FR2444681A1 - NOVEL 1,4-DIHYDROPYRIDINES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS - Google Patents

NOVEL 1,4-DIHYDROPYRIDINES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS

Info

Publication number
FR2444681A1
FR2444681A1 FR7930829A FR7930829A FR2444681A1 FR 2444681 A1 FR2444681 A1 FR 2444681A1 FR 7930829 A FR7930829 A FR 7930829A FR 7930829 A FR7930829 A FR 7930829A FR 2444681 A1 FR2444681 A1 FR 2444681A1
Authority
FR
France
Prior art keywords
novel
preparation
dihydropyridines
medicaments
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7930829A
Other languages
French (fr)
Other versions
FR2444681B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2444681A1 publication Critical patent/FR2444681A1/en
Application granted granted Critical
Publication of FR2444681B1 publication Critical patent/FR2444681B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

L'invention a pour objet de nouvelles 1,4-dihydro-pyridines et leur préparation. Les composés de l'invention répondent à la formule :The subject of the invention is novel 1,4-dihydro-pyridines and their preparation. The compounds of the invention correspond to the formula:

FR7930829A 1978-12-18 1979-12-17 NOVEL 1,4-DIHYDROPYRIDINES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS Granted FR2444681A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1283578A CH639659A5 (en) 1978-12-18 1978-12-18 NEW 1,4-DIHYDROPYRIDINE DERIVATIVES, THEIR PRODUCTION AND USE.

Publications (2)

Publication Number Publication Date
FR2444681A1 true FR2444681A1 (en) 1980-07-18
FR2444681B1 FR2444681B1 (en) 1982-10-29

Family

ID=4386824

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7930829A Granted FR2444681A1 (en) 1978-12-18 1979-12-17 NOVEL 1,4-DIHYDROPYRIDINES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS

Country Status (18)

Country Link
JP (1) JPS5583783A (en)
AU (1) AU536055B2 (en)
BE (1) BE880591A (en)
CH (1) CH639659A5 (en)
CY (1) CY1321A (en)
DE (1) DE2949491A1 (en)
FR (1) FR2444681A1 (en)
GB (2) GB2103203B (en)
HK (1) HK16086A (en)
IE (1) IE49496B1 (en)
IT (1) IT1164097B (en)
KE (1) KE3593A (en)
MY (1) MY8500130A (en)
NL (2) NL193066C (en)
NZ (1) NZ192422A (en)
SE (1) SE445219B (en)
SG (1) SG97585G (en)
ZA (1) ZA796842B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2490092A1 (en) * 1980-09-18 1982-03-19 Sandoz Sa NOVEL PHARMACEUTICAL COMPOSITIONS BASED ON 1,4-DIHYDROPYRIDINE DERIVATIVE

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3022030A1 (en) * 1980-06-12 1981-12-17 Bayer Ag, 5090 Leverkusen 4-THIAZOLE or 4-IMIDAZOLE-SUBSTITUTED, 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS CONTAINING THEM
EP0080220B1 (en) * 1981-11-17 1986-02-19 FISONS plc Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals
ZA83959B (en) * 1982-03-10 1984-09-26 Sandoz Ltd 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
US4414213A (en) * 1982-03-22 1983-11-08 Mead Johnson & Company Dihydropyridyl cyclic imidate esters and their pharmaceutical use
FR2528431B1 (en) * 1982-06-15 1986-01-10 Sandoz Sa NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
IL68975A (en) * 1982-06-15 1987-01-30 Sandoz Ag 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid ester derivatives in optically active form,their preparation and pharmaceutical compositions containing them
JPS5978186A (en) * 1982-10-27 1984-05-04 Yoshitomi Pharmaceut Ind Ltd 1,4-dihydropyridine-3,5-dicarboxylic acid ester derivative
US4794111A (en) * 1984-05-23 1988-12-27 Bayer Aktiengesellschaft Dihydropyridine preparations containing β-blockers
NL194389C (en) * 1984-06-14 2002-03-04 Novartis Ag Process for preparing a solid dispersion of a pharmaceutically active agent that has low water solubility in a solid matrix of a water-soluble polyalkylene glycol as a carrier.
US5260321A (en) * 1984-11-12 1993-11-09 Sandoz Ltd. Use of 1,4-dihydropyridine derivatives and combinations thereof with calcitonins
NL194822C (en) * 1985-10-01 2003-04-03 Novartis Ag Preparation for oral administration with controlled release and method for its preparation.
DE3542794A1 (en) * 1985-12-04 1987-06-11 Bayer Ag ANTI-HYPERTENSIVE COMBINATION PREPARATION
GB8626217D0 (en) * 1986-11-03 1986-12-03 Sandoz Ltd Pharmaceutical compositions
US4816263A (en) * 1987-10-02 1989-03-28 Alza Corporation Dosage form for treating cardiovascular diseases comprising isradipine
KR940003492B1 (en) * 1988-10-27 1994-04-23 주식회사 유한양행 Process for preparation of 1,4 dihydropyridine derivatives
DE4222770A1 (en) * 1992-07-10 1994-01-13 Bayer Ag Light-activated 1- (2-nitrobenzyl) -substituted 1,4-dihydropyridines
CN1649614A (en) 2002-02-22 2005-08-03 新河药品股份有限公司 Active agent delivery systems and methods for protecting and administering active agents
WO2005023787A1 (en) * 2003-09-10 2005-03-17 Shasun Chemicals And Drugs Limited Process for the manufacture of 2,1,3-benzoxadiazole-4-carboxaldehyde
CN103613584B (en) * 2013-11-27 2016-04-27 沈阳药科大学 The method of a kind of Isrodipine synthetic product aftertreatment

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000150A1 (en) * 1977-06-20 1979-01-10 Sandoz Ag Dihydropyridine derivatives, process for their production and pharmaceutical compositions containing them.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670824C3 (en) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridine-33-dicarboxylic acid alkyl ester
FR2320750A1 (en) * 1975-08-12 1977-03-11 Hexachimie 1,4-DIHYDRO PYRIDINES AND THEIR THERAPEUTIC APPLICATION
DE2616991A1 (en) * 1976-04-17 1977-10-27 Bayer Ag Thio-substd. dihydro-pyridine derivs. - coronary vasodilators and antihypertensives prepd. e.g. by reacting dicarbonyl cpds. with amines and thio-substd. ketones
JPS5373327A (en) * 1976-12-13 1978-06-29 Matsushita Electric Ind Co Ltd Power source system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000150A1 (en) * 1977-06-20 1979-01-10 Sandoz Ag Dihydropyridine derivatives, process for their production and pharmaceutical compositions containing them.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2490092A1 (en) * 1980-09-18 1982-03-19 Sandoz Sa NOVEL PHARMACEUTICAL COMPOSITIONS BASED ON 1,4-DIHYDROPYRIDINE DERIVATIVE

Also Published As

Publication number Publication date
AU536055B2 (en) 1984-04-19
IE792445L (en) 1980-06-18
FR2444681B1 (en) 1982-10-29
HK16086A (en) 1986-03-14
SG97585G (en) 1986-07-18
IT1164097B (en) 1987-04-08
DE2949491C2 (en) 1988-10-27
NL193066B (en) 1998-05-06
JPH0369910B2 (en) 1991-11-05
SE7910188L (en) 1980-06-19
KE3593A (en) 1986-02-07
GB2037766A (en) 1980-07-16
GB2037766B (en) 1983-02-16
GB2103203A (en) 1983-02-16
BE880591A (en) 1980-06-13
CY1321A (en) 1986-06-27
NL7909024A (en) 1980-06-20
SE445219B (en) 1986-06-09
GB2103203B (en) 1983-06-08
ZA796842B (en) 1981-07-29
MY8500130A (en) 1985-12-31
IT7951095A0 (en) 1979-12-14
AU5389679A (en) 1980-06-26
NZ192422A (en) 1982-09-14
NL193066C (en) 1998-09-08
CH639659A5 (en) 1983-11-30
NL990014I1 (en) 1999-07-01
JPS5583783A (en) 1980-06-24
IE49496B1 (en) 1985-10-16
DE2949491A1 (en) 1980-06-26

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Legal Events

Date Code Title Description
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0169, 920507

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0169, 791217

CL Concession to grant licences
TP Transmission of property