FR2455039B1 - - Google Patents

Info

Publication number
FR2455039B1
FR2455039B1 FR7910653A FR7910653A FR2455039B1 FR 2455039 B1 FR2455039 B1 FR 2455039B1 FR 7910653 A FR7910653 A FR 7910653A FR 7910653 A FR7910653 A FR 7910653A FR 2455039 B1 FR2455039 B1 FR 2455039B1
Authority
FR
France
Prior art keywords
alkyl
cycloalkyl
formula
pyrimido
anoxia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7910653A
Other languages
English (en)
French (fr)
Other versions
FR2455039A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7910653A priority Critical patent/FR2455039A1/fr
Priority to NO794271A priority patent/NO794271L/no
Priority to JP300380A priority patent/JPS55145689A/ja
Priority to EP80400050A priority patent/EP0018857B1/fr
Priority to US06/112,238 priority patent/US4358451A/en
Priority to GR60963A priority patent/GR74394B/el
Priority to ES487713A priority patent/ES487713A1/es
Priority to AU54630/80A priority patent/AU528634B2/en
Priority to DK16980A priority patent/DK16980A/da
Priority to ZA00800242A priority patent/ZA80242B/xx
Priority to IL59128A priority patent/IL59128A/xx
Priority to DE8080400050T priority patent/DE3061648D1/de
Priority to PT70698A priority patent/PT70698A/pt
Priority to AT80400050T priority patent/ATE2253T1/de
Priority to CA343,698A priority patent/CA1129854A/en
Publication of FR2455039A1 publication Critical patent/FR2455039A1/fr
Application granted granted Critical
Publication of FR2455039B1 publication Critical patent/FR2455039B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FR7910653A 1979-04-26 1979-04-26 Pyrimido et imidazo-pyrido-indole-diones et leur application en therapeutique Granted FR2455039A1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
FR7910653A FR2455039A1 (fr) 1979-04-26 1979-04-26 Pyrimido et imidazo-pyrido-indole-diones et leur application en therapeutique
NO794271A NO794271L (no) 1979-04-26 1979-12-27 Fremgangsmaate for fremstilling av indol-dioner
JP300380A JPS55145689A (en) 1979-04-26 1980-01-14 Pyrimidoo and imidazoopyridoindole derivative
IL59128A IL59128A (en) 1979-04-26 1980-01-15 Pyrimido-and imidazo-pyrido-indoledione derivatives,their preparation and pharmaceutical compositions containing them
GR60963A GR74394B (show.php) 1979-04-26 1980-01-15
ES487713A ES487713A1 (es) 1979-04-26 1980-01-15 Procedimiento para preparar derivados de pirimido e imida- zo-pirido-indoles
AU54630/80A AU528634B2 (en) 1979-04-26 1980-01-15 Pyrimido- and imidazo-pyroindole derivatives
DK16980A DK16980A (da) 1979-04-26 1980-01-15 Fremgangsmaade til fremstilling af derivater af pyrido og imidazopyridoindoler
EP80400050A EP0018857B1 (fr) 1979-04-26 1980-01-15 Pyrimido et imidazo-pyrido-indole-diones, leur préparation et leur application en thérapeutique
US06/112,238 US4358451A (en) 1979-04-26 1980-01-15 Pyrimido- and imidazo-pyridoindole derivatives
DE8080400050T DE3061648D1 (en) 1979-04-26 1980-01-15 Pyrimido and imidazo-pyrido-indole-diones, their preparation and therapeutic use
PT70698A PT70698A (fr) 1979-04-26 1980-01-15 Procede de preparation de pyrimid et imidazo-pyrido-indolediones
AT80400050T ATE2253T1 (de) 1979-04-26 1980-01-15 Pyrimido und imidazo-pyrido-indol-dione, ihre herstellung und therapeutische verwendung.
CA343,698A CA1129854A (en) 1979-04-26 1980-01-15 Process for the preparation of pyrimido- and imidazo derivatives
ZA00800242A ZA80242B (en) 1979-04-26 1980-01-15 Pyrimido-and imidazo-pyridoindole derivatives for use in therapy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7910653A FR2455039A1 (fr) 1979-04-26 1979-04-26 Pyrimido et imidazo-pyrido-indole-diones et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2455039A1 FR2455039A1 (fr) 1980-11-21
FR2455039B1 true FR2455039B1 (show.php) 1983-05-13

Family

ID=9224796

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7910653A Granted FR2455039A1 (fr) 1979-04-26 1979-04-26 Pyrimido et imidazo-pyrido-indole-diones et leur application en therapeutique

Country Status (15)

Country Link
US (1) US4358451A (show.php)
EP (1) EP0018857B1 (show.php)
JP (1) JPS55145689A (show.php)
AT (1) ATE2253T1 (show.php)
AU (1) AU528634B2 (show.php)
CA (1) CA1129854A (show.php)
DE (1) DE3061648D1 (show.php)
DK (1) DK16980A (show.php)
ES (1) ES487713A1 (show.php)
FR (1) FR2455039A1 (show.php)
GR (1) GR74394B (show.php)
IL (1) IL59128A (show.php)
NO (1) NO794271L (show.php)
PT (1) PT70698A (show.php)
ZA (1) ZA80242B (show.php)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3246932A1 (de) * 1982-12-16 1984-06-20 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte 5h-pyrimido(5,4-b)indole
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US7595311B2 (en) 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
TWI329111B (en) * 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
CN102379684B (zh) 2005-04-28 2014-11-19 普罗透斯数字保健公司 药物信息系统
FR2901795A1 (fr) * 2006-05-30 2007-12-07 Fourtillan Snc Derives de pyrimidino[1',6'-1,2]pyrido[3,4-b]indoles et leur utilisation en therapeutique
CN101594878A (zh) 2006-09-18 2009-12-02 雷普特药品公司 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗
NZ616673A (en) 2009-02-20 2014-08-29 To Bbb Holding B V Glutathione-based drug delivery system
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1076114A (en) * 1975-02-10 1980-04-22 Mitsubishi Chemical Industries Limited 1,5-alkylene-3-aryl hydantoin derivatives

Also Published As

Publication number Publication date
AU528634B2 (en) 1983-05-05
DE3061648D1 (en) 1983-02-24
IL59128A (en) 1982-07-30
IL59128A0 (en) 1980-05-30
NO794271L (no) 1980-10-28
EP0018857A1 (fr) 1980-11-12
ATE2253T1 (de) 1983-02-15
GR74394B (show.php) 1984-06-28
CA1129854A (en) 1982-08-17
US4358451A (en) 1982-11-09
PT70698A (fr) 1980-02-01
AU5463080A (en) 1980-10-30
EP0018857B1 (fr) 1983-01-19
ES487713A1 (es) 1980-06-16
JPS55145689A (en) 1980-11-13
FR2455039A1 (fr) 1980-11-21
ZA80242B (en) 1980-12-31
DK16980A (da) 1980-10-27

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Legal Events

Date Code Title Description
ST Notification of lapse