FR2476486A1 - LICE DESTRUCTION PRODUCT - Google Patents
LICE DESTRUCTION PRODUCT Download PDFInfo
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- FR2476486A1 FR2476486A1 FR8103379A FR8103379A FR2476486A1 FR 2476486 A1 FR2476486 A1 FR 2476486A1 FR 8103379 A FR8103379 A FR 8103379A FR 8103379 A FR8103379 A FR 8103379A FR 2476486 A1 FR2476486 A1 FR 2476486A1
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- lice
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- 241001674048 Phthiraptera Species 0.000 title claims abstract description 24
- 230000006378 damage Effects 0.000 title claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 230000002195 synergetic effect Effects 0.000 claims abstract description 9
- 239000003599 detergent Substances 0.000 claims abstract description 8
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 7
- 239000008158 vegetable oil Substances 0.000 claims abstract description 7
- 239000012153 distilled water Substances 0.000 claims abstract description 6
- 239000002304 perfume Substances 0.000 claims abstract description 6
- 125000002091 cationic group Chemical group 0.000 claims abstract description 4
- 239000002904 solvent Substances 0.000 claims abstract description 4
- 239000000126 substance Substances 0.000 claims abstract description 4
- 239000002728 pyrethroid Substances 0.000 claims abstract 3
- RLLPVAHGXHCWKJ-UHFFFAOYSA-N permethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-UHFFFAOYSA-N 0.000 claims description 18
- 229960000490 permethrin Drugs 0.000 claims description 16
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 12
- DVBJBNKEBPCGSY-UHFFFAOYSA-M cetylpyridinium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 DVBJBNKEBPCGSY-UHFFFAOYSA-M 0.000 claims description 12
- VEMKTZHHVJILDY-UXHICEINSA-N bioresmethrin Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OCC1=COC(CC=2C=CC=CC=2)=C1 VEMKTZHHVJILDY-UXHICEINSA-N 0.000 claims description 10
- 239000004359 castor oil Substances 0.000 claims description 9
- 235000019438 castor oil Nutrition 0.000 claims description 9
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 9
- 235000019441 ethanol Nutrition 0.000 claims description 8
- 229960002483 decamethrin Drugs 0.000 claims description 4
- OWZREIFADZCYQD-NSHGMRRFSA-N deltamethrin Chemical compound CC1(C)[C@@H](C=C(Br)Br)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 OWZREIFADZCYQD-NSHGMRRFSA-N 0.000 claims description 4
- 239000000470 constituent Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 5
- 239000002917 insecticide Substances 0.000 abstract description 2
- 239000013543 active substance Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 6
- 238000003197 gene knockdown Methods 0.000 description 5
- NYPJDWWKZLNGGM-UHFFFAOYSA-N fenvalerate Chemical compound C=1C=C(Cl)C=CC=1C(C(C)C)C(=O)OC(C#N)C(C=1)=CC=CC=1OC1=CC=CC=C1 NYPJDWWKZLNGGM-UHFFFAOYSA-N 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- 208000028454 lice infestation Diseases 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- QAQSNXHKHKONNS-UHFFFAOYSA-N 1-ethyl-2-hydroxy-4-methyl-6-oxopyridine-3-carboxamide Chemical compound CCN1C(O)=C(C(N)=O)C(C)=CC1=O QAQSNXHKHKONNS-UHFFFAOYSA-N 0.000 description 2
- 241000255925 Diptera Species 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000000749 insecticidal effect Effects 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 240000000731 Fagus sylvatica Species 0.000 description 1
- 235000010099 Fagus sylvatica Nutrition 0.000 description 1
- 101100170542 Mus musculus Disp1 gene Proteins 0.000 description 1
- 241000257159 Musca domestica Species 0.000 description 1
- 241000257226 Muscidae Species 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 241000517324 Pediculidae Species 0.000 description 1
- 241000517307 Pediculus humanus Species 0.000 description 1
- 241000517305 Pthiridae Species 0.000 description 1
- 240000004460 Tanacetum coccineum Species 0.000 description 1
