FR2455039A1 - Pyrimido et imidazo-pyrido-indole-diones et leur application en therapeutique - Google Patents
Pyrimido et imidazo-pyrido-indole-diones et leur application en therapeutiqueInfo
- Publication number
- FR2455039A1 FR2455039A1 FR7910653A FR7910653A FR2455039A1 FR 2455039 A1 FR2455039 A1 FR 2455039A1 FR 7910653 A FR7910653 A FR 7910653A FR 7910653 A FR7910653 A FR 7910653A FR 2455039 A1 FR2455039 A1 FR 2455039A1
- Authority
- FR
- France
- Prior art keywords
- alkyl
- pyrimido
- imidazo
- diones
- pyrido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- AMBZNXNKAKZDHN-UHFFFAOYSA-N 3,10,12,14-tetrazatetracyclo[7.7.0.02,6.011,15]hexadeca-1,3,5,7,9,11,13,15-octaene Chemical class C1=C2N=CN=C2N=C2C=CC3=CC=NC3=C21 AMBZNXNKAKZDHN-UHFFFAOYSA-N 0.000 abstract 1
- 206010002660 Anoxia Diseases 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- -1 R2=H Chemical group 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000004089 psychotropic agent Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7910653A FR2455039A1 (fr) | 1979-04-26 | 1979-04-26 | Pyrimido et imidazo-pyrido-indole-diones et leur application en therapeutique |
| NO794271A NO794271L (no) | 1979-04-26 | 1979-12-27 | Fremgangsmaate for fremstilling av indol-dioner |
| JP300380A JPS55145689A (en) | 1979-04-26 | 1980-01-14 | Pyrimidoo and imidazoopyridoindole derivative |
| CA343,698A CA1129854A (en) | 1979-04-26 | 1980-01-15 | Process for the preparation of pyrimido- and imidazo derivatives |
| IL59128A IL59128A (en) | 1979-04-26 | 1980-01-15 | Pyrimido-and imidazo-pyrido-indoledione derivatives,their preparation and pharmaceutical compositions containing them |
| PT70698A PT70698A (fr) | 1979-04-26 | 1980-01-15 | Procede de preparation de pyrimid et imidazo-pyrido-indolediones |
| AU54630/80A AU528634B2 (en) | 1979-04-26 | 1980-01-15 | Pyrimido- and imidazo-pyroindole derivatives |
| GR60963A GR74394B (enrdf_load_stackoverflow) | 1979-04-26 | 1980-01-15 | |
| DK16980A DK16980A (da) | 1979-04-26 | 1980-01-15 | Fremgangsmaade til fremstilling af derivater af pyrido og imidazopyridoindoler |
| ZA00800242A ZA80242B (en) | 1979-04-26 | 1980-01-15 | Pyrimido-and imidazo-pyridoindole derivatives for use in therapy |
| ES487713A ES487713A1 (es) | 1979-04-26 | 1980-01-15 | Procedimiento para preparar derivados de pirimido e imida- zo-pirido-indoles |
| US06/112,238 US4358451A (en) | 1979-04-26 | 1980-01-15 | Pyrimido- and imidazo-pyridoindole derivatives |
| EP80400050A EP0018857B1 (fr) | 1979-04-26 | 1980-01-15 | Pyrimido et imidazo-pyrido-indole-diones, leur préparation et leur application en thérapeutique |
| DE8080400050T DE3061648D1 (en) | 1979-04-26 | 1980-01-15 | Pyrimido and imidazo-pyrido-indole-diones, their preparation and therapeutic use |
| AT80400050T ATE2253T1 (de) | 1979-04-26 | 1980-01-15 | Pyrimido und imidazo-pyrido-indol-dione, ihre herstellung und therapeutische verwendung. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7910653A FR2455039A1 (fr) | 1979-04-26 | 1979-04-26 | Pyrimido et imidazo-pyrido-indole-diones et leur application en therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2455039A1 true FR2455039A1 (fr) | 1980-11-21 |
| FR2455039B1 FR2455039B1 (enrdf_load_stackoverflow) | 1983-05-13 |
Family
ID=9224796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7910653A Granted FR2455039A1 (fr) | 1979-04-26 | 1979-04-26 | Pyrimido et imidazo-pyrido-indole-diones et leur application en therapeutique |
Country Status (15)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3246932A1 (de) * | 1982-12-16 | 1984-06-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | Substituierte 5h-pyrimido(5,4-b)indole |
| JP4202250B2 (ja) | 2001-07-25 | 2008-12-24 | バイオマリン ファーマシューティカル インコーポレイテッド | 血液脳関門輸送を調節するための組成物および方法 |
| US7595311B2 (en) | 2002-05-24 | 2009-09-29 | Exelixis, Inc. | Azepinoindole derivatives as pharmaceutical agents |
| TWI329111B (en) | 2002-05-24 | 2010-08-21 | X Ceptor Therapeutics Inc | Azepinoindole and pyridoindole derivatives as pharmaceutical agents |
| CN101287411B (zh) | 2005-04-28 | 2013-03-06 | 普罗秋斯生物医学公司 | 药物信息系统及其用途 |
| FR2901795A1 (fr) * | 2006-05-30 | 2007-12-07 | Fourtillan Snc | Derives de pyrimidino[1',6'-1,2]pyrido[3,4-b]indoles et leur utilisation en therapeutique |
| MX2009002893A (es) | 2006-09-18 | 2009-07-10 | Raptor Pharmaceutical Inc | Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap). |
| CA2752373C (en) | 2009-02-20 | 2017-10-10 | To-Bbb Holding B.V. | Glutathione-based drug delivery system |
| EP2427178B1 (en) | 2009-05-06 | 2023-01-04 | Laboratory Skin Care, Inc. | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1076114A (en) * | 1975-02-10 | 1980-04-22 | Mitsubishi Chemical Industries Limited | 1,5-alkylene-3-aryl hydantoin derivatives |
-
1979
- 1979-04-26 FR FR7910653A patent/FR2455039A1/fr active Granted
- 1979-12-27 NO NO794271A patent/NO794271L/no unknown
-
1980
- 1980-01-14 JP JP300380A patent/JPS55145689A/ja active Pending
- 1980-01-15 US US06/112,238 patent/US4358451A/en not_active Expired - Lifetime
- 1980-01-15 AU AU54630/80A patent/AU528634B2/en not_active Ceased
- 1980-01-15 AT AT80400050T patent/ATE2253T1/de not_active IP Right Cessation
- 1980-01-15 PT PT70698A patent/PT70698A/pt unknown
- 1980-01-15 ZA ZA00800242A patent/ZA80242B/xx unknown
- 1980-01-15 CA CA343,698A patent/CA1129854A/en not_active Expired
- 1980-01-15 IL IL59128A patent/IL59128A/xx unknown
- 1980-01-15 DK DK16980A patent/DK16980A/da not_active Application Discontinuation
- 1980-01-15 EP EP80400050A patent/EP0018857B1/fr not_active Expired
- 1980-01-15 ES ES487713A patent/ES487713A1/es not_active Expired
- 1980-01-15 DE DE8080400050T patent/DE3061648D1/de not_active Expired
- 1980-01-15 GR GR60963A patent/GR74394B/el unknown
Non-Patent Citations (1)
| Title |
|---|
| EXBK/63 * |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2455039B1 (enrdf_load_stackoverflow) | 1983-05-13 |
| IL59128A (en) | 1982-07-30 |
| ES487713A1 (es) | 1980-06-16 |
| JPS55145689A (en) | 1980-11-13 |
| DE3061648D1 (en) | 1983-02-24 |
| AU528634B2 (en) | 1983-05-05 |
| ATE2253T1 (de) | 1983-02-15 |
| NO794271L (no) | 1980-10-28 |
| PT70698A (fr) | 1980-02-01 |
| ZA80242B (en) | 1980-12-31 |
| US4358451A (en) | 1982-11-09 |
| EP0018857A1 (fr) | 1980-11-12 |
| GR74394B (enrdf_load_stackoverflow) | 1984-06-28 |
| EP0018857B1 (fr) | 1983-01-19 |
| IL59128A0 (en) | 1980-05-30 |
| DK16980A (da) | 1980-10-27 |
| CA1129854A (en) | 1982-08-17 |
| AU5463080A (en) | 1980-10-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |