FR2453845A1 - Procede de purification d'esters alkyliques inferieurs de l'a-l-aspartyl-l-phenylalanine - Google Patents

Procede de purification d'esters alkyliques inferieurs de l'a-l-aspartyl-l-phenylalanine

Info

Publication number
FR2453845A1
FR2453845A1 FR8008054A FR8008054A FR2453845A1 FR 2453845 A1 FR2453845 A1 FR 2453845A1 FR 8008054 A FR8008054 A FR 8008054A FR 8008054 A FR8008054 A FR 8008054A FR 2453845 A1 FR2453845 A1 FR 2453845A1
Authority
FR
France
Prior art keywords
aspartyl
phenylalanine
lower alkyl
alkyl esters
purification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8008054A
Other languages
English (en)
Other versions
FR2453845B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Publication of FR2453845A1 publication Critical patent/FR2453845A1/fr
Application granted granted Critical
Publication of FR2453845B1 publication Critical patent/FR2453845B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/801—Peptide sweetners

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

L'INVENTION CONCERNE UN PROCEDE DE PURIFICATION D'ESTERS ALKYLIQUES INFERIEURS DE L'A-L-ASPARTYL-L-PHENYLALANINE. ON MET L'ESTER ALKYLIQUE INFERIEUR DE L'A-L-ASPARTYL-L-PHENYLALANINE EN CONTACT AVEC UNE RESINE ECHANGEUSE D'ANIONS DU TYPE CL DANS UN SOLVANT AQUEUX. LES IMPURETES SONT ALORS ADSORBEES PAR LA RESINE ECHANGEUSE D'ANIONS, ET L'ESTER ALKYLIQUE INFERIEUR DE L'A-L-ASPARTYL-L-PHENYLALANINE EST RECUPERE DANS UN ETAT PURIFIE. LES ESTERS ALKYLIQUES INFERIEURS DE L'A-L-ASPARTYL-L-PHENYLALANINE, EN PARTICULIER L'ESTER METHYLIQUE, SONT INTERESSANTS EN TANT QU'EDULCORANTS.
FR8008054A 1979-04-10 1980-04-10 Procede de purification d'esters alkyliques inferieurs de l'a-l-aspartyl-l-phenylalanine Granted FR2453845A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54043274A JPS6049199B2 (ja) 1979-04-10 1979-04-10 α−Ｌ−アスパルチル−Ｌ−フエニルアラニン低級アルキルエステルの精製法

Publications (2)

Publication Number Publication Date
FR2453845A1 true FR2453845A1 (fr) 1980-11-07
FR2453845B1 FR2453845B1 (fr) 1984-12-07

Family

ID=12659233

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8008054A Granted FR2453845A1 (fr) 1979-04-10 1980-04-10 Procede de purification d'esters alkyliques inferieurs de l'a-l-aspartyl-l-phenylalanine

Country Status (7)

Country Link
US (1) US4309341A (fr)
JP (1) JPS6049199B2 (fr)
CA (1) CA1148943A (fr)
CH (1) CH643531A5 (fr)
DE (1) DE3013701A1 (fr)
FR (1) FR2453845A1 (fr)
GB (1) GB2047711B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032621A1 (fr) * 1998-11-25 2000-06-08 The Nutrasweet Company PROCEDE DE PURIFICATION DE N- [N-(3,3-DIMETHYLBUTYL)L-α-ASPARTYL]L-PHENYLALANINE 1-ESTER METHYLIQUE

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2516077A1 (fr) * 1981-11-06 1983-05-13 Human Pharm Sa Laboratoires Procede de preparation de l'ester-methylique de l'a-aspartyl phenylalanine
JPS58177952A (ja) * 1982-04-12 1983-10-18 Ajinomoto Co Inc Ｌ−α−アスパルチル−Ｌ−フエニルアラニンメチルエステルの晶析法
IT1197461B (it) * 1983-05-13 1988-11-30 Debi Derivati Biologici Procedimento per la preparazione dell'estere metilico di alfa-l-aspartil-l-fenil-alanina
JPH0657719B2 (ja) * 1986-06-03 1994-08-03 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの回収方法
JP2728936B2 (ja) * 1989-06-14 1998-03-18 三井東圧化学株式会社 α―Ｌ―アスパルチル―Ｌ―スェニルアラニンメチルエステルの製造方法
JPH05194587A (ja) * 1992-01-14 1993-08-03 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの精製法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2078640A5 (en) * 1970-02-21 1971-11-05 Beecham Group Ltd Alpha-asparaginyl dipeptides prepn
FR2185630A1 (fr) * 1972-05-25 1974-01-04 Ajinomoto Kk

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1309605A (en) * 1970-01-31 1973-03-14 Ajinomoto Kk Process for producing alpha-dipeptide esters of l-aspartic acid
JPS4941425B1 (fr) * 1970-10-26 1974-11-08
JPS5113737A (en) * 1974-07-23 1976-02-03 Ajinomoto Kk Arufua ll asuparuchiru ll fueniruaraninteikyuarukiruesuteruno seizoho

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2078640A5 (en) * 1970-02-21 1971-11-05 Beecham Group Ltd Alpha-asparaginyl dipeptides prepn
FR2185630A1 (fr) * 1972-05-25 1974-01-04 Ajinomoto Kk

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032621A1 (fr) * 1998-11-25 2000-06-08 The Nutrasweet Company PROCEDE DE PURIFICATION DE N- [N-(3,3-DIMETHYLBUTYL)L-α-ASPARTYL]L-PHENYLALANINE 1-ESTER METHYLIQUE

Also Published As

Publication number Publication date
DE3013701A1 (de) 1980-10-23
JPS55136257A (en) 1980-10-23
CH643531A5 (de) 1984-06-15
CA1148943A (fr) 1983-06-28
FR2453845B1 (fr) 1984-12-07
JPS6049199B2 (ja) 1985-10-31
GB2047711B (en) 1983-02-02
US4309341A (en) 1982-01-05
GB2047711A (en) 1980-12-03
DE3013701C2 (fr) 1989-06-01

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Legal Events

Date Code Title Description
ST Notification of lapse