- VXSIXFKKSNGRRO-MXOVTSAMSA-N [(1s)-2-methyl-4-oxo-3-[(2z)-penta-2,4-dienyl]cyclopent-2-en-1-yl] (1r,3r)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate;[(1s)-2-methyl-4-oxo-3-[(2z)-penta-2,4-dienyl]cyclopent-2-en-1-yl] (1r,3r)-3-[(e)-3-methoxy-2-methyl-3-oxoprop-1-enyl Chemical class CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)O[C@@H]1C(C)=C(C\C=C/C=C)C(=O)C1.CC1(C)[C@H](/C=C(\C)C(=O)OC)[C@H]1C(=O)O[C@@H]1C(C)=C(C\C=C/C=C)C(=O)C1 VXSIXFKKSNGRRO-MXOVTSAMSA-N 0.000 description 1
- ROVGZAWFACYCSP-MQBLHHJJSA-N [2-methyl-4-oxo-3-[(2z)-penta-2,4-dienyl]cyclopent-2-en-1-yl] (1r,3r)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OC1C(C)=C(C\C=C/C=C)C(=O)C1 ROVGZAWFACYCSP-MQBLHHJJSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- CKQVRZJOMJRTOY-UHFFFAOYSA-N octadecanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCCCC(O)=O CKQVRZJOMJRTOY-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229940015367 pyrethrum Drugs 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
- A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
Abstract
Description
La présente invention est relative a un produit de destruction des poux possédant une action synergique. Le produit conforme à la présente invention agit mieux que les produits connus et ne provoque aucun effet irritant sur la peau. The present invention relates to a lice destroying product having a synergistic action. The product according to the present invention acts better than the known products and does not cause any irritating effect on the skin.
Malheureusement, les poux de tête et les poux du pubis sont de plus en plus répandus ces derniers temps. Les produits de destruction des poux actuellement commercialisés (pour la plupart des solutions telles que ',ERGO" et "NEOCIKLOTOX" fabriquées par la Société BIOGAL, Debrecen,
Hongrie), ont l'inconvénient qu'après leur application c'est-à-dire après frottement des cheveux ou du corps avec ces produits - ils doivent être enlevés par lavage. Après le lavage des cheveux, ou après un bain, l'action desdits produits disparalt et la personne traitée peut à nouveau avoir des poux en peu de temps.Unfortunately, head lice and pubic lice have become more common lately. Lice destruction products currently marketed (mostly solutions such as ', ERGO' and 'NEOCIKLOTOX' manufactured by BIOGAL, Debrecen,
Hungary), have the disadvantage that after their application that is to say after rubbing hair or body with these products - they must be removed by washing. After washing the hair, or after a bath, the action of said products disappears and the person treated can again have lice in a short time.
L'invention s'est fixé pour but de créer un produit détruisant les poux, produit qui, en dépit d'une concentration faible en principes actifs, tue rapidement, autant que possible en quelques minutes et de manière sûre les poux et les lentes (oeufs des poux), qui, après avoir été appliqué sur les cheveux ou les poils du corps, ou sur les vêtements, agit durant un temps prolongé, qui n'irrite ni la peau ni les yeux et qui n'a pas besoin d'hêtre enlevé par un lavage après son application. The object of the invention is to create a product that destroys lice, a product which, despite a low concentration of active ingredients, kills lice and nits as quickly as possible within a few minutes ( lice eggs), which, after being applied to the hair or body hair, or on the clothing, acts for a prolonged period of time, does not irritate the skin or the eyes and does not need to beech removed by washing after its application.
Il faut choisir, comme constituant actif, des composés qui ne sont pas toxiques à la concentration utilisée, et qui ne peuvent pas être absorbés par la peau. As an active ingredient, it is necessary to choose compounds which are not toxic at the concentration used and which can not be absorbed by the skin.
Les pyrethroides répondent à ces exigences. Les pyréthroides sont les analogues synthétiques des pyréthrines. Pyrethroids meet these requirements. Pyrethroids are the synthetic analogues of pyrethrins.
Leur action insecticide est connue (cf. M. Elliott, N.F. Janes: "Pyrethroìds A New Class of Insecticide", Chem. Soc.Their insecticidal action is known (see M. Elliott, N.F. Janes: "Pyrethroids A New Class of Insecticide", Chem Soc.
Review, vol. 7, nO 4/1978). Review, vol. 7, No. 4/1978).
La Demanderesse a trouvé à présent, de façon surprenante, que 1 action des pyréthroides peut être augmentée dans une mesure importante lorsque ceux-ci sont utilisés en combinaison avec des huiles végétales et/ou des détergents. The Applicant has now surprisingly found that the action of pyrethroids can be increased to a significant extent when these are used in combination with vegetable oils and / or detergents.
La présente invention a en conséquence pour objet, un produit détruisant les poux, qui est caractérisé en ce qu'il contient de 0,1 à 5,0 % de pyréthroides photostables et, comme substance à effet de synergie, de 0,2 à 10 % d'huiles végétales et/ou de 0,6 à 60 % de détergents cationiques ou non ioniques, ainsi que, comme solvants organiques, de 25 à 80 % d'alcanols inférieurs, éventuellement de 13 à 40 % d'eau distillée et, si on le désire, de 0,1 à 1,0 % de parfums. The subject of the present invention is therefore a lice-destroying product, which is characterized in that it contains from 0.1 to 5.0% of photostable pyrethroids and, as a synergistic substance, from 0.2 to 10% of vegetable oils and / or from 0.6 to 60% of cationic or nonionic detergents and, as organic solvents, from 25 to 80% of lower alkanols, possibly from 13 to 40% of distilled water and, if desired, 0.1 to 1.0% perfume.
Parmi les pyréthroldes photostables, on préfère en particulier la perméthrine, la décaméthrine et le fenvalérate. Le produit conforme à l'invention contient un ou plusieurs pyréthroldes en une quantité comprise entre 0,1 et 5,0 %, et de préférence à raison d'environ 0,5 %. Of the photostable pyrethroids, permethrin, decamethrin and fenvalerate are particularly preferred. The product according to the invention contains one or more pyrethroids in an amount of between 0.1 and 5.0%, and preferably about 0.5%.
Comme huile végétale possédant un effet de syner gie, on peut mentionner l'huile de ricin, comme détergent possédant un effet de synergie, le stérogénol (bromure de cétylpyridinium). Une action particulièrement bonne est obtenue en appliquant simultanément les deux substances à effet de synergie; cependant, l'effet des composants utilisés seuls est également appréciable. As a vegetable oil having a synergetic effect, castor oil can be mentioned as a synergistically effective detergent, sterogenol (cetylpyridinium bromide). A particularly good action is obtained by simultaneously applying the two synergistic substances; however, the effect of the components used alone is also appreciable.
Afin d'éviter l'apparition de phénomènes d'allergies et une irritation de la peau, la proportion de l'eau et des solvants organiques est assez élevée dans le composition conforme à l'invention. Une combinaison de solvants consistant en éthanol à 96 %, en isopropanol et en eau dans un rapport d'environ 54:25:13, s'est révélée comme particu lièrement favorable. (Dans tous les exemples, les formules et les démonstrations de l'activité qui vont suivre, on a utilisé comme alcool éthylique à 96 %, du spiritus concentratissimus conforme à Ph. Hg. VI). In order to avoid the occurrence of allergic phenomena and irritation of the skin, the proportion of water and organic solvents is quite high in the composition according to the invention. A combination of solvents consisting of 96% ethanol, isopropanol and water in a ratio of about 54:25:13 was found to be particularly favorable. (In all the examples, formulas and demonstrations of the activity which follow, 96% ethyl alcohol was used as spiritus concentratissimus according to Ph. Hg. VI).
Le stérogénol possède en soi une action insecticide peu importante, action qui n'a cependant aucune influence sur l'activité de la composition conforme à l'in vention. Sterogenol has in itself a small insecticidal action, action which however has no influence on the activity of the composition according to the invention.
L'action à effet synergique de l'huile végétale et du détergent, a été démontrée à l'aide de l'essai-type suivant : cinq solutions différentes ont été préparées, dont la première contenait, outre les solvants, de l'huile de ricin et du stérogénol, la deuxième seulement de la perméthrine, la troisième de la perméthrine et de l'huile de ricin, la quatrième de la perméthrine et du stérogénol, et la cinquième de la perméthrine, de l'huile de ricin et du stérogénol. Les compositions de ces solutions sont indiquées dans le Tableau qui va suivre. The synergistic action of vegetable oil and detergent has been demonstrated using the following standard test: five different solutions were prepared, the first containing, in addition to the solvents, oil castor oil and sterogenol, the second only permethrin, the third permethrin and castor oil, the fourth permethrin and sterogenol, and the fifth permethrin, castor oil and stérogénol. The compositions of these solutions are indicated in the following table.
Composant 1 2 3 4 5
Composant 1 2 3 4 5
Perméthrine (g) - 0,5 0,5 0,5 0,5
Huile de ricin (g) 1,0 - 1,0 - 1,0
Stérogénol (g) 0,6 - - 0,6 0,6
Alcool éthylique à
96 % (ml) 59,4 61 60,0 55,0 54,0
Isopropanol (ml) 25,0 25,0 25,0 25,0 25,0
Eau distillée (ml) 13,0 13,0 13,0 13,0 13,0 (Le stérogénol est disponible dans le commerce sous la forme d'une solution alcoolique à 10 % de bromure de cétylpyridinium).
Component 1 2 3 4 5
Component 1 2 3 4 5
Permethrin (g) - 0.5 0.5 0.5 0.5
Castor oil (g) 1.0 - 1.0 - 1.0
Sterogenol (g) 0.6 - - 0.6 0.6
Ethyl alcohol to
96% (ml) 59.4 61 60.0 55.0 54.0
Isopropanol (ml) 25.0 25.0 25.0 25.0 25.0
Distilled water (ml) 13.0 13.0 13.0 13.0 13.0 (Sterogenol is commercially available in the form of an alcoholic solution containing 10% cetylpyridinium bromide).
On a plonge dans ces solutions, des morceaux de tissu sur lesquels les poux de corps (pdiculus humanus vestimenti) avaient déposé de nombreuses lentes. Puis, ces morceaux de tissu ont été séchés à la température ambiante et on les a fait incuber pendant 8 jours à 300C dans un appareil à thermostat. Puis le nombre total des lentes sur chaque morceau de tissu, ainsi que celui des lentes détruites (ces lentes ont la forme dun tonnelet et le couvercle de ce tonnelet n'est pas ouvert chez les lentes détruites) ont été déterminés en les comptant. Le degré de destruction est exprimé par le rapport du nombre de lentes détruites au nombre total. Les résultats sont résumés dans le Tableau I ci-après. In these solutions, pieces of tissue were plunged onto which the body lice (pdiculus humanus vestimenti) had deposited many nits. Then, these pieces of tissue were dried at room temperature and incubated for 8 days at 300C in a thermostat apparatus. Then the total number of nits on each piece of cloth, as well as that of the nits destroyed (these nits have the shape of a keg and the lid of this keg is not open in the nits destroyed) were determined by counting them. The degree of destruction is expressed as the ratio of the number of slow destroyed to the total number. The results are summarized in Table I below.
TABLEAU I
<tb> <SEP> Solution <SEP> nO <SEP> Nombre <SEP> total <SEP> de <SEP> Lentes <SEP> Mortalité
<tb> <SEP> lentes <SEP> détruites
<tb> <SEP> 1 <SEP> 213 <SEP> 32 <SEP> 15,0
<tb> <SEP> 2 <SEP> 186 <SEP> 96 <SEP> 51,0
<tb> <SEP> 3 <SEP> 197 <SEP> 117 <SEP> 59,4
<tb> <SEP> 4 <SEP> 225 <SEP> 182 <SEP> 80,9
<tb> <SEP> 5 <SEP> 196 <SEP> 191 <SEP> 97,4
<tb> K
<tb>
I1 ressort de ce Tableau qu'aussi bien l'huile de ricin que le stérogénol,améliorent dans une large mesure le degré de destruction obtenu par la perméthrine, mais que l'on obtient cependant l'action optimale lorsque les deux substances à effet de synergie sont mises en oeuvre simultanément.<tb><SEP> Solution <SEP> nO <SEP> Number <SEP> total <SEP> of <SEP> Slow <SEP> Mortality
<tb><SEP> slow <SEP> destroyed
<tb><SEP> 1 <SEP> 213 <SEP> 32 <SEP> 15.0
<tb><SEP> 2 <SEP> 186 <SEP> 96 <SEP> 51.0
<tb><SEP> 3 <SEP> 197 <SEP> 117 <SEP> 59.4
<tb><SEP> 4 <SEP> 225 <SEP> 182 <SEP> 80.9
<tb><SEP> 5 <SEP> 196 <SEP> 191 <SEP> 97.4
<tb> K
<Tb>
It can be seen from this Table that both castor oil and sterogenol greatly improve the degree of destruction achieved by permethrin, but that the optimum effect is obtained when the two synergy are implemented simultaneously.
Lors de l'examen de poux vivants, il a été constaté que les additifs à effet de synergie augmentent également notablement l'action dite "knock-down" des pyréthroides. L'action de "knock-down" a été examinée comme suit : les solutions de 0,1 mg et de 0,033 mg de perméthrine préparées avec 2 ml de méthyléthylcétone, ont été introduites respectivement dans des boites de Pétri polies. D'autre part, des boites de Pétri ont été préparées qui contenaient,'outre la perméthrine, également du stérogénol en quantités différentes. Les rapports perméthrine:stérogénol = 1:0,5 , 1:1 1:2, 1:4 et 1:8 ont été testés. During the examination of live lice, it was found that the synergistic additives also significantly increase the so-called "knock-down" action of the pyrethroids. The "knock-down" action was examined as follows: The solutions of 0.1 mg and 0.033 mg of permethrin, prepared with 2 ml of methyl ethyl ketone, were respectively introduced into polished Petri dishes. On the other hand, Petri dishes were prepared which contained, besides permethrin, also sterogenol in different amounts. The permethrin: sterogenol ratios = 1: 0.5, 1: 1 1: 2, 1: 4 and 1: 8 were tested.
Dans chaque boite de Pétri, on a mis 20 mouches domestiques (musca domestica) et le nombre des mouches tuées a été compté toutes les cinq minutes. A partir du graphique de la mortalité, la valeur de la DK50, c'est-à-dire le temps nécessaire à la destruction de la moitié des mouches, a été déterminée. Chaque essai a été répété à deux reprises. Les résultats sont indiqués dans le Tableau 2 qui va suivre. In each Petri dish, 20 houseflies (Musca domestica) were placed and the number of flies killed was counted every five minutes. From the mortality graph, the value of the DK50, that is the time required to destroy half of the flies, was determined. Each test was repeated twice. The results are shown in Table 2 which follows.
TABLEAU 2 Perméthrine D1t 0 (min) pour un rapport mg/boîte de Pétri 5 perméthrine:stérogénol de
1:0 1:0,5 1:1 1:2 1:4 1:8
1:0 1:0,5 1:1 1:2 1:4 1:8
0,1 10,2 7,7 6,8 8,3 9,4 10,7
0,0333 14,2 11,9 9,5 10,5 12,1 15,3
Il ressort de ce Tableau que le temps de la
DK50 a été considérablement raccourci, ce qui veut dire que
lors de l'addition de stérogénol, l'action de "knock-down"
s'est produite plus tôt. Pour un rapport de 1:1, le temps
aété réduit d'environ 30 %. Le même essai a été fait avec
la décaméthrine à la place de la perméthrine, et les résul
tats ont été analogues.Cela est d'autant plus surprenant
que des essais effectués par la Demanderesse ont montré
que la faible action de "knock-down" de la perméthrine ne
pouvait même pas être augmentée par l'addition d'un deuxiè
me pyréthrolde ayant une bonne action de "knock-down".TABLE 2 Permethrin D1t 0 (min) for a ratio mg / petri dish permethrin: sterogenol of
1: 0 1: 0,5 1: 1 1: 2 1: 4 1: 8
1: 0 1: 0,5 1: 1 1: 2 1: 4 1: 8
0.1 10.2 7.7 6.8 8.3 9.4 10.7
0.0333 14.2 11.9 9.5 10.5 12.1 15.3
It appears from this Table that the time of the
DK50 has been significantly shortened, which means that
when adding sterogenol, the action of "knock-down"
occurred earlier. For a ratio of 1: 1, the time
has been reduced by about 30%. The same test was done with
decamethrin instead of permethrin, and the results
states were similar.This is all the more surprising
that tests carried out by the Applicant have shown
that the weak knock-down action of permethrin does not
could not even be increased by the addition of a second
me pyrethrum with a good "knock-down" action.
Le produit conforme à l'invention a été testé éga
lement par application dans des conditions réelles, c'est-à
dire chez des êtres humains vivant dans un environnement à
poux. Quatre groupes de 66 personnes au total ont été trai
tés. En appliquant une seule fois le produit conforme à
l'Exemple 1 ci-dessous, on a obtenu immédiatement la dispa
rition totale des poux, résultat qui a persisté durant plu
sieurs semaines lorsque les personnes traitées ne se la
vaient pas la tête pendant un certain temps après le trai
tement, bien que les personnes concernées aient vécu dans
un environnement à poux.The product according to the invention has been tested ega
by application in real conditions, ie
say in humans living in an environment to
lice. Four groups of 66 people in total were treated
your. By applying the compliant product once
Example 1 below, immediately obtained the dispa
total lice rition, a result that persisted during
weeks when treated people do not
did not mind for a while after the treatment
although the persons concerned have lived in
a rag environment.
La composition des produits de l'invention est
décrite dans les Exemples qui vont suivre.The composition of the products of the invention is
described in the Examples that follow.
I1 doit être bien entendu, toutefois, que ces exem
ples sont donnés uniquement à titre d'illustration de
l'objet de l'invention, dont ils ne constituent en aucune
manière une limitation. It should be understood, however, that these exem
ples are given solely as an illustration of
the subject of the invention, of which they do not constitute any
way a limitation.
EXEMPLE 1 EXEMPLE 2
Perméthrine techn. 0,5 % Décaméthrine 4,0 %
Huile de ricin 1,0 % Huile d'arachide 10,0 %
Stérogénol 0,6 % Laurylsulfate de
Ethanol à 96 % 54,4 % pyridinium 20,0 %
Isopropanol 25,0 % Ethanol à 96 % 50,0 %
Eau distillée 13,0 % Eau 15 %
Parfum "Bodietta" 0,5 % Composition de
parfum 1 %
EXEMPLE 3
Fenvalérate 1,0 %
Huile de ricin 5,0 %
Monostéarate de
glycérine 10,0 %
Ethanol à 96 % 20,0 %
Isopropanol 25,0 %
Composition de
parfum 1,0 %
Eau distillée 38,0 %
Les préparations peuvent être conservées dans un flacon de couleur foncée et à un endroit frais durant deux années.EXAMPLE 1 EXAMPLE 2
Permethrin techn. 0.5% Decamethrin 4.0%
Castor oil 1.0% Peanut oil 10.0%
Sterolol 0.6% Lauryl sulphate
96% ethanol 54.4% pyridinium 20.0%
Isopropanol 25.0% Ethanol 96% 50.0%
Distilled water 13.0% Water 15%
Perfume "Bodietta" 0,5% Composition of
perfume 1%
EXAMPLE 3
Fenvalerate 1.0%
Castor oil 5.0%
Monostearate
glycerin 10.0%
96% ethanol 20.0%
Isopropanol 25.0%
Composition of
1.0% perfume
Distilled water 38.0%
The preparations can be stored in a dark colored bottle and in a cool place for two years.
Ainsi que cela ressort de ce qui précède, l'invention ne se limite nullement à ceux de ses modes de réalisation et d'application qui viennent d'être décrits de façon plus explicite ; elle en embrasse, au contraire, toutes les variantes qui peuvent venir à l'esprit du technicien en la matière, sans s'écarter du cadre, ni de la portée, de la présente invention. As is apparent from the above, the invention is not limited to those of its embodiments and applications which have just been described more explicitly; it embraces, on the contrary, all the variants that may come to the mind of the technician in the field, without departing from the scope or scope of the present invention.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU80430A HU182802B (en) | 1980-02-26 | 1980-02-26 | Fotostabil delousing (insecticide) composition containing synthetic piretroides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2476486A1 true FR2476486A1 (en) | 1981-08-28 |
| FR2476486B1 FR2476486B1 (en) | 1984-11-23 |
Family
ID=10949564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8103379A Granted FR2476486A1 (en) | 1980-02-26 | 1981-02-20 | LICE DESTRUCTION PRODUCT |
Country Status (12)
| Country | Link |
|---|---|
| AT (1) | AT372244B (en) |
| BE (1) | BE887600A (en) |
| CH (1) | CH647650A5 (en) |
| CS (1) | CS226422B2 (en) |
| DD (1) | DD156511A5 (en) |
| DE (1) | DE3107129A1 (en) |
| FR (1) | FR2476486A1 (en) |
| GB (1) | GB2072013B (en) |
| HU (1) | HU182802B (en) |
| NL (1) | NL8100876A (en) |
| PL (1) | PL125709B1 (en) |
| RO (1) | RO81516B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3208334A1 (en) * | 1982-03-09 | 1983-09-15 | Bayer Ag, 5090 Leverkusen | PESTICIDE POUR-ON FORMULATIONS |
| DE3208333A1 (en) * | 1982-03-09 | 1983-09-15 | Bayer Ag, 5090 Leverkusen | PESTICIDAL FORMULATIONS |
| EP0121363B1 (en) * | 1983-03-31 | 1989-05-31 | T And R Chemicals, Inc. | Pyrethroid-containing pharmaceutical compositions |
| AU596867B2 (en) * | 1986-09-29 | 1990-05-17 | Del Laboratories, Inc. | Pediculicidal/ovicidal shampoo composition |
| DE19528529A1 (en) * | 1995-08-03 | 1997-02-06 | Bayer Ag | Pesticides |
| CN115968876A (en) * | 2023-01-12 | 2023-04-18 | 中山榄菊日化实业有限公司 | Long-acting insecticidal ultra-low volume liquid and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2357177A1 (en) * | 1976-07-06 | 1978-02-03 | Inchcape Chemco Ltd | PESTICIDE COMPOSITIONS BASED ON PYRETHROIDS, ESSENCE OF PEPPER, ESSENCE OF EUCALYPTUS AND GERANIOL |
| GB2012585A (en) * | 1977-12-20 | 1979-08-01 | Ici Ltd | Insecticides |
| EP0006630A1 (en) * | 1978-07-03 | 1980-01-09 | Ciba-Geigy Ag | Alpha-phenyl-alpha-cyclopropane acetic acid esters, process for their preparation and their use as insecticides |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB660131A (en) * | 1947-09-18 | 1951-10-31 | Mckesson & Robbins Inc | Parasiticidal lotions |
| US3492402A (en) * | 1967-02-01 | 1970-01-27 | Mclaughlin Gormley King Co | Pyrethroid insecticidal compositions containing an emulsifier and a bacterio-fungistat |
| US3864388A (en) * | 1970-12-29 | 1975-02-04 | Sumitomo Chemical Co | Alkynyl esters of {60 -alkoxy-{60 -phenyl alkenoic acid |
| GB1511646A (en) * | 1974-05-08 | 1978-05-24 | Wellcome Found | Method for insecticide use |
| US3966959A (en) * | 1975-02-13 | 1976-06-29 | American Cyanamid Company | Insecticidal and acaricidal, pyrethroid compounds |
| FR2341307A1 (en) * | 1976-02-19 | 1977-09-16 | Roussel Uclaf | PYRETHRINOIDS FOR MEDICINAL PRODUCTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| SE446527B (en) * | 1976-09-21 | 1986-09-22 | Roussel Uclaf | NEW CYCLOPROPANCARBOXYLIC ACID ESTERS WITH A POLYHALOGENATED SUBSTITUENT, SET FOR PREPARATION OF IT AND USE thereof IN PESTICIDE COMPOSITIONS |
| GB1591105A (en) * | 1976-12-24 | 1981-06-17 | Wellcome Found | Pest control |
| GB1591106A (en) * | 1976-12-24 | 1981-06-17 | Wellcome Found | Pest control |
| FR2377198A2 (en) * | 1977-01-13 | 1978-08-11 | Roussel Uclaf | Compsns. for topical treatment of cattle scabies - contg. an ester of 2,2-di:methyl 3-substd. vinyl cyclopropane carboxylic acid |
| DE2704066A1 (en) * | 1977-02-01 | 1978-08-03 | Neudorff & Co Chem Fab W | Insecticidal combinations of permethrin and pyrethroid(s) - for general use, having fast activity |
| GB1602971A (en) * | 1977-03-11 | 1981-11-18 | Wellcome Found | Synergistic pesticidal compositions |
| GB2021416A (en) * | 1978-05-16 | 1979-12-05 | Wellcome Found | Pest control |
| DE2844271A1 (en) * | 1978-10-11 | 1980-04-24 | Bayer Ag | 3-CHLOROSTYRYL-2,2-DIMETHYL-CYCLOPROPANCARBONIC ACID (4-FLUORO-3-PHENOXY-ALPHA-CYANO-BENZYL) -ESTER, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS EECTOPARASITICIDES |
| FR2484256B1 (en) * | 1979-06-29 | 1986-10-24 | Roussel Uclaf | METHOD FOR CONTROLLING PEST OF HOT BLOOD ANIMALS |
| IT1123122B (en) * | 1979-09-12 | 1986-04-30 | Montedison Spa | INSECTICIDE LIQUID COMPOSITIONS CONTAINING SYNTHETIC PYRETROIDS |
-
1980
- 1980-02-26 HU HU80430A patent/HU182802B/en unknown
-
1981
- 1981-02-18 AT AT0073481A patent/AT372244B/en not_active IP Right Cessation
- 1981-02-20 FR FR8103379A patent/FR2476486A1/en active Granted
- 1981-02-20 BE BE1/10146A patent/BE887600A/en not_active IP Right Cessation
- 1981-02-20 GB GB8105466A patent/GB2072013B/en not_active Expired
- 1981-02-23 NL NL8100876A patent/NL8100876A/en not_active Application Discontinuation
- 1981-02-24 PL PL1981229837A patent/PL125709B1/en unknown
- 1981-02-24 DD DD81227835A patent/DD156511A5/en not_active IP Right Cessation
- 1981-02-25 CH CH1259/81A patent/CH647650A5/en unknown
- 1981-02-25 RO RO103518A patent/RO81516B/en unknown
- 1981-02-25 CS CS811351A patent/CS226422B2/en unknown
- 1981-02-26 DE DE19813107129 patent/DE3107129A1/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2357177A1 (en) * | 1976-07-06 | 1978-02-03 | Inchcape Chemco Ltd | PESTICIDE COMPOSITIONS BASED ON PYRETHROIDS, ESSENCE OF PEPPER, ESSENCE OF EUCALYPTUS AND GERANIOL |
| GB2012585A (en) * | 1977-12-20 | 1979-08-01 | Ici Ltd | Insecticides |
| EP0006630A1 (en) * | 1978-07-03 | 1980-01-09 | Ciba-Geigy Ag | Alpha-phenyl-alpha-cyclopropane acetic acid esters, process for their preparation and their use as insecticides |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2072013B (en) | 1984-11-07 |
| ATA73481A (en) | 1983-02-15 |
| DE3107129A1 (en) | 1981-12-24 |
| AT372244B (en) | 1983-09-12 |
| CS226422B2 (en) | 1984-03-19 |
| DD156511A5 (en) | 1982-09-01 |
| RO81516B (en) | 1983-04-30 |
| GB2072013A (en) | 1981-09-30 |
| HU182802B (en) | 1984-03-28 |
| FR2476486B1 (en) | 1984-11-23 |
| BE887600A (en) | 1981-08-20 |
| PL125709B1 (en) | 1983-06-30 |
| PL229837A1 (en) | 1981-11-13 |
| RO81516A (en) | 1983-04-29 |
| CH647650A5 (en) | 1985-02-15 |
| NL8100876A (en) | 1981-09-16 |
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| ST | Notification of lapse |