FR2475737A1 - Perfectionnements apportes aux procedes de conservation d'hematies par lyophilisation en vue de leur utilisation dans des reactions d'hemagglutination et hematies non agglutinables spontanement obtenues par ce procede - Google Patents
Perfectionnements apportes aux procedes de conservation d'hematies par lyophilisation en vue de leur utilisation dans des reactions d'hemagglutination et hematies non agglutinables spontanement obtenues par ce procede Download PDFInfo
- Publication number
- FR2475737A1 FR2475737A1 FR8002658A FR8002658A FR2475737A1 FR 2475737 A1 FR2475737 A1 FR 2475737A1 FR 8002658 A FR8002658 A FR 8002658A FR 8002658 A FR8002658 A FR 8002658A FR 2475737 A1 FR2475737 A1 FR 2475737A1
- Authority
- FR
- France
- Prior art keywords
- red blood
- aldehyde
- blood cells
- specific protein
- tannin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000035931 haemagglutination Effects 0.000 title claims abstract description 15
- 238000004108 freeze drying Methods 0.000 title claims abstract description 12
- 210000003743 erythrocyte Anatomy 0.000 title claims description 61
- 238000011282 treatment Methods 0.000 title claims description 24
- 238000004321 preservation Methods 0.000 title description 5
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract description 48
- 150000001299 aldehydes Chemical class 0.000 claims abstract description 28
- 210000004369 blood Anatomy 0.000 claims abstract description 17
- 239000008280 blood Substances 0.000 claims abstract description 17
- 230000008569 process Effects 0.000 claims abstract description 16
- 238000006243 chemical reaction Methods 0.000 claims abstract description 14
- 239000003146 anticoagulant agent Substances 0.000 claims abstract description 5
- 229940127090 anticoagulant agent Drugs 0.000 claims abstract description 3
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 3
- 239000000427 antigen Substances 0.000 claims description 44
- 102000036639 antigens Human genes 0.000 claims description 44
- 108091007433 antigens Proteins 0.000 claims description 44
- 229920001864 tannin Polymers 0.000 claims description 25
- 239000001648 tannin Substances 0.000 claims description 25
- 235000018553 tannin Nutrition 0.000 claims description 25
- 238000010790 dilution Methods 0.000 claims description 21
- 239000012895 dilution Substances 0.000 claims description 21
- 108090000623 proteins and genes Proteins 0.000 claims description 20
- 102000004169 proteins and genes Human genes 0.000 claims description 19
- 210000004027 cell Anatomy 0.000 claims description 13
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 12
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 11
- 239000008363 phosphate buffer Substances 0.000 claims description 10
- 230000003612 virological effect Effects 0.000 claims description 9
- 238000005119 centrifugation Methods 0.000 claims description 8
- 239000003153 chemical reaction reagent Substances 0.000 claims description 8
- 206010070834 Sensitisation Diseases 0.000 claims description 7
- 239000000872 buffer Substances 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 230000008313 sensitization Effects 0.000 claims description 7
- 238000004448 titration Methods 0.000 claims description 7
- 238000012360 testing method Methods 0.000 claims description 6
- 238000005406 washing Methods 0.000 claims description 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 5
- 238000010257 thawing Methods 0.000 claims description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
- 230000001580 bacterial effect Effects 0.000 claims description 4
- 239000008101 lactose Substances 0.000 claims description 4
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 3
- 244000045947 parasite Species 0.000 claims description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 239000007853 buffer solution Substances 0.000 claims description 2
- 241001529453 unidentified herpesvirus Species 0.000 claims description 2
