 1 is lower alkyl, lower alkoxy, cycloalkyl having 3 to 6 carbon atoms epoxy lower alkyl, lower alkenyl, lower alkenyloxy, hydroxymethyl, halogenyl having one to three substituents independently selected from the group containing fluoro groups, chloro, brca. and iodo, lower alkoxy-lower alkyl, lower alkylthio-1-alkyl, lower alkyl-lower alkyl, phenoxy-lower alkyl. phnylthic-lower alkyl or   phyllo-substituted lower alkyl having one or two   killing on the nucleus, chosen ind.penda: .ilent in the group comprising fluoro, chloro, bromo, iodo radicals; lower alkyl and lower alkoxy; and R2 is hydrogen, chloro, bromo, iodo, lower alkyl, phenyl, substituted phenyl having one or two substituents on the ring independently selected from the group consisting of fluoro, chloro, bromo, iodo or lower alkyl; characterized in that it comprises the following steps: (a) contacting an arylaminolacone of formula: ## STR1 ## 2485013.   wherein Ar 1 and R 2 are as defined above: with a thiolate salt of the formula MSR wherein M is an alkali metal cation and R is   a lower alkyl, lower alkenyl, aryl- lower alkyl,   in an inert organic liquid vehicle under conditions   reactive reactions at temperatures in the range of about 20 to 200 C so as to form the corresponding compound of formula: . R2 H I Ar - N - CH - CH 2 - CH - SR I C = O I (I)   OM- wherein Ar, M, R and R2 have the definitions given above; (b) contacting said compound of formula I with an acid under reactive conditions so as to   to form the corresponding 1-arylamino-1-carboxy-3-thiopropane ing;   (c) contacting said 1-arylamino-1-carboxy   3-thiopropane with an acyl halide of formula: 1 "1 R -C-X   in which R 1 has the definition given above and X is the chloro or bromo radical;   in an inert organic solvent under reactive conditions.   at temperatures in the range of about 0 to 120 C to form the corresponding acylated product selected from the formulas: O -   g! ## STR2 ## wherein R 1 is CH 2 R 2 - CH 2 CH 2 CH 2 -CH-SR C = O OH (IIa) O g CR1 R2   Embedded image in which Ar, R and R 2 are as defined above, wherein R 1, R 2 and R 2 are as defined above; and R is a lower alkyl radical, or (d) contacting the acylated product of step (c) with a cyclizing agent selected from compounds that esterify a saturated fatty acid with a primary alcohol of low molecular weight, in an inert organic solvent under reactive conditions   to form the corresponding compound of formula III.   5. Process according to claim 1, characterized   in that the thiolate salt has the formula MSR and the product of step (b) has the formula: CR1 Ar - N - Ar - N - CH - I C = O OR3 R2 I CH2CH - SR   (II) formulas wherein Ar, R1 and R are as defined in claim 1; M is a cation, R is a radical   lower alkyl, lower alkenyl or aryl-lower alkyl   and R3 is hydrogen or the radical of formula where it is 1 1 -CR in which   R is selected from the same substitute group killing only R1.   6. Method according to one of claims 1   and 2, characterized in that the compound of formula (A)   is 3- (2,6-dimethylphenylamino) -gamma-butyrolactone.   7. The process of claim 1, wherein   in that step (b) is implemented in a inert organic solvent.   8. A process according to claim 1, characterized   in that the salt 1- (arylamino) -3-thiopropane-carboxy-   lique is contacted with about 2 to 2.2 moles of said   acyl halide per mole of said salt in said step (b).   9. Process according to one of the claims   1 and 2, characterized in that step (c) is implemented   at temperatures in the range of approxi- from 0 to 120 C.   10. Process according to one of the claims   1 and 2, characterized in that step (a) is   works in an inert organic liquid.   11. Method according to one of claims 1   and 2, characterized in that step (c) is implemented in an inert organic solvent.   12. Process according to claim 2, characterized   in that step (d) is implemented in a inert organic solvent.   13. A process according to claim 2, characterized   in that in step (c), the 1- (arylamino) -l-   carboxy-3-thiopropane is treated with about 1 to 1.1 moles   said acyl halide per mole of said 1- (arylamino) - carboxy-3-thiopropane.   14. Process according to one of the claims   3 and 4, characterized in that the inert organic liquid of step (a) is selected from 1,2-dimethoxyethane, diglyme and mixtures thereof, and the inert organic solvents of steps (b) and (c) are independently selected from crystallizable acetic acid, dichloromethane, 1,2-dichloroethane, toluene and mixtures thereof,   R2 being preferably a hydrogen atom.   15. Process according to claim 4, characterized   in that the condensation agent by cyclisa-   is chosen between phosphorus trichloride and crystallizable acetic acid mixtures containing a small amount of sulfuric acid, the organic liquid   inert of step (a) being preferably 1,2-dimethoxy-   ethane and inert organic solvents steps   (b) and (c) preferably each being the chloride of thylène.   16. The method of claim 15, wherein   characterized in that the starting material of formula A is (2,6-dimethylphenylamino) -gamma-butyrothiolactone and the acyl halide is methoxyacetyl chloride, the product of formula III having the formula: O Cil C-CH200H3 N CH3   17. Process according to any one of the   1, 2, 4 and 16, characterized in that the thiolate salt is an alkali metal thiolate,   preferably sodium 2-methyl-2-propanethiolate.   18. Compound characterized in that it meets the formula: o CR1 R2 / I Ar - N - CH - CH 2 - CH - SR C = O OR3 II   wherein Ar is an aryl or substituted aryl radical having one to four substituents independently selected from   the fluoro, chloro, bromo, iodo, lower alkyl,   lower alkoxy; R is lower alkyl, lower alkenyl, aryl-lower alkyl, R1 is lower alkyl, lower alkoxy, cycloalkyl having 3 to 6 carbon atoms epoxy lower alkyl, lower alkenyl, alkenyloxy, lower, hydroxymethyl; a haloalkyl radical having   one to three halogen substituents and 1 to 6 carbon atoms;   bone; a lower alkoxyalkyl, lower alkylthioalkyl, lower phenylthioalkyl, lower phenoxyalkyl, lower phenylthioalkyl or phenoxyalkyl radical   lower or substituted lower phinylthio having one or two   killing on the nucleus, chosen indefinitely in the group of fluoro, chloro, brcou, iodo radicals; lower alkyl and lower alkoxy, R2 is hydrogen or a chloro, bromo, lower alkyl, phenyl, substituted phenyl radical having one or two substituents on the ring independently selected from the group of fluoro, chloro, bromo, iodo or lower alkyl radicals; ; and R3 is hydrogen or the radical of formula O   -CR in which R1 has the definition given above, R   being preferably selected from tertiary radicals butyl, allyl and benzyl.   19. Process for the preparation of a compound   according to claim 18, characterized in that it consists in introducing the corresponding compound of formula: R2 H |   Ar-N-CH-CH2-CH-SR IC = OO (M1) 1 / m, wherein Ar, R and R2 have the meanings given in claim 18 and M1 is hydrogen or a cation, and m 'is the valence of M, in contact with an acyl halide of the formula: ## STR1 ## wherein X is chloro or bromo and R 1 is as defined in claim 18, under reactive conditions so as to form the   corresponding compound according to claim 18.   20. Process for the preparation of a compound of mule: Ar -NH CH-CH2 () / C / CH-R S in which   Ar and R2 have the definition given in the   claim 1, characterized in that it comprises the following steps: (a) reaction of a compound of formula: Ar-NH CH-CH2   Wherein Ar and R are as defined above; with a thiolate salt under reactive conditions and (b) reacting the product obtained in step (a) with a reagent capable of performing the esterification of a saturated carboxylic fatty acid by contact with a primary alcohol of low molecular weight, the product of the step   (a) preferably being converted to the acid prior to pe (b).   21. Process according to claim 20, characterized in that the thiolate salt is a 2-methyl-2-propanethiolate and the reagent of step (b) is phosphorus trichloride, Ar being preferably 2,6-dimethylphenyl group.