FR2444680A1 - Nouvelles 1,4-dihydropyridines, leur preparation et leur application comme medicaments - Google Patents
Nouvelles 1,4-dihydropyridines, leur preparation et leur application comme medicamentsInfo
- Publication number
- FR2444680A1 FR2444680A1 FR7930827A FR7930827A FR2444680A1 FR 2444680 A1 FR2444680 A1 FR 2444680A1 FR 7930827 A FR7930827 A FR 7930827A FR 7930827 A FR7930827 A FR 7930827A FR 2444680 A1 FR2444680 A1 FR 2444680A1
- Authority
- FR
- France
- Prior art keywords
- alkyl
- cycloalkyl
- benzothiadiazole
- phenylalkyl
- aminoalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003218 coronary vasodilator agent Substances 0.000 title abstract 2
- LKMLPKOIPUNVKG-UHFFFAOYSA-N 1,2,3-benzothiadiazole-4-carbaldehyde Chemical compound O=CC1=CC=CC2=C1N=NS2 LKMLPKOIPUNVKG-UHFFFAOYSA-N 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 14
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 4
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- FNQJDLTXOVEEFB-UHFFFAOYSA-N 1,2,3-benzothiadiazole Chemical compound C1=CC=C2SN=NC2=C1 FNQJDLTXOVEEFB-UHFFFAOYSA-N 0.000 abstract 1
- SLLFVLKNXABYGI-UHFFFAOYSA-N 1,2,3-benzoxadiazole Chemical compound C1=CC=C2ON=NC2=C1 SLLFVLKNXABYGI-UHFFFAOYSA-N 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 239000005964 Acibenzolar-S-methyl Substances 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 101100440695 Dictyostelium discoideum corB gene Proteins 0.000 abstract 1
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 230000002213 calciumantagonistic effect Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- -1 sulphamoyl Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1289078A CH643841A5 (en) | 1978-12-18 | 1978-12-18 | Novel 1,4-dihydropyridine derivatives, their preparation and use |
| CH1288878A CH640852A5 (en) | 1978-12-18 | 1978-12-18 | 1,4-Dihydropyridine derivatives, their preparation and use |
| CH347279 | 1979-04-11 | ||
| CH562779 | 1979-06-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2444680A1 true FR2444680A1 (fr) | 1980-07-18 |
| FR2444680B1 FR2444680B1 (fi) | 1982-10-15 |
Family
ID=27428632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7930827A Granted FR2444680A1 (fr) | 1978-12-18 | 1979-12-17 | Nouvelles 1,4-dihydropyridines, leur preparation et leur application comme medicaments |
Country Status (6)
| Country | Link |
|---|---|
| AU (1) | AU538515B2 (fi) |
| DK (1) | DK525179A (fi) |
| ES (1) | ES8104276A1 (fi) |
| FI (1) | FI793848A (fi) |
| FR (1) | FR2444680A1 (fi) |
| IT (1) | IT1120900B (fi) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2490092A1 (fr) * | 1980-09-18 | 1982-03-19 | Sandoz Sa | Nouvelles compositions pharmaceutiques a base d'un derive de la 1,4-dihydropyridine |
| FR2493847A1 (fr) * | 1980-11-10 | 1982-05-14 | Sandoz Sa | Nouveaux derives de la 4-(2,1,3-benzoxadiazole-4-yl)-1,4-dihydropyridine, leur preparation et leur application comme medicaments |
| FR2523128A1 (fr) * | 1982-03-10 | 1983-09-16 | Sandoz Sa | Nouveaux derives de la 1,4-dihydropyridine, leur preparation et medicaments contenant ces derives |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI83957C (fi) * | 1984-09-28 | 1991-09-25 | Byk Gulden Lomberg Chem Fab | Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara diarylfoereningar. |
| KR970011302B1 (ko) * | 1992-08-14 | 1997-07-09 | 재단법인 한국화학연구소 | 제초성 퀴놀리닐옥사디아졸 유도체 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0000150A1 (en) * | 1977-06-20 | 1979-01-10 | Sandoz Ag | Dihydropyridine derivatives, process for their production and pharmaceutical compositions containing them. |
-
1979
- 1979-12-10 DK DK525179A patent/DK525179A/da not_active Application Discontinuation
- 1979-12-10 FI FI793848A patent/FI793848A/fi not_active Application Discontinuation
- 1979-12-14 IT IT51096/79A patent/IT1120900B/it active
- 1979-12-17 ES ES486989A patent/ES8104276A1/es not_active Expired
- 1979-12-17 AU AU53897/79A patent/AU538515B2/en not_active Ceased
- 1979-12-17 FR FR7930827A patent/FR2444680A1/fr active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0000150A1 (en) * | 1977-06-20 | 1979-01-10 | Sandoz Ag | Dihydropyridine derivatives, process for their production and pharmaceutical compositions containing them. |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2490092A1 (fr) * | 1980-09-18 | 1982-03-19 | Sandoz Sa | Nouvelles compositions pharmaceutiques a base d'un derive de la 1,4-dihydropyridine |
| FR2493847A1 (fr) * | 1980-11-10 | 1982-05-14 | Sandoz Sa | Nouveaux derives de la 4-(2,1,3-benzoxadiazole-4-yl)-1,4-dihydropyridine, leur preparation et leur application comme medicaments |
| FR2523128A1 (fr) * | 1982-03-10 | 1983-09-16 | Sandoz Sa | Nouveaux derives de la 1,4-dihydropyridine, leur preparation et medicaments contenant ces derives |
Also Published As
| Publication number | Publication date |
|---|---|
| AU5389779A (en) | 1980-07-17 |
| FR2444680B1 (fi) | 1982-10-15 |
| FI793848A (fi) | 1980-06-19 |
| IT7951096A0 (it) | 1979-12-14 |
| ES486989A0 (es) | 1981-04-01 |
| IT1120900B (it) | 1986-03-26 |
| ES8104276A1 (es) | 1981-04-01 |
| DK525179A (da) | 1980-06-19 |
| AU538515B2 (en) | 1984-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |