FR2450256B1 - - Google Patents

Info

Publication number
FR2450256B1
FR2450256B1 FR8000284A FR8000284A FR2450256B1 FR 2450256 B1 FR2450256 B1 FR 2450256B1 FR 8000284 A FR8000284 A FR 8000284A FR 8000284 A FR8000284 A FR 8000284A FR 2450256 B1 FR2450256 B1 FR 2450256B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8000284A
Other languages
French (fr)
Other versions
FR2450256A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Publication of FR2450256A1 publication Critical patent/FR2450256A1/fr
Application granted granted Critical
Publication of FR2450256B1 publication Critical patent/FR2450256B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR8000284A 1979-02-27 1980-01-08 Derives d'acide epoxysuccinique a activite inhibitrice de la thiolprotease neutre activee par du calcium Granted FR2450256A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2236579A JPS55115878A (en) 1979-02-27 1979-02-27 Epoxysuccinic acid derivative

Publications (2)

Publication Number Publication Date
FR2450256A1 FR2450256A1 (fr) 1980-09-26
FR2450256B1 true FR2450256B1 (ja) 1983-05-13

Family

ID=12080591

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8000284A Granted FR2450256A1 (fr) 1979-02-27 1980-01-08 Derives d'acide epoxysuccinique a activite inhibitrice de la thiolprotease neutre activee par du calcium

Country Status (6)

Country Link
US (2) US4333879A (ja)
JP (1) JPS55115878A (ja)
DE (1) DE3000628A1 (ja)
FR (1) FR2450256A1 (ja)
GB (1) GB2046730B (ja)
IT (1) IT1188891B (ja)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57169478A (en) * 1981-04-10 1982-10-19 Nippon Chemiphar Co Ltd Piperazine derivative
JPS6276A (ja) * 1985-03-26 1987-01-06 Toyo Jozo Co Ltd 酵素阻害性新規物質
US5068354A (en) * 1989-05-18 1991-11-26 Taisho Pharmaceutical Co., Ltd. Epoxysuccinic acid derivatives
CA2047226A1 (en) * 1989-12-27 1991-06-28 Jun-Ichi Haruta 1,3,2-dioxathiolane oxide derivative
JP2808877B2 (ja) * 1990-09-29 1998-10-08 大正製薬株式会社 エポキシスクシナム酸誘導体およびその中間体
JPH04120450U (ja) * 1991-04-16 1992-10-28 エヌオーケー株式会社 水耕栽培装置
EP0641563A4 (en) * 1992-05-20 1995-04-19 Taisho Pharmaceutical Co Ltd CATARACT REMEDY AND PROCESS FOR PRODUCING THE SAME.
US5556853A (en) * 1993-10-29 1996-09-17 Takeda Chemical Industries, Ltd. Epoxysuccinic acid derivatives
AU2537695A (en) * 1994-05-31 1995-12-21 Takeda Chemical Industries Ltd. Epoxysuccinic acid derivatives, their production and use
US5733911A (en) * 1996-01-26 1998-03-31 Hitachi Chemical Co., Ltd. Method for inducing death of neoplastic cells using piperazne derivatives
ES2201524T3 (es) * 1997-09-04 2004-03-16 Nippon Chemiphar Co., Ltd. Derivados de epoxisuccinamida.
DE10023430A1 (de) * 2000-05-12 2001-11-15 Bayer Ag Substituierte N-Benzoyl-N'-(tetrazolylphenyl)-harnstoffe
CN100478030C (zh) * 2003-05-08 2009-04-15 北京摩力克科技有限公司 抗传染性非典型性肺炎药物作用靶标及其预防和治疗药物
WO2007038772A1 (en) * 2005-09-28 2007-04-05 American Life Science Pharmaceuticals Novel drugs for dementia
WO2008042480A2 (en) 2006-06-13 2008-04-10 The Board Of Trustees Of The Leland Stanford Junior University Epoxide inhibitors of cysteine proteases
US20100216875A1 (en) * 2006-12-20 2010-08-26 Gregory Hook Methods of treating alzheimer's disease
US9403843B2 (en) * 2012-02-01 2016-08-02 The Trustees Of Columbia University In The City Of New York Cysteine protease inhibitors and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS548759B2 (ja) * 1973-03-06 1979-04-18
GB1469797A (en) * 1974-11-07 1977-04-06 Pfizer Ltd Antibacterial cephalosporin derivatives
GB1595168A (en) 1977-03-03 1981-08-12 Taisho Pharmaceutical Co Ltd Expoxysuccinic acid derivatives
US4091221A (en) * 1977-03-17 1978-05-23 Shell Oil Company 3-(Benzoyl)oxiranecarboxamides

Also Published As

Publication number Publication date
DE3000628A1 (de) 1980-09-04
JPS55115878A (en) 1980-09-06
JPH0154348B2 (ja) 1989-11-17
GB2046730B (en) 1983-05-05
DE3000628C2 (ja) 1988-09-08
FR2450256A1 (fr) 1980-09-26
US4333879A (en) 1982-06-08
IT8047529A1 (it) 1981-07-07
IT1188891B (it) 1988-01-28
GB2046730A (en) 1980-11-19
US4382889A (en) 1983-05-10
IT8047529A0 (it) 1980-01-07

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Legal Events

Date Code Title Description
ST Notification of lapse