FR2440375A1 - Derives de nucleoside et leur application therapeutique - Google Patents
Derives de nucleoside et leur application therapeutiqueInfo
- Publication number
- FR2440375A1 FR2440375A1 FR7927023A FR7927023A FR2440375A1 FR 2440375 A1 FR2440375 A1 FR 2440375A1 FR 7927023 A FR7927023 A FR 7927023A FR 7927023 A FR7927023 A FR 7927023A FR 2440375 A1 FR2440375 A1 FR 2440375A1
- Authority
- FR
- France
- Prior art keywords
- therapeutic application
- nucleoside derivatives
- nucleoside
- antileucemic
- guanosine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003833 nucleoside derivatives Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 abstract 2
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 abstract 1
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 abstract 1
- 229920000388 Polyphosphate Polymers 0.000 abstract 1
- 230000005916 anti-leucemic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229940029575 guanosine Drugs 0.000 abstract 1
- 239000001205 polyphosphate Substances 0.000 abstract 1
- 239000002718 pyrimidine nucleoside Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13470878A JPS55102600A (en) | 1978-10-31 | 1978-10-31 | Guanosine derivative, and antileukemic agent containing the same |
| JP256479A JPS5594400A (en) | 1979-01-11 | 1979-01-11 | Guanosine derivative and anti-leukemic agent containing the same |
| JP256579A JPS5594399A (en) | 1979-01-11 | 1979-01-11 | Pyrimidine-nucleoside derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2440375A1 true FR2440375A1 (fr) | 1980-05-30 |
| FR2440375B1 FR2440375B1 (enExample) | 1983-03-04 |
Family
ID=27275413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7927023A Granted FR2440375A1 (fr) | 1978-10-31 | 1979-10-31 | Derives de nucleoside et leur application therapeutique |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4297347A (enExample) |
| DE (1) | DE2944084A1 (enExample) |
| FR (1) | FR2440375A1 (enExample) |
| GB (1) | GB2037289B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5735516A (en) | 1980-08-11 | 1982-02-26 | Yamasa Shoyu Co Ltd | Agent for increasing radiosensitivity or agent for increasing effect of substance having activity similar to radiation |
| JPS61112093A (ja) * | 1984-11-05 | 1986-05-30 | Wakunaga Seiyaku Kk | ヌクレオチド誘導体 |
| US5187266A (en) * | 1986-06-30 | 1993-02-16 | Board Of Regents The University Of Texas System | Antitumor aldophosphamide glycoside and dideoxyuridine derivatives |
| US5654286A (en) * | 1993-05-12 | 1997-08-05 | Hostetler; Karl Y. | Nucleotides for topical treatment of psoriasis, and methods for using same |
| DE19618727C2 (de) * | 1996-05-09 | 2000-02-17 | Deutsches Krebsforsch | Herstellung alkylierter Nucleosid-3'-Phosphate |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2277591A1 (fr) * | 1974-07-11 | 1976-02-06 | Chugai Pharmaceutical Co Ltd | Composition pharmaceutique pour la prevention et le traitement de l'alcoolisme |
| FR2287910A1 (fr) * | 1974-10-15 | 1976-05-14 | Asahi Chemical Ind | Derives nucleotidiques et procede de preparation de ceux-ci |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1433279A (fr) * | 1964-05-19 | 1966-03-25 | Kyowa Hakko Kogyo Kk | Procédé de préparation de l'acide 5'-guanylique |
| US3299042A (en) * | 1964-06-22 | 1967-01-17 | Lipkin David | Iodination of the heterocyclic bases in nucleosides, nucleotides, nucleoside-5'-polyphosphates, and nucleic acids |
| US3475409A (en) * | 1966-07-14 | 1969-10-28 | Asahi Chemical Ind | Process for preparing ribonucleoside-5'-monophosphate |
| US3462416A (en) * | 1967-01-30 | 1969-08-19 | Upjohn Co | Hydrogenated pyrimidine nucleosides and nucleotides |
| US3830798A (en) * | 1968-03-22 | 1974-08-20 | Ralston Purina Co | Hydrolysis of ribonucleic acid containing material |
| US4141972A (en) * | 1974-03-29 | 1979-02-27 | Sanraku-Ocean Co., Ltd. | Purine nucleoside 5'-phosphate (mono, di or tri) 3'(2')-diphosphates and processes for their preparation |
| DE2510327C2 (de) * | 1974-03-29 | 1983-05-05 | Sanraku-Ocean Co., Ltd., Tokyo | Verfahren zur Herstellung von Purinnukleosid-5'-phosphat-(mono-, di- oder tri-)-3'-(2')-diphosphaten |
-
1979
- 1979-10-29 GB GB7937442A patent/GB2037289B/en not_active Expired
- 1979-10-31 US US06/089,887 patent/US4297347A/en not_active Expired - Lifetime
- 1979-10-31 FR FR7927023A patent/FR2440375A1/fr active Granted
- 1979-10-31 DE DE19792944084 patent/DE2944084A1/de not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2277591A1 (fr) * | 1974-07-11 | 1976-02-06 | Chugai Pharmaceutical Co Ltd | Composition pharmaceutique pour la prevention et le traitement de l'alcoolisme |
| FR2287910A1 (fr) * | 1974-10-15 | 1976-05-14 | Asahi Chemical Ind | Derives nucleotidiques et procede de preparation de ceux-ci |
Non-Patent Citations (5)
| Title |
|---|
| CHEMICAL ABSTRACTS, volume 62, No. 10, 10 mai 1965 et SEVENTH COLLECTIVE INDEX, volumes 56 - 65, 1962-1966, page 1169F, réf.: 12234b, COLUMBUS, OHIO (US) & IZV. TSENTR. LAB. BIOKHIM. BULGAR, AKAD. NAUK. 2, 39-46 (1964), L.V. VULCHEVA et al.: 'Fractionation of the free nucleotides from the anterior lobe of bovine hypophysis' * |
| CHEMICAL ABSTRACTS, volume 75, No. 9, 30 août 1971, réf.: 58644c, page 11 COLUMBUS, OHIO (US) & J. BIOL. CHEM. 1971, 246(13), 4371-3, G.EDLIN et al.: 'Synthesis of guanosine 5'-diphosphate, 2'-(or 3'-diphosphate, and related nucleotides in a variety of physiological conditions' * |
| CHEMICAL ABSTRACTS, volume 87, No. 3, 18 juillet 1977, réf.:20602x page 447, COLUMBUS, OHIO (US) & AGRIC. BIOL. CHEM., 1977, 41(4), 641-6, A. SATO et al.: 'Production of nucleic acid related substances by fermentative processes. XLVI. Accumulation of guanosine polyphosphates by Brevibacterium ammoniagenes, conditions for the accumulation' * |
| CHEMICAL ABSTRACTS, volume 90, No. 19, 7 mai 1979, réf.: 147175c, page 180, COLUMBUS, OHIO (US) & PROC. JPN. ACAD., SER. B 1978, 54(10), 645-50, N. KATUNUMA et al.: 'Chemical structure and biological function of amplifying factors of glucocorticoid actions' * |
| CHEMICAL ABSTRACTS, volume 90, No. 19, 7 mai 1979, réf.: 147176d, page 180, COLUMBUS, OHIO (US) & BIOCHEM. BIOPHYS. RES. COMMUN., 1979, 86(2), 420-7, H. KIDO et al.: 'Purification and structure of a new nucleotide from Proteus mirabilis that amplifies induction of tyrosine aminotransferase by glucocorticoid' * |
Also Published As
| Publication number | Publication date |
|---|---|
| US4297347A (en) | 1981-10-27 |
| DE2944084A1 (de) | 1980-06-04 |
| GB2037289B (en) | 1983-05-05 |
| FR2440375B1 (enExample) | 1983-03-04 |
| GB2037289A (en) | 1980-07-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |