FR2460947A1 - Nouveau derives n-substitues du tetrahydropyridinyl-indole, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant - Google Patents

Nouveau derives n-substitues du tetrahydropyridinyl-indole, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant Download PDF

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Publication number
FR2460947A1
FR2460947A1 FR7918217A FR7918217A FR2460947A1 FR 2460947 A1 FR2460947 A1 FR 2460947A1 FR 7918217 A FR7918217 A FR 7918217A FR 7918217 A FR7918217 A FR 7918217A FR 2460947 A1 FR2460947 A1 FR 2460947A1
Authority
FR
France
Prior art keywords
carbon atoms
formula
radical
alkyl radical
addition salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7918217A
Other languages
English (en)
French (fr)
Other versions
FR2460947B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Jacques Guillaume
Lucien Nedelec
Claude Dumont
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7918217A priority Critical patent/FR2460947A1/fr
Priority to SE8004129A priority patent/SE8004129L/xx
Priority to HU801535A priority patent/HU184791B/hu
Priority to HU801536A priority patent/HU184792B/hu
Priority to ZA00803793A priority patent/ZA803793B/xx
Priority to ZA00803789A priority patent/ZA803789B/xx
Priority to US06/163,967 priority patent/US4333939A/en
Priority to US06/163,966 priority patent/US4324790A/en
Priority to DE8080401005T priority patent/DE3062614D1/de
Priority to AT80401005T priority patent/ATE2954T1/de
Priority to EP80401005A priority patent/EP0022705B1/fr
Priority to GB8022010A priority patent/GB2055815B/en
Priority to IT49229/80A priority patent/IT1148265B/it
Priority to CA000356009A priority patent/CA1145752A/fr
Priority to ES493308A priority patent/ES8107213A1/es
Priority to CA000356010A priority patent/CA1146559A/fr
Priority to PT71550A priority patent/PT71550B/pt
Priority to SU802947298A priority patent/SU936813A3/ru
Priority to IE1456/80A priority patent/IE50067B1/en
Priority to JP9408280A priority patent/JPS5615282A/ja
Priority to IE1457/80A priority patent/IE50006B1/en
Priority to PT71549A priority patent/PT71549B/pt
Priority to BE0/201379A priority patent/BE884279A/fr
Priority to LU82614A priority patent/LU82614A1/fr
Priority to CH5360/80A priority patent/CH653332A5/fr
Priority to DK300180A priority patent/DK152048C/da
Priority to DE19803026365 priority patent/DE3026365A1/de
Priority to NL8004011A priority patent/NL8004011A/nl
Priority to DK300280A priority patent/DK300280A/da
Priority to AU60360/80A priority patent/AU534606B2/en
Priority to JP9408380A priority patent/JPS5615283A/ja
Priority to AU60359/80A priority patent/AU535197B2/en
Priority to ES493311A priority patent/ES8107214A1/es
Priority to AT0365280A priority patent/AT374196B/de
Publication of FR2460947A1 publication Critical patent/FR2460947A1/fr
Application granted granted Critical
Publication of FR2460947B1 publication Critical patent/FR2460947B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
FR7918217A 1979-07-13 1979-07-13 Nouveau derives n-substitues du tetrahydropyridinyl-indole, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant Granted FR2460947A1 (fr)

Priority Applications (34)

Application Number Priority Date Filing Date Title
FR7918217A FR2460947A1 (fr) 1979-07-13 1979-07-13 Nouveau derives n-substitues du tetrahydropyridinyl-indole, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
SE8004129A SE8004129L (sv) 1979-07-13 1980-06-03 Nya tetrahydropyridin-4-yl-indolderivat samt salter derav, framstellning och anvendning derav sasom lekemedel samt kompositioner innehallande dessa foreningar
HU801536A HU184792B (en) 1979-07-13 1980-06-20 Process for producing tetrahydropyridyl-indol derivatives
HU801535A HU184791B (en) 1979-07-13 1980-06-20 Process for preparing derivatives of tetrahydro-pyrid-4-yl-indole
ZA00803793A ZA803793B (en) 1979-07-13 1980-06-25 Derivatives of tetrahydropyrid-4-yl-indole and their salts, their preparation, their ise as medicaments and the compositions containing them
ZA00803789A ZA803789B (en) 1979-07-13 1980-06-25 Process for preparing new derivatives of tetrahydropyridinyl indoles and their salts
US06/163,967 US4333939A (en) 1979-07-13 1980-06-30 Tetrahydropyridinyl-indoles
US06/163,966 US4324790A (en) 1979-07-13 1980-06-30 Antipsychotic tetrahydropyridinyl-indoles, compositions and method of use
DE8080401005T DE3062614D1 (en) 1979-07-13 1980-07-02 Derivatives of tetrahydropyridinyl-indol and their salts, their preparation, their application as medicines, and compositions containing them
AT80401005T ATE2954T1 (de) 1979-07-13 1980-07-02 Tetrahydropyridinyl-indol-derivate und ihre salze, ihre herstellung, ihre anwendung als arzneimittel und sie enthaltende zusammensetzungen.
EP80401005A EP0022705B1 (fr) 1979-07-13 1980-07-02 Nouveaux dérivés du tétrahydropyridinyl-indole et leurs sels, leur préparation, leur application comme médicaments et les compositions les renfermant
GB8022010A GB2055815B (en) 1979-07-13 1980-07-04 Indoles
DK300180A DK152048C (da) 1979-07-13 1980-07-11 Analogifremgangsmaade til fremstilling af n-substituerede tetrahydropyridinylindolderivater eller farmaceutisk acceptable salte deraf.
ES493308A ES8107213A1 (es) 1979-07-13 1980-07-11 Procedimiento de preparacion de nuevos derivados n-sustitui-dos de tetrahidropiridinil-indol
CA000356010A CA1146559A (fr) 1979-07-13 1980-07-11 Procede de preparation de nouveaux derives du tetrahydropyridin-4-yl indole et de leurs sels
PT71550A PT71550B (fr) 1979-07-13 1980-07-11 Procede de preparation de nouveaux derives du tetrahydropyridin-4-yl-indole et de leurs sels
IT49229/80A IT1148265B (it) 1979-07-13 1980-07-11 Tetraidropiridin-4-il indolo e loro sali procedimento per la loro preparazione loro impiego come medicamenti e composizioni che li contengono
IE1456/80A IE50067B1 (en) 1979-07-13 1980-07-11 New derivatives of tetrahydropyridinylindole and their salts,processes for their preparation and compositions containing them
JP9408280A JPS5615282A (en) 1979-07-13 1980-07-11 Tetrahydropyridylindole novel derivatives* their salt* these manufacture* use as drug and composition containing same
IE1457/80A IE50006B1 (en) 1979-07-13 1980-07-11 Derivatives of tetrahydropyrid-4-yl-indole
PT71549A PT71549B (fr) 1979-07-13 1980-07-11 Procede de preparation de nouveaux derives du tetrahydropropy- ridinyl-indole et de leurs sels
BE0/201379A BE884279A (fr) 1979-07-13 1980-07-11 Nouveaux derives du tetrahydropyridin-4-yl indole et leurs sels, leur preparation, leur application comme medicaments et les compositions les renfermant
LU82614A LU82614A1 (fr) 1979-07-13 1980-07-11 Nouveaux derives du tetrahydropyridin-4-yl indole et leurs sels,leur preparation,leur application comme medicaments et les compositions les renfermant
CH5360/80A CH653332A5 (fr) 1979-07-13 1980-07-11 Derives du tetrahydropyridin-4-yl indole et leurs sels, leur preparation et les medicaments les renfermant.
CA000356009A CA1145752A (fr) 1979-07-13 1980-07-11 Procede de preparation de nouveaux derives du n'tetrahydropyridinyl-indoles et de leurs sels
DE19803026365 DE3026365A1 (de) 1979-07-13 1980-07-11 Neue tetrahydropyridin-4-yl-indol- derivate und deren salze, ihre herstellung, ihre verwendung als arzneimittel und die sie enthaltenden zusammensetzungen
NL8004011A NL8004011A (nl) 1979-07-13 1980-07-11 Tetrahydropyridin-4-ylindoolderivaten.
DK300280A DK300280A (da) 1979-07-13 1980-07-11 Fremgangsmaade til fremstilling af tetrahydropyridin-4-ylindolderivater eller salte deraf
AU60360/80A AU534606B2 (en) 1979-07-13 1980-07-11 Tetrahydro pyrid-4-yl-indole derivatives
JP9408380A JPS5615283A (en) 1979-07-13 1980-07-11 Tetrahydropyridylindole novel derivatives* their salt* these manufacture* use as drug and composition containing same
AU60359/80A AU535197B2 (en) 1979-07-13 1980-07-11 Tetrahydropyridyl - indole derivatives
ES493311A ES8107214A1 (es) 1979-07-13 1980-07-11 Procedimiento de preparacion de nuevos derivados de tetrahi-dropiridin-4-il-indol
SU802947298A SU936813A3 (ru) 1979-07-13 1980-07-11 Способ получени производных тетрагидропиридинилиндола или их солей с кислотами
AT0365280A AT374196B (de) 1979-07-13 1980-07-14 Verfahren zur herstellung neuer derivate des tetrahydropyridin-4-yl indols und ihrer salze

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7918217A FR2460947A1 (fr) 1979-07-13 1979-07-13 Nouveau derives n-substitues du tetrahydropyridinyl-indole, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant

Publications (2)

Publication Number Publication Date
FR2460947A1 true FR2460947A1 (fr) 1981-01-30
FR2460947B1 FR2460947B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1981-07-10

Family

ID=9227845

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7918217A Granted FR2460947A1 (fr) 1979-07-13 1979-07-13 Nouveau derives n-substitues du tetrahydropyridinyl-indole, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant

Country Status (16)

Country Link
US (1) US4324790A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0022705B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JPS5615282A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE2954T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU535197B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE884279A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1145752A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3062614D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK152048C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (2) ES8107213A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2460947A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU184792B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE50067B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT71549B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SU (1) SU936813A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (2) ZA803793B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2533924A1 (fr) * 1982-10-05 1984-04-06 Roussel Uclaf Nouveaux derives du 4-(1h-indol-3-yl)a-methyl piperidine-1-ethanol, leurs sels, le procede de preparation, l'application a titre de medicaments et les compositions les renfermant
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
US4742057A (en) * 1985-12-05 1988-05-03 Fujisawa Pharmaceutical Co., Ltd. Antiallergic thiazole compounds
US5214059A (en) * 1989-07-03 1993-05-25 Hoechst-Roussel Pharmaceuticals Incorporated 2-(aminoaryl) indoles and indolines as topical antiinflammatory agents for the treatment of skin disorders
US5846982A (en) * 1996-06-14 1998-12-08 Eli Lilly And Company Inhibition of serotonin reuptake
US7375219B2 (en) * 2005-04-13 2008-05-20 Neuraxon, Inc. Substituted indole compounds having NOS inhibitory activity
CN101466709B (zh) * 2006-04-13 2013-03-20 轴突公司 具有nos抑制活性的1,5和3,6-取代的吲哚化合物
EP2220074A4 (en) * 2007-11-16 2012-01-04 Neuraxon Inc 3,5-SUBSTITUTED INDOL COMPOUNDS WITH NOS AND NOREPINEPHRINE RECOVERY-HEMDERING EFFECT
AU2008323526A1 (en) * 2007-11-16 2009-05-22 Neuraxon, Inc. Indole compounds and methods for treating visceral pain
WO2009064505A1 (en) * 2007-11-16 2009-05-22 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods for treating visceral pain

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2193584B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1972-07-28 1975-08-08 Roussel Uclaf
DE2322470A1 (de) 1973-05-04 1974-11-21 Boehringer Sohn Ingelheim Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung
IL48508A (en) * 1974-12-09 1979-10-31 Roussel Uclaf Pharmaceutical compositions comprising piperidylindole derivatives
FR2362628A1 (fr) * 1976-08-26 1978-03-24 Roussel Uclaf Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments
SU639243A1 (ru) * 1976-12-27 1979-11-25 Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвийской Сср 1-/4-(4-Фторфенил)-4-оксибутил/ -4- (индолил-31)-1,2,3,6-тетрагидропиридин или его соли, обладающие психотропными свойствами
FR2444678A2 (fr) * 1978-12-22 1980-07-18 Roussel Uclaf Nouveau procede de preparation de derives du piperidyl-indole et de leurs sels

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/75 *

Also Published As

Publication number Publication date
JPS5615283A (en) 1981-02-14
EP0022705A1 (fr) 1981-01-21
PT71549A (fr) 1980-08-01
ZA803789B (en) 1981-06-24
JPS5615282A (en) 1981-02-14
DE3062614D1 (en) 1983-05-11
JPS6351154B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1988-10-13
ZA803793B (en) 1981-06-24
AU6035980A (en) 1981-01-15
PT71549B (fr) 1981-12-14
FR2460947B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1981-07-10
US4324790A (en) 1982-04-13
ES493308A0 (es) 1981-08-16
IE50067B1 (en) 1986-02-05
AU535197B2 (en) 1984-03-08
JPS6348872B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1988-09-30
ES8107213A1 (es) 1981-08-16
DK152048C (da) 1988-10-10
ES493311A0 (es) 1981-08-16
ES8107214A1 (es) 1981-08-16
HU184792B (en) 1984-10-29
SU936813A3 (ru) 1982-06-15
DK152048B (da) 1988-01-25
DK300180A (da) 1981-01-14
CA1145752A (fr) 1983-05-03
ATE2954T1 (de) 1983-04-15
BE884279A (fr) 1981-01-12
EP0022705B1 (fr) 1983-04-06
IE801456L (en) 1981-01-13

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