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 229940121357 antivirals Drugs 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 230000003071 parasitic effect Effects 0.000 claims 1
- 101150081424 grm gene Proteins 0.000 description 18
- 210000002966 serum Anatomy 0.000 description 15
- 239000000243 solution Substances 0.000 description 9
- 239000000203 mixture Substances 0.000 description 7
- 230000004520 agglutination Effects 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 4
- 239000008188 pellet Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241001494479 Pecora Species 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 230000002269 spontaneous effect Effects 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 2
- 102000018634 MRG Human genes 0.000 description 2
- 108050007760 MRG Proteins 0.000 description 2
- AIJULSRZWUXGPQ-UHFFFAOYSA-N Methylglyoxal Chemical compound CC(=O)C=O AIJULSRZWUXGPQ-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- -1 aliphatic aldehyde Chemical class 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 230000000890 antigenic effect Effects 0.000 description 2
- 101150038956 cup-4 gene Proteins 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Inorganic materials [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 208000034530 PLAA-associated neurodevelopmental disease Diseases 0.000 description 1
- 101710162991 PRKC apoptosis WT1 regulator protein Proteins 0.000 description 1
- 102100040853 PRKC apoptosis WT1 regulator protein Human genes 0.000 description 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000120 cytopathologic effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000008098 formaldehyde solution Substances 0.000 description 1
- RFMVISMHEXLWPW-UHFFFAOYSA-N formaldehyde;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound O=C.OC(=O)CC(O)(C(O)=O)CC(O)=O RFMVISMHEXLWPW-UHFFFAOYSA-N 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 238000002552 multiple reaction monitoring Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2496/00—Reference solutions for assays of biological material
- G01N2496/05—Reference solutions for assays of biological material containing blood cells or plasma
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Dentistry (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8002658A FR2475737A1 (fr) | 1980-02-07 | 1980-02-07 | Perfectionnements apportes aux procedes de conservation d'hematies par lyophilisation en vue de leur utilisation dans des reactions d'hemagglutination et hematies non agglutinables spontanement obtenues par ce procede |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8002658A FR2475737A1 (fr) | 1980-02-07 | 1980-02-07 | Perfectionnements apportes aux procedes de conservation d'hematies par lyophilisation en vue de leur utilisation dans des reactions d'hemagglutination et hematies non agglutinables spontanement obtenues par ce procede |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2475737A1 true FR2475737A1 (fr) | 1981-08-14 |
| FR2475737B1 FR2475737B1 (enrdf_load_stackoverflow) | 1984-10-05 |
Family
ID=9238308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8002658A Granted FR2475737A1 (fr) | 1980-02-07 | 1980-02-07 | Perfectionnements apportes aux procedes de conservation d'hematies par lyophilisation en vue de leur utilisation dans des reactions d'hemagglutination et hematies non agglutinables spontanement obtenues par ce procede |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2475737A1 (enrdf_load_stackoverflow) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0296874A1 (en) * | 1987-06-25 | 1988-12-28 | Fisher Scientific Company | Hematology control or calibrator with red cell components of enhanced stability |
| EP0851231A1 (de) * | 1996-12-23 | 1998-07-01 | Albrecht Prof. Dr. Wendel | Verwendung von tiefgefrorenem Blut für biologische Untersuchungsverfahren |
| EP1425383A4 (en) * | 2001-08-23 | 2005-11-09 | Immunivest Corp | STABILIZATION OF CELLS AND BIOLOGICAL PREPARATIONS FOR ANALYSIS |
| US7951590B2 (en) * | 1999-06-02 | 2011-05-31 | Mg Pharmacy Ltd. | Storage agent for preservation of an animal cell, tissue or organ, and preserved process of the same |
| CN115399314A (zh) * | 2022-11-01 | 2022-11-29 | 天津德祥生物技术股份有限公司 | 一种能冻干保存的人abo血型反定型红细胞及保存方法 |
| US11604026B2 (en) | 2019-03-14 | 2023-03-14 | Terumo Bct Biotechnologies, Llc | Lyophilization loading tray assembly and system |
| US11634257B2 (en) | 2017-10-09 | 2023-04-25 | Terumo Bct Biotechnologies, Llc | Lyophilization container and method of using same |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1360485A (fr) * | 1962-02-05 | 1964-05-08 | Wellcome Found | Production de réactifs immunologiques destinés aux essais d'hémoagglutination |
| FR1521350A (fr) * | 1965-09-10 | 1968-04-19 | Princeton Lab | Détection de la mononucléose |
| FR1592231A (enrdf_load_stackoverflow) * | 1967-11-13 | 1970-05-11 | ||
| FR2043696A6 (enrdf_load_stackoverflow) * | 1969-05-27 | 1971-02-19 | Abbott Lab | |
| FR2291496A1 (fr) * | 1974-11-16 | 1976-06-11 | Mochida Pharm Co Ltd | Support pour mesures immunochimiques |
-
1980
- 1980-02-07 FR FR8002658A patent/FR2475737A1/fr active Granted
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1360485A (fr) * | 1962-02-05 | 1964-05-08 | Wellcome Found | Production de réactifs immunologiques destinés aux essais d'hémoagglutination |
| FR1521350A (fr) * | 1965-09-10 | 1968-04-19 | Princeton Lab | Détection de la mononucléose |
| FR1592231A (enrdf_load_stackoverflow) * | 1967-11-13 | 1970-05-11 | ||
| FR2043696A6 (enrdf_load_stackoverflow) * | 1969-05-27 | 1971-02-19 | Abbott Lab | |
| FR2291496A1 (fr) * | 1974-11-16 | 1976-06-11 | Mochida Pharm Co Ltd | Support pour mesures immunochimiques |
Non-Patent Citations (1)
| Title |
|---|
| EXBK/57 * |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0296874A1 (en) * | 1987-06-25 | 1988-12-28 | Fisher Scientific Company | Hematology control or calibrator with red cell components of enhanced stability |
| EP0851231A1 (de) * | 1996-12-23 | 1998-07-01 | Albrecht Prof. Dr. Wendel | Verwendung von tiefgefrorenem Blut für biologische Untersuchungsverfahren |
| US9784753B2 (en) | 1996-12-23 | 2017-10-10 | Albrecht Wendel | Biological system to test in vitro if a substance is immune reactive |
| US7951590B2 (en) * | 1999-06-02 | 2011-05-31 | Mg Pharmacy Ltd. | Storage agent for preservation of an animal cell, tissue or organ, and preserved process of the same |
| EP1425383A4 (en) * | 2001-08-23 | 2005-11-09 | Immunivest Corp | STABILIZATION OF CELLS AND BIOLOGICAL PREPARATIONS FOR ANALYSIS |
| US11634257B2 (en) | 2017-10-09 | 2023-04-25 | Terumo Bct Biotechnologies, Llc | Lyophilization container and method of using same |
| US11604026B2 (en) | 2019-03-14 | 2023-03-14 | Terumo Bct Biotechnologies, Llc | Lyophilization loading tray assembly and system |
| US11609043B2 (en) | 2019-03-14 | 2023-03-21 | Terumo Bct Biotechnologies, Llc | Lyophilization container fill fixture, system and method of use |
| US11609042B2 (en) | 2019-03-14 | 2023-03-21 | Terumo Bct Biotechnologies, Llc | Multi-part lyophilization container and method of use |
| US11740019B2 (en) | 2019-03-14 | 2023-08-29 | Terumo Bct Biotechnologies, Llc | Lyophilization loading tray assembly and system |
| US11747082B2 (en) | 2019-03-14 | 2023-09-05 | Terumo Bct Biotechnologies, Llc | Multi-part lyophilization container and method of use |
| US11815311B2 (en) | 2019-03-14 | 2023-11-14 | Terumo Bct Biotechnologies, Llc | Lyophilization container fill fixture, system and method of use |
| US11994343B2 (en) | 2019-03-14 | 2024-05-28 | Terumo Bct Biotechnologies, Llc | Multi-part lyophilization container and method of use |
| CN115399314A (zh) * | 2022-11-01 | 2022-11-29 | 天津德祥生物技术股份有限公司 | 一种能冻干保存的人abo血型反定型红细胞及保存方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2475737B1 (enrdf_load_stackoverflow) | 1984-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |